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1.
Int J Cardiol ; 2019 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-31761399

RESUMO

BACKGROUND: The optimal cutoff for systolic blood pressure (SBP) level to define high-risk pulmonary embolism (PE) remains to be defined. METHODS: To evaluate the relationship between SBP levels on admission and mortality in patients with acute symptomatic PE, the current study included 39,257 consecutive patients with acute symptomatic PE from the RIETE registry between 2001 and 2018. Primary outcomes included all-cause and PE-specific 30-day mortality. Secondary outcomes included major bleeding and recurrent venous thromboembolism (VTE). RESULTS: There was a linear inverse relationship between admission SBP and 30-day all-cause and PE-related mortality that persisted after multivariable adjustment. Patients in the lower SBP strata had higher rates of all-cause death (reference: SBP 110-129 mmHg) (adjusted odds ratio [OR] 2.9; 95% confidence interval [CI], 2.0-4.2 for SBP <70 mmHg; and OR 1.7; 95% CI, 1.4-2.1 for SBP 70-89 mmHg). The findings for 30-day PE-related mortality were similar (adjusted OR 4.4; 95% CI, 2.7-7.2 for SBP <70 mmHg; and OR 2.6; 95% CI, 1.9-3.4 for SBP 70-89 mmHg). Patients in the higher strata of SBP had significantly lower rates of 30-day all-cause mortality compared with the same reference group (adjusted OR 0.7; 95% CI, 0.5-0.9 for SBP 170-190 mmHg; and OR 0.6; 95% CI, 0.4-0.9 for SBP >190 mmHg). Consistent findings were also observed for 30-day PE-related death. CONCLUSIONS: In patients with acute symptomatic PE, a low SBP portends an increased risk of all-cause and PE-related mortality. The highest mortality was observed in patients with SBP <70 mmHg.

2.
Orphanet J Rare Dis ; 14(1): 196, 2019 08 09.
Artigo em Inglês | MEDLINE | ID: mdl-31399146

RESUMO

BACKGROUND: Limited data exist about the clinical presentation, ideal therapy and outcomes of patients with hereditary hemorrhagic telangiectasia (HHT) who develop venous thromboembolism (VTE). METHODS: We used the data in the RIETE Registry to assess the clinical characteristics, therapeutic approaches and clinical outcomes during the course of anticoagulant therapy in patients with HHT according to initial presentation as pulmonary embolism (PE) or deep venous thrombosis (DVT). RESULTS: Of 51,375 patients with acute VTE enrolled in RIETE from February 2009 to January 2019, 23 (0.04%) had HHT: 14 (61%) initially presented with PE and 9 (39%) with DVT alone. Almost half (47.8%) of the patients with VTE had a risk factor for VTE. Most PE and DVT patients received low-molecular-weight heparin for initial (71 and 100%, respectively) and long-term therapy (54 and 67%, respectively). During anticoagulation for VTE, the rate of bleeding events (major 2, non-major 6) far outweighed the rate of VTE recurrences (recurrent DVT 1): 50.1 bleeds per 100 patient-years (95%CI: 21.6-98.7) vs. 6.26 recurrences (95%CI: 0.31-30.9; p = 0.020). One major and three non-major bleeding were epistaxis. No patient died of bleeding. One patient died shortly after being diagnosed with acute PE. CONCLUSIONS: During anticoagulation for VTE in HHT patients, there were more bleeding events than VTE recurrences. Most bleeding episodes were non-major epistaxis.

3.
Clin Cardiol ; 42(3): 346-351, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30706520

RESUMO

INTRODUCTION: Some previous studies have suggested a high prevalence of pulmonary embolism (PE) during exacerbations of chronic obstructive pulmonary disease (ECOPD). The SLICE trial aims to assess the efficacy and safety of an active strategy for the diagnosis and treatment of PE (vs usual care) in patients hospitalized because of ECOPD. METHODS: SLICE is a phase III, prospective, international, multicenter, randomized, open-label, and parallel-group trial. A total of 746 patients hospitalized because of ECOPD will be randomized in a 1:1 fashion to receive either an active strategy for the diagnosis and anticoagulant treatment of PE or usual care (ie, standard care without any diagnostic test for diagnosing PE). The primary outcome is a composite of all-cause death, non-fatal (recurrent) venous thromboembolism (VTE), or readmission for ECOPD within 90 days after enrollment. Secondary outcomes are (a) death from any cause within 90 days after enrollment, (b) non-fatal (recurrent) VTE within 90 days after enrollment, (c) readmission within 90 days after enrollment, and (d) length of hospital stay. RESULTS: Enrollment started in September 2014 and is expected to proceed until 2020. Median age of the first 443 patients was 71 years (interquartile range, 64-78), and 26% were female. CONCLUSIONS: This multicenter trial will determine the value of detecting PEs in patients with ECOPD. This has implications for COPD patient morbidity and mortality. TRIAL REGISTRATION NUMBER: NCT02238639.


