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Viruses ; 12(5)2020 05 22.
Artigo em Inglês | MEDLINE | ID: mdl-32456089


Mammalian Orthoreoviruses (MRV) are segmented dsRNA viruses in the family Reoviridae. MRVs infect mammals and cause asymptomatic respiratory, gastro-enteric and, rarely, encephalic infections. MRVs are divided into at least three serotypes: MRV1, MRV2 and MRV3. In Europe, swine MRV (swMRV) was first isolated in Austria in 1998 and subsequently reported more than fifteen years later in Italy. In the present study, we characterized two novel reassortant swMRVs identified in one same Italian farm over two years. The two viruses shared the same genetic backbone but showed evidence of reassortment in the S1, S4, M2 segments and were therefore classified into two serotypes: MRV3 in 2016 and MRV2 in 2018. A genetic relation to pig, bat and human MRVs and other unknown sources was identified. A considerable genetic diversity was observed in the Italian MRV3 and MRV2 compared to other available swMRVs. The S1 protein presented unique amino acid signatures in both swMRVs, with unexpected frequencies for MRV2. The remaining genes formed distinct and novel genetic groups that revealed a geographically related evolution of swMRVs in Italy. This is the first report of the complete molecular characterization of novel reassortant swMRVs in Italy and Europe, which suggests a greater genetic diversity of swMRVs never identified before.

Variação Genética , Orthoreovirus de Mamíferos/genética , Infecções por Reoviridae/virologia , Doenças dos Suínos/virologia , Animais , Proteínas do Capsídeo/genética , Chlorocebus aethiops , Europa (Continente) , Genoma Viral , Humanos , Itália , Mutação , Orthoreovirus de Mamíferos/classificação , Orthoreovirus de Mamíferos/isolamento & purificação , Filogenia , Sorogrupo , Suínos , Células Vero
Emerg Microbes Infect ; 9(1): 851-854, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-32403984


A second case of a novel rabies variant described once in a capuchin monkey from Mato Grosso, Brazil, was discovered in a rabid wild kinkajou from the same region, indicating a public health risk following exposure to either of the two animals.

Cebus/virologia , Procyonidae/virologia , Vírus da Raiva/isolamento & purificação , Raiva/transmissão , Animais , Brasil/epidemiologia , Genes Virais , Filogenia , Saúde Pública , Vírus da Raiva/genética