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J Vasc Interv Radiol ; 23(3): 363-7, 2012 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-22265245


PURPOSE: To determine the safety and outcomes of performing endovascular interventions across pacemaker (PM) lead-related central vein stenosis/occlusion. MATERIALS AND METHODS: Clinical and imaging records from April 2002 to August 2010 were reviewed for patients presenting with clinically significant central venous stenosis or central venous obstruction with indwelling PM leads and were evaluated to determine if any lead dysfunction or complications occurred following intervention. Thirteen patients were identified who underwent 14 interventions. Outcomes were assessed based on recurrent clinical symptoms and repeat venograms, and patency was determined with Kaplan-Meier analysis. RESULTS: All procedures were technically successful (100%) with no procedural complications. All patients underwent balloon angioplasty; two patients also underwent stent placement for persistent flow-limiting stenosis within the superior vena cava. No incidence of PM or lead dysfunction, infection, or need for PM intervention was identified in any patient at the time of the index procedure and at 30 or 90 days. In the two patients who received stents across PM leads, no manifestations of PM or lead dysfunction or infection, or need for intervention, were identified at 1 year after stent placement in one patient and at 3 years in the other patient. For eight patients, sufficient follow-up studies were available, with 30-, 60-, and 120-day primary patency rates of 87.5%, 75%, and 50%, respectively. CONCLUSIONS: Endovascular interventions across PM leads resulted in no adverse clinical cardiac or PM sequelae, but with limited primary patency compared with historical outcomes for central venous interventions in the absence of PM leads.

Angioplastia com Balão , Marca-Passo Artificial/efeitos adversos , Doenças Vasculares/terapia , Angioplastia com Balão/efeitos adversos , Angioplastia com Balão/instrumentação , Constrição Patológica , Desenho de Equipamento , Humanos , Estimativa de Kaplan-Meier , Ontário , Flebografia , Estudos Retrospectivos , Stents , Resultado do Tratamento , Doenças Vasculares/diagnóstico por imagem , Doenças Vasculares/etiologia , Doenças Vasculares/fisiopatologia , Grau de Desobstrução Vascular , Veias/fisiopatologia
Ann Thorac Surg ; 90(3): 979-85, 2010 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-20732527


BACKGROUND: Wire cerclage closure of sternotomy is the standard of care despite evidence of pathologic sternal displacement (> 2 mm) during physiologic distracting forces (coughing). Postoperative functional recovery, respiration, pain, sternal dehiscence, and infection are influenced by early bone stability. This translational research report provides proof-of-concept (part A) and first-in-man clinical data (part B) with use of a triglyceride-based porous adhesive to rapidly enhance the stability of conventional sternal closure. METHODS: In part A, fresh human cadaver blocks were subjected to midline sternotomy and either conventional wire closure or modified adhesive closure. After 24 hours at 37 degrees C, using a biomechanical test apparatus, a step-wise increase in lateral distracting force simulated physiologic stress. Sternal displacement was measured by microdisplacement sensors. In part B, a selected clinical case series was performed and sternal perfusion assessed by serial single photon emission computed tomography imaging. RESULTS: Wire closure resulted in measurable bony displacement with increasing load. Pathologic displacement (> or = 2 mm) was observed in all regional segments at loads 400 newton (N) or greater. In contrast, adhesive closure completely eliminated pathologic displacement at forces 600 N or less (p < 0.001). In patients, adhesive closure was not associated with adverse events such as adhesive migration, embolization, or infection. There was excellent qualitative correlation between cadaver and clinical computed tomographic images. Sternal perfusion was not compromised by adhesive closure. CONCLUSIONS: This first-in-man series provides proof-of-concept indicating that a novel biologic bone adhesive is capable of rapid sternal fixation and complete elimination of pathologic sternal displacement under physiologic loading conditions. A randomized clinical trial is warranted to further define the potential risks and benefits of this innovative technique.

Cimentos Ósseos , Fios Ortopédicos , Óleo de Rícino , Polímeros , Esterno/cirurgia , Cadáver , Humanos , Complicações Pós-Operatórias/prevenção & controle , Procedimentos Cirúrgicos Torácicos/métodos
Ann Thorac Surg ; 81(6): 2063-78; discussion 2078, 2006 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-16731131


BACKGROUND: Cardiovascular disease is the main cause of morbidity and mortality in patients with Marfan syndrome. Many patients with presumed Marfan syndrome do not meet current diagnostic criteria. This study reviews the surgical aspects of aortic disease in 300 patients referred with the diagnosis of Marfan syndrome. METHODS: During a 16-year period, 300 patients with presumed Marfan syndrome underwent 398 operations on the aorta and branch arteries, including 125 aortic root operations, 59 aortic arch repairs, 31 descending thoracic aortic repairs, and 178 thoracoabdominal aortic repairs. Based on medical record review, patients were classified as confirmed Marfan syndrome if documented features satisfied current diagnostic criteria; patients not meeting these criteria were classified as suspected Marfan syndrome. RESULTS: There were 17 operative deaths (4.3%) after the 398 operations. Survival after the initial referral operation was 96.2% +/- 1.5% at 1 year, 82.7% +/- 2.4% at 5 years, and 74.6% +/- 3.1% at 10 years. Presentations, operative details, and outcomes were remarkably similar in the 137 patients (45.7%) with confirmed Marfan syndrome and the 163 patients (54.3%) with suspected Marfan syndrome. Freedom from repair failure, however, was significantly better in patients with confirmed Marfan syndrome (90.3% +/- 2.3% at 10 years) than in those with suspected Marfan syndrome (82.0% +/- 3.1% at 10 years; p = 0.001). CONCLUSIONS: Operative treatment of the full spectrum of aortic disease in Marfan patients enables excellent long-term survival. Similarities in surgical aspects of aortic disease suggest that patients with features of Marfan syndrome who do not meet diagnostic criteria should be managed in the same manner as patients with confirmed Marfan syndrome.

Doenças da Aorta/cirurgia , Síndrome de Marfan/cirurgia , Adolescente , Adulto , Idoso , Aneurisma Dissecante/cirurgia , Aorta Abdominal/cirurgia , Aorta Torácica/cirurgia , Aneurisma Aórtico/cirurgia , Aneurisma da Aorta Abdominal/cirurgia , Aneurisma da Aorta Torácica/cirurgia , Doenças da Aorta/etiologia , Implante de Prótese Vascular , Criança , Comorbidade , Feminino , Humanos , Complicações Intraoperatórias/mortalidade , Tábuas de Vida , Masculino , Síndrome de Marfan/complicações , Síndrome de Marfan/diagnóstico , Pessoa de Meia-Idade , Complicações Pós-Operatórias/mortalidade , Estudos Retrospectivos , Análise de Sobrevida , Resultado do Tratamento