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Pharmacol Biochem Behav ; 189: 172841, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-31893526


Environmental pollution caused by antipsychotic residues is a relevant ecological problem. Studies revealed that residues of these drugs are present in a wide range of different ecosystems and can have adverse effects on non-target organisms even in low environmental concentrations. Among these antipsychotic drugs, aripiprazole (APPZ) is a second-generation atypical antipsychotic that is a partial agonist of dopaminergic and serotoninergic receptors. APPZ is used to treat schizophrenia, bipolar disorder, autism, obsessive-compulsive disorder, and anxiety or panic disorders. Thus, in this study we posed the following question: "What will be the behavioral effects of waterborne APPZ on fish?" To answer this question, we exposed adult zebrafish to different APPZ concentrations (0.556, 5.56, and 556 ng/L) for 15 min and evaluated their exploratory, anxiety-like, social, and anti-predatory behaviors. Our results showed that, despite the apparent beneficial reversal of stress-induced social impairment and anxiety-like behavior, APPZ exposure impaired the anti-predatory reaction of adult zebrafish. Taken altogether, our results show that APPZ-exposed zebrafish may have a decreased perception of predators, even at concentrations lower than those already detected in the environment. A failure to exhibit an antipredatory response may favor the predator, decrease the fitness of the prey species, and, consequently, affect the food chain. Our results highlight the risks and consequences associated with APPZ residues in water, which may affect aquatic life and endanger species that depend on appropriate behavioral responses for survival.

Sci Rep ; 7(1): 14121, 2017 10 26.
Artigo em Inglês | MEDLINE | ID: mdl-29074994


The ability to avoid and escape from predators are clearly relevant behaviors from the ecological perspective and directly interfere with the survival of organisms. Detected in the aquatic environment, risperidone can alter the behavior of exposed species. Considering the risk of exposure in the early stages of life, we exposed zebrafish embryos to risperidone during the first 5 days of life. Risperidone caused hyperactivity in exposed larvae, which in an environmental context, the animals may be more vulnerable to predation due to greater visibility or less perception of risk areas.

Comportamento Animal/efeitos dos fármacos , Resíduos de Drogas/farmacologia , Larva/efeitos dos fármacos , Psicotrópicos/farmacologia , Risperidona/farmacologia , Poluentes Químicos da Água/farmacologia , Peixe-Zebra , Animais , Relação Dose-Resposta a Droga
Zebrafish ; 14(1): 51-59, 2017 02.
Artigo em Inglês | MEDLINE | ID: mdl-27672711


In this study, we show that an adaptation of the spinning test can be used as a model to study the exercise-exhaustion-recovery paradigm in fish. This forced swimming test promotes a wide range of changes in the hypothalamus-pituitary-interrenal axis functioning, intermediary metabolism, as well in fish behavior at both exercise and recovery periods. Our results pointed that this adapted spinning test can be considered a valuable tool for evaluating drugs and contaminant effects on exercised fish. This can be a suitable protocol both to environmental-to evaluate contaminants that act in fish energy mobilization and recovery after stressors-and translational perspectives-effects of drugs on exercised or stressed humans.

Glucose/análise , Hidrocortisona/análise , Condicionamento Físico Animal/métodos , Natação , Peixe-Zebra/fisiologia , Animais , Comportamento Animal , Creatina Quinase/análise , Metabolismo Energético , Modelos Animais , Estresse Fisiológico , Peixe-Zebra/sangue
Sci Rep ; 6: 37612, 2016 11 22.
Artigo em Inglês | MEDLINE | ID: mdl-27874070


Here we provide, at least to our knowledge, the first evidence that aripiprazole (APPZ) in the water blunts the stress response of exposed fish in a concentration ten times lower than the concentration detected in the environment. Although the mechanism of APPZ in the neuroendocrine axis is not yet determined, our results highlight that the presence of APPZ residues in the environment may interfere with the stress responses in fish. Since an adequate stress response is crucial to restore fish homeostasis after stressors, fish with impaired stress response may have trouble to cope with natural and/or imposed stressors with consequences to their welfare and survival.

Aripiprazol/toxicidade , Estresse Fisiológico/efeitos dos fármacos , Poluentes Químicos da Água/toxicidade , Peixe-Zebra/fisiologia , Animais , Feminino , Hidrocortisona/metabolismo , Masculino
PLoS One ; 10(10): e0140800, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26473477


The presence of drugs and their metabolites in surface waters and municipal effluents has been reported in several studies, but its impacts on aquatic organisms are not yet well understood. This study investigated the effects of acute exposure to the antipsychotic risperidone on the stress and behavioral responses in zebrafish. It became clear that intermediate concentration of risperidone inhibited the hypothalamic-pituitary-interrenal axis and displayed anxiolytic-like effects in zebrafish. The data presented here suggest that the presence of this antipsychotic in aquatic environments can alter neuroendocrine and behavior profiles in zebrafish.

Ansiolíticos/efeitos adversos , Sistema Hipotálamo-Hipofisário/metabolismo , Sistema Hipófise-Suprarrenal/metabolismo , Risperidona/efeitos adversos , Poluentes Químicos da Água/efeitos adversos , Peixe-Zebra/metabolismo , Animais , Ansiolíticos/farmacologia , Comportamento Animal/efeitos dos fármacos , Sistema Hipotálamo-Hipofisário/patologia , Sistema Hipófise-Suprarrenal/patologia , Risperidona/farmacologia , Poluentes Químicos da Água/farmacologia
Braz. j. vet. res. anim. sci ; 37(5): 382-387, 2000. ilus, graf
Artigo em Português | LILACS | ID: lil-327435


Três vias de fornecimento de dietas pós-operatórias foram comparadas na cicatrizaçäo de esofagostomia cervical. Foram utilizados 15 cäes, divididos em três grupos (GI, GII e GIII). No GI foi procedida à fluidoterapia durante 48 horas, alimento líquido durante mais 48 horas e pastoso por 72 horas (dieta tradicional), no GII o alimento foi fornecido por sonda faringogástrica, colocada por faringostomia, e no GIII por sonda gástrica, implantada por gastrostomia endoscópica percutânea. Para avaliar a cicatrizaçäo, foram realizados exame clínico diário e esofagoscopias semanais, durante seis semanas. A endoscopia perceberam-se algumas ocorrências indesejáveis que retardam a cicatrizaçäo da mucosa esofágica: edema entre os pontos na primeira endoscopia pós-operatória (GI) e ulceraçöes na mucosa esofágica pelo atrito da sonda faringogástrica sobre a cicatriz (GII). A alimentaçäo por sonda gástrica resultou em menor tempo de cicatrizaçäo (1,40 ñ 0,55 semanas, p < 0,01), em comparaçäo aos alimentados por sonda faringogástrica (4,25 ñ 1,50 semanas). No GIII as características clínicas da cicatrizaçäo foram de melhor qualidade, provavelmente devido à ausência de movimentos de deglutiçäo e de atrito do bolo alimentar sobre a ferida cirúrgica. Com base nos resultados, recomenda-se o uso de nutriçäo enteral por sonda gástrica colocada por gastrostomia endoscópica percutânea, durante os primeiros sete dias de pós-operatório, e, na ausência de um endoscópio, a dieta tradicional, que resulta em cicatrizaçäo de melhor qualidade do que o uso de sonda por faringostomia

Animais , Feminino , Esofagostomia , Gastrostomia , Faringostomia , Período Pós-Operatório