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2.
Appl Radiat Isot ; 152: 156-161, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31302533

RESUMO

Meteorites have been arousing the curiosity of mankind since antiquity. However, the interest in these objects goes far beyond mere curiosity in the study of such materials, which has great importance due essentially to the information they can provide. The importance of studying meteorites is associated about the earliest conditions and processes during the formation and earliest history of the solar system. So, in this study, the characterization of two meteorite fragments was performed using X-ray computed microtomography (micro-CT) and X-ray microfluorescence (micro-XRF). These techniques were used for their non-destructive characteristics and the ability to provide information about the structure and composition the meteorites. The micro-CT images showed encrusted structures within both samples. However, while in Lunar meteorites spheroidal structures very similar to small grains internally grouped in clusters were found, in the Martian meteorite a very peculiar structure was identified. Besides that, the micro-CT it was also possible to evaluate the different density materials that compose the samples. The micro-XRF results accounted for the presence of the elements Si, Ca, Ti, Cr, Mn, Fe, Ni and Sr in the Lunar sample, as well as of Si, S, K, Ca, Ti, Cr, Mn, Fe, Cu, Zn, Sr and Y in the Martian sample. The results obtained are effective for the characterization of meteorites, proving thus that it is possible to obtain important information about the chemical composition, as well as about the distribution and the internal structure of these materials, evaluating aspects such as density and porosity.

3.
Sci Rep ; 7: 44348, 2017 03 09.
Artigo em Inglês | MEDLINE | ID: mdl-28276501

RESUMO

Global climate change is likely to constrain low latitude range edges across many taxa and habitats. Such is the case for NE Atlantic marine macroalgal forests, important ecosystems whose main structuring species is the annual kelp Saccorhiza polyschides. We coupled ecological niche modelling with simulations of potential dispersal and delayed development stages to infer the major forces shaping range edges and to predict their dynamics. Models indicated that the southern limit is set by high winter temperatures above the physiological tolerance of overwintering microscopic stages and reduced upwelling during recruitment. The best range predictions were achieved assuming low spatial dispersal (5 km) and delayed stages up to two years (temporal dispersal). Reconstructing distributions through time indicated losses of ~30% from 1986 to 2014, restricting S. polyschides to upwelling regions at the southern edge. Future predictions further restrict populations to a unique refugium in northwestern Iberia. Losses were dependent on the emissions scenario, with the most drastic one shifting ~38% of the current distribution by 2100. Such distributional changes might not be rescued by dispersal in space or time (as shown for the recent past) and are expected to drive major biodiversity loss and changes in ecosystem functioning.


Assuntos
Kelp/fisiologia , Modelos Estatísticos , Feófitas/fisiologia , Dispersão Vegetal/fisiologia , Oceano Atlântico , Biodiversidade , Mudança Climática , Ecossistema , Estações do Ano
4.
Rev. bras. plantas med ; 17(4): 505-514, out.-dez. 2015. tab, graf
Artigo em Português | LILACS | ID: lil-763221

RESUMO

RESUMOO melão de São Caetano, planta trepadeira originaria do leste indiano e sul da Índia, é encontrada no bioma caatinga. Neste trabalho objetivou-se avaliar a biometria dos frutos e o número de sementes por fruto do melão de São Caetano. Os frutos foram coletados em área de vegetação nativa do campus da Universidade Federal Rural do Semi-Árido (UFERSA), situada no município de Mossoró, RN, seguindo para o laboratório de fitotecnia para a determinação das seguintes características: comprimento, diâmetro e peso dos frutos, bem como o número de sementes por fruto. As análises descritivas e gráficas foram realizadas utilizando o pacote estatístico software R-project. As variáveis, comprimento e diâmetro apresentaram baixa amplitude de variação e bons valores de coeficiente de variação. Já o peso do fruto e o número de sementes por fruto mostraram alta amplitude de variação. Verificou-se alto grau de simetria e distribuição mesocúrtica para todas as características avaliadas nesse estudo. Constatou-se também a correlação linear simples positiva significativa entre o comprimento e o diâmetro, e não significativa entre o peso e o número de sementes por fruto, e que os dados referentes a todas as características do fruto do melão de São Caetano avaliadas neste trabalho se ajustaram à distribuição normal de probabilidade, o que permite a realização de inferências com base estatística.


