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1.
Artigo em Russo | MEDLINE | ID: mdl-31626220

RESUMO

AIM: To evaluate the efficacy and safety of cortexin in the complex of rehabilitation measures for verticalization in patients with ischemic stroke in the acute period. MATERIAL AND METHODS: The study included 90 patients with hemispheric ischemic stroke. Patients of the first group (n=30) received cortexin in a dose of 20 mg per day intramuscularly for 10 days, along with basic therapy during early verticalization. Patients of the second group (n=30) received basic therapy during early verticalization and patients of the third group (n=30) received only basic therapy without verticalization. To assess the severity of condition, NIHSS, modified Rankin scale, the Barthel index, the Rivermead mobility index, MMSE, MOCA were used. To study cardiovascular function in patients, the segmental part of the autonomic nervous system was studied: a test with isometric load, a Valsalva test, a test based on the change in heart rate with slow deep breathing. All studies were conducted before and 10-14 days after treatment. RESULTS AND CONCLUSION: The most complete regression of neurological deficits and manifestations of cardiac autonomic neuropathy during the acute period of ischemic stroke was observed in the group of patients treated with cortexin (20 mg per day for 10 days), along with basic therapy and early verticalization, compared to the groups, which received basic therapy with early verticalization or basic therapy without verticalization.


Assuntos
Isquemia Encefálica , Peptídeos e Proteínas de Sinalização Intercelular , Acidente Vascular Cerebral , Isquemia Encefálica/tratamento farmacológico , Humanos , Peptídeos e Proteínas de Sinalização Intercelular/uso terapêutico , Peptídeos , Acidente Vascular Cerebral/tratamento farmacológico , Resultado do Tratamento
2.
Artigo em Russo | MEDLINE | ID: mdl-30874524

RESUMO

AIM: To make a critical assessment of the therapeutic effect of complex therapy with cortexin and recognan (citicoline) for cognitive impairments in patients with chronic cerebrovascular pathology. MATERIAL AND METHODS: Presented is an analysis of results of the multicenter observation program to assess the efficacy of cortexin and recognan (citicoline) in the treatment of cognitive impairments in patients with chronic cerebrovascular pathology. Three hundred and nine patients with chronic cerebrovascular pathology, including 134 (43.4%) men and 175 (56.6%) women, aged from 30 to 80, average age 63.4±9.4 years, with confirmed cognitive deficit were examined. The diagnosis was established on the basis of complaints, case reports, the results of CT/MRI studies, as well as assessments of the neurological status and cognitive functions. Cognitive impairments were confirmed by the number of points on the Mini-mental state examination (MMSE) and the Clock drawing test. The assessment of depression was made with the Mini Geriatric Depression Scale (MGDS). All patients received cortexin and recognan (citicoline) ('Geropharm', Russia) at doses 10 mg/day for 10 days and 1000 mg/day for 1 month, respectively. RESULTS AND CONCLUSION: Complex therapy with cortexin and recognan (citicoline) showed high efficacy in the treatment of vascular cognitive disorders. The results of the study allow us to recommend the complex administration of cortexin and recognan (citicoline) ('Geropharm', Russia) in doses of 10 mg/day for 10 days and 1000 mg/day for 1 month, respectively, for chronic cerebrovascular pathology.


Assuntos
Disfunção Cognitiva , Adulto , Idoso , Idoso de 80 Anos ou mais , Citidina Difosfato Colina , Feminino , Humanos , Peptídeos e Proteínas de Sinalização Intercelular , Masculino , Pessoa de Meia-Idade , Peptídeos , Federação Russa
3.
Artigo em Russo | MEDLINE | ID: mdl-30132453

RESUMO

AIM: To study the efficacy and prolonged effect of repeated treatment with low-doses of the neuroprotection drug cortexin (30 mg, (10+10+10, morning, noon, day), daily) in patients in the acute period of hemispheric ischemic stroke. MATERIAL AND METHODS: One hundred and twenty-two patients with hemispheric ischemic stroke were studied. Patients of the first group (n=30) received cortexin in a dose of 20 mg (10+10) intramuscularly along with basic therapy, patients of the second group (n=30) received two courses of cortexin in the same dose for 10 days each with a break of 10 days in-between, patients of the third group (n=30) received only basic therapy, patients of the fourth group (n=32) received cortexin in a dose of 30 mg (10+10+10), two courses for 10 days each with a break of 10 days in-between. NIHSS, modified Rankin scale, Barthel index, Rivermead mobility index, MMSE, MOCA-test were used to evaluate the severity of the condition. RESULTS AND CONCLUSION: The most complete regression of neurological deficit during the acute period of ischemic stroke was observed in the fourth group of patients (30 mg (10+10+10) of cortexin, two courses) compared to the 1-3 groups.


