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1.
Photodiagnosis Photodyn Ther ; 33: 102151, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33346059

RESUMO

INTRODUCTION: This study aimed to evaluate the influence of glycolic acid-based final irrigant for photosensitizer removal of photodynamic therapy on the microhardness and colour change of the dentin structure. METHODS: Eighty extracted single-rooted human incisors were used. Sample preparation and root split resulted in 160 samples, 80 samples being used for microhardness and 80 samples for colour change evaluation. In the first, PDT protocol was performed and 80 samples were randomly divided into 4 groups (n = 20), according to the final irrigation protocol: distilled water (DW); 17 % ethylenediaminetetraacetic acid (EDTA); QMix; 17 % glycolic acid (GA). Microhardness was evaluated using the Vicker tester, before and after, PDT and final irrigation protocols, calculating the percentage of microhardness reduction. In the second evaluation, PDT and final irrigation protocols were performed in the same way. Colour change was evaluated using digital spectrophotometer before and after these protocols, calculating the ΔE colour change using the CIELAB system (L*a*b* values). Specific statistical analysis was performed for both evaluations (α = 5%). RESULTS: The highest percentage of microhardness reduction was observed in 17 % EDTA, QMix and 17 % GA groups, with no significant difference among them (p > 0.05). Furthermore, none of these protocols was effective in photosensitizer removal, and all final irrigation protocols were statically similar to control group (p > 0.05). CONCLUSIONS: GA promotes microhardness reduction and also contributes to the colourization of dentin structure during the photosensitizer removal process, followingPDT .

2.
Photodiagnosis Photodyn Ther ; 29: 101625, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31866534

RESUMO

INTRODUCTION: This study aimed to evaluate the antimicrobial action of calcium hypochlorite(Ca[OCl]2) and sodium hypochlorite (NaOCl) with reciprocating instrumentation and photodynamic therapy(PDT), and its influence on root dentin structure. METHODS: One hundred and ten human teeth were used to antimicrobial evaluation, inoculated with Enterococcus faecalis and divided into 11 groups (n = 10): G1 - distilled water(control); G2-1 % NaOCl; G3-5.25 % NaOCl; G4-1 % Ca(OCl)2; G5-5.25 % Ca(OCl)2; G6-PDT; G7-distilled water + PDT; G8-1 % NaOCl + PDT; G9-5.25 % NaOCl + PDT; G10-1 % Ca(OCl)2+PDT; G11-5.25 % Ca(OCl)2+PDT. In all groups, except G6, the root canals were instrumented with #R50 Reciproc file in the working length in association with tested chemical auxiliary substance. The counting of colony forming units (CFUs) was performed to calculate the bacterial percentage reduction of each group. Following, 55 bovine teeth were used to microhardness evaluation and divided into the same 11 groups (n = 5), with no instrumentation and immersion in the tested protocols. The modification of root dentin microhardness was evaluated by using the Vicker tester. Finally, 33 bovine teeth were used to organic components evaluation and divided into the same 11 groups (n = 3), with no instrumentation and immersion in the tested protocols. The modification of organic components of root dentin was evaluated by light microscopy. Specific statistical analysis was performed for each evaluation. RESULTS: The higher bacterial reduction was observed in groups 3,4,5,8,9,10 and 11, with no statistical difference between them (p > 0.05). The higher microhardness reduction was observed in groups 8,9,10 e 11, with no statistical difference between them (p > 0.05). The highest modification on organic components was observed in groups 3,5,9 and 11, with no statistical difference between them (p > 0.05). CONCLUSIONS: The association of Ca(OCl)2, reciprocating instrumentation and PDT promotes effective antimicrobial action. Moreover, lower modification was induced in microhardness and organic components of root dentin, by using Ca(OCl)2 in low concentration associated to PDT.

3.
Photodiagnosis Photodyn Ther ; 26: 224-228, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30965149

RESUMO

INTRODUCTION: This study aimed to evaluate the influence of final irrigation protocols and type of resin cement on the bond strength of glass fiber posts (GFPs) in root dentin previously treated with photodynamic therapy (PDT). METHODS: One hundred root canals were prepared up to #4 Gates Glidden drill to receive the GFPs. All samples were subjected to PDT, and randomly divided into five groups (n = 20) according to final irrigation protocol: distilled water + ultrasonic activation [US]; 17% EDTA; QMix; 17% EDTA + US; and QMix + US. Each group was randomly divided into 2 subgroups (n = 10) according to the type of resin cement used for cementation of GFPs: Rely-X ARC dual-resin; or Rely-X U200 (#M, St Paul, MN, USA) self-adhesive resin cement. Bond strength was evaluated using the push-out test. Failure patterns were observed under an optical microscope. Bond strengths were compared using two-way ANOVA, followed by the Tukey post-hoc test; failure modes were compared using the chi-squared test (α = 5%). RESULTS: The use of US over final irrigants improved the bond strength of GFPs, regardless of resin cement used (p < 0.05). The type of resin cement did not influence the bond strength of GFPs (p < 0.05). There was a higher predominance of cohesive failure in all groups, regardless of resin cement tested (p < 0.05). CONCLUSIONS: The use of US on final irrigation improved the bond strength of GFPs, while the type of resin cement (dual or self-adhesive) did not influence the bond strength of GFPs in root dentin previously treated with PDT.


Assuntos
Dentina/efeitos dos fármacos , Fotoquimioterapia/métodos , Técnica para Retentor Intrarradicular , Cimentos de Resina/química , Irrigantes do Canal Radicular/farmacologia , Biguanidas/farmacologia , Ácido Edético/farmacologia , Humanos , Técnicas In Vitro , Teste de Materiais , Polímeros/farmacologia , Distribuição Aleatória , Ultrassom
4.
Photodiagnosis Photodyn Ther ; 26: 137-141, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30902793

RESUMO

INTRODUCTION: The aim of this study was to evaluate the influence of final irrigation protocols and endodontic sealer on bond strength of root filling material on root dentin previously treated with photodynamic therapy (PDT). METHODS: One hundred root canals were prepared up to #F3 file of Pro-Taper system to receive the root filling material. All samples were submitted to PDT and randomly divided into five groups (n = 20) according to final irrigation protocols: Group 1-distilled water + ultrasonic activation (US); Group 2-17% EDTA; Group 3-QMix; Group 4-17% EDTA + US; Group 5-QMix + US. Each group was randomly divided into two subgroups (n = 10), according to the endodontic sealer used for cementation of gutta-percha points: AH Plus or MTA Fillapex. The bond strength was evaluated by a push-out test. The patterns of failure were observed under optical microscopy. The bond strength was evaluated using a two-way Anova followed by the Tukey post-hoc test, and the failure mode was evaluated using the chi-square test (α = 5%). RESULTS: The use of 17% EDTA and QMix associated or not to US improved the bond strength of root filling material with either endodontic sealer (p < 0.05). AH Plus showed higher bond strength than MTA Fillapex (p < 0.05). There was a higher predominance of cohesive failure in all groups, regardless of the tested final irrigation protocols and endodontic sealer (p < 0.05). CONCLUSIONS: The use of 17% EDTA and QMix, regardless of association with US, and the use of AH Plus improve the bond strength of the root filling material on root dentin previously treated with PDT.


Assuntos
Dentina/efeitos dos fármacos , Materiais Restauradores do Canal Radicular/farmacologia , Irrigantes do Canal Radicular/farmacologia , Preparo de Canal Radicular/métodos , Biguanidas/farmacologia , Colagem Dentária , Ácido Edético/farmacologia , Resinas Epóxi/farmacologia , Guta-Percha/farmacologia , Humanos , Técnicas In Vitro , Teste de Materiais , Fotoquimioterapia , Fármacos Fotossensibilizantes , Polímeros/farmacologia , Distribuição Aleatória
5.
Photodiagnosis Photodyn Ther ; 19: 170-174, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28619615

RESUMO

INTRODUCTION: The aim of the present study was to evaluate, in vitro, the influence of the addition of chlorhexidine to photosensitiser in the antimicrobial activity of photodynamic therapy in root canals infected by Enterococcus faecalis. METHODS: The root canals of 50 single-rooted human extracted teeth were enlarged up to a file F3 of Pro-Taper system, autoclaved, inoculated with Enterococcus faecalis and incubated for 14days. The samples were divided into five groups (n=10) according to the protocol of decontamination: G1 (control group) - no procedure was performed; G2-photosensitiser (0.01% methylene blue); G3-2% chlorhexidine gel; G4-photodynamic therapy; and G5-photodynamic therapy with photosensitiser modified by chlorhexidine. Microbiological test (CFU counting) was performed to evaluate the effectiveness of proposed treatments. Data were subjected to one-way ANOVA followed by post-hoc Tukey test (α=0.05). RESULTS: Group 3 (CHX) showed the lowest mean contamination (2.03 log10 CFU/mL), being statistically different from all other all groups (p<0.05). There was no statistically significant difference between groups 4 (PDT) and 5 (PDT+CHX) (p<0.05), being more effectives against E. faecalis when compared to groups 1 (NT) and 2 (MB), and less effective when compared to group 2 (CHX). CONCLUSIONS: The addition of chlorhexidine to photosensitiser did not result in a better decontamination potential of photodynamic therapy alone over root canals infected by E. faecalis.


Assuntos
Anti-Infecciosos/farmacologia , Clorexidina/farmacologia , Enterococcus faecalis/efeitos dos fármacos , Azul de Metileno/farmacologia , Fotoquimioterapia/métodos , Fármacos Fotossensibilizantes/farmacologia , Anti-Infecciosos/administração & dosagem , Clorexidina/administração & dosagem , Cavidade Pulpar/microbiologia , Humanos , Azul de Metileno/administração & dosagem , Fármacos Fotossensibilizantes/administração & dosagem , Irrigantes do Canal Radicular/uso terapêutico , Preparo de Canal Radicular/métodos , Células-Tronco
6.
Photodiagnosis Photodyn Ther ; 17: 216-220, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-28065860

RESUMO

INTRODUCTION: The aim of the present study was to evaluate the influence of ultrasonic activation (US) of the final irrigant in the removal of the photosensitizer from root canal walls after photodynamic therapy. METHODS: The root canals of 60 single-rooted bovine extracted teeth were filled with 0.01% methylene blue and submitted to photodynamic therapy for 90s. After that, the roots were divided into six groups (n=10) according to the final irrigation protocol: distilled water (DW), DW+US, 17% EDTA, QMix, EDTA+US, and QMix+US. Then, the samples were submitted to scanning electron microscopy where a scoring system was used to evaluate the images and effectiveness of proposed treatments in the cervical, middle and apical regions of the root canals. The data were statistically analyzed by the Kruskal-Wallis and Mann-Whitney U tests for intergroup comparisons as well as the Wilcoxon and Friedman tests for intragroup comparisons at 5% of significance. RESULTS: The 17% EDTA+US and QMix+US treatments were most effective in the removal of the photosensitizer in all regions of the root canal; the difference was statistically significant when compared to all other groups (p<0.05). There were no significant differences in the intragroup analysis comparing the effectiveness in the different regions of the same group (p<0.05). CONCLUSIONS: US can aid 17% EDTA and QMix in removing the photosensitizer after photodynamic therapy and contributes to cleaning root canal walls.


Assuntos
Cavidade Pulpar , Azul de Metileno/efeitos adversos , Fotoquimioterapia/métodos , Fármacos Fotossensibilizantes/efeitos adversos , Irrigantes do Canal Radicular/farmacologia , Ultrassom/métodos , Animais , Biguanidas/administração & dosagem , Bovinos , Ácido Edético/administração & dosagem , Azul de Metileno/uso terapêutico , Microscopia Eletrônica de Varredura , Fotoquimioterapia/efeitos adversos , Fármacos Fotossensibilizantes/uso terapêutico , Polímeros/administração & dosagem , Água/administração & dosagem
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