ABSTRACTThe melon from Sao Caetano is a climbing plant, originally from India and South East India and is found in the savanna biome. This study aimed to evaluate the biometric fruit and the number of seeds per fruit of the melon Sao Caetano. The fruits were collected inside a native vegetation area of the campus at the Universidade Federal Rural do Semi-Árido (UFERSA), located in the city of Mossoró, RN. They were then taken to the laboratory of crop science, for the determination of the following characteristics: length, diameter and fruit weight as well as number of seeds per fruit. The descriptive and graphical analyzes were performed by using the statistical package R -project software. The length and diameter variables exhibited a low amplitude variation and a good value for the coefficient of variation. However, the fruit weight and number of seeds per fruit showed a high amplitude variation. There was a high degree of symmetry and a flattened distribution for all traits evaluated in this study. It was also found significant positive simple linear correlation between the length and diameter, and no significant difference between the weight and number of seeds per fruit. The data related to all features of the São Caetano melon fruit evaluated in this study were adjusted to normal distribution of probability which allows the performance of interferences with statistical basis.


Assuntos
Biometria/métodos , Frutas/classificação , Momordica charantia/anatomia & histologia , Sementes/classificação , Estatística
5.
Rev. bras. plantas med ; 17(3): 462-467, Jul-Sep/2015. tab, graf
Artigo em Português | LILACS | ID: lil-752544

RESUMO

RESUMO O uso de esterco bovino é de suma importância para os agricultores familiares que produzem coentro na região de Mossoró-RN, pois esse insumo é amplamente disponível e utilizado pelos agricultores. Objetivando-se avaliar o Rendimento do coentro fertilizado com esterco bovino em diferentes doses e tempos de incorporação ao solo foi conduzido um experimento no período de setembro a novembro de 2011, na Fazenda Experimental Rafael Fernandes, da Universidade Federal Rural do Semi-Árido - UFERSA, Brasil. Os tratamentos consistiram da combinação de quatro doses de esterco bovino incorporadas ao solo: 15,0; 30,0; 45,0 e 60,0 t ha-1 em base seca, com quatro tempos de incorporação: 28; 49; 64 e 80 dias antes da semeadura do coentro - DAS, mais um tratamento controle (ausência de adubação). O delineamento experimental utilizado foi em blocos completos casualizados com os tratamentos arranjados em esquema fatorial 4 x 4 + 1 com 3 repetições. A cultivar de coentro utilizado foi a Verdão e as variáveis determinadas foram altura e número de hastes por planta e rendimento de coentro. O coentro respondeu à aplicação de esterco bovino, produzindo rendimentos máximos de 6453 e 6349 kg ha-1 de massa verde, com a dose de 60 t ha-1 e aos quarenta e seis dias de incorporação antes da semeadura, respectivamente.


ABSTRACT The use of manure is very important to family farmers who produce coriander in the region of Mossoró-RN, because this input is widely available and used by farmers. Aiming to evaluate the yield of the coriander fertilized with manure at different doses and incorporation times in the soil, a trial was conducted from September to November 2011, at the Experimental Farm Rafael Fernandes in the Universidade Federal Rural do Semi-Árido (UFERSA), Mossoró-RN, Brazil. The treatments consisted on the combination of four levels of manure incorporated into the soil: 15.0; 30.0; 45.0 and 60.0 t ha-1 at dry basis, with four incorporation times: 28; 49; 64 and 80 days before the coriander"s sowing - DAS, plus a control treatment (without fertilization). The experimental design was a randomized complete block with treatments arranged in a 4 x 4 + 1, with three replications. The coriander planted was the "Verdão" and the specific variables were height and number of stalks per plant and yield of the coriander. The coriander responded to the application of the manure, producing maximum yields of 6453 and 6349 kg ha-1 of fresh mass, with the dose of 60 t ha-1 and at forty-six days of incorporation before the sowing, respectively.