Assuntos
Isquemia Encefálica , Acidente Vascular Cerebral , Humanos , Injeções Intramusculares , Fármacos Neuroprotetores , Índice de Gravidade de Doença , Resultado do Tratamento
4.
Artigo em Russo | MEDLINE | ID: mdl-29171488

RESUMO

AIM: To assess the efficacy and safety of recognan in patients with acute ischemic stroke (IS). MATERIAL AND METHODS: Seventy-nine patients, aged from 30 to 80 years, were examined in the early stage of IS. All patients received recognan (citicoline) in dose of 1000 mg/daily during 15 days. The recovery of cognitive functions (MMSE), level of consciousness (Glasgow Coma Scale), severity of focal neurological deficit (NIHSS) and functional recovery (Rankin scale, Barthel index, Rivermead Mobility Index) were assessed. RESULTS AND CONCLUSION: A decrease of cognitive impairment, improvement of memory, regression of neurological symptoms and increase in the motor activity were observed. Recognan used in dose of 1000 mg/daily during 15 days in the complex treatment of patients with IS promotes the recovery of cognitive function, reduces neurological symptoms and improves the recovery of motor activity.


Assuntos
Citidina Difosfato Colina/uso terapêutico , Nootrópicos/uso terapêutico , Acidente Vascular Cerebral/tratamento farmacológico , Adulto , Idoso , Idoso de 80 Anos ou mais , Isquemia Encefálica/complicações , Cognição/efeitos dos fármacos , Disfunção Cognitiva/prevenção & controle , Citidina Difosfato Colina/farmacologia , Feminino , Escala de Coma de Glasgow , Humanos , Masculino , Memória/efeitos dos fármacos , Pessoa de Meia-Idade , Nootrópicos/farmacologia , Recuperação de Função Fisiológica , Acidente Vascular Cerebral/etiologia , Acidente Vascular Cerebral/psicologia
5.
Artigo em Russo | MEDLINE | ID: mdl-29053121

RESUMO

AIM: To study the efficacy of a current regimen of treatment with cavinton for infusions and cavinton comforte in patients with ischemic stroke in acute and early recovery periods and to evaluate an impact of treatment on erythrocyte deformity using atomic power microscopy. MATERIAL AND METHODS: One hundred and sixty-four patients with hemispheric ischemic stroke, aged from 30 to 79 years, were randomized into main (n=100) and control (n=64) groups. Patients of the main group received complex treatment (basic therapy and cavinton R for drop infusions (10 intravenously during 10 days) followed by cavinton R comforte in dose 10 mg, 1 tablet 3 times a day during 90 days). Patients of the control group received basic therapy only. NIHSS, the Rankin scale, the Barthel index, MMSE, MоCA, the Rivermead scale, Beck depression scale, HADS were used to measure the severity of patient's state. To study the erythrocyte membrane by estimating Young's modulus, dry preparations were made with the following scanning of erythrocytes using atomic power microscopy. RESULTS: Positive changes on all scales were observed in both groups. Higher scores on NIHSS, Rankin, Barthel, MоCA, MMSE, Rivermead mobility index were found in the main group compared to the controls. There were no differences in scores on the Beck depression scale and HADS. A decrease in Young's modulus was found in the main group while in the control group this index remained unchanged. CONCLUSION: More rapid and complete regression of neurological deficit, better recovery of self-care function, cognitive function and social activity, an increase in erythrocyte membrane elasticity were found in the main group compared to the control one. These results indicate the efficacy of cavinton R and cavinton R comforte in the regimen used in complex treatment in acute and early recovery periods after ischemic stroke.


Assuntos
Isquemia Encefálica/complicações , Acidente Vascular Cerebral/tratamento farmacológico , Acidente Vascular Cerebral/etiologia , Alcaloides de Vinca/uso terapêutico , Adulto , Idoso , Cognição , Quimioterapia Combinada , Módulo de Elasticidade , Membrana Eritrocítica , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Índice de Gravidade de Doença , Resultado do Tratamento , Alcaloides de Vinca/administração & dosagem
6.
Artigo em Russo | MEDLINE | ID: mdl-28884715

RESUMO

AIM: To study the efficacy and safety of recognan (citicoline) in the treatment of cognitive and depressive disorders in chronic cerebrovascular pathology (chronic brain ischemia) developed in patients with arterial hypertension and/or atherosclerosis. MATERIAL AND METHODS: Seven hundred and thirty-six patients with cerebrovascular pathology, cognitive impairment and mild dementia were examined. The sample included 279 (37.9%) men and 457 (62.1%) women aged from 35 to 80 years (mean age 64.5±8.7 years). The drug recognan ('Gerofarm', Russia) was administered in the dose of 1000 mg daily during 30 days. Recovery of cognitive functions was assessed with MSSE, correction of visual/spatial coordination with CDT, depression severity with MGDS. RESULTS: The improvement of cognitive function, memory and visual/spatial coordination, decrease in depression severity were observed during the treatment. CONCLUSION: Recognan reduced cognitive dysfunction and disturbances of visual/spatial coordinationas well as had a positive effect on the emotional sphere decreasing the level of depression.


Assuntos
Isquemia Encefálica/complicações , Disfunção Cognitiva/tratamento farmacológico , Citidina Difosfato Colina/uso terapêutico , Demência/tratamento farmacológico , Hipertensão/complicações , Arteriosclerose Intracraniana/complicações , Nootrópicos/uso terapêutico , Adulto , Idoso , Idoso de 80 Anos ou mais , Isquemia Encefálica/psicologia , Cognição , Disfunção Cognitiva/etiologia , Citidina Difosfato Colina/administração & dosagem , Demência/etiologia , Depressão/tratamento farmacológico , Depressão/etiologia , Feminino , Humanos , Hipertensão/psicologia , Arteriosclerose Intracraniana/psicologia , Masculino , Memória , Testes de Estado Mental e Demência , Pessoa de Meia-Idade , Nootrópicos/administração & dosagem , Resultado do Tratamento
7.
Artigo em Russo | MEDLINE | ID: mdl-28805757

RESUMO

AIM: To study an influence of cytoflavin therapy on the cerebral hemodynamics in patients with various stages of hypertensive disease (HD). MATERIAL AND METHODS: One hundred and forty patients with HD, I-III stages, were randomized into 2 groups: patients of group 1 received complex treatment (antihypertensive therapy and cytoflavin), patients of group 2 were treated with antihypertensive therapy. The control group consisted of 30 healthy people. The changes in cerebral hemodynamics using the algorithm of the complex ultrasound study of cerebral vascular system were assessed. RESULTS: Disturbances of hemodynamics at all structural/functional levels of cerebral vascular system were found in all HD stages. There were a decrease in the blood flow through the common carotid, inner carotid, spinal and middle cerebral arteries, reactivity of veins of Rosenthal, blood flow through veins of Rosenthal and inner jugular veins and an increase of blood flow through spinal veins. The hemodynamic study showed that in group 1 there was the increase of blood flow through common carotid, inner carotid, middle cerebral arteries in stage I and through spinal arteries in stage I-II of HD; improvement of the reactivity of veins of Rosenthal, restoration of blood flow parameters through the veins of Rosenthal and inner jugular veins to control values, the decrease in blood flow velocity through the spinal veins in all HD stages. CONCLUSION: HD is accompanied by the damage of all structural/functional levels of cerebral vascular system. The use of cytoflavin in the complex therapy of HD exerts a positive influence on the cerebral hemodynamics reducing the severity of arterial insufficiency in the initial stages of disease, improving microcirculation and venous hemodynamics in all HD stages.


Assuntos
Circulação Cerebrovascular/efeitos dos fármacos , Mononucleotídeo de Flavina/farmacologia , Hemodinâmica/efeitos dos fármacos , Hipertensão/tratamento farmacológico , Inosina Difosfato/farmacologia , Niacinamida/farmacologia , Succinatos/farmacologia , Idoso , Anti-Hipertensivos/uso terapêutico , Velocidade do Fluxo Sanguíneo/efeitos dos fármacos , Encéfalo/irrigação sanguínea , Encéfalo/diagnóstico por imagem , Combinação de Medicamentos , Quimioterapia Combinada , Feminino , Mononucleotídeo de Flavina/uso terapêutico , Humanos , Inosina Difosfato/uso terapêutico , Masculino , Microcirculação/efeitos dos fármacos , Pessoa de Meia-Idade , Niacinamida/uso terapêutico , Succinatos/uso terapêutico , Ultrassonografia
8.
Zh Nevrol Psikhiatr Im S S Korsakova ; 117(12): 116-123, 2017.
Artigo em Russo | MEDLINE | ID: mdl-29376994

RESUMO

The review covers the topic of cerebral venous thrombosis (CVT) in women taking hormonal contraceptives. The paper gives the definition of CVT, the history and analysis of epidemiological data. It was shown that the increased risk of CVT occurs due to the influence of hormonal contraceptives on the system of hemostasis and severity of the risk depends on the preparation formula, the way and duration of its administration. The authors show the role of combination of hormonal contraceptives with other risk factors and predisposing conditions for the development of thrombosis. The rules for choosing the method of contraception in accordance with generally accepted recommendations are suggested. The description of pathogenic mechanisms of CVT, clinical picture and disease as well as neuroimaging criteria and the rules for choosing a diagnostic method are presented. The authors provide the description of complex therapy in the acute period of the disease, the rules for secondary prevention. Particular attention is paid to the possibility of using dipyridamole, which has a pleiotropic effect, influencing all the components of the Virchov triad, as a part of a complex therapy and secondary prevention.