Assuntos
Anticoagulantes/uso terapêutico , Tomografia Computadorizada Multidetectores/métodos , Doença Pulmonar Obstrutiva Crônica/complicações , Embolia Pulmonar/diagnóstico , Ensaios Clínicos Controlados Aleatórios como Assunto/métodos , Terapia Trombolítica/métodos , Ultrassonografia/métodos , Idoso , Ensaios Clínicos Fase III como Assunto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Multicêntricos como Assunto , Guias de Prática Clínica como Assunto , Estudos Prospectivos , Doença Pulmonar Obstrutiva Crônica/diagnóstico , Embolia Pulmonar/etiologia , Embolia Pulmonar/terapia , Reprodutibilidade dos Testes
4.
Thromb Res ; 173: 166-171, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-30385047

RESUMO

BACKGROUND AND AIMS: Sex-specific differences exist for the initial presentation of acute venous thromboembolism (VTE): men are more likely to present with proximal deep vein thrombosis (DVT) in the lower limbs (versus pulmonary embolism [PE] or isolated distal DVT [IDDVT]) than women. We studied in detail the influence of sex, age, and VTE risk factors on the initial presentation of IDDVT versus proximal DVT. METHODS: A total of 24,911 patients with a first episode of objectively diagnosed acute symptomatic lower-limb DVT (without symptomatic PE) were enrolled in RIETE (years 2000-2017) and included in the present analysis. RESULTS: A total of 4266 (17.1%) patients had IDDVT. No trend for more IDDVT diagnoses was observed over time. Women aged 40-69 had a higher proportion of IDDVT, especially between 40 and 49 years (+6.7%; 95CI +3.7%; +9.9%), whereas men had more often proximal DVT. The presenting location of first acute DVT depended on sex, age, and the prevalence and type of VTE risk factors. Recent surgery was independently associated with a diagnosis of IDDVT in both women and men, whereas active cancer and pregnancy were associated with proximal DVT. CONCLUSIONS: The interaction between age and VTE risk factors influences the presenting location (distal versus proximal) of the first acute lower-limb DVT observed in women and men. Our observations extend to IDDVT the concept that different clinical manifestations of acute VTE may not fully share the same pathophysiological mechanisms: this contributes to explain sex-specific prognostic differences.


Assuntos
Tromboembolia Venosa/epidemiologia , Trombose Venosa/epidemiologia , Doença Aguda , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Humanos , Pessoa de Meia-Idade , Estudos Prospectivos , Fatores de Risco , Fatores Sexuais , Adulto Jovem
6.
Thromb Res ; 164: 69-74, 2018 04.
Artigo em Inglês | MEDLINE | ID: mdl-29499439

RESUMO

INTRODUCTION: Current guidelines recommend the use of anticoagulant therapy in patients with symptomatic splanchnic vein thrombosis (SVT) and suggest no routine anticoagulation in those with incidental SVT. METHODS: We used the RIETE (Registro Informatizado Enfermedad Trombo Embólica) registry to assess the rate and severity of symptomatic venous thromboembolism (VTE) recurrences and major bleeding events appearing during the course of anticoagulation in patients with symptomatic or incidental SVT. RESULTS: In March 2017, 521 patients with SVT were recruited. Of them, 212 (41%) presented with symptomatic SVT and 309 had incidental SVT. Most (93%) patients received anticoagulant therapy (median, 147 days). During the course of anticoagulation, 20 patients developed symptomatic VTE recurrences (none died) and 26 had major bleeding (fatal bleeding, 5). On multivariable analysis, patients with incidental SVT had a non-significantly higher risk for symptomatic VTE recurrences (adjusted hazard ratio [HR]: 2.04; 95%CI: 0.71-5.88) and a similar risk for major bleeding (HR: 1.12; 95%CI: 0.47-2.63) than those with symptomatic SVT. Active cancer was associated with at increased risk for VTE recurrences (HR: 3.06; 95%CI: 1.14-8.17) and anaemia (HR: 4.11; 95%CI: 1.45-11.6) or abnormal prothrombin time (HR: 4.10; 95%CI: 1.68-10.1) were associated with at increased risk for major bleeding. CONCLUSIONS: The rates of recurrent SVT and major bleeding were similar between patients with incidental or symptomatic SVT. Because the severity of bleeding complications during anticoagulation may outweigh the severity of VTE recurrences in both groups, further studies should identify those SVT patients who benefit from anticoagulant therapy.


