Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 742
Filtrar
1.
Int J Nurs Stud ; 111: 103768, 2020 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-32971449

RESUMO

BACKGROUND: Sexual dysfunction is a common long-term complication of cervical cancer and its treatment. However, due to traditional Chinese culture, there are few studies on interventions to improve sexual function in China. OBJECTIVES: To evaluate the effectiveness of a nurse-led positive psychology intervention on sexual function, depression and subjective well-being amongst postoperative patients with early-stage cervical cancer. DESIGN: A randomized controlled trial. SETTINGS AND METHODS: Patients who had undergone radical hysterectomy for early-stage cervical cancer and were followed up in gynaecological clinics were recruited via convenience sampling from three tertiary hospitals in Chongqing, China. Patients who met the inclusion criteria and agreed to participate (N = 91) were randomly assigned to a nurse-led positive psychology intervention (intervention group, n = 46) or usual care (control group, n = 45). The Female Sexual Function Index, Self-rating Depression Scale and Index of Well-being were used to assess sexual function, depression and subjective well-being, respectively, at baseline and 3 and 6 months after the intervention. Data were analysed by the chi-square test, Mann-Whitney U test, t-test and Pearson correlation analysis. RESULTS: Compared with participants in the control group, participants in the intervention group showed significant improvements in sexual function (mean difference [MD]: -3.95, P = 0.005 at 3 months post-intervention; MD: -4.36, P = 0.001 at 6 months post-intervention). In addition, at 3 and 6 months after the intervention, the number of patients with improvements in their levels of depression and well-being in the intervention group was higher than that in the control group (P<0.05). The Pearson correlation analysis results showed that there was a negative correlation between sexual function and level of depression in patients (r =-0.612, P<0.001) and that sexual function was positively correlated with subjective well-being (r = 0.638, P<0.001). CONCLUSION: The intervention group experienced significant improvements in sexual function, depression and subjective well-being. These findings suggest that a nurse-led positive psychology intervention should be implemented for postoperative patients with early-stage cervical cancer.

2.
Int Immunopharmacol ; 88: 106937, 2020 Sep 02.
Artigo em Inglês | MEDLINE | ID: mdl-32890792

RESUMO

OBJECTIVE: Ischemic stroke is one of the leading causes of death globally, and inflammation is considered as a vital contributor to the pathophysiology of ischemic stroke. Recently, microRNA-421-3p-derived macrophages is found to promote motor function recovery in spinal cord injury. Here, we explored whether microRNA-421-3p is involved in inflammation responses during cerebral ischemia/reperfusion (I/R) injury and its molecular mechanism. METHODS: An in vivo experimental animal model of intraluminal middle cerebral artery occlusion/reperfusion (MCAO/R) and in vitro model of microglial subjected to oxygen-glucose deprivation and reoxygenation (OGD/R) were used. The effects of microRNA-421-3p on cerebral I/R injury and its underlying mechanism were detected by quantitative real-time PCR, western blotting, immunofluorescence staining, RNA immunoprecipitation, flow cytometry, luciferase reporter assay, and bioinformatics analysis. RESULTS: We find that microRNA-421-3p is significantly decreased in cerebral I/R injury in vitro and in vivo. Furthermore, overexpression of microRNA-421-3p evidently suppresses pro-inflammatory factor expressions and inhibits NF-κB p65 protein expression and nuclear translocation in BV2 microglia cells treated with OGD/R. However, microRNA-421-3p neither promotes p65 mRNA expression, nor affects p65 mRNA or protein stability. Moreover, we find the m6A 'reader' protein YTH domain family protein 1 (YTHDF1) is the specific target of microRNA-421-3p, and YTHDF1 specifically binds to the m6a site of p65 mRNA to promote its translation. CONCLUSION: microRNA-421-3p prevents inflammatory response in cerebral ischemia/reperfusion injury through targeting YTHDF1 to inhibit p65 mRNA translation. These findings provide novel insights into understanding the molecular pathogenesis of cerebral I/R injury.