Assuntos
Coriandrum/crescimento & desenvolvimento , Esterco/análise , Solo/classificação , Verduras/classificação
6.
Appl Radiat Isot ; 94: 182-190, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25216366

RESUMO

Microtomographic (µCT) and thin section (TS) images were analyzed and compared regarding porosity and its distribution along the samples. The results show that µCT, although limited by its resolution, shows relevant information about the distribution of porosity and quantification of connected and non-connected pores. TS have no limitations concerning resolution, but are limited by the experimental data and can only give information about connected pores. These two methods have their own advantages but when paired together they are able to make for a more complete analysis.

7.
Mol Ecol ; 23(11): 2797-810, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24766057

RESUMO

The climate-driven dynamics of species ranges is a critical research question in evolutionary ecology. We ask whether present intraspecific diversity is determined by the imprint of past climate. This is an ongoing debate requiring interdisciplinary examination of population genetic pools and persistence patterns across global ranges. Previously, contrasting inferences and predictions have resulted from distinct genomic coverage and/or geographical information. We aim to describe and explain the causes of geographical contrasts in genetic diversity and their consequences for the future baseline of the global genetic pool, by comparing present geographical distribution of genetic diversity and differentiation with predictive species distribution modelling (SDM) during past extremes, present time and future climate scenarios for a brown alga, Fucus vesiculosus. SDM showed that both atmospheric and oceanic variables shape the global distribution of intertidal species, revealing regions of persistence, extinction and expansion during glacial and postglacial periods. These explained the distribution and structure of present genetic diversity, consisting of differentiated genetic pools with maximal diversity in areas of long-term persistence. Most of the present species range comprises postglacial expansion zones and, in contrast to highly dispersive marine organisms, expansions involved only local fronts, leaving distinct genetic pools at rear edges. Besides unravelling a complex phylogeographical history and showing congruence between genetic diversity and persistent distribution zones, supporting the hypothesis of niche conservatism, range shifts and loss of unique genetic diversity at the rear edge were predicted for future climate scenarios, impoverishing the global gene pool.


Assuntos
Clima , Fucus/genética , Pool Gênico , Variação Genética , Oceano Atlântico , Genética Populacional , Modelos Genéticos , Filogeografia , Dinâmica Populacional
8.
Appl Radiat Isot ; 70(7): 1272-6, 2012 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-22206910

RESUMO

Bone quality is an evaluation index often applied in order to interpret clinical observations made upon bone health, such as bone mineral density, micro and macro architecture, and mineral content. Conventional inspection techniques do not provide full information on trabecular bone quality. This study shows the high resolution potential and the non-destructive character of X-ray microtomography and microfluorescence upon the application of such techniques for evaluating bone quality. The mineral content assessment was performed by two-dimensional concentration mappings of calcium, zinc, and strontium. The results showed significant changes in bone morphology.

9.
Phytopathology ; 100(2): 172-82, 2010 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-20055651

RESUMO

ABSTRACT The basidiomycetous fungus Rhizoctonia solani anastomosis group (AG)-1 IA is a major pathogen in Latin America causing sheath blight (SB) of rice. Particularly in Venezuela, the fungus also causes banded leaf and sheath blight (BLSB) on maize, which is considered an emerging disease problem where maize replaced traditional rice-cropping areas or is now planted in adjacent fields. Our goals in this study were to elucidate (i) the effects of host specialization on gene flow between sympatric and allopatric rice and maize-infecting fungal populations and (ii) the reproductive mode of the fungus, looking for evidence of recombination. In total, 375 isolates of R. solani AG1 IA sampled from three sympatric rice and maize fields in Venezuela (Portuguesa State) and two allopatric rice fields from Colombia (Meta State) and Panama (Chiriquí State) were genotyped using 10 microsatellite loci. Allopatric populations from Venezuela, Colombia, and Panama were significantly differentiated (Phi(ST) of 0.16 to 0.34). Partitioning of the genetic diversity indicated differentiation between sympatric populations from different host species, with 17% of the total genetic variation distributed between hosts while only 3 to 6% was distributed geographically among the sympatric Venezuelan fields. We detected symmetrical historical migration between the rice- and the maize-infecting populations from Venezuela. Rice- and maize-derived isolates were able to infect both rice and maize but were more aggressive on their original hosts, consistent with host specialization. Because the maize- and rice-infecting populations are still cross-pathogenic, we postulate that the genetic differentiation was relatively recent and mediated via a host shift. An isolation with migration analysis indicated that the maize-infecting population diverged from the rice-infecting population between 40 and 240 years ago. Our findings also suggest that maize-infecting populations have a mainly recombining reproductive system whereas the rice-infecting populations have a mixed reproductive system in Latin America.


Assuntos
Interações Hospedeiro-Patógeno , Oryza/microbiologia , Rhizoctonia/genética , Zea mays/microbiologia , Frequência do Gene , Especiação Genética , Genótipo , América Latina , Repetições de Microssatélites , Dinâmica Populacional , Rhizoctonia/patogenicidade
10.
Genet Mol Res ; 8(4): 1519-24, 2009 Dec 23.
Artigo em Inglês | MEDLINE | ID: mdl-20082264

RESUMO

One hundred and fifteen unrelated Mangalarga Marchador horses were sampled from three geographically distinct regions of Minas Gerais State, Brazil (South, Southeast, and Northeast) and tested for 10 microsatellite loci. Genetic diversity and population structure parameters were estimated with ARLEQUIN 3.0, CERVUS 2.0, POPGENE 1.31, GENEPOP on the web, STRUCTURE 2.0, and SPAGEDI 1.2 software packages. Under Hardy-Weinberg assumptions, seven markers were at equilibrium (LEX014, LEX017, LEX019, SGCV23, TKY321, VHL20, and VIASH39), while two (ASB3 and LEX031) presented significant homozygote excess. Seventy-four alleles were identified in these nine markers, with a mean of 8.22 alleles. Mean heterozygosity was 0.637 and polymorphism information content was 0.662. Markers ASB3, LEX019, SGCV23, TKY321, and VHL20 were highly informative (PIC >0.7) and may be useful for eventual expansion of parentage test panels. The F(ST) value (0.0562) indicated relatively little geographical structure. However, based on a Bayesian-based cluster analysis under a three-cluster model, 94% of the 115 individuals were correctly assigned to the subpopulations from where they were sampled. Mean pairwise f was relatively high (0.11), and in spite of the efforts towards non-consanguineous sampling, 1% of the pairs of individuals shared over 50% of the alleles. These results strongly suggest that the population is genetically structured. Under a conservation genetics approach, two strategies are recommended: avoidance of crosses between highly endogamic individuals and stimulation of crosses between individuals from those regions for which low genetic flow was identified.


Assuntos
Variação Genética , Genética Populacional , Cavalos/genética , Animais , Endogamia
11.
Mol Ecol Resour ; 8(3): 686-9, 2008 May.
Artigo em Inglês | MEDLINE | ID: mdl-21585871

RESUMO

Ten polymorphic microsatellite loci were isolated and characterized from the rice- and maize-infecting Basidiomycete fungus Rhizoctonia solani anastomosis group AG-1 IA. All loci were polymorphic in two populations from Louisiana in USA and Venezuela. The total number of alleles per locus ranged from four to eight. All 10 loci were also useful for genotyping soybean-infecting R. solani AG-1 isolates from Brazil and USA. One locus, TC06, amplified across two other AG groups representing different species, showing species-specific repeat length polymorphism. This marker suite will be used to determine the global population structure of this important pathogenic fungus.