Assuntos
Anticoagulantes/uso terapêutico , Hemorragia/etiologia , Circulação Esplâncnica/fisiologia , Trombose Venosa/tratamento farmacológico , Anticoagulantes/farmacologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva , Resultado do Tratamento
7.
PLoS One ; 13(2): e0192750, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29444151

RESUMO

BACKGROUND: Community-acquired pneumonia (CAP) is a major public health problem with high short- and long-term mortality. The main aim of this study was to develop and validate a specific prognostic index for one-year mortality in patients admitted for CAP. METHODS: This was an observational, prospective study of adults aged ≥18 years admitted to Galdakao-Usansolo Hospital (Bizkaia, Spain) from January 2001 to July 2009 with a diagnosis of CAP surviving the first 15 days. The entire cohort was divided into two parts, in order to develop a one-year mortality predictive model in the derivation cohort, before validation using the second cohort. RESULTS: A total of 2351 patients were included and divided into a derivation and a validation cohort. After deaths within 15 days were excluded, one-year mortality was 10.63%. A predictive model was created in order to predict one-year mortality, with a weighted score that included: aged over 80 years (4 points), congestive heart failure (2 points), dementia (6 points), respiratory rate ≥30 breaths per minute (2 points) and blood urea nitrogen >30 mg/dL (3 points) as predictors of higher risk with C-index of 0.76. This new model showed better predictive ability than current risk scores, PSI, CURB65 and SCAP with C-index of 0.73, 0.69 and 0.70, respectively. CONCLUSIONS: An easy-to-use score, called the one-year CAPSI, may be useful for identifying patients with a high probability of dying after an episode of CAP.


Assuntos
Infecções Comunitárias Adquiridas/mortalidade , Mortalidade Hospitalar , Hospitalização , Alta do Paciente , Pneumonia/mortalidade , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos
8.
Thromb Haemost ; 117(8): 1630-1636, 2017 07 26.
Artigo em Inglês | MEDLINE | ID: mdl-28517021

RESUMO

Treatment of patients with cancer-associated venous thromboembolism (VTE) remains a major challenge. The modified Ottawa score is a clinical prediction rule evaluating the risk of VTE recurrences during the first six months of anticoagulant treatment in patients with cancer-related VTE. We aimed to validate the Ottawa score using data from the RIETE registry. A total of 11,123 cancer patients with VTE were included in the analysis. According to modified Ottawa score, 2,343 (21 %) were categorised at low risk for VTE recurrences, 4,525 (41 %) at intermediate risk, and 4,255 (38 %) at high risk. Overall, 477 episodes of VTE recurrences were recorded during the course of anticoagulant therapy, with an incidence rate for low, intermediate, and high risk groups of 6.88 % (95 % CI 5.31-8.77), 11.8 % (95 % CI 10.1-13.6), and 21.3 % (95 % CI 18.8-24.1) patient-years, respectively. Overall mortality had an incidence rate of 21.1 % (95 % CI 18.2-24.3), 79.4 % (95 % CI: 74.9-84.1), and 134.7 % (95 % CI: 128.3-141.4) patient-years, respectively. The accuracy and discriminating power of the modified Ottawa score for VTE recurrence was modest, with low sensitivity, specificity and positive predictive value, and a C-statistics of 0.58 (95 % CI: 0.56-0.61). In our analysis, the modified Ottawa score did not accurately predict VTE recurrence among patients with cancer-associated thrombosis, thus hindering its use in clinical practice. It is time to define a new score including other clinical predictors.


Assuntos
Técnicas de Apoio para a Decisão , Neoplasias/complicações , Embolia Pulmonar/tratamento farmacológico , Tromboembolia Venosa/tratamento farmacológico , Trombose Venosa/tratamento farmacológico , Idoso , Idoso de 80 Anos ou mais , Anticoagulantes/uso terapêutico , Europa (Continente) , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias/diagnóstico , Neoplasias/mortalidade , Valor Preditivo dos Testes , Embolia Pulmonar/diagnóstico , Embolia Pulmonar/etiologia , Embolia Pulmonar/mortalidade , Recidiva , Sistema de Registros , Medição de Risco , Fatores de Risco , Fatores de Tempo , Resultado do Tratamento , Tromboembolia Venosa/diagnóstico , Tromboembolia Venosa/etiologia , Tromboembolia Venosa/mortalidade , Trombose Venosa/diagnóstico , Trombose Venosa/etiologia , Trombose Venosa/mortalidade
9.
Med. clín (Ed. impr.) ; 145(1): 7-13, jul. 2015. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-138553

RESUMO

Fundamento y objetivo: El objetivo de este estudio fue conocer la prevalencia de la infección tuberculosa en inmigrantes adolescentes indocumentados utilizando una estrategia con la prueba de la tuberculina (PT) para el cribado inicial y el QuantiFERON®-TB Gold In-Tube (QFT-GIT) como prueba confirmativa. Pacientes y método: Se incluyeron inmigrantes adolescentes recién llegados a 2 centros de alojamiento del País Vasco (España) entre los años 2007 y 2012. La PT se aplicó en todos los participantes, y el QFT-GIT, selectivamente en los reactores con una PT ≥ 5 mm. Resultados: Completaron el estudio 845 inmigrantes, mayoritariamente africanos (99,5%). Un 51% de los inmigrantes con una PT ≥ 5 mm fue QFT-GIT positivo, que corresponde el 17% de toda la muestra. Se encontraron 2 casos con tuberculosis activa (2/845: 0,24%). La concordancia entre la PT (≥ 10 mm) y el QFT-GIT fue del 63%, con un 57% de resultados concordantes positivos y un 96% de concordantes negativos. Hubo 246 casos con PT ≥ 10 mm (29%), con diferencias significativas entre magrebíes (21,5%) y subsaharianos (67%) (p < 0,001). La vacunación con el bacilo Calmette-Guérin fue un predictor independiente de tener una PT ≥ 10 mm (odds ratio [OR] 2,11, p < 0,001) y de la discordancia PT+/QFT-GIT−, tanto para una PT ≥ 5 como para una PT ≥ 10 mm (OR 2,16, intervalo de confianza del 95% [IC 95%] 1,46-3,20, y OR 1,91, IC 95% 1,23-2,97, respectivamente). La proporción de QFT-GIT positivo aumentó significativamente con el incremento de la positividad de la PT, con asociación positiva en todos los tramos analizados: 10-14 mm (OR 7,95, IC 95% 1,79-35,33), 15-19 mm (OR 35, IC 95% 7,93-154,52) y ≥ 20 mm (OR 91,3, IC 95% 18,20-458,11). Conclusión: La alta prevalencia de infección tuberculosa latente en los inmigrantes de origen subsahariano hace recomendable la implementación de programas de cribado en esta población. Utilizando el QFT-GIT se redujo en un 43% el número de candidatos a la quimioprofilaxis con arreglo a la PT (≥ 10 mm) (AU)


Background and objective: The aim of this study was to determine the prevalence of tuberculosis infection in undocumented immigrant teenagers using a tuberculin skin test (TST) for initial screening and cuantiFERON®-TB Gold In-Tube (QFT-GIT) as a confirmatory test. Patient and method: From 2007 to 2012, under 19 year-old immigrant teenagers from 2 accommodation centers of the Basque Country (Spain) were included in the study. The TST was done in all of them and the QFT-GIT was done in selected patients with a TST ≥ 5 mm. Results: Eight hundred and forty-five immigrants were included, most of them from Africa (99.5%). Fifty-one percent of immigrants with TST ≥ 5 mm has a positive QFT-GIT. We found 2 cases of active tuberculosis (2/845: 0.24%). The concordance between TST (≥ 10 mm) and QFT-GIT was 63%, with 57% of positive concordance cases and 96% of negative concordances. There were 246 cases with TST ≥ 10 mm (29%), with significant differences between Magrebis (21.5%) and Subsaharians (67%) (P < .001). Vaccination with Calmette-Guéin bacille was an independent predictor for having a TST ≥ 10 mm (OR: 2.11; P < .001) and for the discordance TST+/QFT-GIT−, both for a TST ≥ 5 and a TST ≥ 10 mm (OR 2.16, 95% confidence interval [95% CI] 1.46-3.20, and OR 1.91 95% CI 1.23-2.97, respectively). The positive value of QFT-GIT increased significantly as the TST increased, with a positive association in all the cut-off points analyzed: 10-14 mm (OR 7.95, 95% CI 1.79-35.33), 15-19 mm (OR 35, 95% CI 7.93-154.52) and ≥ 20 mm (OR 91.3, 95% CI 18.20-458.11). Conclusion: Due to the high prevalence of latent tuberculosis infection in Subsaharian immigrants, we recommend implementing screening programs in this population. Using QFT-GIT, the number of candidates for chemoprophylaxis was reduced to 43% compared with TST alone (≥ 10 mm) (AU)


Assuntos
Adolescente , Humanos , Masculino , Tuberculose/epidemiologia , Tuberculose/diagnóstico , Teste Tuberculínico , Monitoramento Epidemiológico/tendências , Tuberculose/prevenção & controle , Saúde do Adolescente , Migrantes , Programas de Rastreamento , Valor Preditivo dos Testes , Espanha/epidemiologia , África ao Sul do Saara/epidemiologia
10.
PLoS One ; 10(6): e0128741, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26076483

RESUMO

Current guidelines of antithrombotic therapy suggest early initiation of vitamin K antagonists (VKA) in non-cancer patients with venous thromboembolism (VTE), and long-term therapy with low-molecular weight heparin (LMWH) for those with cancer. We used data from RIETE (international registry of patients with VTE) to report the use of long-term anticoagulant therapy over time and to identify predictors of anticoagulant choice (regarding international guidelines) in patients with- and without cancer. Among 35,280 patients without cancer, 82% received long-term VKA (but 17% started after the first week). Among 4,378 patients with cancer, 66% received long term LMWH as monotherapy. In patients without cancer, recent bleeding (odds ratio [OR] 2.70, 95% CI 2.26-3.23), age >70 years (OR 1.15, 95% CI 1.06-1.24), immobility (OR 2.06, 95% CI 1.93-2.19), renal insufficiency (OR 2.42, 95% CI 2.15-2.71) and anemia (OR 1.75, 95% CI 1.65-1.87) predicted poor adherence to guidelines. In those with cancer, anemia (OR 1.83, 95% CI 1.64-2.06), immobility (OR 1.51, 95% CI 1.30-1.76) and metastases (OR 3.22, 95% CI 2.87-3.61) predicted long-term LMWH therapy. In conclusion, we report practices of VTE therapy in real life and found that a significant proportion of patients did not receive the recommended treatment. The perceived increased risk for bleeding has an impact on anticoagulant treatment decision.


Assuntos
Anticoagulantes/uso terapêutico , Tromboembolia Venosa/tratamento farmacológico , Idoso , Idoso de 80 Anos ou mais , Prescrições de Medicamentos/estatística & dados numéricos , Feminino , Fibrinolíticos/uso terapêutico , Seguimentos , Fidelidade a Diretrizes , Heparina de Baixo Peso Molecular , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias/complicações , Fatores de Tempo , Tromboembolia Venosa/diagnóstico , Tromboembolia Venosa/etiologia , Vitamina K/antagonistas & inibidores
11.
Med Clin (Barc) ; 145(1): 7-13, 2015 Jul 06.
Artigo em Espanhol | MEDLINE | ID: mdl-24747025

RESUMO

BACKGROUND AND OBJECTIVE: The aim of this study was to determine the prevalence of tuberculosis infection in undocumented immigrant teenagers using a tuberculin skin test (TST) for initial screening and QuantiFERON(®)-TB Gold In-Tube (QFT-GIT) as a confirmatory test. PATIENT AND METHOD: From 2007 to 2012, under 19 year-old immigrant teenagers from 2 accommodation centers of the Basque Country (Spain) were included in the study. The TST was done in all of them and the QFT-GIT was done in selected patients with a TST≥5mm. RESULTS: Eight hundred and forty-five immigrants were included, most of them from Africa (99.5%). Fifty-one percent of immigrants with TST ≥ 5 mm has a positive QFT-GIT. We found 2 cases of active tuberculosis (2/845: 0.24%). The concordance between TST (≥ 10 mm) and QFT-GIT was 63%, with 57% of positive concordance cases and 96% of negative concordances. There were 246 cases with TST ≥ 10 mm (29%), with significant differences between Magrebis (21.5%) and Subsaharians (67%) (P<.001). Vaccination with Calmette-Guéin bacille was an independent predictor for having a TST ≥ 10 mm (OR: 2.11; P<.001) and for the discordance TST+/QFT-GIT-, both for a TST≥5 and a TST≥10mm (OR 2.16, 95% confidence interval [95% CI] 1.46-3.20, and OR 1.91 95% CI 1.23-2.97, respectively). The positive value of QFT-GIT increased significantly as the TST increased, with a positive association in all the cut-off points analyzed: 10-14 mm (OR 7.95, 95% CI 1.79-35.33), 15-19 mm (OR 35, 95% CI 7.93-154.52) and ≥ 20 mm (OR 91.3, 95% CI 18.20-458.11). CONCLUSION: Due to the high prevalence of latent tuberculosis infection in Subsaharian immigrants, we recommend implementing screening programs in this population. Using QFT-GIT, the number of candidates for chemoprophylaxis was reduced to 43% compared with TST alone (≥ 10 mm).


Assuntos
Emigrantes e Imigrantes , Testes de Liberação de Interferon-gama , Programas de Rastreamento/métodos , Tuberculose/diagnóstico , Adolescente , África ao Sul do Saara/etnologia , Vacina BCG , Estudos Transversais , Emigrantes e Imigrantes/estatística & dados numéricos , Humanos , Técnicas Imunoenzimáticas , Masculino , Programas de Rastreamento/estatística & dados numéricos , Prevalência , Estudos Prospectivos , Reprodutibilidade dos Testes , Espanha/epidemiologia , Teste Tuberculínico , Tuberculose/epidemiologia , Tuberculose/prevenção & controle , Vacinação/estatística & dados numéricos
12.
Med. clín (Ed. impr.) ; 140(7): 289-295, abr. 2013. tab, ilus
Artigo em Espanhol | IBECS | ID: ibc-110405

RESUMO

Fundamento y objetivos: El objetivo del estudio fue comparar la prueba de la tuberculina (PT) y el QuantiFERON-TB® Gold In-Tube (QFT) en el diagnóstico de la infección latente tuberculosa (ILT) en una población de contactos de enfermos con tuberculosis pulmonar, y analizar la influencia de distintas variables en la discordancia. Pacientes y método: Entre marzo de 2008 y septiembre de 2010, de una población de 300.000 habitantes del País Vasco, se analizaron todos los contactos de pacientes con tuberculosis pulmonar. A todos se les realizó la PT y se midió el valor del QFT. Se analizaron diferentes variables sociodemográficas y la vacunación, analizándose la discordancia entre ambas pruebas. Resultados: Un total de 704 sujetos fueron incluidos en el estudio, con una edad media de 27 años. De ellos, 397 estaban vacunados, siendo la proporción similar entre autóctonos y extranjeros. El incremento de la edad hasta los 59 años (odds ratio [OR] 10,53; p<0,001), ser extranjero (OR 2,71; p=0,02) y la vacunación (OR 4,22; p<0,001) fueron variables predictoras de la discordancia entre una PT positiva y un QFT negativo. Conclusiones: Parece que el QFT, solo o combinado con la PT, es un método seguro para el diagnóstico de la ILT y que su utilización contribuiría a una selección más específica de los individuos que necesitan un tratamiento preventivo (AU)


Background and objectives: Our objetive is to compare the tuberculin skin test (TST) and the QuantiFERON-TB® Gold In-Tube (QFT) in the diagnosis of latent tuberculosis infection (LTI) in a population of contacts of patients with pulmonary tuberculosis, and to analyze the influence of different variables in the discordance. Patients and method: From March 2008 to September 2010, among a population of 300,000 inhabitants of the Basque Country, we analyzed all contacts of patients with pulmonary tuberculosis. All patients underwent the TST and the value of QFT was measured. Sociodemographic variables and vaccination were examined and we analyzed the discordance between the 2 tests. Results: Seven hundred and four were included in the study, with a mean age of 27 years. Of these, 397 were vaccinated, with similar proportion between native and foreign. Increasing the age to 59 years (odds ratio [OR] 10.53, P<.001), being foreign (OR 2.71, P=.02) and vaccination (OR 4.22, P<.001) were predictors of the discordance between a positive TST and negative QFT. Conclusions: It seems that the QFT, alone or combined with the TST, is a safe method for the diagnosis of LTI and its use would contribute to a more specific selection of individuals who would need preventive treatment (AU)


Assuntos
Humanos , Teste Tuberculínico/métodos , Tuberculose/diagnóstico , Interferon gama , Busca de Comunicante/métodos , Mycobacterium tuberculosis/isolamento & purificação , Transmissão de Doença Infecciosa/estatística & dados numéricos
13.
Med Clin (Barc) ; 140(7): 289-95, 2013 Apr 15.
Artigo em Espanhol | MEDLINE | ID: mdl-23339888

RESUMO

BACKGROUND AND OBJECTIVES: Our objective is to compare the tuberculin skin test (TST) and the QuantiFERON-TB(®) Gold In-Tube (QFT) in the diagnosis of latent tuberculosis infection (LTI) in a population of contacts of patients with pulmonary tuberculosis, and to analyze the influence of different variables in the discordance. PATIENTS AND METHOD: From March 2008 to September 2010, among a population of 300,000 inhabitants of the Basque Country, we analyzed all contacts of patients with pulmonary tuberculosis. All patients underwent the TST and the value of QFT was measured. Sociodemographic variables and vaccination were examined and we analyzed the discordance between the 2 tests. RESULTS: Seven hundred and four were included in the study, with a mean age of 27 years. Of these, 397 were vaccinated, with similar proportion between native and foreign. Increasing the age to 59 years (odds ratio [OR] 10.53, P<.001), being foreign (OR 2.71, P=.02) and vaccination (OR 4.22, P<.001) were predictors of the discordance between a positive TST and negative QFT. CONCLUSIONS: It seems that the QFT, alone or combined with the TST, is a safe method for the diagnosis of LTI and its use would contribute to a more specific selection of individuals who would need preventive treatment.


Assuntos
Testes de Liberação de Interferon-gama , Tuberculose Latente/diagnóstico , Teste Tuberculínico , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Busca de Comunicante , Feminino , Humanos , Lactente , Tuberculose Latente/prevenção & controle , Tuberculose Latente/transmissão , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Espanha , Vacinação/estatística & dados numéricos , Adulto Jovem
14.
Thromb Res ; 129 Suppl 1: S16-9, 2012 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-22682127

RESUMO

BACKGROUND: The natural history of unsuspected pulmonary embolism (PE) in patients with cancer has not been thoroughly studied. METHODS: We used the RIETE Registry data to compare the clinical characteristics, treatment strategies and outcome in cancer patients with unsuspected PE and in those presenting with symptomatic, acute PE. RESULTS: Up to December 2011, 78 cancer patients with unsuspected PE and 1,994 with symptomatic PE had been enrolled. Patients with unsuspected PE more likely had colorectal cancer than those with symptomatic PE (28% vs. 13%), and less likely had prostate (3.8% vs. 10%) or hematologic (1.3% vs. 6.4%) cancer, or prior venous thromboembolism (3.8% vs. 12%). While the patients were receiving anticoagulant therapy, the incidence of PE recurrences (0% vs. 1.9%) or major bleeding (2.6% vs. 4.8%) were similar. After completion of anticoagulation, recurrent PE developed in 2.6% vs. 1.4% of patients, and major bleeding in 0% vs. 0.4%, respectively. CONCLUSIONS: Our findings suggest that the clinical characteristics and outcome in cancer patients with unsuspected PE are quite similar to those in patients with symptomatic PE.


Assuntos
Anticoagulantes/uso terapêutico , Neoplasias/tratamento farmacológico , Neoplasias/epidemiologia , Embolia Pulmonar/tratamento farmacológico , Embolia Pulmonar/epidemiologia , Sistema de Registros/estatística & dados numéricos , Comorbidade , Europa (Continente)/epidemiologia , Feminino , Humanos , Masculino , Prevalência , Prognóstico , Medição de Risco , Resultado do Tratamento
15.
J Asthma ; 49(2): 201-8, 2012 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-22308974

RESUMO

INTRODUCTION: Patients with asthma also tend to have anxiety and depression. These comorbidities may affect asthma control and quality of life. The objective of this study was to assess the impact of anxiety and depression on asthma control and quality of life. PATIENTS AND METHODS: Cross-sectional study of asthma outpatients was conducted at two hospitals in the Basque Country (northern Spain). Data collected included sociodemographic variables, asthma symptoms, treatment, number of exacerbations, level of control, quality of life, presence of psychological morbidities, and level of physical activity. Spirometry was performed in accordance with the recommendations of the Spanish Society of Pneumology and Thoracic Surgery. RESULTS: Among 354 asthmatics, 77% had poor or partial control of their condition, 31% had anxiety alone, 2% had depression alone, and 10% had anxiety plus depression. Poor asthma control was associated with anxiety plus depression (odds ratio (OR): 3.61; 95% confidence interval (CI): 1.05-12.41) as well as with female patients (OR: 1.85; 95% CI: 1.11-3.10). Anxiety had an independent effect on reduced quality of life across all domains; anxiety plus depression had an even greater effect. CONCLUSION: Among patients with asthma, anxiety and depression adversely affect asthma control and quality of life, raising the possibility that treating these psychological comorbidities could improve asthma control and quality of life.


Assuntos
Ansiedade/fisiopatologia , Asma/psicologia , Depressão/fisiopatologia , Qualidade de Vida , Adolescente , Adulto , Idoso , Asma/terapia , Comorbidade , Estudos Transversais , Feminino , Volume Expiratório Forçado , Humanos , Masculino , Saúde Mental , Pessoa de Meia-Idade
16.
Thromb Res ; 127(4): 303-8, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21247617

RESUMO

BACKGROUND: Echocardiography remains a clinically useful screening test for chronic thromboembolic pulmonary hypertension (CTEPH) in patients with a history of pulmonary embolism (PE). To devise an effective screening strategy, the definition of a high-risk group is necessary. METHODS: We examined a total of 744 patients with acute symptomatic pulmonary embolism (PE) who were enrolled in a Spanish multicenter study. Patients were monitored every 6months during the first two years, and then once a year thereafter. Transthoracic echocardiography was used to screen patients with a clinical suspicion of CTEPH during follow-up. Pulmonary arterial hypertension was defined as an estimated pulmonary artery systolic pressure (PAP)>50mm Hg. The index thromboembolic episode was considered severe if: (a) the patient was immobilized for medical reasons; or (b) systolic blood pressure was less than 90mm Hg; or (c) troponin T values were above the reference range. RESULTS: The incidence of PAP>50mm Hg at 36months was 8.3% (95% confidence interval=4.6%-14.5%). Statistical analysis showed a highly significant association between a severe index thromboembolic episode and the subsequent detection of PAP>50mm Hg on echocardiography, with high positive likelihood ratio (2.40) and negative predictive value (>0.97). CONCLUSIONS: Patients with a severe index thromboembolic episode would constitute a high-risk group for the development of CTEPH. This group of patients should be subjected to a strict follow-up protocol.


Assuntos
Hipertensão Pulmonar/diagnóstico por imagem , Pulmão/diagnóstico por imagem , Embolia Pulmonar/diagnóstico por imagem , Idoso , Idoso de 80 Anos ou mais , Artérias/diagnóstico por imagem , Doença Crônica , Feminino , Seguimentos , Hospitalização , Humanos , Hipertensão Pulmonar/epidemiologia , Incidência , Pulmão/irrigação sanguínea , Masculino , Pessoa de Meia-Idade , Embolia Pulmonar/epidemiologia , Fatores de Risco , Espanha/epidemiologia , Ultrassonografia
17.
Arch. bronconeumol. (Ed. impr.) ; 47(1): 50-51, ene. 2011. tab
Artigo em Espanhol | IBECS | ID: ibc-88173

RESUMO

En esta nota mostramos la elevada prevalencia de silicosis encontrada en una marmolería tras una exposición a una novedosa presentación de sílice.Se trata de un estudio observacional, prospectivo, en el que se han estudiado 11 trabajadores que se exponen desde 1995 a diversas presentaciones de superficies de cuarzo. Los puestos de trabajo se dividen en dos grupos: por una parte 4 sujetos desarrollan trabajos de corte en el taller; el resto de los trabajadores trabaja en el montaje. Hasta la fecha no han utilizado sistemas de protección respiratoria específicos.Se han diagnosticado 6 casos de silicosis, lo que supone una prevalencia de enfermedad para este ámbito del 54,5%. De los 6 afectados, 5 (83,33%) son montadores.Destacamos el elevado riesgo de desarrollo de silicosis en el manejo de los diversos productos que conforman la gama de superficies de cuarzo(AU)


In this note we present the increased prevalence of silicosis found in a marble factory after exposure to a new presentation of silica.A prospective, observational study was conducted on 11 workers who were exposed to different presentations of quartz surfaces since 1995. The jobs were divided into two groups: 4 subjects worked in the cutting workshop; the rest of the workers worked in assembly. Up to that date they had not used any specific respiratory protection apparatus.Six cases of silicosis have been diagnosed, which assumes a disease prevalence in this environment of 54.5%. Of the 6 affected, 5 (83.3% are assemblers.We highlight the high risk of developing silicosis in the handling of different products which make up the range of quartz surfaces(AU)


Assuntos
Humanos , Masculino , Adulto , Pessoa de Meia-Idade , Silicose/epidemiologia , Quartzo/efeitos adversos , Sílica Livre/efeitos adversos , Exposição Ocupacional/efeitos adversos
18.
Arch Bronconeumol ; 47(1): 50-1, 2011 Jan.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-21190766

RESUMO

In this note we present the increased prevalence of silicosis found in a marble factory after exposure to a new presentation of silica. A prospective, observational study was conducted on 11 workers who were exposed to different presentations of quartz surfaces since 1995. The jobs were divided into two groups: 4 subjects worked in the cutting workshop; the rest of the workers worked in assembly. Up to that date they had not used any specific respiratory protection apparatus. Six cases of silicosis have been diagnosed, which assumes a disease prevalence in this environment of 54.5%. Of the 6 affected, 5 (83.3% are assemblers. We highlight the high risk of developing silicosis in the handling of different products which make up the range of quartz surfaces.


Assuntos
Carbonato de Cálcio/efeitos adversos , Doenças Profissionais/induzido quimicamente , Doenças Profissionais/epidemiologia , Exposição Ocupacional/efeitos adversos , Quartzo/efeitos adversos , Silicose/epidemiologia , Silicose/etiologia , Adulto , Humanos , Pessoa de Meia-Idade , Prevalência , Estudos Prospectivos
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