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Prikl Biokhim Mikrobiol ; 51(4): 434-40, 2015.
Artigo em Russo | MEDLINE | ID: mdl-26353409


Substances of a peptide nature isolated from the hepatopancreas of the king crab Paralithodes camtschaticus exhibited physicochemical properties and membranotropic and specific activities similar to those of membranotropic homeostatic tissue-specific bioregulators previously found in different mammalian and plant tissues. Their biological effect on vertebrate tissues was demonstrated on a model of roller organotypic cultivation of Pleurodeles waltl newt liver tissue.

Anomuros/química , Fígado/efeitos dos fármacos , Peptídeos/química , Animais , Especificidade de Órgãos , Peptídeos/isolamento & purificação , Peptídeos/farmacologia , Salamandridae
Prikl Biokhim Mikrobiol ; 50(2): 177-83, 2014.
Artigo em Russo | MEDLINE | ID: mdl-25272735


The culture fluid of the fungus Fusarium sambucinum was investigated for the presence of new peptide-containing bioregulators, previously identified in various mammalian and plant tissues. A fraction containing peptides with molecular weights from 1000 to 2000 Da, which exhibited specific membranotropic activity and a number of physical and chemical properties characteristic of this group of bioregulators, was obtained. The effects of this fraction on the model roller organotypic cultivation of liver tissue of the Pleurodeles waltl newt in vitro were investigated for the first time. This fraction caused the additional activation of pigmented liver cells of newt (analogues to Kupffer cells of the liver of mammals) and provided the maintenance of cell-cell adhesive interactions in tissues. The results show that a new group of peptide bioregulators was present in the culture medium of the fungus F. sambucinum.

Fatores Biológicos/farmacologia , Fusarium/metabolismo , Fígado/efeitos dos fármacos , Ativação de Macrófagos/efeitos dos fármacos , Peptídeos/farmacologia , Animais , Fatores Biológicos/química , Fatores Biológicos/isolamento & purificação , Adesão Celular/efeitos dos fármacos , Fracionamento Químico , Meios de Cultura/química , Fígado/citologia , Peso Molecular , Peptídeos/química , Peptídeos/isolamento & purificação , Salamandridae , Junções Íntimas/efeitos dos fármacos , Técnicas de Cultura de Tecidos
Izv Akad Nauk Ser Biol ; (2): 227-34, 2011.
Artigo em Russo | MEDLINE | ID: mdl-21506397


The role of ground fires in transformation of organic substances in the ground cover of larch stands in the permafrost zone of Central Siberia was studied, as was the postfire restoration dynamics of organic substances. Ground fires lead to a considerable decrease in concentrations and resources of organic carbon and its individual fractions in the ground cover, and restoration takes many decades.

Carbono/análise , Conservação dos Recursos Naturais , Incêndios , Agricultura Florestal , Larix/crescimento & desenvolvimento , Solo/normas , Biomassa , Ecologia , Substâncias Húmicas/análise , Sibéria , Solo/análise
Biull Eksp Biol Med ; 91(5): 548-50, 1981 May.
Artigo em Russo | MEDLINE | ID: mdl-7260384


Electrophoretic analysis of histones bound to DNA and remaining free in the mixtures of DNA with the total histone of chromatin in a medium of physiological ionic strength has shown that even the minimal weight excess of the total histone with reference to DNA (1.1:1) leads to the formation of nucleohistone impoverished in HI fraction because of histone competition for DNA. Within the histone/DNA ratio equal to 1.4, H3, H4, H2A and H2B are bound to DNA without competition, i.e. at a ratio in which they are added to DNA. Provided the histone/DNA ratio is higher in the mixture, there form nucleohistones enriched with H3 and H4 fractions. The role of histone competition for DNA in eu- and heterochromatin assembly is discussed.

Cromatina/biossíntese , DNA/metabolismo , Histonas/metabolismo , Animais , Ligação Competitiva , Bovinos , Heterocromatina/metabolismo , Técnicas In Vitro
Antibiotiki ; 23(7): 622-5, 1978 Jul.
Artigo em Russo | MEDLINE | ID: mdl-354511


The antifungal activity of terrilitine, an enzymatic preparation of microbial origin and its effect on the activity of antifungal polyenic antibiotics and griseofulvine were studied in vitro. It was found with the method of serial dilutions in Sabourand's liquid medium that terrilitine was active against C. albicans and certain dermatophytes. In combination with amphotericin B, amphoglucamine, mycoheptine, levorin, nystatin or griseofulvin it increased the activity of these antibiotics 2-16 times.

Amilases/farmacologia , Antifúngicos/farmacologia , Aspergillus/enzimologia , Peptídeo Hidrolases/farmacologia , Candida albicans/efeitos dos fármacos , Relação Dose-Resposta a Droga , Combinação de Medicamentos , Interações Medicamentosas , Griseofulvina/farmacologia , Trichophyton/efeitos dos fármacos