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1.
J Cardiovasc Pharmacol Ther ; : 1074248420925021, 2020 May 13.
Artigo em Inglês | MEDLINE | ID: mdl-32400177

RESUMO

BACKGROUND: Older patients with cancer are at high risk of developing venous thromboembolism (VTE) and bleeding. Aspirin may decrease VTE in the general population without significant bleeding. Here, we examined whether aspirin is associated with reduced rates of VTE in older patients with cancer. METHODS AND RESULTS: Using the National Inpatient Sample 2016, we retrospectively identified a cohort of patients with cancer ≥65 years old who received aspirin and a similar cohort who did not receive aspirin (n = 31 654, each). The cohorts were matched for age, sex, race, patient demographics, insurance, hospital demographics, and 9 comorbidities (smoking, obesity, hypertension, hyperlipidemia, diabetes, chronic kidney disease, chronic obstructive pulmonary disease, congestive heart failure, and history of deep venous thrombosis [DVT]/pulmonary embolism [PE]). Primary outcomes were discharge diagnosis of acute PE or acute DVT. Secondary outcomes were inhospital mortality, bleeding, length of hospital stay (LOS), and total hospitalization cost. The aspirin group, compared with the nonaspirin group, had a significantly lower incidence of acute PE (matched, 2.1% vs 2.6%, P < .001), acute DVT (matched, 2.3% vs 3.2%, P < .001), and inhospital mortality (matched 4.0% vs 6.5%, P < .001); shorter LOS (matched, 5.29 ± 5.01 vs 6.20 ± 6.56 days, P < .001); and lower total costs (matched, US$14 700 ± 15 031 vs US$16 363 ± 20 219, P < .001). The primary and secondary outcomes were similar before and after propensity matching. We found no increase in bleeding in the aspirin group compared to the nonaspirin group: gastrointestinal bleeding (matched, 3.8% vs 4.0%, P= .168), hematuria (matched, 3.5% vs 3.7%, P = .102), hemoptysis (matched, 0.9% vs 0.9%, P = .532), and hemorrhagic stroke (matched, 0.8% vs 0.8%, P = .443). In subgroup analyses, aspirin was associated with decreased inhospital mortality, mostly in patients with lung, colon, pancreatic, prostate, breast cancer, lymphoma, and leukemia. CONCLUSIONS: Among older patients with cancer, aspirin was associated with lower VTE incidence and overall inhospital mortality without significantly increased bleeding.

2.
Artigo em Inglês | MEDLINE | ID: mdl-32415365

RESUMO

PURPOSE: To investigate the efficacy and safety of intravenous tranexamic acid (IV-TXA) in patients undergoing intertrochanteric fracture surgery. METHODS: A total of 122 patients were included in this double-blinded trial and equally randomized to receive 1 g of IV-TXA or normal saline 10 min before incision and 3 h later. The primary efficacy outcome was calculated hidden blood loss (HBL). The secondary efficacy outcome was allogeneic erythrocyte transfusion rate during hospitalization. Safety outcome was a composite of thromboembolic events including deep venous thrombosis (DVT) up to 90 days. A meta-analysis combining this study with previous randomized controlled trials in hip fracture surgery (total sample size: 1112 patients) was also conducted. RESULTS: The mean HBL in TXA group (640.96 ± 421.63 ml) was significantly lower than that in placebo group (1010.11 ± 398.96 ml, P < 0.001). The rate of erythrocyte transfusions was 29.5% in TXA group and 60.7% in placebo group (P = 0.001). The incidence of thromboembolic events at 90 days was 4.9% in TXA group and 1.6% in placebo group (P = 0.619). The updated meta-analysis showed that IV-TXA significantly reduced erythrocyte transfusion in hip fracture surgery (risk ratio 0.60, 95% confidence intervals 0.53-0.68), and IV-TXA caused no increased risk of thromboembolic events (risk difference 0.01, 95% confidence intervals - 0.02-0.04). CONCLUSION: IV-TXA could effectively reduce the HBL and allogeneic erythrocyte transfusion requirements in patients undergoing intertrochanteric fracture surgery without an increase of thromboembolic events including DVT. TRIAL REGISTRATION: Clinical trials: safety and efficiency of tranexamic acid in hip fracture patients. Date of registration: August 31, 2018. TRIAL REGISTRATION NUMBER: ChiCTR1800018110.

