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1.
Einstein (Sao Paulo) ; 18: eGS4442, 2020.
Artigo em Inglês, Português | MEDLINE | ID: mdl-31576910

RESUMO

OBJECTIVE: To analyze the legal demands of tiotropium bromide to treat chronic obstructive pulmonary disease. METHODS: We included secondary data from the pharmaceutical care management systems made available by the Paraná State Drug Center. RESULTS: Public interest civil action and ordinary procedures, among others, were the most common used by the patients to obtain the medicine. Two Health Centers in Paraná (Londrina and Umuarama) concentrated more than 50% of the actions. The most common specialty of physicians who prescribed (33.8%) was pulmonology. There is a small financial impact of tiotropium bromide on general costs with medicines of the Paraná State Drug Center. However, a significant individual financial impact was observed because one unit of the medicine represents 38% of the Brazilian minimum wage. CONCLUSION: Our study highlights the need of incorporating this medicine in the class of long-acting anticholinergic bronchodilator in the Brazilian public health system.


Assuntos
Broncodilatadores/economia , Medicamentos Essenciais/provisão & distribução , Necessidades e Demandas de Serviços de Saúde/legislação & jurisprudência , Função Jurisdicional , Doença Pulmonar Obstrutiva Crônica/economia , Brometo de Tiotrópio/economia , Brasil , Medicamentos Essenciais/economia , Acesso aos Serviços de Saúde/economia , Acesso aos Serviços de Saúde/legislação & jurisprudência , Acesso aos Serviços de Saúde/tendências , Necessidades e Demandas de Serviços de Saúde/economia , Necessidades e Demandas de Serviços de Saúde/tendências , Humanos , Programas Nacionais de Saúde , Doença Pulmonar Obstrutiva Crônica/tratamento farmacológico , Estudos Retrospectivos , Estatísticas não Paramétricas , Fatores de Tempo
2.
ABCS health sci ; 43(3): 136-140, 20 dez 2018. ilus
Artigo em Português | LILACS | ID: biblio-967911

RESUMO

INTRODUÇÃO: Com o propósito de estimular a adesão aos antirretrovirais e minimizar os riscos de resistência a estes medicamentos, o Ministério da Saúde (MS) passou a disponibilizar o medicamento 3 em 1, uma coformulação de tenofovir (300 mg), lamivudina (300 mg) e efavirenz (600 mg), o qual inova com uso de um único comprimido diário. OBJETIVO: Estimar a adesão aos medicamentos antirretrovirais da primeira linha de tratamento contra o HIV. MÉTODOS: Verificação da frequência dos retornos mensais de pacientes a um dispensário dos medicamentos antirretrovirais fornecidos pelo MS. RESULTADOS: Os pacientes em tratamento com o medicamento 3 em 1 foram mais assíduos e retornaram com frequência 65% maior ao dispensário. CONCLUSÃO: Com a introdução do 3 em 1 confirma-se que a simplificação de esquemas terapêuticos é uma medida que facilita a adesão ao tratamento. Isso gera a expectativa de manter por mais tempo os indivíduos em uso da primeira linha de tratamento, retardando a necessidade de recorrer a outras linhas terapêuticas mais onerosas, com maior número de medicamentos e riscos associados.


INTRODUCTION: In order to stimulate adherence to antiretrovirals and minimize the risks of viral mutations and resistance to these drugs, the Ministry of Health (MS) started providing the 3-in-1 drug, a co-formulation of tenofovir (300 mg), lamivudine (300 mg) and efavirenz (600 mg), which innovates by the use of a single daily tablet. OBJECTIVE: Estimating the adherence to antiretroviral drugs in the first line of HIV treatment. METHODS: Verification of the frequency of monthly patient returns to a dispensary of antiretroviral drugs provided by MS. RESULTS: Patients treated with the 3-in-1 medication were more assiduous and returned 65% higher at the dispensary. CONCLUSION: The introduction of 3-in-1 confirms that the simplification of therapeutic schemes is a measure that facilitates adherence to treatment. This generates the expectation of keeping individuals in the first line of treatment longer, delaying the need to resort to other more expensive therapeutic lines, with a higher number of drugs and associated risks.