12.
Food Chem Toxicol ; 45(10): 1975-8, 2007 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-17574317

RESUMO

In the present work we evaluated both the mutagenicity and antimutagenicity of the Pothomorphe umbellata root extract (PUE) and its isolated active principle, the 4-nerolidylcatechol (4-NC), in bone marrow cells of mice using the micronucleus test. Swiss male mice were orally treated for 4 days with PUE (200, 100 or 50mg/kg/day) or 4-NC (50, 25 or 12.5mg/kg/day) prior to exposition with a single dose (200mg/kg) of cyclophosphamide (CP), 24h after the end of the treatment. The results demonstrated that the PUE and 4-NC did not have any mutagenic effect on mouse bone marrow cells; quite the opposite, there was a protective effect against genotoxicity induced by cyclophosphamide. Taken together, under the conditions tested herein, mice treated with PUE and 4-NC showed, in a dose-dependent manner, protective effect against CP-induced genotoxicity. Due to their ability to prevent chromosomal damage, with apparent low toxicity and cost, PUE or pure 4-NC are likely to open a field of interest concerning their possible use in clinical applications.


Assuntos
Antimutagênicos , Antineoplásicos Alquilantes/antagonistas & inibidores , Antineoplásicos Alquilantes/toxicidade , Catecóis/farmacologia , Ciclofosfamida/antagonistas & inibidores , Ciclofosfamida/toxicidade , Mutagênicos , Piperaceae/química , Animais , Aberrações Cromossômicas/efeitos dos fármacos , Relação Dose-Resposta a Droga , Eritrócitos/efeitos dos fármacos , Eritrócitos/ultraestrutura , Masculino , Camundongos , Testes para Micronúcleos , Extratos Vegetais/química , Raízes de Plantas/química
13.
Res Vet Sci ; 80(2): 209-17, 2006 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-16112696

RESUMO

Palicourea species may produce bovine toxicity. Palicourea corymbifera grows in terra firme forests within the Amazon rain forest and in Tropical America, particularly in spots that gave place to gazing areas. The lyophilized extract done with the aerial organs of P. corymbifera were analyzed in male and female mice. Results revealed a significant toxicity: LD50 was 1.10 (1.04-1.15)g/kg for male mice, and 1.05 (1.00-1.10)g/kg for female mice. Locomotion was affected as well as there were reflexes linked to environmental stimuli in addition to changes in posture. Progressive central nervous system stimulus signs such as trembling and convulsions were detected, the latter followed by the animal's death. Macroscopic histopathological exams performed on the liver, kidneys and lungs of mice submitted to necropsy did not indicate the existence of lesions. General activity of animals, measured in an open field, was reduced as a result of the administration of the extract. Duration of locomotion and rearing frequency were reduced, in opposition to an increase in the duration of immobility. Thin layer chromatography analysis showed that monofluoroacetic acid is present in the lyophilized extract, but other qualitative techniques as gas chromatography/mass spectrometry and 19F nuclear magnetic resonance showed that the MFAA was not present in the extract, and that the toxicity is related to other compound, although the toxic profile is very similar to that of MFAA. P. corymbifera was shown to be significantly toxic to laboratory animals and investigation of the possible toxic substance shall be done.


Assuntos
Extratos Vegetais/toxicidade , Rubiaceae/toxicidade , Animais , Relação Dose-Resposta a Droga , Feminino , Dose Letal Mediana , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Atividade Motora/efeitos dos fármacos , Plantas Tóxicas/toxicidade
14.
Climacteric ; 6(4): 321-9, 2003 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-15006253