3.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao ; 42(2): 263-269, 2020 Apr 28.
Artigo em Chinês | MEDLINE | ID: mdl-32385036

RESUMO

Bladder cancer has high morbidity and mortality rates worldwide. Its incidence is high in western countries and has shown an increasing trend in China. While radical cystectomy combined with pelvic lymph node dissection (PLND) is the standard treatment for bladder cancer,the optimal range of PLND remains controversial. In addition,the prognostic value of lymph node factors is also unclear. This article reviews research advances in PLND.

4.
Int J Mol Sci ; 21(10)2020 May 12.
Artigo em Inglês | MEDLINE | ID: mdl-32408717

RESUMO

Soil salinity is a main abiotic stress in agriculture worldwide. The Na+/H+ antiporters (NHXs) play pivotal roles in intracellular Na+ excretion and vacuolar Na+ compartmentalization, which are important for plant salt stress resistance (SSR). However, few systematic analyses of NHXs has been reported in allotetraploid rapeseed so far. Here, a total of 18 full-length NHX homologs, representing seven subgroups (NHX1-NHX8 without NHX5), were identified in the rapeseed genome (AnAnCnCn). Number variations of BnaNHXs might indicate their significantly differential roles in the regulation of rapeseed SSR. BnaNHXs were phylogenetically divided into three evolutionary clades, and the members in the same subgroups had similar physiochemical characteristics, gene/protein structures, and conserved Na+ transport motifs. Darwin´s evolutionary pressure analysis suggested that BnaNHXs suffered from strong purifying selection. The cis-element analysis revealed the differential transcriptional regulation of NHXs between the model Arabidopsis and B. napus. Differential expression of BnaNHXs under salt stress, different nitrogen forms (ammonium and nitrate), and low phosphate indicated their potential involvement in the regulation of rapeseed SSR. Global landscapes of BnaNHXs will give an integrated understanding of their family evolution and molecular features, which will provide elite gene resources for the genetic improvement of plant SSR through regulating the NHX-mediated Na+ transport.

5.
BMC Microbiol ; 20(1): 115, 2020 May 14.
Artigo em Inglês | MEDLINE | ID: mdl-32410574

RESUMO

BACKGROUND: Bacterial biofilms are surface-adherent microbial communities in which individual cells are surrounded by a self-produced extracellular matrix of polysaccharides, extracellular DNA (eDNA) and proteins. Interactions among matrix components within biofilms are responsible for creating an adaptable structure during biofilm development. However, it is unclear how the interactions among matrix components contribute to the construction of the three-dimensional (3D) biofilm architecture. RESULTS: DNase I treatment significantly inhibited Bacillus subtilis biofilm formation in the early phases of biofilm development. Confocal laser scanning microscopy (CLSM) and image analysis revealed that eDNA was cooperative with exopolysaccharide (EPS) in the early stages of B. subtilis biofilm development, while EPS played a major structural role in the later stages. In addition, deletion of the EPS production gene epsG in B. subtilis SBE1 resulted in loss of the interaction between EPS and eDNA and reduced the biofilm biomass in pellicles at the air-liquid interface. The physical interaction between these two essential biofilm matrix components was confirmed by isothermal titration calorimetry (ITC). CONCLUSIONS: Biofilm 3D structures become interconnected through surrounding eDNA and EPS. eDNA interacts with EPS in the early phases of biofilm development, while EPS mainly participates in the maturation of biofilms. The findings of this study provide a better understanding of the role of the interaction between eDNA and EPS in shaping the biofilm 3D matrix structure and biofilm formation.

6.
Ann Palliat Med ; 9(2): 463-471, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32233620

RESUMO

Whole-breast radiotherapy after breast-conserving surgery (BCS) can improve patient survival while reducing local tumor recurrence. Although standard breast radiotherapy can achieve good tumor control and cosmetic effects with low toxicity, the 5- to 7-week treatment time is relatively long for patients and can result in wasted medical resources. Therefore, there is a growing trend toward hypofractionated radiotherapy (HFRT), which accelerates partial-breast irradiation. Both short-course radiotherapy and conventional fractionated radiotherapy are safe and effective treatment modes, with similar survival and local tumor control effects as those of conventional radiotherapy (CRT), and adverse reactions can be tolerated. Compared with conventional fractionated radiotherapy, short-course radiotherapy saves medical resources and has a shorter total treatment time, reduced treatment costs, and an improved quality of life for patients.


Assuntos
Neoplasias da Mama/radioterapia , Recidiva Local de Neoplasia/prevenção & controle , Hipofracionamento da Dose de Radiação , Neoplasias da Mama/patologia , Feminino , Humanos , Mastectomia Segmentar , Estadiamento de Neoplasias , Dosagem Radioterapêutica , Radioterapia Adjuvante , Resultado do Tratamento
7.
BMC Plant Biol ; 20(1): 151, 2020 Apr 08.
Artigo em Inglês | MEDLINE | ID: mdl-32268885

RESUMO

BACKGROUND: Nitrogen (N), referred to as a "life element", is a macronutrient essential for optimal plant growth and yield production. Amino acid (AA) permease (AAP) genes play pivotal roles in root import, long-distance translocation, remobilization of organic amide-N from source organs to sinks, and other environmental stress responses. However, few systematic analyses of AAPs have been reported in Brassica napus so far. RESULTS: In this study, we identified a total of 34 full-length AAP genes representing eight subgroups (AAP1-8) from the allotetraploid rapeseed genome (AnAnCnCn, 2n = 4x = 38). Great differences in the homolog number among the BnaAAP subgroups might indicate their significant differential roles in the growth and development of rapeseed plants. The BnaAAPs were phylogenetically divided into three evolutionary clades, and the members in the same subgroups had similar physiochemical characteristics, gene/protein structures, and conserved AA transport motifs. Darwin's evolutionary analysis suggested that BnaAAPs were subjected to strong purifying selection pressure. Cis-element analysis showed potential differential transcriptional regulation of AAPs between the model Arabidopsis and B. napus. Differential expression of BnaAAPs under nitrate limitation, ammonium excess, phosphate shortage, boron deficiency, cadmium toxicity, and salt stress conditions indicated their potential involvement in diverse nutrient stress responses. CONCLUSIONS: The genome-wide identification of BnaAAPs will provide a comprehensive insight into their family evolution and AAP-mediated AA transport under diverse abiotic stresses. The molecular characterization of core AAPs can provide elite gene resources and contribute to the genetic improvement of crop stress resistance through the modulation of AA transport.

8.
Clin Cardiol ; 2020 Mar 18.
Artigo em Inglês | MEDLINE | ID: mdl-32187718

RESUMO

BACKGROUND: Anxiety disorders are prevalent in patients with myocardial infarction (MI), but the effects of anxiety disorders on in-hospital outcomes within MI patients have not been well studied. HYPOTHESIS: To examine the effects of concurrent anxiety disorders on in-hospital outcomes in MI patients. METHODS: We conducted a retrospective cohort study in patients with a principal diagnosis of MI with and without anxiety disorders in the National Inpatient Sample 2016. A total of 129 305 primary hospitalizations for acute MI, 35 237 with ST-segment elevation myocardial infarction (STEMI), and 94 068 with non-ST elevation myocardial infarction (NSTEMI) were identified. Of these, 13 112 (10.1%) had anxiety (7.9% in STEMI and 11.0% in NSTEMI). We compared outcomes of anxiety and nonanxiety groups after propensity score matching for the patient and hospital demographics and relevant comorbidities. RESULTS: After propensity score matching, the anxiety group had a lower incidence of in-hospital mortality (3.0% vs 4.4%, P < .001), cardiac arrest (2.1% vs 2.8%, P < .001), cardiogenic shock (4.9% vs 5.6%, P = .007), and ventricular arrhythmia (6.7% vs 7.9%, P < .001) than the nonanxiety group. In the NSTEMI subgroup, the anxiety group had significantly lower rates of in-hospital mortality (2.3% vs 3.5%, P < .001), cardiac arrest (1.1% vs 1.5%, P = .008), and cardiogenic shock (2.8% vs 3.5%, P = .008). In the STEMI subgroup, we found no differences in in-hospital outcomes (all P > .05) between the matched groups. CONCLUSION: Although we found that anxiety was associated with better in-hospital outcomes, subgroup analysis revealed that this only applied to patients admitted for NSTEMI instead of STEMI.

9.
Artigo em Inglês | MEDLINE | ID: mdl-32179681

RESUMO

Electronic phase separation in complex oxides is the inhomogeneous spatial distribution of electronic phases, involving length scales much larger than those of structural defects or nonuniform distribution of chemical dopants. While experimental efforts focused on phase separation and established its correlation with nonlinear responses under external stimuli, it remains controversial whether phase separation requires quenched disorder for its realization. Early theory predicted that if perfectly "clean" samples could be grown, both phase separation and nonlinearities would be replaced by a bicritical-like phase diagram. Here, using a layer-by-layer superlattice growth technique we fabricate a fully chemically ordered "tricolor" manganite superlattice, and compare its properties with those of isovalent alloyed manganite films. Remarkably, the fully ordered manganite does not exhibit phase separation, while its presence is pronounced in the alloy. This suggests that chemical-doping-induced disorder is crucial to stabilize the potentially useful nonlinear responses of manganites, as theory predicted.

10.
Medicine (Baltimore) ; 99(8): e19132, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32080089

RESUMO

The osteoporosis was common complication of ankylosing spondylitis (AS), but it was frequently unrecognized in the initial stage of the disease. This study was to compare areal bone mineral density (BMD) of hip joints in early AS patients with that in healthy controls, to explore the progress of bone loss in cortex and spongiosa in early AS.Quantitative computed tomography (QCT) of hip was performed in 60 AS patients (modified New York criteria for AS, with grade 2 sacroiliitis in computed tomography) and 57 healthy controls. The QCT measurements of AS patients were compared with the measurements of healthy controls.The AS patients had lower areal BMD in cortical bone and total bone of proximal femur in early AS patients (P < .01), than the controls. But there were not significant different of areal BMD in spongiosa of proximal femur between the early AS patients and healthy controls. Strong correlations were found between body mass index BMI, areal BMD in cortical bone (rs = 0.410, P < .001; rs = 0.422, P < .001) and total bone (rs = 0.368, P < .001; rs = 0.266, P = .003) both in AS patients and healthy controls.The results indicate that osteopenia/osteoporosis is general in early stage of AS. What is more, the osteopenia/osteoporosis in cortex is earlier than in spongiosa of proximal femur in early AS.


Assuntos
Densidade Óssea/fisiologia , Articulação do Quadril/metabolismo , Osteoporose/etiologia , Espondilite Anquilosante/complicações , Adulto , Índice de Massa Corporal , Doenças Ósseas Metabólicas/complicações , Doenças Ósseas Metabólicas/diagnóstico por imagem , Feminino , Fêmur/anatomia & histologia , Fêmur/patologia , Articulação do Quadril/diagnóstico por imagem , Articulação do Quadril/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Sacroileíte/classificação , Sacroileíte/complicações , Sacroileíte/diagnóstico por imagem , Espondilite Anquilosante/classificação , Tomografia Computadorizada por Raios X/métodos
11.
Environ Int ; 137: 105485, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32004708

RESUMO

Elucidating the effects of nanoparticles (NPs) on key bacterial functions not only deepens our understanding of nano-toxicity mechanisms, but also guides us in the design criteria for manufacturing safe nanomaterials. In this study, bacterial growth, biofilm development and the expression of biofilm-related genes were monitored in Pseudomonas putida KT2440, a plant-beneficial bacterium, following exposure to ZnO NPs. Low concentrations of NPs (0.5-30 mg L-1) significantly promoted bacterial growth and biofilm formation, while higher concentrations (>30 mg L-1) significantly inhibited biofilm formation. Confocal laser scanning microscopy revealed that microscope slides coated with 0.5 mg L-1 of ZnO NPs showed enhanced bacterial colonization and biomass production, but at higher concentrations (250 mg L-1), biomass production was about 11 times lower than that of the substrate without NPs. Increased protein and sugar contents of the biofilm matrix corroborated the stimulating effects of low concentrations of ZnO NPs. Physiological data were supported by changes in the expression of genes associated with oxidative stress and biofilm development. ZnO NPs at 0.5 mg L-1 stimulated the expression of quorum sensing, lipopolysaccharide biosynthesis, and antibiotic resistance genes; high concentrations of ZnO NPs (250 mg L-1) down-regulated biofilm formation-related genes and up-regulated antioxidant genes. Our results indicate that long-term release of low concentrations of ZnO NPs to the environment would promote undesired biofilm formation and increased resistance to antibiotics.

12.
Chemosphere ; 249: 126143, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32062557

RESUMO

Aggregates are the basic structural units of soils. Fine soil aggregates are crucial pools for the retention of heavy metals. In this study, we evaluated the accumulation characteristics of exogenous Cu in the <2 µm aggregate fractions from a Histosol for an aging of 28 months by nano-scale secondary ion mass spectrometry (NanoSIMS) and synchrotron micro-X-ray fluorescence (micro-XRF). Results showed that the correlations between Cu and Fe/Al/Mn increased from 0.10-0.17 to 0.55-0.63, while those between Cu and C decreased sharply from 0.61 to 0.10 and then increased to 0.36, indicating that exogenous Cu tended to accumulate on inorganic mineral components. The carbon NEXAFS data suggested that the relative content of aromatic and carboxyl carbon decreased from 8.1% and 30.8% to 3.6% and 17.8% at month 12, and increased to 5.9% and 26.0% at month 28, respectively. However, an opposite trend was found for alkyl and carbonyl carbon which showed an increase at month 12 followed by a decrease afterwards. The consistency for the correlations between Cu and C with the changes of aromatic and carboxyl carbon indicated their key roles in the binding of Cu on the organic components in the <2 µm aggregates of Histosol. These direct observations offer a better understanding on the interactions of heavy metals with various soil components which is critical for the risk assessment and fate evaluation of exogenous Cu in soil ecosystems.

13.
Artigo em Inglês | MEDLINE | ID: mdl-31948082

RESUMO

The expansion of urban areas due to population increase and economic expansion creates demand and depletes natural resources, thereby causing land use changes in the main cities. This study focuses on land cover datasets to characterize impervious surface (urban area) expansion in select cities from 1993 to 2017, using supervised classification maximum likelihood techniques and by quantifying impervious surfaces. The results indicate an increasing trend in the impervious surface area by 35% in Bishkek, 75% in Osh, and 15% in Jalal-Abad. The overall accuracy (OA) for the image classification of two different datasets for the three cities was between 82% and 93%, and the kappa coefficients (KCs) were approximately 77% and 91%. The Landsat images with other supplementary data showed positive urban growth in all of the cities. The GDP, industrial growth, and urban population growth were driving factors of impervious surface sprawl in these cities from 1993 to 2017.Landscape Expansion Index (LEI) results also provided good evidence for the change of impervious surfaces during the study period. The results emphasize the idea of applying future planning and sustainable urban development procedures for sustainable use of natural resources and their management, which will increase life quality in urban areas and environments.

14.
Nanoscale ; 2020 Jan 29.
Artigo em Inglês | MEDLINE | ID: mdl-31993622

RESUMO

Lithium ion capacitors (LICs) are regarded as one of the most promising energy storage devices since they can bridge the gap between lithium ion batteries and supercapacitors. However, the mismatches in specific capacity, high-rate behavior, and cycling stability between the two electrodes are the most critical issues that need to be addressed, severely limiting the large energy density and long cycling life of LICs while delivering high-power density output. Herein, quinone and ester-type oxygen-modified carbon has been successfully obtained by chemical activation with alkali, which is beneficial to the absorption of PF6- together with lithium ions, which would largely improve the electrode kinetics. In particular, the cathode capacity is considerably enhanced with the increase in the amount of oxygen functional groups. Moreover, for the full carbon LIC device, an energy density of 144 W h kg-1 is exhibited at the power density of 200 W kg-1. Surprisingly, even after 10 000 cycles at 20 000 W kg-1, a capacity retention of 70.8% is successfully achieved. These remarkable results could be ascribed to the enhancement of cathode capacity and the acceleration of anode kinetics. Furthermore, the density functional theory (DFT) calculations prove that the oxygen functional groups can deliver enhanced electrochemical activity for lithium storage through surface-induced redox reactions. This elaborate study may open an avenue for resolving the issues with the electrode materials of LICs and deepen the understanding on the surface engineering strategies for incorporating oxygen-functional groups.

15.
J Colloid Interface Sci ; 565: 35-42, 2020 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-31931297

RESUMO

Nanoscale ternary chalcogenides have attracted increasing research interest due to their merits of tunable properties and diverse applications in energy and biomedical fields. In this article, silver indium sulfide quantum dots supported by glutathione and polyethyleneimine as dual-ligands have been synthesized through an environmentally friendly and reproducible aqueous method. An emission quantum yield up to 37.2% has been achieved by glutathione as co-ligand bearing electron-rich groups, much higher than that of polyethyleneimine coated quantum dots (4.97%). Both spectroscopic and structural characterizations demonstrate that the photoluminescence enhancement is attributed to change of surface properties by glutathione as co-ligand. Dynamic light scattering (DLS) results and thermogravimetric analysis (TGA) reveal that glutathione covers the QDs with a higher density on the nanocrystal surface than other co-ligands. Therefore, it can effectively passivate the surface trap centers, thus decreasing the non-radiative emission. Moreover, the resultant silver indium sulfide quantum dots present surprisingly long lifetime of 3.69 µs, excellent fluorescent stability and low cytotoxicity, which enables them to be ideal candidate for real-time bioimaging.

16.
J Minim Access Surg ; 2020 Jan 03.
Artigo em Inglês | MEDLINE | ID: mdl-31929221

RESUMO

Background: Enteric duplication is a congenital anomaly with varied clinical presentation that requires surgical resection for definitive treatment. Ileocaecal (IC) duplications are duplications located at the IC junction, not clearly identified in all the published series. The reported treatment is IC resection and ileocolic anastomosis. The purpose of our study was to present our experience in successfully resection of IC duplication by laparoscope, thus avoiding bowel resection in children. Materials and Methods: A retrospective review was conducted of medical records of 15 patients with diagnosis of IC duplication, treated in the Department of Paediatric Surgery of our hospital, within the period from November 2013 to September 2018. Results: Laparoscopic resection of IC duplication was successfully performed in all children without bowel resection. The operation time was 50-90 min (55 ± 10 min), and the post-operative hospitalization time was 5-7 days (average, 6 days). The 15 patients were followed up for 6-12 months (average, 10 months). No recurrence was found by abdominal ultrasound examination. The wound had small scars with good appearance of umbilicus. Conclusions: The laparoscopic approach allows for confirming the diagnosis and accurately defining the exact site of duplication, as well as for effective and safe treatment. Laparoscopic excision of IC duplication without bowel resection is a safe option and is worth promoting.

17.
Hypertens Res ; 43(2): 121-131, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31624353

RESUMO

This study aimed to investigate whether hypertension phenotypes such as white-coat hypertension (WCHT), diagnosed with the addition of nighttime blood pressure (BP) criteria, are related to coronary artery stenosis (CAS) and cardiac arrhythmia. In this cross-sectional observational study, 844 participants who did not use antihypertensive, lipid-lowering, and antiplatelet drugs were selected. The subjects were divided into normotensive (NT), WCHT, masked hypertension (MHT), and sustained hypertension (SHT) groups based on the results of clinic BP measurement and ambulatory BP monitoring. Coronary angiography and ambulatory electrocardiography were performed to determine the participants' CAS and cardiac arrhythmia status. Coronary angiography revealed 556 patients with CAS and 288 participants with normal coronary arteries. The chi-squared test showed that the incidence of CAS was higher in the MHT and SHT groups than in the NT group, while no significant change was found in the WCHT group (P = 0.003, P < 0.001, P = 0.119). The logarithm of the Gensini score was used to compare the degree of CAS between the groups. Multiple linear regression analysis showed that the degree of CAS was higher in the WCHT, MHT, and SHT groups than in the NT group (P < 0.05). The incidences of frequent atrial premature beats, atrial tachycardia, and ventricular cardiac arrhythmia were significantly higher in the WCHT and SHT groups than in the NT group, while only ventricular cardiac arrhythmia changes were observed in the MHT group. This study found that hypertension phenotypes such as WCHT were closely associated with CAS and cardiac arrhythmia.

18.
Pest Manag Sci ; 76(3): 868-879, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31429196

RESUMO

BACKGROUND: 4-Hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.27) has been a good target for herbicide discovery. In order to discover novel HPPD herbicides, a series of pyrazole aromatic ketone analogs were designed and synthesized. RESULTS: The 25 pyrazole aromatic ketone analogs synthesized were tested for herbicidal activity and compounds A1, A3, A4, A17, A20 and A25 displayed excellent herbicidal activity against Chenopodium serotinum, Stellaria media and Brassica juncea at 37.5 g ha-1 . In addition, compounds A1, A5, A9, A10, A16, A17, A20 and A25 exhibited good crop selectivity for wheat, maize and rice at 150 g ha-1 . Inhibition activities against AtHPPD proved the compounds were HPPD inhibitors. The structure-activity relationship of these pyrazole aromatic ketone analogs was studied using molecular docking. CONCLUSION: These pyrazole aromatic ketone derivatives could be used as lead structures for development of HPPD herbicides against dicotyledonous weeds with further structure modification. © 2019 Society of Chemical Industry.

19.
J Drug Target ; 28(1): 102-110, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31100991

RESUMO

Generally, definite intestine targeting and immediate drug releasing are both important for the treatment of colon cancer via oral administration of anti-cancer drugs. We developed a highly specific oral colon-targeted pulsatile capsule, based on the effective enzyme-responsive 'pulse plug', which can be degraded under mannanase abundant in colon. Indomethacin (IN) solid dispersion immediate-release pellets were filled in an insoluble capsule body, a guar gum-lactose-hydroxypropyl methylcellulose (HPMC) composed tablet was embedded on the top of capsule as the 'pulse plug', and then covered by enteric soluble cap. In this study, the influence of the proportion of guar gum/lactose/HPMC, the viscosity of HPMC, and the tablet weight on the degradation behaviour of the plug tablet was investigated. The drug-releasing profiles of those pulsatile capsules in different simulated colon medium verified the 'pulse plug' could realise the colon-targeted pulsatile drug-releasing. Furthermore, the rabbit pharmacokinetic experiments showed that the in vivo time lag of drug loaded pulsatile capsules was significantly extended to 5.61 ± 0.08 h (p<.01), compared with that (0.33 ± 0.47 h) of the marketed tablets (YUNPENG®). These results indicated that colon-targeted pulsatile capsules would be effective oral delivering system for colon cancers therapy.

20.
J Hazard Mater ; 382: 120976, 2020 01 15.
Artigo em Inglês | MEDLINE | ID: mdl-31454608

RESUMO

Biofouling is the Achilles Heel of membrane processes. The accumulation of organic foulants and growth of microorganisms on the membrane surface reduce the permeability, shorten the membrane life, and increase the energy consumption. Advancements in novel carbon-based materials (CBMs) present significant opportunities in mitigating biofouling of membrane processes. This article provides a comprehensive review of the recent progress in the application of CBMs in antibiofouling membrane. It starts with a detailed summary of the different antibiofouling mechanisms of CBM-containing membrane systems. Next, developments in membrane modification using CBMs, especially carbon nanotubes and graphene family materials, are critically reviewed. Further, the antibiofouling potential of next-generation carbon-based membranes is surveyed. Finally, the current problems and future opportunities of applying CBMs for antibiofouling membranes are discussed.

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