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Ter Arkh ; 75(3): 36-40, 2003.
Artigo em Russo | MEDLINE | ID: mdl-12718218


AIM: To study the activity of angiotensin-converting enzyme (ACE) in patients with pneumonia and chronic obstructive lung diseases (COLD). MATERIAL AND METHODS: Sixty nine patients with pneumonia and 77 with COLD were examined. The activity of ACE in the serum and bronchoalveolar lavage (BAL) and the effects of leukocytic elastase and concentrations of zinc, endogenous inhibitors, and activators were studied. RESULTS: The patients with pneumonia in the acute phase of the disease have been found to have low ACE activity in both blood and BAL. As the inflammatory process comes to an end, ACE activity normalizes. In the patients with COLD, the activity of ACE is primarily decreased at remission. When COLD aggravates, the activity of ACE in blood and BAL increases. In pneumonia and COLD, the changes in ACE activity are more profound in BAL than in blood. CONCLUSION: The only cause of the altered activity of ACE in patients with COLD and pneumonia is a change in the concentration of the enzyme.

Peptidil Dipeptidase A/metabolismo , Doença Pulmonar Obstrutiva Crônica/metabolismo , Líquido da Lavagem Broncoalveolar , Humanos
Vopr Med Khim ; 48(2): 204-14, 2002.
Artigo em Russo | MEDLINE | ID: mdl-12189629


The activity of angiotensin converting enzyme (ACE) was analysed in blood serum and bronchial fluid of 69 patients with acute pneumonia and 77 patients with chronic obstructive pulmonary diseases (COPD). In patients with pneumonia in acute phase ACE activity was lower in both serum and bronchial fluid. During recovery of patients with acute pneumonia ACE activity was normalizated. In patients with COPD ACE activity was lower in remission stage and higher (both serum and bronchial fluid) during COPD exacerbation. The changes of ACE activity were more pronounced in bronchial fluid than serum in both COPD and pneumonia.

Pneumonia/enzimologia , Doença Pulmonar Obstrutiva Crônica/enzimologia , Renina/metabolismo , Biomarcadores/sangue , Humanos , Doença Pulmonar Obstrutiva Crônica/sangue
Voen Med Zh ; (4): 48-51, 80, 1993 Apr.
Artigo em Russo | MEDLINE | ID: mdl-8328143


According to the structural metabolic theory of radiation injuries radiotoxins perform a leading role in the development of disorders. The experiments have disclosed the characteristic features of the development of toxemia in irradiated organism. These data have served as a ground for studying the efficiency of various methods of detoxication. Metabolic plasmapheresis is seemed to be of most pronounced effect in comparison with other methods of detoxication. On the basis of the results of these studies several practical recommendations were provided for performing an early disintoxicative therapy in patients with radiation injuries.

Lesões por Radiação/terapia , Desintoxicação por Sorção , Adulto , Doença de Hodgkin/sangue , Doença de Hodgkin/complicações , Doença de Hodgkin/radioterapia , Humanos , Masculino , Lesões por Radiação/sangue , Lesões por Radiação/etiologia , Radioterapia/efeitos adversos , Fatores de Tempo , Toxemia/sangue , Toxemia/etiologia , Toxemia/terapia
Lab Delo ; (11): 50-2, 1991.
Artigo em Russo | MEDLINE | ID: mdl-1722851


Biologic integral methods for indication of blood toxicity, the migration activity of intact donor leukocytes in agar, and the splenocytotoxic test were used in radiotoxemia assessment in 62 oncologic patients with radiation reactions and in studies on the efficacy of detoxifying therapy with polyvisoline, a new blood substitute, in 25 subjects. Both the methods for studies of the blood serum toxicity were found sufficiently informative and unsophisticated, but the splenocytotoxic test proved to be more sensitive, simple, and rapid.

Doença de Hodgkin/radioterapia , Radioterapia/efeitos adversos , Toxemia/etiologia , Neoplasias do Colo do Útero/radioterapia , Testes Imunológicos de Citotoxicidade , Feminino , Humanos , Masculino , Toxemia/diagnóstico