RESUMO

OBJECTIVE: To assess the influence of psychosocial factors, behavior and hormones on postmenopausal sexuality. METHODS: Nine hundred and ninety-nine women (age range 41-60 years) underwent physical and supplementary tests and answered questionnaires regarding sexual behavior. Sixty healthy women with 1 or more years of amenorrhea, without hormone replacement therapy and with a partner capable of intercourse were chosen from this group. Logistic regression models with dependent variables (sexual satisfaction and orgasmic capacity) and independent variables (sexual initiation, psychosocial factors, behavior, relationship, menopause and hormones) were developed. RESULTS: Important variables for sexual satisfaction were: good self-esteem (p< 0.01), first orgasm obtained by masturbation (p = 0.004), major personal income (p = 0.007), sexual initiation in adulthood (p = 0.008), value physical contact with partner (p = 0.021) and major orgasmic capacity p = 0.040). The following contributed (towards orgasmic capacity with the partner: sexual initiation in adulthood (p = 0.012), regular physical activity (p = 0.040) and higher testosterone levels (p = 0.050). CONCLUSIONS: The importance of relationship, psychological, hormonal, economic and behavioral factors confirm the complexity of sexuality, and we note that current as well as prior events seem to affect the sexual satisfaction and orgasmic capacity of healthy postmenopausal women.


Assuntos
Pós-Menopausa , Sexualidade , Adulto , Fatores Etários , Feminino , Humanos , Modelos Logísticos , Pessoa de Meia-Idade , Atividade Motora , Autoimagem , Comportamento Sexual , Parceiros Sexuais , Fatores Socioeconômicos , Inquéritos e Questionários , Testosterona/sangue
15.
Arq Neuropsiquiatr ; 57(1): 6-13, 1999 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-10347716

RESUMO

We evaluated the epidemiological, clinical, laboratory and therapeutical aspects of 41 patients with thymomatous myasthenia gravis. Thirty five patients (85.36%) were submitted to thymectomy. Follow-up ranged from two to 18 years. Diagnosis of thymoma was based upon clinical investigations and CT scan of the anterior mediastinum and in 11 patients supported by immunological tests of anti-striated muscle antibodies with a positive result in more than 80% of cases. Histopathologic examination of all thymomectomized patients confirmed the diagnosis of thymoma. There was a significant predominance of benign over malignant thymoma. Occurred higher prevalence of male patients and of patients over 40 years of age. The therapeutical strategy to control myasthenic clinical findings was the same as that for non-thymomatous myasthenia gravis. The corticosteroids associated to cytotoxic drugs were less often used. Radiotherapy of the anterior mediastinum was more often used in patients having invasive tumors submitted to surgery or not. With regard to survival and control of myasthenia gravis, especially in younger patients and in those submitted to early surgery, results of treatment were surprisingly favorable.


Assuntos
Miastenia Gravis/complicações , Timoma/complicações , Neoplasias do Timo/complicações , Adulto , Idoso , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Miastenia Gravis/cirurgia , Timoma/cirurgia , Neoplasias do Timo/cirurgia
16.
Mudanças ; 6(9): 13-28, 1998.
Artigo | Index Psicologia - Periódicos técnico-científicos | ID: psi-15951

RESUMO

O presente estudo tem o objetivo de verificar a presenca de dogmatismo entre estudantes universitarios e se esta caracteristica varia de acordo com o curso escolhido pelos sujeitos. Parte do pressuposto de que os mais dogmaticos teriam mais dificuldades em se adaptar em equipes de trabalho do mercado profissional. Foram submetidos a Escala de Dogmatismo forma E de Rokeach, adaptacao brasileira, 300 sujeitos matriculados no 3 ano, as idades variando de 19 a 50 anos. Os resultados apontam para incidencia estatisticamente normal. Entretanto, os futuros dentistas, administradores com habilitacao em Comercio Exterior e publicitarios sao significativamente mais dogmaticos do que futuros psicologos e jornalistas, confirmando a hipotese inicial. Foi feita uma analise de itens, e os resultados apontam para a adequacao da versao da Escala utilizada na pesquisa.


Assuntos
Socialização , Ocupações , Socialização , Ocupações
17.
Appl Radiat Isot ; 48(10-12): 1437-42, 1997.
Artigo em Inglês | MEDLINE | ID: mdl-9463870

RESUMO

The microfocus radiography system has been realized by means of a microfocus X-ray tube (maximum 160 kV), an image intensifier data collector and a five degree of freedom manipulation table. An 8-bit image acquisition PC-card and software were included to compose the microtomography system. To assemble the system, an image quantitative analysis was carried out by evaluation of the focal spot size, modulation transfer function of the system, and the 'defect discernibility curves'. The 2D microtomographies were carried out using the mean of 10 image central lines in each projection. Image processing techniques were also used to obtain better results. The image reconstruction program is based on a filtered backprojection algorithm using a special window. Images of various types of samples were carried out in order to verify the performance of the system.


