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JBJS Case Connect ; 11(3)2021 09 02.
Artigo em Inglês | MEDLINE | ID: mdl-34473664


CASE: A 62-year-old woman with a medical history of nail-patella syndrome (NPS) presented with chronic right shoulder pain. Physical examination revealed that her right shoulder had a restricted range of motion. Radiograph of the shoulder revealed arthritic changes with glenohumeral joint space narrowing, inferior humeral head osteophytes, and posterior glenoid wear. The patient was successfully treated with total shoulder arthroplasty (TSA). The patient had an uneventful postoperative course and was satisfied with her quality of life at the 30-month follow-up. CONCLUSION: TSA may be successfully performed with careful reaming of the hypoplastic glenoid fossa in patients with NPS.

J Pediatr Orthop B ; 29(4): 409-411, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32044858


Stress fractures of the first rib occur infrequently in adolescent athletes; therefore, there have been few case reports. Initial radiographs do not always lead to the diagnosis of first rib stress fractures. This study proposed a classification system and a possible mechanism for stress fractures of the first rib using three-dimensional computed tomography (3D-CT). The data of 10 stress fractures of the first rib in adolescent athletes obtained using 3D-CT between 2007 and 2018 were reviewed. Fractures of the first rib were classified according to the location and type of the fracture line. Stress fractures of the first rib were classified into three types: type 1, center-transverse fracture; type 2, center to posterior-oblique fracture; and type 3, posterior-transverse fracture. There were three type 1 fractures, five type 2 fractures, and two type 3 fractures. The fracture lines of types 1 and 2 were on the deep groove of the subclavian artery between the anterior and middle scalene muscle attachments, which is the thinnest and weakest portion of the first rib. However, the fracture line of type 3 was across the posterior part of the first rib and located slightly away from the deep groove of the subclavian artery. A 3D-CT classification of stress fractures of the first rib in adolescent athletes was proposed. Our results suggested that there are three types of the fracture and different mechanisms that cause this type of injury. This classification system helped to implement adequate conservative therapeutic plans based on the proposed mechanism.

Traumatismos em Atletas , Fraturas de Estresse , Costelas , Tomografia Computadorizada por Raios X/métodos , Adolescente , Traumatismos em Atletas/classificação , Traumatismos em Atletas/diagnóstico , Traumatismos em Atletas/etiologia , Traumatismos em Atletas/terapia , Fenômenos Biomecânicos/fisiologia , Tratamento Conservador/métodos , Feminino , Fraturas de Estresse/classificação , Fraturas de Estresse/diagnóstico , Fraturas de Estresse/etiologia , Fraturas de Estresse/fisiopatologia , Humanos , Imageamento Tridimensional/métodos , Masculino , Seleção de Pacientes , Costelas/diagnóstico por imagem , Costelas/lesões
Brain Res ; 1439: 15-26, 2012 Feb 23.
Artigo em Inglês | MEDLINE | ID: mdl-22265332


Nomifensine is a dopamine/norepinephrine reuptake inhibitor. Nomifensine and some of its structural analogues produce behavioral effects indicative of indirect dopaminergic agonist properties, such as hyperlocomotion. By contrast, the deaminated and demethylated nomifensine analogue 4-phenyl-1,2,3,4-tetrahydroisoquinoline (PTIQ) is reported to have amphetamine-antagonistic properties, as demonstrated by inhibition of methamphetamine (METH)-induced dopamine release in the nucleus accumbens and METH-induced hyperlocomotion in rats. In the present study, we examined the effect of PTIQ (10mg/kg, i.p.) and nomifensine (3mg/kg, i.p.) on METH (5 or 10mg/kg, i.p.)-induced stereotypical behavior in mice in order to determine whether PTIQ and nomifensine inhibit and augment, respectively, METH-induced stereotypical behavior. Unexpectedly, our observations demonstrated that both PTIQ and nomifensine significantly augmented METH-induced stereotypical behavior and locomotion in mice. This augmentation is likely the result of additive effects on dopaminergic function by METH in combination with PTIQ or nomifensine. These results suggest that, contrary to some reports, PTIQ may display dopaminergic agonist properties in mice.

Dopaminérgicos/farmacologia , Metanfetamina/farmacologia , Nomifensina/farmacologia , Comportamento Estereotipado/efeitos dos fármacos , Tetra-Hidroisoquinolinas/farmacologia , Análise de Variância , Animais , Locomoção/efeitos dos fármacos , Masculino , Metanfetamina/administração & dosagem , Camundongos , Camundongos Endogâmicos ICR , Atividade Motora/efeitos dos fármacos , Distribuição Aleatória