3.
J Am Chem Soc ; 2020 Sep 23.
Artigo em Inglês | MEDLINE | ID: mdl-32924478

RESUMO

Encapsulation of metal nanocatalysts by support-derived materials is well known as a classical strong metal-support interaction (SMSI) effect that occurs almost exclusively with active oxide supports and often blocks metal-catalyzed surface reactions. In the present work this classical SMSI process has been surprisingly observed between metal nanoparticles, e.g., Ni, Fe, Co, and Ru, and inert hexagonal boron nitride (h-BN) nanosheets. We find that weak oxidizing gases such as CO2 and H2O induce the encapsulation of nickel (Ni) nanoparticles by ultrathin boron oxide (BOx) overlayers derived from the h-BN support (Ni@BOx/h-BN) during the dry reforming of methane (DRM) reaction. In-situ surface characterization and theory calculations reveal that surface B-O and B-OH sites in the formed BOx encapsulation overlayers work synergistically with surface Ni sites to promote the DRM process rather than blocking the surface reactions.

4.
Mol Cell Biochem ; 2020 Sep 25.
Artigo em Inglês | MEDLINE | ID: mdl-32975696

RESUMO

Whether allicin can suppress the angiogenesis via inhibiting the activity of vascular endothelial cells (VECs) in preventing epidural hypertrophic scars remains unknown. VECs were treated by allicin at a gradient of concentrations. Cell activity was measured by CCK-8 assay, scratch assay and flow cytometry. Reverse-transcription PCR and Western Blot were used to measure the expression levels of relevant genes and proteins. After treated with allicin at concentrations of 0, 25, 50 and 100 mg/L, the viability of VECs significantly decreased at 24 h (p < 0.001*) and 48 h (p < 0.001*), and migration rate significantly decreased in scratch assay (p = 0.017*) and in Transwell assay (p = 0.021*). As the concentrations of allicin increased, the apoptosis rate of VECs rose up (p = 0.018*). There was no significant difference on cell numbers at S phase (p = 0.25), but cell numbers at G1 phase decreased (p = 0.039*) and at G2 phase increased (p = 0.047*). With the increase of allicin concentrations, the ability of tube formation for VECs significantly decreased (p < 0.001*). Comparing with control group, the expression of PCNA and BCL-2 decreased (p < 0.001*), while the expression of BAX increased significantly (p < 0.001*). Regarding to JAK2/STAT3 pathway, the expression levels of JAK3 and STAT3 decreased significantly with the increase of allicin concentrations (p < 0.001*). Allicin can suppress the activity of VECs probably by regulating JAK2/STAT3 pathway.

5.
Circulation ; 2020 Sep 09.
Artigo em Inglês | MEDLINE | ID: mdl-32900241

RESUMO

Background: Hydrogen sulfide (H2S) has anti-hypertension and anti-inflammatory effects, and its endogenous-generation key enzyme cystathionine γ lyase (CSE) is expressed in CD4+ T cells. However, the role of CD4+ T-cell endogenous CSE/H2S in the development of hypertension is unclear. Methods: Peripheral blood lymphocytes were isolated from hypertensive patients or spontaneously hypertensive rats (SHRs), then H2S production and expression of its generation enzymes, cystathionine ß synthase (CBS) and CSE, were measured to determine the major H2S generation system changes in hypertension. Mice with CSE-specific knockout in T cells (CKO, by CD4cre mice hybridization) and CD4 null mice were generated for investigating the pathophysiological relevance of the CSE/H2S system. Results: In lymphocytes, H2S from CSE but not CBS responded to blood pressure (BP) changes, supported by lymphocyte CSE protein changes and negative correlation between H2S production with systolic BP (sBP) and diastolic BP (dBP) but positive correlation with serum level of interleukin 10 (IL-10, an anti-inflammatory cytokine). Deletion of CSE in T cells elevated BP (5-8 mmHg) under the physiological condition and exacerbated angiotensin II (AngII)-induced hypertension. In keeping with hypertension, mesenteric artery dilation impaired, association with arterial inflammation, an effect attributed to reduced immunoinhibitory T regulatory cell (Treg) numbers in blood and kidney, thus causing excess CD4+ and CD8+ T-cell infiltration in perivascular adipose tissues and kidney. CSE knockout CD4+-T cell transfer into CD4 null mice, also showed the similar phenotypes confirming the role of endogenous CSE/H2S action. Adoptive transfer of Tregs (to CKO mice) reversed hypertension, vascular relaxation impairment and immunocyte infiltration, which confirmed that CKO-induced hypertension was due in part to the reduced Treg numbers. Mechanistically, endogenous CSE/H2S promoted Treg differentiation and proliferation by activating AMP-activated protein kinase (AMPK). In part, it depended on activation of its upstream kinase, liver kinase B1 (LKB1), by sulfhydration to facilitate its substrate binding and phosphorylation. Conclusions: The constitutive sulfhydration of LKB1 by CSE-derived H2S activates its target kinase, AMPK, and promotes Treg differentiation and proliferation, which attenuates the vascular and renal immune-inflammation, thereby preventing hypertension.