Assuntos
Tomografia Computadorizada por Raios X/métodos , Processamento de Imagem Assistida por Computador/métodos , Tomografia Computadorizada por Raios X/instrumentação
18.
Arq Neuropsiquiatr ; 54(4): 601-7, 1996 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-9201341

RESUMO

Myasthenic gravis may affect both inspiratory and expiratory muscles. Respiratory involvement occurred in almost all patients with myasthenia gravis in all clinical forms of the disease: 332 lung function tests done in 324 myasthenic patients without respiratory symptoms (age 34.6 +/- 18.3 years) were examined. Lung volumes analysis showed that all the patients of both sexes with generalized or ocular myasthenia gravis showed "myasthenic pattern". Male patients with "ocular" form only presented the "myasthenic pattern" with lung impairment and had, from the lung function point of view, a more benign behaviour. Female patients with the "ocular" form exhibited a behaviour of respiratory variables similar to that of the generalized form. It was not observed modification of the variables that suggested obstruction of the higher airways. The "myasthenic pattern" was rarely observed in other neuromuscular diseases, except in patients with laryngeal stenosis.


Assuntos
Miastenia Gravis/diagnóstico , Miastenia Gravis/fisiopatologia , Respiração , Adulto , Feminino , Fluxo Expiratório Forçado , Humanos , Medidas de Volume Pulmonar , Masculino , Ventilação Pulmonar , Volume Residual , Capacidade Vital
19.
Arq Neuropsiquiatr ; 52(3): 376-85, 1994 Sep.
Artigo em Português | MEDLINE | ID: mdl-7893213

RESUMO

It is synthetized the evolution of the researches on myasthenia gravis at the Department of Neurology of the Hospital das Clínicas of the Faculty of Medicine, Medical School of the University of São Paulo (Brazil) between 1950 and 1992. The most important results observed about therapeutical, clinical and pathophysiological researches are reviewed. Immunologic studies and advances on molecular biology are emphasized.


Assuntos
Miastenia Gravis/história , Brasil , História do Século XX , Hospitais Universitários , Humanos , Miastenia Gravis/diagnóstico , Miastenia Gravis/imunologia , Miastenia Gravis/terapia
20.
Auris Nasus Larynx ; 21(4): 215-8, 1994.
Artigo em Inglês | MEDLINE | ID: mdl-7779022

RESUMO

Ten patients with atrophy of the tongue, from a group of 752 with generalized acquired myasthenia gravis (MG), were studied. Tongue atrophy developed late in the majority of patients and was accompanied by tongue paresis (70% of the cases) and eventually associated to atrophy of other muscles of the palate, especially the uvula. All the patients exhibited severe forms of MG with bulbar involvement, mainly persistent dysphonia and dysphagia, almost always refractory to treatment. There is no correlation among atrophy of the tongue, sex, and thymus pathology. There is correlation between severeness of symptoms and early, persistent and treatment refractory dysphonia and dysphagia.


Assuntos
Transtornos da Articulação/etiologia , Atrofia Muscular/etiologia , Atrofia Muscular/fisiopatologia , Miastenia Gravis/complicações , Língua/fisiopatologia , Adulto , Idade de Início , Transtornos de Deglutição/etiologia , Feminino , Humanos , Imunossupressores/uso terapêutico , Masculino , Pessoa de Meia-Idade , Miastenia Gravis/tratamento farmacológico , Oftalmoplegia/etiologia , Prednisona/uso terapêutico , Índice de Gravidade de Doença , Timectomia , Timo/cirurgia , Resultado do Tratamento , Úvula/fisiopatologia , Distúrbios da Voz/etiologia
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