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1.
In. Sousa, Amanda Guerra Moraes Rego; Timerman, Ari; Sousa, José Eduardo Moraes Rego. Tratado sobre doença arterial coronária. São Paulo, Atheneu, 2017. p.61-8, ilus.
Monografia em Português | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1084705
2.
In. Sousa, Amanda Guerra Moraes Rego; Timerman, Ari; Sousa, José Eduardo Moraes Rego. Tratado sobre doença arterial coronária. São Paulo, Atheneu, 2017. p.483-90, tab.
Monografia em Português | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1084712
3.
In. Sousa, Amanda Guerra Moraes Rego; Timerman, Ari; Sousa, José Eduardo Moraes Rego. Tratado sobre doença arterial coronária. São Paulo, Atheneu, 2017. p.491-502, tab.
Monografia em Português | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1084713
4.
In. Sousa, Amanda Guerra Moraes Rego; Timerman, Ari; Sousa, José Eduardo Moraes Rego. Tratado sobre doença arterial coronária. São Paulo, Atheneu, 2017. p.89-98.
Monografia em Português | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1084742
5.
In. Santos, Elizabete Silva dos; Trindade, Pedro Henrique Duccini Mendes; Moreira, Humberto Graner. Tratado Dante Pazzanese de emergências cardiovasculares. São Paulo, Atheneu, 2016. p.11-37, ilus, tab.
Monografia em Português | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1083408
6.
In. Timerman, Ari; Sousa, Amanda Guerra de Moraes Rego; Fragata Filho, Abilio Augusto; Armaganijan, Dikran; Bertolami, Marcelo Chiara; Meneghelo, Romeu Sergio. Condutas terapêuticas do Instituto Dante Pazzanese de Cardiologia. São Paulo, Atheneu, 2 ed; 2014. p.89-100, ilus, tab.
Monografia em Português | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1082010
7.
Chest ; 143(4): 978-983, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23288434

RESUMO

BACKGROUND: Obstructive sleep apnea (OSA) is a strong and independent risk factor for the development of hypertension, particularly resistant hypertension, and cardiovascular diseases. Patients with resistant hypertension have a high prevalence of OSA in association with elevated aldosterone levels, high salt intake, and salt-sensitive BP. The objective of this study was to determine whether dietary salt and aldosterone are associated with severity of OSA in patients with resistant hypertension. METHODS: Ninety-seven patients with resistant hypertension were prospectively evaluated by overnight polysomnography and 24-h urinary sodium and aldosterone levels while maintaining their usual diet. Hyperaldosteronism was defined as a plasma renin activity of < 1 ng/mL/h and urinary aldosterone level of ≥ 12 µg/24 h. RESULTS: Overall, patients' mean clinic BP was 156.3 ± 22.4/88.9 ± 13.3 mm Hg while taking an average of 4.3 ± 1.1 antihypertensive medications. Prevalence of OSA was 77.3%. Twenty-eight (28.9%) patients had hyperaldosteronism. Urinary sodium level was an independent predictor of severity of OSA only in patients with hyperaldosteronism. CONCLUSIONS: The findings suggest that dietary salt is related to the severity of OSA in patients with resistant hypertension and hyperaldosteronism. The results support dietary salt restriction as a treatment strategy for reduction of OSA severity in these patients.


Assuntos
Hiperaldosteronismo/epidemiologia , Hipertensão/epidemiologia , Índice de Gravidade de Doença , Apneia Obstrutiva do Sono/diagnóstico , Apneia Obstrutiva do Sono/epidemiologia , Sódio na Dieta/efeitos adversos , Aldosterona/urina , Pressão Sanguínea/fisiologia , Comorbidade , Estudos Transversais , Feminino , Humanos , Hiperaldosteronismo/urina , Hipertensão/urina , Masculino , Pessoa de Meia-Idade , Polissonografia , Prevalência , Estudos Prospectivos , Apneia Obstrutiva do Sono/urina , Sódio/urina
8.
J Geriatr Cardiol ; 9(2): 101-7, 2012 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-22916054

RESUMO

The aging of the population is, currently, a major phenomenon, drawing the attention of a number of investigators. The significant increase of life expectancies over the past few decades, in addition to social and economic consequences, has lead to a major change in the morbidity and mortality profile of elders. Heart failure (HF) is a condition in which the heart can not pump enough blood to meet the body's needs. HF is predominantly a disorder of the elderly with rates increasing exponentially. The prevalence of HF approximately doubles with each decade of life. As people live longer, the occurrence of HF rises, as well as other conditions that complicate its treatment. Impaired heart function implies a reduced duration of survival. Fortunately, many factors that can prevent HF and improve outcome are known and can be applied at any stage. This review emphasizes the importance of factors inherent in aging itself, focusing on heart disease, particularly as a disease of aging, can help critically refine management of this acute and chronic disease, as well as foster preventive strategies to reduce the incidence of this common malady.

9.
Am. j. geriatr. cardiol ; 9(2): 101-107, 2012. ilus, tab
Artigo em Inglês | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1059497

RESUMO

The aging of the population is, currently, a major phenomenon, drawing the attention of a number of investigators. The significantincrease of life expectancies over the past few decades, in addition to social and economic consequences, has lead to a major change in themorbidity and mortality profile of elders. Heart failure (HF) is a condition in which the heart can not pump enough blood to meet the body'sneeds. HF is predominantly a disorder of the elderly with rates increasing exponentially. The prevalence of HF approximately doubles witheach decade of life. As people live longer, the occurrence of HF rises, as well as other conditions that complicate its treatment. Impaired heartfunction implies a reduced duration of survival. Fortunately, many factors that can prevent HF and improve outcome are known and can beapplied at any stage. This review emphasizes the importance of factors inherent in aging itself, focusing on heart disease, particularly as adisease of aging, can help critically refine management of this acute and chronic disease, as well as foster preventive strategies to reduce theincidence of this common malady.


Assuntos
Hipertensão , Idoso , Insuficiência Cardíaca
10.
In. Timerman, Ari; Bertolami, Marcelo; Ferreira, João Fernando Monteiro. Manual de Cardiologia. São Paulo, Atheneu, 2012. p.193-197, tab.
Monografia em Português | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1080109
11.
In. Timerman, Ari; Bertolami, Marcelo; Ferreira, João Fernando Monteiro. Manual de Cardiologia. São Paulo, Atheneu, 2012. p.937-942.
Monografia em Português | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1080147
12.
In. Anon. Livro-texto da Sociedade Brasileira de Cardiologia. Barueri, SP, Manole, 2012. p.110-116.
Monografia em Português | LILACS, Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1081172
13.
In. Anon. Livro-texto da Sociedade Brasileira de Cardiologia. Barueri, SP, Manole, 2012. p.117-128.
Monografia em Português | LILACS, Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1081173
14.
In. Anon. Livro-texto da Sociedade Brasileira de Cardiologia. Barueri, SP, Manole, 2012. p.1551-1564, ilus, tab.
Monografia em Português | LILACS, Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1081218
17.
Arq Bras Cardiol ; 94(4): 556-63, 2010 Apr.
Artigo em Português | MEDLINE | ID: mdl-20498929

RESUMO

The nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most often prescribed drugs in the world. This heterogeneous class of drugs includes aspirin and several other selective or non-selective cyclooxygenase (COX) inhibitors. The non-selective NSAIDs are the oldest ones and are called traditional or conventional NSAIDs. The selective NSAIDs are called COX-2 inhibitors. In recent years, the safety of NSAID use in clinical practice has been questioned, especially that of the selective COX-2 inhibitors. The evidence on the increase in cardiovascular risk with the use of NSAIDs is still scarce, due to the lack of randomized and controlled studies with the capacity of evaluating relevant cardiovascular outcomes. However, the results of prospective clinical trials and meta-analyses indicate that the selective COX-2 inhibitors present important adverse cardiovascular effects, which include increased risk of myocardial infarction, cerebrovascular accident, heart failure, kidney failure and arterial hypertension. The risk of these adverse effects is higher among patients with a previous history of cardiovascular disease or those at high risk to develop it. In these patients, the use of COX-2 inhibitors must be limited to those for which there is no appropriate alternative and, even in these cases, only at low doses and for as little time as possible. Although the most frequent adverse effects have been related to the selective COX-2 inhibition, the absence of selectiveness for this isoenzyme does not completely eliminate the risk of cardiovascular events; therefore, all drugs belonging to the large spectrum of NSAIDs should only be prescribed after consideration of the risk/benefit balance.


Assuntos
Anti-Inflamatórios não Esteroides/efeitos adversos , Doenças Cardiovasculares/induzido quimicamente , Inibidores de Ciclo-Oxigenase/efeitos adversos , Insuficiência Renal/induzido quimicamente , Acidente Vascular Cerebral/induzido quimicamente , Encéfalo/irrigação sanguínea , Encéfalo/efeitos dos fármacos , Sistema Cardiovascular/efeitos dos fármacos , Humanos , Rim/efeitos dos fármacos , Fatores de Risco
18.
Arq. bras. cardiol ; 94(4): 556-563, abr. 2010. tab, ilus
Artigo em Português | LILACS, Sec. Est. Saúde SP | ID: lil-546701

RESUMO

Os anti-inflamatórios não esteroides (AINEs) encontram-se entre os medicamentos mais prescritos em todo o mundo. Essa classe heterogênea de fármacos inclui a aspirina e vários outros agentes inibidores da ciclo-oxigenase (COX), seletivos ou não. Os AINEs não seletivos são os mais antigos, e designados como tradicionais ou convencionais. Os AINEs seletivos para a COX-2 são designados COXIBEs. Nos últimos anos, tem sido questionada a segurança do uso dos AINEs na prática clínica, particularmente dos inibidores seletivos da COX-2. As evidências sobre o aumento do risco cardiovascular com o uso de AINEs são ainda incompletos, pela ausência de ensaios randomizados e controlados com poder para avaliar desfechos cardiovasculares relevantes. Entretanto, os resultados de estudos clínicos prospectivos e de meta-análises indicam que os inibidores seletivos da COX-2 exercem importantes efeitos cardiovasculares adversos, que incluem aumento do risco de infarto do miocárdio, acidente vascular cerebral, insuficiência cardíaca, insuficiência renal e hipertensão arterial. O risco desses efeitos adversos é maior em pacientes com história prévia de doença cardiovascular ou com alto risco para desenvolvê-la. Nesses pacientes, o uso de inibidores da COX-2 deve ser limitado àqueles para os quais não há alternativa apropriada e, mesmo assim, somente em doses baixas e pelo menor tempo necessário. Embora os efeitos adversos mais frequentes tenham sido relacionados à inibição seletiva da COX-2, a ausência de seletividade para essa isoenzima não elimina completamente o risco de eventos cardiovasculares, de modo que todos os fármacos do largo espectro dos AINEs somente devem ser prescritos após consideração do balanço risco/benefício.


The nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most often prescribed drugs in the world. This heterogeneous class of drugs includes aspirin and several other selective or non-selective cyclooxygenase (COX) inhibitors. The non-selective NSAIDs are the oldest ones and are called traditional or conventional NSAIDs. The selective NSAIDs are called COX-2 inhibitors. In recent years, the safety of NSAID use in clinical practice has been questioned, especially that of the selective COX-2 inhibitors. The evidence on the increase in cardiovascular risk with the use of NSAIDs is still scarce, due to the lack of randomized and controlled studies with the capacity of evaluating relevant cardiovascular outcomes. However, the results of prospective clinical trials and meta-analyses indicate that the selective COX-2 inhibitors present important adverse cardiovascular effects, which include increased risk of myocardial infarction, cerebrovascular accident, heart failure, kidney failure and arterial hypertension. The risk of these adverse effects is higher among patients with a previous history of cardiovascular disease or those at high risk to develop it. In these patients, the use of COX-2 inhibitors must be limited to those for which there is no appropriate alternative and, even in these cases, only at low doses and for as little time as possible. Although the most frequent adverse effects have been related to the selective COX-2 inhibition, the absence of selectiveness for this isoenzyme does not completely eliminate the risk of cardiovascular events; therefore, all drugs belonging to the large spectrum of NSAIDs should only be prescribed after consideration of the risk/benefit balance.


Assuntos
Humanos , Anti-Inflamatórios não Esteroides/efeitos adversos , Doenças Cardiovasculares/induzido quimicamente , Inibidores de Ciclo-Oxigenase/efeitos adversos , Insuficiência Renal/induzido quimicamente , Acidente Vascular Cerebral/induzido quimicamente , Encéfalo/irrigação sanguínea , Encéfalo/efeitos dos fármacos , Sistema Cardiovascular/efeitos dos fármacos , Rim/efeitos dos fármacos , Fatores de Risco
20.
Rev. bras. hipertens ; 16(4): 211-214, out.-dez. 2009.
Artigo em Português | LILACS | ID: lil-556456

RESUMO

Diuréticos, especialmente tiazídicos e correlatos, têm sido utilizados no tratamento da hipertensão arterial há mais de 40 anos e permanecem como uma das cinco classes de medicamentos anti-hipertensivos de primeira linha. Diuréticos continuam sendo utilizados em monoterapia, mas sobretudo em associações fixas ou não, com os demais agentes anti-hipertensivos devido à potencialização de seus efeitos redutores da pressão arterial. São fármacos de baixo custo e boa tolerabilidade. Suas principais reações adversas relacionam-se a distúrbios eletrolíticos e metabólicos, os quais se tornaram menos frequentes e menos intensos com a utilização de doses menores do que as empregadas inicialmente. Neste artigo são discutidos os principais efeitos colaterais do uso crônico dos diuréticos, bem como as consequências de algumas interações medicamentosas com outros agentes anti-hipertensivose fármacos em geral.


Diuretics, especially tiazides and correlates, have been used in the treatment of the arterial hypertension for more than 40 years and remain as one of the five Top line antihypertensive classes. Diuretics continue being used in monotherapy, but over all in associations, fixed or not, witht he other antihypertensive agents due the potencialization of its reducing effect of the arterial pressure. They are drugs of low cost and good tolerability. Their main adverse reactions are related to electrolytic and metabolic disturbs, which have become less frequent and less intensive with the use of lower doses in comparison with the doses employed initially. In this article the main collateral effects of the chronic use of diuretics, are discussed as well as the consequences of some drugs interactions with other antihypertensive agents and drugs of general uses.


Assuntos
Anti-Hipertensivos/efeitos adversos , Diuréticos , Hipertensão/terapia
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