Assuntos
Humanos , HIV/efeitos dos fármacos , Antirretrovirais/administração & dosagem , Antirretrovirais/farmacologia , Adesão à Medicação , Adesão à Medicação/estatística & dados numéricos , Cooperação e Adesão ao Tratamento/estatística & dados numéricos
3.
Rev Soc Bras Med Trop ; 51(1): 39-43, 2018 Jan-Feb.
Artigo em Inglês | MEDLINE | ID: mdl-29513840

RESUMO

INTRODUCTION: Rabies is an acute zoonotic disease, caused by a rhabdovirus that can affect all mammals, and is commonly transmitted by the bite of a rabid animal. The definitive diagnosis is laboratorial, by the Fluorescent Antibody Test (FAT) as a quick test and Mouse Inoculation Test (MIT) as a confirmatory test (gold standard). Studies conducted over the past three decades indicate that MIT and Virus Isolation in Cell Culture (VICC) can provide the same effectiveness, the latter being considered superior in bioethics and animal welfare. The aim of this study was to compare VICC with MIT, in terms of accuracy, biosafety and occupational health, supply and equipment costs, bioethics and animal welfare, in a Brazilian public health lab. METHODS: We utilized 400 samples of animal neurological tissue to compare the performance of VICC against MIT. The variables analyzed were accuracy, biosafety and occupational health, time spent in performing the tests, supply and equipment costs, bioethics and animal welfare evaluation. RESULTS: Both VICC and MIT had almost the same accuracy (99.8%), although VICC presented fewer risks regarding biosafety and mental health of the technicians, and reduced time between inoculation and obtaining the results (approximately 22 days less). In addition, VICC presented lower supply costs (86.5% less), equipment costs (32.6% less), and the advantage of not using animals. CONCLUSIONS: These results confirm that VICC can replace MIT, offering the same accuracy and better features regarding cost, results, biosafety and occupational health, and bioethics and animal welfare.


Assuntos
Temas Bioéticos , Técnicas de Cultura de Células/métodos , Contenção de Riscos Biológicos , Imunofluorescência/métodos , Saúde do Trabalhador , Vírus da Raiva/imunologia , Raiva/diagnóstico , Bem-Estar do Animal , Animais , Técnicas de Cultura de Células/economia , Custos e Análise de Custo , Imunofluorescência/economia , Camundongos , Vírus da Raiva/isolamento & purificação , Reprodutibilidade dos Testes , Fatores de Risco , Sensibilidade e Especificidade
4.
Rev. Soc. Bras. Med. Trop ; 51(1): 39-43, Jan.-Feb. 2018. tab
Artigo em Inglês | LILACS-Express | ID: biblio-897046

RESUMO

Abstract INTRODUCTION: Rabies is an acute zoonotic disease, caused by a rhabdovirus that can affect all mammals, and is commonly transmitted by the bite of a rabid animal. The definitive diagnosis is laboratorial, by the Fluorescent Antibody Test (FAT) as a quick test and Mouse Inoculation Test (MIT) as a confirmatory test (gold standard). Studies conducted over the past three decades indicate that MIT and Virus Isolation in Cell Culture (VICC) can provide the same effectiveness, the latter being considered superior in bioethics and animal welfare. The aim of this study was to compare VICC with MIT, in terms of accuracy, biosafety and occupational health, supply and equipment costs, bioethics and animal welfare, in a Brazilian public health lab. METHODS: We utilized 400 samples of animal neurological tissue to compare the performance of VICC against MIT. The variables analyzed were accuracy, biosafety and occupational health, time spent in performing the tests, supply and equipment costs, bioethics and animal welfare evaluation. RESULTS: Both VICC and MIT had almost the same accuracy (99.8%), although VICC presented fewer risks regarding biosafety and mental health of the technicians, and reduced time between inoculation and obtaining the results (approximately 22 days less). In addition, VICC presented lower supply costs (86.5% less), equipment costs (32.6% less), and the advantage of not using animals. CONCLUSIONS: These results confirm that VICC can replace MIT, offering the same accuracy and better features regarding cost, results, biosafety and occupational health, and bioethics and animal welfare.

5.
J Sci Food Agric ; 98(8): 3084-3088, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29205367

RESUMO

BACKGROUND: Quality control in the wheat industry comprises numerous analyses that are time-consuming and demand numerous procedures and specific apparatus. The application of multivariate calibration techniques contributes to the interpretation of the data generated during these analyses. The present study aimed to correlate a representative number of wheat properties with the treatment applied to the wheat seeds using multivariate calibration techniques. RESULTS: In the present study, a wheat pilot planting experiment applying different fungicides combination as a seed treatment (carbendazim, carbendazim + thiram, carboxin + thiram, and triadimenol) was conducted. The resulting wheat grains were subjected to 33 analyses routinely performed in industry. A principal components analysis indicated all analyses were relevant for the different seed treatment discrimination. Afterwards, a k-nearest neighbors discriminative model was developed and was able to classify the seed treatments. In accordance with this model, the most relevant variables for the seed treatment discrimination were the rheological properties of the dough. CONCLUSION: It was possible to develop a discriminative model that directly correlated the wheat seed treatment with the properties of the resulting grains and flours. © 2017 Society of Chemical Industry.