Assuntos
Anticoncepcionais/efeitos adversos , Dipiridamol/uso terapêutico , Trombose Intracraniana/induzido quimicamente , Trombose Intracraniana/tratamento farmacológico , Trombose Venosa/induzido quimicamente , Trombose Venosa/tratamento farmacológico , Anticoncepcionais/administração & dosagem , Suscetibilidade a Doenças , Feminino , Humanos , Trombose Intracraniana/epidemiologia , Trombose Intracraniana/prevenção & controle , Fatores de Risco , Trombose Venosa/epidemiologia , Trombose Venosa/prevenção & controle
9.
Zh Nevrol Psikhiatr Im S S Korsakova ; 116(8 Pt 2): 40-43, 2016.
Artigo em Russo | MEDLINE | ID: mdl-27905386

RESUMO

AIM: To study the effect of repeated low-dose course of neuroprotection by drug cortexin on cognitive impairment in the acute and early recovery periods of hemispheric ischemic stroke. MATERIAL AND METHODS: The study involved 90 patients with poluchennym ischemic stroke. Patients of the first group received cortexin 20 mg (10+10) intramuscularly on the background of basic therapy, patients of the second group (n=30) received cortexin 20 mg (10+10) two courses for 10 days each with a break in between of 10 days, the patients of the third group - only basic therapy. For the objectification of cognitive impairment used a scale MMSE, a test of 5 words, the battery of frontal dysfunction, clock drawing test, MOCA test. RESULTS: It was noted more rapid and complete regression of cognitive disorders in patients of the 1st and 2nd groups, in comparison with patients of the 3rd group. However, the best effect of the therapy was observed still in the group of patients treated with the double rate of the drug cortexin.


Assuntos
Disfunção Cognitiva/tratamento farmacológico , Fármacos Neuroprotetores/uso terapêutico , Peptídeos/uso terapêutico , Acidente Vascular Cerebral/complicações , Isquemia Encefálica , Transtornos Cognitivos , Disfunção Cognitiva/etiologia , Humanos , Injeções Intramusculares , Peptídeos e Proteínas de Sinalização Intercelular , Neuroproteção , Testes Neuropsicológicos
10.
Artigo em Russo | MEDLINE | ID: mdl-27845314

RESUMO

AIM: To study the effectiveness and sustained effects of early appointment of a repeated course of low-dose drug cortexin neuroprotection in patients in acute and recovery period of hemispheric ischemic stroke. MATERIAL AND METHODS: The study included 90 patients with hemispheric ischemic stroke. Patients of the first group received 20 mg cortexin (10+10) intramuscularly on basic therapy, the patients of the second group (n=30) was obtained cortexin 20 mg (10+10) in the two courses each for 10 days with an interval between them in 10 days, patients of the third group - only basic therapy. For objectification severity used NIH stroke scale, modified Rankin scale, the Barthel index, the Rivermead mobility index, MMSE. RESULTS AND CONCLUSION: Appointment in acute hemispheric ischemic stroke drug cortexin repeated course leads to more complete regression of neurological deficit, compared to the comparison group and the group of patients who received one course of medication cortexin, for all acute and early recovery period of ischemic stroke from 11-13 days of illness.


Assuntos
Isquemia Encefálica/complicações , Peptídeos/uso terapêutico , Reabilitação do Acidente Vascular Cerebral , Acidente Vascular Cerebral/tratamento farmacológico , Idoso , Feminino , Humanos , Injeções Intramusculares , Peptídeos e Proteínas de Sinalização Intercelular , Masculino , Pessoa de Meia-Idade , Peptídeos/administração & dosagem , Índice de Gravidade de Doença , Acidente Vascular Cerebral/etiologia , Resultado do Tratamento
11.
Klin Med (Mosk) ; 94(2): 138-43, 2016.
Artigo em Russo | MEDLINE | ID: mdl-27459764

RESUMO

AIM: To study the neuroprotective effect of a repeated course of low dose cortexin therapy on the quality of life in the early rehabilitative period after hemispheric ischemic stroke (IS). MATERIALS AND METHODS: 90 patients were divided into group 1 treated with cortexin (10 mg i/m twice daily (morning and afternoon) in addition to basal treatment, group 2 given the repeated course of the same treatment, and control group (basal therapy alone). The standard SF-36 questionnaire was used to assess the quality of life. RESULTS: Treatment of patients following acute hemispheric ischemic stroke with cortexin (10 mg i/m twice daily) and the repeated course of the same treatment after 10 days resulted in the accelerated and more complete normalization of the quality of life in the early rehabilitation petriod (starting from days 21-27 days after the onset of disease) than in the patients given a single course of cortexin therapy or basal treatment alone.


