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1.
Medicine (Baltimore) ; 100(2): e24071, 2021 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-33466166

RESUMO

ABSTRACT: The study included 38 ulnar nerves in 20 healthy subjects. High-resolution ultrasound and Shear wave elastography were used to evaluate the ulnar nerve at the mid forearm. The mean cross-sectional area of the ulnar nerve was 7.1 mm2. The mean shear elastic modulus of the nerve in the short axis was 27.4 kPa. The mean shear elastic modulus of the nerve in long axis was 24.7 kPa. No statistical relation could be noted between elasticity measurements in long and short axes. The ulnar nerve elastic modulus also showed no correlation with CSA neither in the long axis nor short axis. Age, height, weight, and body mass index showed no correlation with the ulnar elastic modulus in short or long axes. The elastic modulus of the ulnar nerve has been determined in healthy subjects and can serve as a reference for future assessment of compressive neuropathies of the ulnar nerve.


Assuntos
Técnicas de Imagem por Elasticidade/métodos , Antebraço/diagnóstico por imagem , Antebraço/inervação , Nervo Ulnar/diagnóstico por imagem , Adulto , Feminino , Voluntários Saudáveis , Humanos , Masculino , Pessoa de Meia-Idade , Valores de Referência
2.
Medicine (Baltimore) ; 99(37): e22120, 2020 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-32925760

RESUMO

The purpose of this study is to study sonoelastographic features of the saphenous nerve.The study included 72 saphenous nerves in 36 healthy subjects. High resolution ultrasound and Shearwave elastography were used to evaluate the saphenous nerve. Cross sectional area (CSA) and stiffness were measured.The mean CSA of the saphenous nerve was 5.7 mm. The mean shear elastic modulus of the saphenous nerve in the short axis was 29.5 kPa. The mean shear elastic modulus of the saphenous nerve in long axis was 29.9 kPa. The saphenous nerve elastic modulus also showed no correlation with CSA in neither the long axis nor short axis. Positive correlation between elasticity measurements in the long and short axes. Age, height, weight, and BMI showed no correlation with saphenous nerve elastic modulus in short or long axes.The elastic modulus of the saphenous nerve has been determined in healthy subjects and can serve as a reference for future assessment of the saphenous nerve before different procedures.


Assuntos
Técnicas de Imagem por Elasticidade , Elasticidade/fisiologia , Nervos Periféricos/diagnóstico por imagem , Nervos Periféricos/fisiologia , Coxa da Perna/inervação , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Valores de Referência , Coxa da Perna/diagnóstico por imagem , Adulto Jovem
3.
Mult Scler Relat Disord ; 29: 111-117, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30708308

RESUMO

BACKGROUND: Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system. Depression is common among MS patients. In patients without MS, lower vitamin D levels were associated with higher depression scores and severity. Supplementation of vitamin D was associated with significant improvement of depressive symptoms. OBJECTIVE: to evaluate the relation between vitamin D levels and depression scores, and the effect of vitamin D replacement on the depressive symptoms in patients with MS. METHODS: The study included 35 patients with relapsing remitting multiple sclerosis. Neurological, psychiatric, and radiological evaluations were done. Participants received 10,000 IU of cholecalciferol daily for 12 months. RESULTS: Vitamin D level was low at baseline. Depressive symptoms were high at baseline and improved with vitamin D replacement although, Expanded Disability Status Scale (EDSS) score was not improving. Vitamin D levels correlated negatively with depressive symptoms at baseline and follow up periods. CONCLUSION: Lower vitamin D levels are associated with higher depressive scores, and vitamin D replacement could improve depressive symptoms in patients with relapsing remitting multiple sclerosis.


Assuntos
Depressão/tratamento farmacológico , Esclerose Múltipla Recidivante-Remitente/tratamento farmacológico , Esclerose Múltipla Recidivante-Remitente/fisiopatologia , Avaliação de Resultados em Cuidados de Saúde , Vitamina D/sangue , Vitamina D/farmacologia , Adulto , Colecalciferol/farmacologia , Depressão/sangue , Depressão/fisiopatologia , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Esclerose Múltipla Recidivante-Remitente/sangue , Vitamina D/administração & dosagem
5.
Medicine (Baltimore) ; 97(24): e11104, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29901629

RESUMO

The objective of this study is to determine whether the cross sectional area (CSA) measurement of the median nerve at the wrist differ between carpal tunnel syndrome (CTS) in diabetic patients with and without diabetic polyneuropathy (DPN).This study included 44 patients with type II diabete millitus (DM) with CTS, 32 patients with CTS and DPN, 46 patients with idiopathic CTS, and 42 healthy subjects. Ultrasonographic measurement of the CSA of the median nerve was made at the level of the wrist, together with nerve conduction studies.The median CSA at the wrist was significantly larger in all patient groups compared with healthy subjects. The median nerve CSA was significantly larger in diabetic patients with CTS than patients with idiopathic CTS. The median nerve CSA at wrist was significantly smaller in patients with CTS and DPN compared with diabetic patients with CTS only.The median nerve CSA at the wrist was larger in diabetic patients with CTS than patients with idiopathic CTS and CTS with DPN. Median nerve CSA can help to differentiate between diabetic patients with CTS with and without DPN.


Assuntos
Síndrome do Túnel Carpal/diagnóstico por imagem , Diabetes Mellitus Tipo 2/complicações , Neuropatias Diabéticas/complicações , Nervo Mediano/diagnóstico por imagem , Ultrassonografia/métodos , Adulto , Síndrome do Túnel Carpal/etiologia , Síndrome do Túnel Carpal/fisiopatologia , Neuropatias Diabéticas/diagnóstico por imagem , Neuropatias Diabéticas/fisiopatologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Condução Nervosa , Punho/diagnóstico por imagem
6.
Neurol Res ; 40(9): 805-810, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-29873619

RESUMO

OBJECTIVES: Sonoelastography is an emerging technology that has been used to evaluate the musculoskeletal system including the brachial plexus of peripheral nerves, which has been only recently considered for study by shear wave elastography. The purpose of this study is to establish the normal sonoelastographic features of the C5-C7 nerve roots of the brachial plexus. METHODS: Forty healthy individuals (21 males and 19 females) were enrolled in the study. Shear wave elastography was used to evaluate the C5-C7 nerve roots of the brachial plexus at the interscalene interval. Normal sonoelastographic values were obtained. RESULTS: The mean shear elastic modulus of the C5 nerve root was 16.9 kPa (range 5.9-28.8 ± 4.9 standard deviation, SD), 15.7 kPa (range 5.4-26.3 ± 4.3 SD) for the C6 nerve root, and 16 kPa (range 8-29 ± 4.6 SD) for the C7 nerve root. There was a significant statistical difference between both sexes in the elastic modulus at the C6 and C7, but not at the C5 nerve roots. Significant inverse correlation with height was noted at the C6 nerve root. There was no statistical significant difference in tissue stiffness between right- and left-handed subjects, age, and body mass index. CONCLUSION: The elastic modulus of the C5-C7 nerve roots has been determined in asymptomatic individuals and can serve as a reference when studying pathological conditions of these structures. ABBREVIATIONS: BMI: body mass index; SWE: shear wave elastography.


Assuntos
Plexo Braquial/diagnóstico por imagem , Técnicas de Imagem por Elasticidade , Raízes Nervosas Espinhais/diagnóstico por imagem , Adulto , Índice de Massa Corporal , Vértebras Cervicais/diagnóstico por imagem , Módulo de Elasticidade , Feminino , Humanos , Masculino , Adulto Jovem
7.
Medicine (Baltimore) ; 97(12): e0179, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29561431

RESUMO

The objective of this study is to estimate the reference values for the lower limb peripheral nerves in adults.The demographics and physical characteristics of 69 adult healthy volunteers were evaluated and recorded. The estimated reference values and their correlations with the age, weight, height, body mass index (BMI) were evaluated.The cross sectional area reference values were obtained at 5 predetermined sites for 3 important lower limb peripheral nerves. Our CSA values correlated significantly with age, weight, and BMI. The normal reference values for each nerve were as follows: Tibial nerve at the popliteal fossa 19 mm ±â€Š6.9, tibial nerve at the level of the medial malleolus 12.7 mm ±â€Š4.5, common peroneal nerve at the popliteal fossa 9.5 mm ±â€Š4, common peroneal nerve fibular head 8.9 mm ±â€Š3.2, sural nerve 3.5 mm ±â€Š1.4.The reference values for the lower limb peripheral nerves were identified. These values could be used for future management of peripheral nerve disorders.


Assuntos
Extremidade Inferior/inervação , Nervos Periféricos/anatomia & histologia , Nervos Periféricos/diagnóstico por imagem , Ultrassonografia , Adulto , Idoso , Envelhecimento , Índice de Massa Corporal , Peso Corporal , Estudos Transversais , Humanos , Extremidade Inferior/anatomia & histologia , Extremidade Inferior/diagnóstico por imagem , Pessoa de Meia-Idade , Tamanho do Órgão , Valores de Referência , Adulto Jovem
8.
Medicine (Baltimore) ; 96(10): e6204, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-28272211

RESUMO

The objective of this study is to estimate the reference values for the number of fascicles and cross-sectional area (CSA) of the ulnar nerve at a single predetermined site by ultrasound in healthy young adult males.The demographic and physical characteristics of 50 adult male volunteers were evaluated and recorded. The subjects were positioned supine with the elbow flexed at 90° and the palm of the hand placed on a hard surface. The ulnar nerve was scanned bilaterally 1 cm proximal to the medial epicondyle in projection of the cubital tunnel. The number of fascicles and mean CSA of the ulnar nerve were identified. In addition, the side-to-side differences of the estimated reference values and their correlations with the age, weight, height, and body mass index (BMI) were evaluated.The mean fascicular number was 5.66 ±â€Š1.48, the mean ultrasound-estimated CSA of the ulnar nerve was 6.54 ±â€Š1.67 mm and both sides were comparable in the mean CSA and fascicular number (6.43 ±â€Š1.80 mm and 5.88 vs 6.64 ±â€Š1.55 mm and 5.44, for right and left side, respectively). No significant correlations were observed between CSA and fascicles number and age, weight, height, or BMI of study subjects.The reference values for the number of fascicles number and the CSA of the ulnar nerve at a single predetermined site were identified. These values could be used for the sonographic diagnosis and follow-up of the ulnar nerve lesions.


Assuntos
Nervo Ulnar/diagnóstico por imagem , Ultrassonografia , Adolescente , Estudos Transversais , Voluntários Saudáveis , Humanos , Masculino , Valores de Referência , Adulto Jovem
9.
Medicine (Baltimore) ; 96(50): e9306, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-29390395

RESUMO

The objective of this study is to estimate the reference values for the upper limb peripheral nerves in adults.The demographics and physical characteristics of 69 adult healthy volunteers were evaluated and recorded. In addition, the side to side differences of the estimated reference values and their correlations with the age, weight, height, and body mass index (BMI) were evaluated.Cross-sectional area reference values of the upper limb nerves did not correlate with height; however, they correlated with age, weight, and BMI in some scanned sites.The data obtained in this study could be helpful in future diagnosis of peripheral nerve disorders of the upper limb.


Assuntos
Nervos Periféricos/diagnóstico por imagem , Extremidade Superior/inervação , Adulto , Idoso , Estudos Transversais , Feminino , Voluntários Saudáveis , Humanos , Masculino , Pessoa de Meia-Idade , Valores de Referência
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