Assuntos
Fungicidas Industriais/farmacologia , Sementes/efeitos dos fármacos , Triticum/química , Benzimidazóis/farmacologia , Pão/análise , Carbamatos/farmacologia , Farinha/análise , Manipulação de Alimentos , Reologia , Sementes/química , Tiram/farmacologia , Triticum/efeitos dos fármacos
6.
Rev. Inst. Adolfo Lutz ; (77): 1-9, 2018. tab, graf
Artigo em Português | Sec. Est. Saúde SP, SESSP-ACVSES, SESSP-IALPROD, Sec. Est. Saúde SP, SESSP-IALACERVO | ID: ses-38187

RESUMO

A redução da incidência de doenças transmitidas pela água foi alcançada com a difusão douso de técnicas de cloração. Apesar dos benefícios desse método de desinfecção, as reações decloro com a matéria orgânica natural presente na água levam à formação de subprodutos dedesinfecção como trihalometanos. Esses produtos já foram associados à incidência de algunstipos de câncer em animais, e muitas vezes podem ser detectados em água tratada e fornecidapara o consumo. Pela legislação brasileira não é obrigatório efetuar o monitoramento detrihalometanos após o tratamento e distribuição de água. Frente a este problema, este estudoteve como objetivo avaliar as concentrações de trihalometanos em água coletada em diferentespontos de abastecimento no município de Colombo...(AU)


The reduction of the incidence of water-borne diseases is achieved with the diffusion of the useof chlorination techniques. However, in spite of the benefits of this disinfection method,the reactions of chlorine with the natural organic matter occurring in the water induce theproduction of disinfection by products such as trihalomethanes. These products have already beenassociated with the incidence of some cancers types. Considering that in the Brazilian legislation,it is not mandatory measuring and controlling the occurrence of trihalomethanes at the exitand during the water distribution to the consumer. This study aimed at analyzing the relationshipbetween chlorination and its by products. Thus, this project evaluated the concentrations oftrihalomethanes in water collected...(AU)


Assuntos
Trialometanos , Água Potável , Cloretos
7.
Rev. Inst. Adolfo Lutz ; (77): 1-9, 2018. tab, graf
Artigo em Português | LILACS, SESSP-ACVSES, SESSP-IALPROD, Sec. Est. Saúde SP, SESSP-IALACERVO | ID: biblio-982812

RESUMO

The reduction of the incidence of water-borne diseases is achieved with the diffusion of the useof chlorination techniques. However, in spite of the benefits of this disinfection method,the reactions of chlorine with the natural organic matter occurring in the water induce theproduction of disinfection by products such as trihalomethanes. These products have already beenassociated with the incidence of some cancers types. Considering that in the Brazilian legislation,it is not mandatory measuring and controlling the occurrence of trihalomethanes at the exitand during the water distribution to the consumer. This study aimed at analyzing the relationshipbetween chlorination and its by products. Thus, this project evaluated the concentrations oftrihalomethanes in water collected at different points of supply in the municipality of Colombo,Paraná, Brazil, during the period from November 2015 to February 2016. Chromatographicmethods were employed, besides the spreadsheets provided by the Health Surveillance ofColombo for comparison. The found values were tabulated and they were compared with thelimits established by the Brazilian Ministry of Health- Ordinance No 05/2017. The results confirmedthat the values of those provided by the concessionaire responsible for the city water treatmentand supply, and being within the standards determined by the legislation.


A redução da incidência de doenças transmitidas pela água foi alcançada com a difusão douso de técnicas de cloração. Apesar dos benefícios desse método de desinfecção, as reações decloro com a matéria orgânica natural presente na água levam à formação de subprodutos dedesinfecção como trihalometanos. Esses produtos já foram associados à incidência de algunstipos de câncer em animais, e muitas vezes podem ser detectados em água tratada e fornecidapara o consumo. Pela legislação brasileira não é obrigatório efetuar o monitoramento detrihalometanos após o tratamento e distribuição de água. Frente a este problema, este estudoteve como objetivo avaliar as concentrações de trihalometanos em água coletada em diferentespontos de abastecimento no município de Colombo, PR, Brasil, durante o período de novembrode 2015 a fevereiro de 2016. Utilizou-se método cromatográfico para as análises, além deplanilhas fornecidas pela Vigilância Sanitária de Colombo. Todos os valores foram comparadoscom os limites estabelecidos na Portaria de Consolidação Nº 05/2017 do Ministério da Saúde.Os resultados confirmaram que os valores de trihalometanos fornecidos pela concessionária,responsável pelo tratamento e fornecimento de água na cidade, atendem aos parâmetros legais.


Assuntos
Humanos , Cloretos , Água Potável , Trialometanos
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