Assuntos
Isquemia Encefálica/tratamento farmacológico , Fármacos Neuroprotetores/farmacologia , Avaliação de Resultados em Cuidados de Saúde , Peptídeos/farmacologia , Qualidade de Vida , Acidente Vascular Cerebral/tratamento farmacológico , Idoso , Idoso de 80 Anos ou mais , Humanos , Peptídeos e Proteínas de Sinalização Intercelular , Pessoa de Meia-Idade , Fármacos Neuroprotetores/administração & dosagem , Peptídeos/administração & dosagem
12.
Ter Arkh ; 88(5): 55-61, 2016.
Artigo em Russo | MEDLINE | ID: mdl-27239928

RESUMO

AIM: To evaluate the impact of incorporating cytoflavin in a treatment regimen for patients with different stages of hypertensive disease (HD). SUBJECTS AND METHODS: The results of treatment were analyzed in 140 patients with HD (53 with Stage I, 50 with Stage II, and 37 with Stage III). According to the treatment regimen, the patients were divided into 2 groups. A study group (n=74) received combination treatment involving antihypertensive therapy and cytoflavin intravenously dropwisely in a single dose of 200 ml of 5% glucose solution for 10 days, then 2 tablets twice daily for 60 days, with a total cycle time being 70 days. A comparison group (n=66) had antihypertensive therapy only. Thirty apparently healthy individuals (a control group) were examined to have reference values. All the patients were examined using conventional clinical and laboratory studies. The patients' complaints and neurological status were assessed using respective questionnaires over time - before and after treatment. RESULTS: The incorporation of cytoflavin in a treatment regimen was ascertained to reduce the degree of anxiety, depressive, dissomnic, and cognitive disorders, improves quality of life in patients with Stage I HD, and lowers the degree of asthenic and autonomic disorders in all disease stages. CONCLUSION: The found efficacy and safety of the drug may recommend its incorporation in combination therapy regimens for Stages I-III HD.


Assuntos
Anti-Hipertensivos/farmacologia , Ansiedade/tratamento farmacológico , Doenças do Sistema Nervoso Autônomo/tratamento farmacológico , Transtornos Cognitivos/tratamento farmacológico , Depressão/tratamento farmacológico , Mononucleotídeo de Flavina/farmacologia , Hipertensão/tratamento farmacológico , Inosina Difosfato/farmacologia , Niacinamida/farmacologia , Succinatos/farmacologia , Adulto , Idoso , Anti-Hipertensivos/administração & dosagem , Combinação de Medicamentos , Quimioterapia Combinada , Feminino , Mononucleotídeo de Flavina/administração & dosagem , Humanos , Inosina Difosfato/administração & dosagem , Masculino , Pessoa de Meia-Idade , Niacinamida/administração & dosagem , Índice de Gravidade de Doença , Succinatos/administração & dosagem , Resultado do Tratamento
13.
Artigo em Russo | MEDLINE | ID: mdl-26356615

RESUMO

AIM: To compare clinical and morphological results of treatment of ischemic stroke in three groups of patients which differed by the forms and duration of an antioxidant therapy. MATERIAL AND METHODS: A randomized clinical trial was performed in 8 vascular centers of the Russian Federation in 2010-2014. It included 373 patients with ischemic stroke in the carotid territory. Patients were randomized into 3 groups to receive different regimens of antioxidant therapy as an adjunct to standard therapy: control group (ascorbic acid; 132 patients); cytoflavin (20 ml per day for 10 days; 133 patients); cytoflavin (the dose was decreased to 10 ml per day from 11th to 20th day) (108 patients). Patient's condition was assessed in 1, 10 and 21 day by a complex of clinical, laboratory and instrumental methods. RESULTS AND CONCLUSION: The analysis of CT in 1th and 21th day revealed a significant 1,5-1,7- fold decrease in the cerebral ischemic lesion in both groups treated with cytoflavin with no significant morphologic changes in the ascorbic acid group. The percentage of patients with ischemic lesion, increased during days 1-21, was 2-fold higher in the ascorbic acid group compared to cytoflavin groups. Morphologic changes were correlated with clinical variables and outcome. In patients with ≥14 points on NIH scale on admission, prolonged 20 day cytoflavin therapy was associated with a more prominent improvement of neurologic, functional and cognitive status compared to 10-day cytoflavin infusion. No differences in clinical variables were observed in patients with mild symptoms (<14 points on NIH scale on admission) receiving cytoflavin for 10 and 20 days.


Assuntos
Antioxidantes/uso terapêutico , Ácido Ascórbico/uso terapêutico , Infarto Encefálico/tratamento farmacológico , Infarto Encefálico/patologia , Mononucleotídeo de Flavina/uso terapêutico , Inosina Difosfato/uso terapêutico , Niacinamida/uso terapêutico , Succinatos/uso terapêutico , Adulto , Idoso , Idoso de 80 Anos ou mais , Antioxidantes/administração & dosagem , Ácido Ascórbico/administração & dosagem , Infarto Encefálico/diagnóstico por imagem , Combinação de Medicamentos , Metabolismo Energético , Feminino , Mononucleotídeo de Flavina/administração & dosagem , Humanos , Infusões Intravenosas , Inosina Difosfato/administração & dosagem , Masculino , Pessoa de Meia-Idade , Niacinamida/administração & dosagem , Federação Russa , Succinatos/administração & dosagem , Tomografia Computadorizada por Raios X , Resultado do Tratamento
14.
Artigo em Russo | MEDLINE | ID: mdl-26120988

RESUMO

OBJECTIVE: To study the effect of vasonit on the structural/functional state of erythrocyte cytoplasmic membrane in patients with ischemic stroke (11) using atomic-power microscopy in vitro. MATERIAL AND METHODS: We examined 45 patients with II. Patients of the main group (n=30) received vasonit and standard treatment, 15 patients of the comparison group received only standard treatment. To assess the severity of patient's condition, we used the NIH stroke scale, modified Rankin scale, the Barthel index and the Rivermead Mobility index. Dried erythrocyte preparations were made to study erythrocyte cytoplasmic membrane. Scanning was performed using an atomic-power microscope manufactured by "SOLVER P47-Pro" (NT-MDT, Russia). RESULTS AND CONCLUSION: A statistically significant positive dynamics of neurological deficit and patient's functional state was found in the 14" day of the study. A significant decrease in Young's modulus value was identified in the main group that suggested the increase in the elasticity of erythrocyte cytoplasmic membrane.


Assuntos
Agonistas alfa-Adrenérgicos/uso terapêutico , Membrana Eritrocítica/efeitos dos fármacos , Nafazolina/uso terapêutico , Acidente Vascular Cerebral/tratamento farmacológico , Adulto , Idoso , Idoso de 80 Anos ou mais , Isquemia Encefálica/complicações , Módulo de Elasticidade/efeitos dos fármacos , Membrana Eritrocítica/patologia , Feminino , Humanos , Masculino , Microscopia de Força Atômica , Pessoa de Meia-Idade , Índice de Gravidade de Doença , Acidente Vascular Cerebral/etiologia , Acidente Vascular Cerebral/patologia
15.
Ter Arkh ; 86(9): 65-70, 2014.
Artigo em Russo | MEDLINE | ID: mdl-25518508

RESUMO

AIM: To evaluate the efficacy of cytoflavin in the treatment of patients with hypertensive encephalopathy (HE). SUBJECTS AND METHODS: One hundred and forty patients aged 39 to 73 years, diagnosed with HE, were examined and randomized to 2 groups. A study group (n = 74) received cytoflavin in a dose of 2 tablets b.i.d. on days 1 to 25 days inclusive during standard basic therapy. A comparison group (n = 66 persons) had standard basic therapy only. A control group consisted of 30 apparently healthy individuals. The investigators studied the frequency of headache, dizziness, and other complaints and the intensity of cephalalgic syndrome, by using a visual analog scale, the quality of life by the Medical Outcomes Study 36-Item Short-Form Health Survey (MOS SF-36) questionnaire, that of sleep by the subjective sleep characteristics questionnaire elaborated at the Moscow City Somnological Center, the level of asthenia by a subjective asthenia rating scale (Multidimensional Fatigue Inventory (MFI-20), and autonomic status, by applying objective and subjective scales on days 1 and 25 of therapy. RESULTS: The study has shown that cytoflavin used in the above dose for 25 days reduces the frequency and magnitude of complaints of headache, dizziness, "venous" complaints, the degree of autonomic and asthenic disorders, and impairments in the quality of sleep and life in the patients with HE at all disease stages. A stepwise discriminant analysis has indicated that the degree of cephalgic syndrome, and autonomic disorders, and worse sleep quality are the most effective points for using the energy-modifier cytoflavin. CONCLUSION: HE treatment based on the current pathogenetic principles may have a preventive impact on the development of HE or slow down the rate of its progression.


Assuntos
Mononucleotídeo de Flavina/administração & dosagem , Cefaleia , Encefalopatia Hipertensiva , Inosina Difosfato/administração & dosagem , Astenia Neurocirculatória , Niacinamida/administração & dosagem , Transtornos do Sono-Vigília , Succinatos/administração & dosagem , Administração Oral , Adulto , Idoso , Relação Dose-Resposta a Droga , Combinação de Medicamentos , Monitoramento de Medicamentos , Metabolismo Energético/efeitos dos fármacos , Feminino , Cefaleia/diagnóstico , Cefaleia/tratamento farmacológico , Cefaleia/etiologia , Humanos , Encefalopatia Hipertensiva/complicações , Encefalopatia Hipertensiva/tratamento farmacológico , Encefalopatia Hipertensiva/metabolismo , Encefalopatia Hipertensiva/fisiopatologia , Encefalopatia Hipertensiva/psicologia , Masculino , Pessoa de Meia-Idade , Astenia Neurocirculatória/diagnóstico , Astenia Neurocirculatória/tratamento farmacológico , Astenia Neurocirculatória/etiologia , Medição da Dor/métodos , Polissonografia , Qualidade de Vida , Índice de Gravidade de Doença , Transtornos do Sono-Vigília/diagnóstico , Transtornos do Sono-Vigília/tratamento farmacológico , Transtornos do Sono-Vigília/etiologia , Resultado do Tratamento , Escala Visual Analógica , Complexo Vitamínico B/administração & dosagem
16.
Artigo em Russo | MEDLINE | ID: mdl-25403301

RESUMO

OBJECTIVE: to study cortexin efficacy in treatment of cognitive and affective disorders in brain ischemia (BI) comorbid to arterial hypertension and/or atherosclerosis. MATERIAL AND METHODS: The results of the all-Russian screening of cortexin efficacy "Cognitive and affective disorders during treatment brain ischemia with cortexin" conducted in 50 000 patients with BI in 70 Russian cities in 2013 were used for an analysis. All patients received cortexin in dose 10 mg/day during 10 days. Patients were examined before treatment and 11 and 30 days after the beginning of treatment. We analyzed treatment results for 500 patients with BI, stage II, mean age 63,7 ± 10,23 years. Treatment efficacy was assessed using 5-score scale of subjective and objective neurological symptoms, the Five words test, the Schulte test, MMSE, Hamilton anxiety scale and a brief version of the Geriatric depression scale. RESULTS AND CONCLUSION: A decrease or complete regression of focal neurological symptoms, positive changes in indicators of cognitive impairment, normalization of emotional status and decrease in depression level were noted during the treatment.


Assuntos
Isquemia Encefálica/tratamento farmacológico , Peptídeos/uso terapêutico , Idoso , Isquemia Encefálica/complicações , Isquemia Encefálica/fisiopatologia , Cognição/efeitos dos fármacos , Transtornos Cognitivos/diagnóstico , Transtornos Cognitivos/etiologia , Feminino , Humanos , Peptídeos e Proteínas de Sinalização Intercelular , Masculino , Pessoa de Meia-Idade , Índice de Gravidade de Doença
17.
Antibiot Khimioter ; 59(7-8): 30-6, 2014.
Artigo em Russo | MEDLINE | ID: mdl-25975105

RESUMO

One hundred forty patients (the average age of 46.7 ± 7.7 years) with hypertensive encephalopathy (HE) were observed. 74 patients of the main group received Cytoflavin in a dose of 2 tablets twise a day in the standard basic therapy. 66 patients of the reference group received the basic therapy alone. The arterial endothelium function was estimated and ultrasonic examination of the hemodynamics at five structurally functional levels of the cerebral vascular course was used. All the patients with HE had endothelial dysfunction, bloodstream depression in the arterial course of the brain vascular system, decreased reactivity of the intracranial veins, difficulty in venous outflow. In the course of the therapy with Cytoflavin restotation of the arterial endothelial function in the patients with HE I stage, the linear and volume speed of bloodstream in the main and intracranial cerebral arteries in the patients with HE I-II stages, restoration of the intracranial veins reactivity, the linear speed of bloodstream in intracranial veins in the patients with all three stages of HE, the linear speed of bloodstream in the main veins up to the control values in the patients with I-III stages of HE were observed. Interrelation between the values of the cerebral hemodynamics and the state of the endothelium function was shown.


Assuntos
Artérias Cerebrais/efeitos dos fármacos , Endotélio Vascular/efeitos dos fármacos , Mononucleotídeo de Flavina/farmacologia , Encefalopatia Hipertensiva/tratamento farmacológico , Inosina Difosfato/farmacologia , Fármacos Neuroprotetores/farmacologia , Niacinamida/farmacologia , Succinatos/farmacologia , Adulto , Idoso , Encéfalo/irrigação sanguínea , Encéfalo/efeitos dos fármacos , Encéfalo/patologia , Artérias Cerebrais/diagnóstico por imagem , Artérias Cerebrais/patologia , Esquema de Medicação , Combinação de Medicamentos , Endotélio Vascular/diagnóstico por imagem , Endotélio Vascular/patologia , Feminino , Hemodinâmica/efeitos dos fármacos , Humanos , Encefalopatia Hipertensiva/diagnóstico por imagem , Encefalopatia Hipertensiva/patologia , Masculino , Pessoa de Meia-Idade , Ultrassonografia
18.
Artigo em Russo | MEDLINE | ID: mdl-23096033

RESUMO

We examined 60 patients with constitutional venous insufficiency, suffering from hypertensive encephalopathy of I and II stages, mean age 43,4± 6,3 years. Patients of the main group (n=30) received Cytoflavin (2 tablets twice a day) and standard therapy (acetylsalicylic acid and antihypertensive drugs). Thirty patients of the parallel group received only standard therapy. At the 25th day of the study, there were the decrease in the number of complaints, including specific "venous complaints", the reduction of cephalalgia syndrome, asthenic and autonomic disorders; the improvement of quality of life and better cerebral hemodynamics on all structural and functional levels.


Assuntos
Dano Encefálico Crônico/tratamento farmacológico , Dano Encefálico Crônico/etiologia , Mononucleotídeo de Flavina/uso terapêutico , Hipertensão/complicações , Inosina Difosfato/uso terapêutico , Niacinamida/uso terapêutico , Succinatos/uso terapêutico , Insuficiência Venosa/tratamento farmacológico , Adulto , Esquema de Medicação , Combinação de Medicamentos , Feminino , Mononucleotídeo de Flavina/administração & dosagem , Mononucleotídeo de Flavina/efeitos adversos , Humanos , Inosina Difosfato/administração & dosagem , Inosina Difosfato/efeitos adversos , Masculino , Pessoa de Meia-Idade , Niacinamida/administração & dosagem , Niacinamida/efeitos adversos , Qualidade de Vida , Succinatos/administração & dosagem , Succinatos/efeitos adversos , Resultado do Tratamento
19.
Artigo em Russo | MEDLINE | ID: mdl-22983227

RESUMO

We studied 209 patients with chronic brain ischemia due to arterial hypertension (hypertonic encephalopathy). 93 patients (44.5%) had clinical-anamnestic features of constitutional phlebopathy and 116 (55.5%) had not. Based on the conception of 5 functional-morphological levels of the vascular brain system, a complex ultrasound study was conducted. The control group included 30 people without cerebrovascular pathology. In hypertonic encephalopathy, pathological processes developing in the 1st and 2nd structural-functional levels (extra- and intracerebral arteries) correspond to remodeling, that is characteristic of arterial hypertension, and do not depend on the presence of the constitutional venous insufficiency. Changes in parameters of the blood flow in the 3rd, 4th and 5th structural-functional levels of the brain's blood supply (microcirculatory bed, head venous system, jugular and spine veins) form a dopplerographic pattern of the cerebral venous dyscirculation which is mostly pronounced in constitutional phlebopathy in patients with hypertonic encephalopathy. This pattern includes the reduction of linear blood flow velocity in nitroglycerine test, lower values of the resistance index and the increase in the linear blood flow velocity in the sinus transversus and Rosenthal vein, lack of ostial valves of the inner jugular veinas well as the decrease of linear and increase in the volume blood flow velocity along it. The methodology of the system approach based on using clinical and instrumental method in the study of cerebral hemodynamics is important for treatment optimization in patients with chronic brain ischemia.


Assuntos
Isquemia Encefálica/fisiopatologia , Cérebro/irrigação sanguínea , Hipertensão/fisiopatologia , Insuficiência Venosa/fisiopatologia , Adulto , Velocidade do Fluxo Sanguíneo , Isquemia Encefálica/complicações , Veias Cerebrais/fisiopatologia , Circulação Cerebrovascular , Doença Crônica , Feminino , Hemodinâmica , Humanos , Hipertensão/complicações , Masculino , Microcirculação , Pessoa de Meia-Idade , Insuficiência Venosa/complicações
20.
Eksp Klin Farmakol ; 74(7): 13-5, 2011.
Artigo em Russo | MEDLINE | ID: mdl-21894761

RESUMO

A complex pharmacological study of the new cytoprotector drug etoksidol in animals with the disturbances of cerebral blood circulation showed that the intravenous introduction of the drug restores autonomous nomotopic driver of rhythm, conductivity in the atria and atrioventricular connection, and refractoriness of the atrioventricular connection, which were violated a result of sharp cerebral ischemia. The new drug does not suppress the inotropic function of the heart in cats and limits the dimensions of the zone of necrosis in rats with the myocardial infarction on the background of deficiency of the cerebral blood flow.


Assuntos
Isquemia Encefálica/tratamento farmacológico , Circulação Cerebrovascular/efeitos dos fármacos , Piridinas/uso terapêutico , Animais , Isquemia Encefálica/fisiopatologia , Artérias Carótidas/fisiopatologia , Artérias Carótidas/cirurgia , Gatos , Modelos Animais de Doenças , Eletrocardiografia/efeitos dos fármacos , Hemodinâmica/efeitos dos fármacos , Hipoxantinas/administração & dosagem , Hipoxantinas/uso terapêutico , Ligadura/efeitos adversos , Ligadura/métodos , Contração Miocárdica/efeitos dos fármacos , Piridinas/administração & dosagem , Piridinas/síntese química , Ratos
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