6.
J Stroke Cerebrovasc Dis ; 29(10): 105126, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32912499

RESUMO

BACKGROUND: Long non-coding RNAs (LncRNAs) have been reported to play important roles in the pathogenesis and development of many diseases, including cerebral ischemia and reperfusion (I/R) injury. In this study, we aimed to investigate the role of LncRNA-Potassium Voltage-Gated Channel Subfamily Q Member 1 opposite strand/antisense transcript 1 (KCNQ1OT1) in cerebral I/R induced neuronal injury, and its underlying mechanisms. METHODS: Primary mouse cerebral cortical neurons treated with oxygen-glucose deprivation and reoxygenation (OGD/R) in vitro and mice subjected to middle cerebral artery occlusion (MCAO) and reperfusion were used to mimic cerebral I/R injury. Small inference RNA (siRNA) was used to knockdown KCNQ1OT1 or microRNA-153-3p (miR-153-3p). Dual-luciferase assay was performed to detect the interaction between KCNQ1OT1 and miR-153-3p and interaction between miR-153-3p and Fork head box O3a (Foxo3). Flow cytometry analysis was performed to detect neuronal apoptosis. qRT-PCR and Western blotting were performed to detect RNA and protein expressions. RESULTS: KCNQ1OT1 and Foxo3 expressions were significantly increased in neurons subjected to I/R injury in vitro and in vivo, and miR-153-3p expression were significantly decreased. Knockdown of KCNQ1OT1 or overexpression of miR-153-3p weakened OGD/R-induced neuronal injury and regulated Foxo3 expressions. Dual-luciferase analysis showed that KCNQ1OT1 directly interacted with miR-153-3p and Foxo3 is a direct target of miR-153-3p. CONCLUSIONS: Our results indicate that LncRNA-KCNQ1OT1 promotes OGD/R-induced neuronal injury at least partially through acting as a competing endogenous RNA (ceRNA) for miR-153-3p to regulate Foxo3a expression, suggesting LncRNA-KCNQ1OT1 as a potential therapeutic target for cerebral I/R injury.

7.
Artigo em Inglês | MEDLINE | ID: mdl-32989148

RESUMO

Emerging evidence suggests a resurgence of COVID-19 in the coming years. It is thus critical to optimize emergency response planning from a broad, integrated perspective. We developed a mathematical model incorporating climate-driven variation in community transmissions and movement-modulated spatial diffusions of COVID-19 into various intervention scenarios. We find that an intensive 8-wk intervention targeting the reduction of local transmissibility and international travel is efficient and effective. Practically, we suggest a tiered implementation of this strategy where interventions are first implemented at locations in what we call the Global Intervention Hub, followed by timely interventions in secondary high-risk locations. We argue that thinking globally, categorizing locations in a hub-and-spoke intervention network, and acting locally, applying interventions at high-risk areas, is a functional strategy to avert the tremendous burden that would otherwise be placed on public health and society.

8.
Protein Cell ; 2020 Sep 28.
Artigo em Inglês | MEDLINE | ID: mdl-32989686

RESUMO

Microbial ecosystem comprises a complex community in which bacteria interact with each other. The potential roles of the intestinal microbiome play in human health have gained considerable attention. The imbalance of gut microbial community has been looked to multiple chronic diseases. Cardiovascular diseases (CVDs) are leading causes of morbidity worldwide and are influenced by genetic and environmental factors. Recent advances have provided scientific evidence that CVD may also be attributed to gut microbiome. In this review, we highlight the complex interplay between microbes, their metabolites, and the potential influence on the generation and development of CVDs. The therapeutic potential of using intestinal microbiomes to treat CVD is also discussed. It is quite possible that gut microbes may be used for clinical treatments of CVD in the near future.

9.
Cell Transplant ; 29: 963689720946020, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32749163

RESUMO

Astragalus membranaceus (Ast) and ligustrazine (Lig) have a protective effect on lower hemorrhagic transformation induced by pharmaceutical thrombolysis. The cerebral ischemia rat model was induced with autologous blood clot injections. A combination of Ast and Lig, or a protein kinase C delta (PKCδ) inhibitor-rottlerin, or a combination of Ast, Lig, and rottlerin was administered immediately after recombinant tissue plasminogen activator injection. The cerebral infarct area, neurological deficits, cerebral hemorrhage status, neuronal damage and tight junctions' changes in cerebral vessels, and the messenger RNA and protein levels of PKCδ, myristoylated alanine-rich C kinase substrate (Marcks), and matrix metallopeptidase 9 (MMP9) were determined after 3 h and 24 h of thrombolysis. The ultrastructure of the neuronal damage and tight junctions was examined under a transmission electron microscope. The expression levels of PKCδ, Marcks, and MMP9 were assessed by immunohistochemistry, western blot, and quantitative real-time polymerase chain reaction . Administration of Ast and Lig not only significantly decreased neurological deficit scores, infarct volumes, and cerebral hemorrhage but also inhibited the disruption due to neuronal dysfunction and the tight junction integrity in the cerebral vessel. Treatment with a combination of Ast and Lig effectively protected ischemia-induced microhemorrhage transformation through PKCδ/Marcks pathway suppression.

10.
J Environ Manage ; 274: 111184, 2020 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-32791324

RESUMO

Resource utilization of wastes through effective separation is a major challenge in the field of water and wastewater treatment. Photocatalytic degradation is a powerful water treatment technology but has no selectivity in degradation of various coexisting contaminants due to its strong oxidation. In this work, a complex film composed of CdS and carboxylmethyl starch (CdS/CMS) was designed and fabricated using in situ formation method. The morphology, composition, and optical property of this film were investigated in detail by various characterization methods. CdS was well distributed in the starch matrix, and the absorption wavelength of this film was still located in the visible light region. This starch-based complex film was used to remove various organic dyes [methylene blue (MB), crystal violet (CV), and rhodamine B (RhB)] from aqueous solutions by two consecutive processes of adsorption enrichment and photocatalysis degradation. 0.1 g of CdS/CMS film can remove approximately 86.72% of MB and 81.03% of CV in 120 min. CdS/CMS still exhibited evidently selective photocatalysis degradation of MB and CV in MB/RhB and CV/RhB binary systems, respectively, and had nearly no effect on RhB. The cationic groups on MB and CV can effectively interact with negatively carboxyl groups of CMS via electrostatic interactions, causing their good affinities; but the anionic groups on RhB had an electrostatic repulsion to the starch matrix. The considerably different affinities of various dyes to CMS triggered strong adsorption preferences and great selective degradation effectiveness. The selectivity of CdS/CMS could not be influenced by pH and some coexisting inorganic anions. Furthermore, this complex film did not require regeneration and could be reused directly with low removal capacity loss. Therefore, a new and simple strategy was provided to realize the effective separation and recovery of target contaminants in water by photocatalytic degradation technology.


Assuntos
Poluentes Químicos da Água/análise , Purificação da Água , Adsorção , Corantes , Amido
11.
Sci Rep ; 10(1): 12867, 2020 Jul 30.
Artigo em Inglês | MEDLINE | ID: mdl-32733059

RESUMO

Lacquer sap is a water-in-oil natural emulsion with high viscosity. In nature, it exudes from the phloem of lacquer tree to repair its wounds in the presence of O2. So far, it is unclear how rapid and smooth polymerization of urushiol is achieved in such a viscous sap. Here, we find that there is a diffuse interface layer with 2.43 nm of thickness between two phases. The interface layer consists of urushiol, urushiol-laccase complex, urushiol-stellacyanin complex and water-insoluble glycoprotein. Polymerization of urushiol is realized by multicomponent synergistic effect. Radicals are first formed by laccase-catalyzed oxidation of urushiol at the interface layer, then are transferred to the urushiol oil phase via wate-insoluble glycoprotein and initiate the polymerization of urushiol there. Stellacyanin inhibits the formation of certain radicals and controls the concentration of phenoxy radicals at the interface layer. Through the inhibition of radicals by stellacyanin and the electron transfer mediated by water-insoluble glycoprotein, the polymerization of urushiol at the interface layer is inhibited. This ensures that O2 can continuously penetrate into the aqueous phase to oxidize the reduced laccase so that the urushiol polymerization can continue smoothly. This polymerization mechanism provides an idea for developing new chemical reaction systems.

12.
Artigo em Inglês | MEDLINE | ID: mdl-32791513

RESUMO

Genetic analyses for bipolar disorder (BD) have achieved prominent success in Europeans in recent years, whereas its genetic basis in other populations remains relatively less understood. We herein report that the leading risk locus for BD in European genome-wide association studies (GWAS), the single-nucleotide polymorphism (SNP) rs9834970 near TRANK1 at 3p22 region, is also genome-wide significantly associated with BD in a meta-analysis of four independent East Asian samples including 5748 cases and 65,361 controls (p = 2.27 × 10-8, odds ratio = 1.136). Expression quantitative trait loci (eQTL) analyses and summary data-based Mendelian randomization (SMR) analyses in multiple human brain samples suggest that lower TRANK1 mRNA expression is a principal BD risk factor explaining its genetic risk signals at 3p22. We also identified another SNP rs4789 in the 3' untranslated region (3'UTR) of TRANK1 showing stronger eQTL associations as well as genome-wide significant association with BD. Despite the relatively unclear neuronal function of TRANK1, our mRNA expression analyses in the human brains and in rat primary cortical neurons reveal that genes highly correlated with TRANK1 are significantly enriched in the biological processes related to dendritic spine, synaptic plasticity, axon guidance and circadian entrainment, and are also more likely to exhibit strong associations in psychiatric GWAS (e.g., the CACNA1C gene). Overall, our results support that TRANK1 is a potential BD risk gene. Further studies elucidating its roles in this illness are needed.

14.
J Hazard Mater ; 403: 123603, 2020 Aug 02.
Artigo em Inglês | MEDLINE | ID: mdl-32777749

RESUMO

A series of actinia-shaped lignin-based adsorbents (LNAEs) featuring lignin(LN) as the core and grafted poly(acrylic acid) (PAA) as the tentacle were designed and fabricated. LNAEs were applied to remove ofloxacin and ciprofloxacin from water, and their maximum adsorption capacities were 0.835 and 0.965 mmol/g at pH 6.0, respectively. However, their adsorption capacities were up to about 20 % and 31 % reductions in the present of NaCl and humic acid, respectively. Electrostatic attraction (EA) and hydrogen bonding (HB), including ordinary HB and negative charged auxiliary HB, were mainly involved in adsorption. Experimental and calculation results indicated HB contributes more than EA. The effects of two structural factors of LNAEs, namely, PAA branched-chain length(L) and distribution density(D), on the adsorption performance associated with HB and EA, were quantitatively discussed using a binary nonlinear model based on phenomenological theory. The fitting results were completely consistent with the experimental findings. D was more efficient than L in promoting HB and EA in adsorption due to the cooperative effects of adjacent branched-chains and enhanced activity of terminal groups. This study provides a better understanding of the structure-activity relationship of surface grafting-modified adsorbents and fundamental guidance for the exploitation and design of novel and efficient adsorbents.

15.
BMC Cancer ; 20(1): 801, 2020 Aug 24.
Artigo em Inglês | MEDLINE | ID: mdl-32831061

RESUMO

BACKGROUND: The main treatment methods for early gastric cancer (EGC) include endoscopic submucosal dissection (ESD) and radical gastrectomy. However, appropriate treatment for patients who exceed the absolute indications for ESD remains unestablished. In China, evidence-based medicine for the expanding indications of ESD and accurate diagnostic staging for EGC patients are lacking. Thus, clinical studies involving Chinese patients with EGC are necessary to select appropriate treatment options and promote China's expanded indications for ESD and diagnostic staging scheme. METHODS: This is a multicenter, ambispective, observational, open-cohort study that is expected to enroll 554 patients with EGC. The study was launched in May 2018 and is scheduled to end in March 2022. All enrolled patients should meet the inclusion criteria. Case report forms and electronic data capture systems are used to obtain clinical data, which includes demographic information, results of perioperative blood- and auxiliary examinations, surgical information, results of postoperative pathology, and the outcomes of postoperative recovery and follow-up. Patients are followed up every 6 months after surgery for a minimum of 5 years. The primary endpoint is the rate of lymph node metastasis (LNM), whereas the secondary endpoints include the following: consistency, sensitivity, and specificity of the results of preoperative examinations and postoperative pathology; cut-off values for LNM; logistic regression model of expanded indications for ESD; and incidence of postoperative complications within the 30-day and 5-year relapse-free survival rates. DISCUSSION: This study will explore and evaluate expanded indications for ESD that match the characteristics of the Chinese population in patients with EGC and will introduce a related staging procedure and examination scheme that is appropriate for China. Ethical approval was obtained from all participating centers. The findings are expected to be disseminated through publications or presentations and will facilitate clinical decision-making in EGC. TRIAL REGISTRATION: The name of the registry is ChiCTR. It was registered on May 9, 2018, with the registration number ( ChiCTR1800016084 ). The clinical trial was launched in May 2018 and will end in March 2022, with enrollment to be completed by December 2021. Trial status: Ongoing.

16.
Endocrine ; 2020 Aug 20.
Artigo em Inglês | MEDLINE | ID: mdl-32816205

RESUMO

PURPOSE: Apparent mineralocorticoid excess (AME) is an ultrarare autosomal recessive disorder resulting from deficiency of 11ß-hydroxysteroid dehydrogenase type 2 (11ßHSD2) caused by mutations in HSD11B2. The purpose of this study was to identify novel compound heterozygous HSD11B2 mutations in a Chinese pedigree with AME and conduct a systematic review evaluating the AME clinical features associated with HSD11B2 mutations. METHODS: Next-generation sequencing was performed in the proband, and Sanger sequencing was used to identify candidate variants in family members, 100 hypertensives, and 100 healthy controls. A predicted structure of 11ßHSD2 was constructed by in silico modeling. A systematic review was used to identify cases of HSD11B2-related AME. Data for genotyping and clinical characterizations and complications were extracted. RESULTS: Next-generation sequencing showed novel compound heterozygous mutations (c.343_348del and c.1099_1101del) in the proband with early-onset hypertension and hypokalemia. Sanger sequencing verified the monoallelic form of the same mutations in five other relatives but not in 100 hypertensives or 100 healthy subjects. In silico structural modeling showed that compound mutations may simultaneously perturb the substrate and coenzyme binding pocket. A systematic review of 101 AME patients with 54 HSD11B2 mutations revealed early-onset hypertension, hypokalemia and homozygous mutations as common features. The homozygous HSD11B2 mutations correlated with low birth weight (r = 0.285, P = 0.02). CONCLUSIONS: We report novel compound heterozygous HSD11B2 mutations in a Chinese teenager with early-onset hypertension, and enriched genotypic and phenotypic spectrums in AME. Genetic testing helps early diagnosis and treatment for AME patients, which may avoid target organ damage.

17.
Curr Opin Pharmacol ; 54: 1-10, 2020 Jun 30.
Artigo em Inglês | MEDLINE | ID: mdl-32619934

RESUMO

Immune checkpoint blockade therapies that target CTLA-4 and PD-1/PD-L1 have ushered in a new era of cancer treatment. Nevertheless, a significant proportion of patients demonstrated primary or acquired resistance. Harnessing gut microbiota has been an emerging novel therapeutic strategy to overcome resistance. Here we summarized the current research status of gut microbiota in immune checkpoint blockade therapies, clinical trials, underlying mechanisms and challenges of microbiome research in checkpoint immunotherapy. Findings from preclinical models, standardized microbiome analysis and progress of multi-omic approaches may better disclose the interaction between gut microbiota and immune checkpoint inhibitors (ICIs) and traditional Chinese medicine can be a potential microbiome modulator to sensitize the response to ICIs.

18.
Artigo em Inglês | MEDLINE | ID: mdl-32643300

RESUMO

We exploit a high-performing resistive-type trace oxygen sensor based on 2D high-mobility semiconducting Bi2 O2 Se nanoplates. Scanning tunneling microscopy combined with first-principle calculations confirms an amorphous Se atomic layer formed on the surface of 2D Bi2 O2 Se exposed to oxygen, which contributes to larger specific surface area and abundant active adsorption sites. Such 2D Bi2 O2 Se oxygen sensors have remarkable oxygen-adsorption induced variations of carrier density/mobility, and exhibit an ultrahigh sensitivity featuring minimum detection limit of 0.25 ppm, long-term stability, high durativity, and wide-range response to concentration up to 400 ppm at room temperature. 2D Bi2 O2 Se arrayed sensors integrated in parallel form are found to possess an oxygen detection minimum of sub-0.25 ppm ascribed to an enhanced signal-to-noise ratio. These advanced sensor characteristics involving ease integration show 2D Bi2 O2 Se is an ideal candidate for trace oxygen detection.

19.
J Colloid Interface Sci ; 579: 853-861, 2020 Jul 03.
Artigo em Inglês | MEDLINE | ID: mdl-32679382

RESUMO

In this paper, a novel 0D/2D heterojunction photocatalyst based on MoS2 QDs/ZnO nanosheets was successfully constructed by a simple two-step process, and its photocatalytic behavior for organic dyes (RhB) degradation and gaseous heavy metals (Hg) removal under ultraviolet light were studied. For the optimum 5% MoS2/ZnO photocatalyst, 95% of RhB could be removed in 50 min, and 99.8% of the gaseous mercury could be removed in 60 min. Besides, MoS2 QDs/ZnO nanosheets also exhibited excellent photocatalytic durability. The constructed 0D/2D heterojunctions could efficiently improve the separation efficiency and charge transfer of photogenerated carriers, thus improving the photocatalytic activity. Therefore, this strategy provided a new way to design bifunctional 0D/2D heterojunction photocatalysts for water treatment and air pollution.

20.
Artigo em Inglês | MEDLINE | ID: mdl-32702156

RESUMO

OBJECTIVE: Evidence-based studies on endovascular approaches for childhood Takayasu arteritis(c-TA) are limited. This study presents the largest real-world scenario up-to-date for c-TA patients undergoing interventions and their post-interventional outcomes. METHODS: Data were collected for c-TA patients admitted from 2002 to 2017. Complication/Re-intervention-free survival were projected by Kaplan-Meier methods. Associated factors for intervention and predictors for post-interventional complications/re-interventions were assessed via regression models. RESULTS: Among 101 patients enrolled, 69(68.3%) underwent 121 interventions(Angioplasty 95; Stenting 26) during 3.1-year follow-up. Compared with non-intervention group, the intervention group independently associated with male population(OR=0.27, p=0.035) and type IV disease(OR=17.92, p=0.001). Male sex also marginally indicated risk for re-intervention(HR=3.22,p=0.05). Baseline retinopathy, delay in diagnosis and descending thoracic aorta involvement associated with stent insertion(p<0.05). Hypertension secondary to renal artery stenosis(RAS, 59.4%) or mid-aorta stenosis(MAS, 14.5%), heart failure(21.7%), claudication(21.7%) were leading clinical hints for interventions. Technical success rate was 96.7%. Over 2.88 years since intervention, 36 lesions occurred complications in 28 patients and 22 lesions in 17 patients, majorly on renal artery or mid-aorta. The 5-year complication-free and re-intervention survivals were 50.7% and 65.8%. Peri-interventional dual antiplatelet therapy(DAPT, HR=0.31), concurrent surgery(HR=26.5), and technical failure(HR=3.65) were independent predictors for complications(p<0.05). Male sex(HR=2.52), retinopathy secondary to hypertension(HR=3.41), and pulmonary artery hypertension(PAH, HR=3.64) were baseline indicators for complications(p<0.05). CONCLUSIONS: Over two-thirds c-TA patients require interventions and 5-year complication-free survival is 50.7%. Male sex, retinopathy, and PAH at baseline alert unfavorable outcomes. Interventions on MAS or RAS in c-TA need specific concerns. DAPT peri-intervention appears to protect c-TA from post-interventional complications.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA