Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 11 de 11
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Pharmacol Res Perspect ; 9(1): e00705, 2021 02.
Artigo em Inglês | MEDLINE | ID: mdl-33421347

RESUMO

Drug-drug interaction (DDI) is a common clinical problem that has occurred as a result of the concomitant use of multiple drugs. DDI may occur in patients under treatment with medications used for coronavirus disease 2019 (COVID-19; i.e., chloroquine, lopinavir/ritonavir, ribavirin, tocilizumab, and remdesivir) and increase the risk of serious adverse reactions such as QT-prolongation, retinopathy, increased risk of infection, and hepatotoxicity. This review focuses on summarizing DDIs for candidate medications used for COVID-19 in order to minimize the adverse reactions.


Assuntos
Antivirais/uso terapêutico , /tratamento farmacológico , Animais , Anticorpos Monoclonais Humanizados/uso terapêutico , Cloroquina/uso terapêutico , Interações Medicamentosas , Humanos , Lopinavir/uso terapêutico , Ribavirina/uso terapêutico , Ritonavir/uso terapêutico
2.
Arch Bone Jt Surg ; 8(2): 204-208, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32490052

RESUMO

Intrathoracic displacement of the humeral head is a very uncommon condition and can be life threatening due to lung or heart injuries. There is a report of this condition where intrathoracic bone fragment was missed. Because of rare incidence there is no guideline for approach and treatment of this condition. We hereby present a case of intrathoracic displacement of fractured humeral head in a man due to a car roll-over accident. This condition requires a concise team workup of trauma and orthopedic surgeons along with the physical therapists for the best possible decision making. Displaced fractured humoral head into the thorax is a rare condition that needs more punctuality for on time diagnosis and team approach.

3.
Asian J Surg ; 43(1): 322-329, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31280997

RESUMO

BACKGROUND: It has been shown that N-acetylcysteine may be useful in correcting postoperative hepatic and renal function in many pathological conditions. The present study aimed to examine the effect of N-acetylcysteine on liver and kidney function tests after surgical bypass in patients with obstructive jaundice. METHODS: & Materials: A total of 30 patients with obstructive jaundice who were candidates for bypass surgery were enrolled in this randomized clinical trial. In the case group, intravenous N-acetylcysteine (200 mg/kg per hour in the first 8 h, followed by 100 mg/kg per hour for another 16 h, the same dose for another 24 h) was administered postoperatively. Liver and renal function tests (serum AST, ALT, ALP, GGT, bilirubin, and creatinine) were compared between two groups, as well as duration of hospitalization and ICU stay. RESULTS: Postoperatively, decrease in mean serum AST (p = 0.01), ALT (p = 0.02), ALP (p = 0.01), GGT (p = 0.04) and bilirubin (total, p = 0.02, direct, p = 0.01) levels compared to the preoperative values was significantly more among cases compared to those in controls. Changes in serum creatinine, however, did not differ significantly between two groups (p = 0.18). Hospital and ICU stays were also not different between two study groups (p = 0.27 and p = 0.94 respectively). CONCLUSION: On the basis of our findings, intravenous N-acetylcysteine in patients with obstructive jaundice could significantly preserve liver function after bypass surgery. Effect of this medication on renal function; however, was not statistically significant. TRIAL REGISTRATION: Iranian Registry of Clinical Trial: IRCT2016041016473N7.


Assuntos
Acetilcisteína/farmacologia , Procedimentos Cirúrgicos do Sistema Biliar/métodos , Icterícia Obstrutiva/fisiopatologia , Icterícia Obstrutiva/cirurgia , Testes de Função Renal , Rim/fisiopatologia , Testes de Função Hepática , Fígado/fisiopatologia , Acetilcisteína/administração & dosagem , Idoso , Feminino , Humanos , Infusões Intravenosas , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Cuidados Pós-Operatórios , Fatores de Tempo
4.
BMC Surg ; 19(1): 76, 2019 Jul 04.
Artigo em Inglês | MEDLINE | ID: mdl-31272434

RESUMO

BACKGROUND: An orbitocranial injury with a penetrating Intraorbital Foreign Body (IOFB) is listed as a rare cause of penetrating trauma. Since this type of trauma is considered a surgical emergency, taking a thorough history along with careful examination to find out the mechanism and cause of the trauma is crucial towards correct diagnosis and management of the disease. CASE PRESENTATION: A 35-year-old male patient was presented to the ER with an occupational craniofacial injury because of an IOFB. The patient underwent an extra-dural orbitocranial craniotomy procedure to remove the foreign body. Interestingly, a plastic foreign body (a piece of a plastic pipe) was removed from the orbital cavity, which was suspected to be a fractured orbital bone, at first place. CONCLUSION: In this study, we demonstrated that plastics could mimic bone structure in a Computerized Tomography (CT) scan leading to possible initial misdiagnosis. Hence high clinical suspicion is necessary for the correct diagnosis of such cases. However, despite the prompt intervention, our patient ended up with permanent vision loss in his injured eye.


Assuntos
Corpos Estranhos no Olho/diagnóstico por imagem , Corpos Estranhos no Olho/cirurgia , Ferimentos Oculares Penetrantes/diagnóstico por imagem , Traumatismos Cranianos Penetrantes/diagnóstico por imagem , Traumatismos Ocupacionais/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Adulto , Cegueira/etiologia , Craniotomia/métodos , Erros de Diagnóstico , Ferimentos Oculares Penetrantes/cirurgia , Traumatismos Cranianos Penetrantes/cirurgia , Humanos , Masculino , Traumatismos Ocupacionais/cirurgia , Traumatismos do Nervo Óptico/etiologia , Traumatismos do Nervo Óptico/cirurgia , Órbita/diagnóstico por imagem , Órbita/lesões , Fraturas Orbitárias/diagnóstico por imagem , Fraturas Orbitárias/cirurgia , Resultado do Tratamento
5.
Asian J Surg ; 42(11): 963-968, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30792049

RESUMO

BACKGROUND/OBJECTIVE: Delayed gastric emptying (DGE) is one of the most frequent complications after pyloric preserving pancreaticoduodenectomy (PPPD). The aim of this study is to evaluate the effect of antecolic versus retrocolic reconstruction of gastroentric anastomosis on DGE after PPPD. METHODS: 30 patients with diagnosis of operable periampullary malignancies who candidate for PPPD, randomized in two equal groups. Gastroentric reconstruction were done in two methods: antecolic and retrocolic. All data were collected by the same person who was completely blinded to the type of the procedure. Duration of the surgery, volume of bleeding and total volume of intraoperative blood product transfusion, time to nasogastric tube (NGT) removal, time to solid fluid toleration, volume of NGT secretions, need for NGT reinsertion, daily nausea after NGT extraction, fistula or leakage, gastric leakage, biliary leakage, postoperative abdominal or gastrointestinal bleeding requiring another operation, wound infection, intra-abdominal abscess, and any other systemic complications were measured and then analysed with SPSS software. RESULTS: According to the results, there was no significant differences between antecolic and retrocolic groups in terms of DGE (p = 0.75). Also, there were no significant differences between two groups in terms of duration of operation, volume of bleeding, blood product requirement, volume of NGT secretions, time to NGT removal, number of NGT re-insertion, time to tolerate solid foods, number of days of vomiting after NGT removal, total hospital stay. CONCLUSION: The route of gastroentric (antecolic and retrocolic) reconstruction has no impact on DGE after PPPD.


Assuntos
Ampola Hepatopancreática , Neoplasias do Ducto Colédoco/cirurgia , Duodenostomia , Esvaziamento Gástrico , Gastroparesia , Jejunostomia , Tratamentos com Preservação do Órgão , Pancreaticoduodenectomia/efeitos adversos , Complicações Pós-Operatórias/cirurgia , Piloro , Adulto , Idoso , Anastomose Cirúrgica , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pancreaticoduodenectomia/métodos , Adulto Jovem
6.
Asian Pac J Cancer Prev ; 19(5): 1277-1280, 2018 May 26.
Artigo em Inglês | MEDLINE | ID: mdl-29801534

RESUMO

Background: Caspases proteins are protease enzymes involved in the initiation and execution of apoptosis process. Regulation of apoptosis process plays an important role in the normal biological events and development. In addition to developmental abnormalities, dysregulated apoptosis system may lead to tumorigenesis, autoimmunity, and other serious health problems. Aberrant regulation of apoptosis may also be the paramount cause of chemoresistance during cancer therapy. It is aimed through this study to evaluate the transcript levels of Caspase 3, 8, and 9 in tumoral tissues from patients with colorectal cancer (CRC) and compare it with normal marginal tissues. Methods: Fifty tumor tissues and their matched marginal tissues, as control group, were obtained from CRC patients. Total mRNA of all tissue samples was extracted and cDNA was synthesized. Using SYBR Green PCR master mix and Real-time gene expression technique, the transcript level of target genes was quantified. Results: Experiments indicated that mRNA expressions of caspase 9 and 3 were downregulated in tumoral tissues from CRC patients in comparison to marginal tissues. In contrast, tumoral tissues expressed mRNA of caspase 8 higher than normal marginal tissues. Modified transcript levels of caspase 3, 8, and 9 were correlated with the clinical manifestations of the patients. Conclusions: Alteration in the mRNA level of caspase genes may be involved in the development of CRC.


Assuntos
Biomarcadores Tumorais/genética , Caspase 3/genética , Caspase 8/genética , Caspase 9/genética , Neoplasias Colorretais/genética , RNA Mensageiro/genética , Estudos de Casos e Controles , Neoplasias Colorretais/enzimologia , Neoplasias Colorretais/patologia , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico
7.
Int J Surg Case Rep ; 42: 67-69, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29248836

RESUMO

INTRODUCTION: Echinococcus granulosus is a parasitic tape worm. The definitive host is the dog and humans are one of its intermediate hosts. It involves organs such as liver and lungs. Uterus involvement is very rare. PRESENTATION OF CASE: We here report a case of primary uterus hydatid cyst that we had to remove her uterine on left ovary and fallopian tube. Generalized toxic shock and infection due to cyst rupture or organ dysfunction due to invasion (like our patient) or pressure of cyst are complications of this cyst. DISCUSSION: Because of low incidence of hydatid cysts in uterus it can be misdiagnosed by mimicking other conditions such as multi-cystic ovarian tumor, hemorrhagic ovarian cyst, endometrioma, cystadenoma, leiomyoma and etc. CONCLUSION: Especially in endemic area for this parasite, one of differential diagnoses of pelvic cyst must be echinococcosis.

9.
Iran J Public Health ; 42(1): 79-85, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23514804

RESUMO

BACKGROUND: Human papilloma virus causes benign and malignant abnormalities in different part of the body. The link between high risk types of HPV and some anogenital and aerodigestive tract cancer is well established. Oral HPV infection plays a role in developing oropharyngeal squamous cell carcinoma. We studied the prevalence of oral HPV in healthy individuals and its relative risk factors. METHODS: Saliva samples of 114 healthy subjects were collected for HPV DNA analysis. Volunteers completed questionnaires and signed a written consent. For data analysis descriptive statistic, chi square test and odds ratio was used. RESULTS: The frequency of oral HPV in healthy individuals was 6.1 %(seven participant).The most frequent type was HPV-18 in five of them. HPV-6 and HPV-66 each was detected in one case. Relation of oral HPV positivity to demographic features and risk factors was not statistically significant. CONCLUSIONS: The prevalence of oral HPV infection in our community is the same as many other communities of developing countries, stressing that HPV-18 were the dominant type.

11.
Eur J Gastroenterol Hepatol ; 23(12): 1172-7, 2011 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-21904206

RESUMO

OBJECTIVE: Upper gastrointestinal (UGI) bleeding is one of the most life-threatening complications, in up to 25% of persons with hemophilia (PWH). Recurrent bleeding is common and can be caused by the Helicobacter pylori infection. Our aim was to evaluate the role of H. pylori infection in UGI bleeding in PWH. MATERIAL AND METHODS: Ninety patients with hereditary bleeding disorders, 30 patients with (group A), and 60 patients without (group B) a history of UGI bleeding episodes were included. The prevalence of H. pylori infection was investigated by stool antigen test, and serum serologic tests including immunoglobulin G and anti-CagA. RESULTS: Among 90 patients (81 men, nine women, mean age 31.30 ± 10.72 years), 66 patients with hemophilia A, 10 patients with hemophilia B, six patients with Von Willebrand disease, five patients with platelet function disorders, and three patients with other factor deficiencies were evaluated. About 46.7% of patients in group A, and 23.3% of patients in group B were anti-CagA-positive (P=0.02), whereas 76.7% of patients in group A and 51.7% of patients in group B had H. pylori immunoglobulin G antibodies (P=0.02). H. pylori antigen in stool was positive in 76.7% in group A and 55% in group B (P=0.03). No statistically significant difference was found between type and severity of diseases and risk of UGI. CONCLUSION: H. pylori infection should be considered as an important cause of UGI bleeding in PWH. We would recommend stool antigen test as a new and noninvasive screening test for diagnosis of H. pylori infection in all patients with hereditary hemorrhagic disorders.


Assuntos
Transtornos Herdados da Coagulação Sanguínea/complicações , Hemorragia Gastrointestinal/etiologia , Infecções por Helicobacter/complicações , Helicobacter pylori/isolamento & purificação , Adolescente , Adulto , Antígenos de Bactérias/análise , Transtornos Herdados da Coagulação Sanguínea/epidemiologia , Criança , Ensaio de Imunoadsorção Enzimática/métodos , Feminino , Hemorragia Gastrointestinal/epidemiologia , Hemorragia Gastrointestinal/microbiologia , Infecções por Helicobacter/diagnóstico , Infecções por Helicobacter/epidemiologia , Helicobacter pylori/imunologia , Humanos , Irã (Geográfico)/epidemiologia , Masculino , Pessoa de Meia-Idade , Prevalência , Estudos Prospectivos , Adulto Jovem
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA