Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Mais filtros

Base de dados
Intervalo de ano de publicação
Tuberculosis (Edinb) ; 117: 7-17, 2019 07.
Artigo em Inglês | MEDLINE | ID: mdl-31378272


The currently available methods are unable to directly detect dormant forms of Mycobacterium tuberculosis (Mtb) in vivo. The persistence of Mtb in the host body is detectable only in an indirect manner via the immunological response to Mtb-specific antigens. It is commonly recognized that the pathogen prevalently exists in the human body in a latent stage. Additional research efforts focusing on the Mtb dormancy are needed for development of sterilizing drugs, which are necessary to control LTBI and stop TB epidemic. To this end, the in vitro models of Mtb dormancy may be useful. This review briefly describes the phenomenon of Mtb dormancy and its role in the context of tuberculosis as a persistent bacterial infection; then the article characterizes in details the in vitro methods used for modeling the Mtb dormancy in bacterial cultures.

Tuberculose Latente/microbiologia , Modelos Biológicos , Mycobacterium tuberculosis/isolamento & purificação , Antibióticos Antituberculose/farmacologia , Fenômenos Fisiológicos Bacterianos , Proliferação de Células/genética , Proliferação de Células/fisiologia , Tolerância a Medicamentos , Regulação da Expressão Gênica/fisiologia , Humanos , Mycobacterium tuberculosis/efeitos dos fármacos , Mycobacterium tuberculosis/genética , Mycobacterium tuberculosis/fisiologia