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J Tissue Viability ; 28(3): 161-166, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31128964


OBJECTIVE: The aim of this study was to evaluate the impact of High Voltage Pulsed Current (HVPC) on the integration of total skin grafts in rats submitted to nicotine action. MATERIALS AND METHODS: For this purpose, 60 adult Wistar rats randomly distributed in 6 groups of 10 animals were analyzed. The electrical stimulation (anodic and cathodic stimulation, motor level, 30 min at 10 Hz; minimum voltage 20 µs and 100 µs pulse interval) was applied for seven days, starting on the third day after surgery and after the dressing was removed from the graft. RESULTS: Anodic HVPC promoted greater graft integration, demonstrating a lower percentage of tissue contraction, a lower number of inflammatory infiltrates and a greater amount of vascular endothelial growth factor (VEGF), as well as a higher number of newly formed blood vessels. CONCLUSIONS: HVPC can positively influence the integration of skin grafts in nicotine-treated rats. anodic HVPC is shown to promote greater integration in relation to a lower percentage of tissue contraction, a lower number of inflammatory infiltrates and a greater amount of vascular endothelial growth factor and newformed blood vessels. Whereas, the cathodic polarity has presented smaller amount of tissue gap.

Terapia por Estimulação Elétrica/normas , Nicotina/efeitos adversos , Transplante de Pele/normas , Análise de Variância , Animais , Modelos Animais de Doenças , Terapia por Estimulação Elétrica/métodos , Terapia por Estimulação Elétrica/estatística & dados numéricos , Masculino , Nicotina/uso terapêutico , Ratos , Ratos Wistar/lesões , Transplante de Pele/métodos , Cicatrização/efeitos dos fármacos , Cicatrização/fisiologia
J Ther Ultrasound ; 4: 21, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27536356


BACKGROUND: Skin function is dependent on its biomechanical characteristics, resistance, malleability, and elasticity. Therapeutic ultrasound may increase cutaneous malleability thus and optimize the rehabilitation process on specific diseases. The aim of this study is to evaluate possible alterations of biomechanical characteristics of the normal skin after therapeutic ultrasound application. METHODS: Thirty-one volunteers took part of the study, and the average age was 31.61 ± 8.37 years old. Biomechanical characteristics evaluation of the skin was performed with the Cutometer MPA 580 (Courage + Khazaka Electronic-Köln, Germany) of 2-mm probe hole and 500-mbar vacuum. Skin characteristics were analyzed before and after therapeutic ultrasound application, and the variables R0 (distensibility), R2 (gross elasticity), and R6 (viscoelasticity) were used for the study. Areas of therapeutic ultrasound application (continuous, 3 MHz, 1 W/cm(2) SATA) were defined at the upper limbs and standardized using a neoprene template. Sociodemographic data of volunteers were analyzed using SPSS 15.0. To analyze the distribution of the data, the Shapiro-Wilk test was used, which showed the normal distribution for R0 values, R2 and R6. For this procedure, the PROC TTEST from SAS® 9.0 software and Minitab 16 software, with significance, was set at the 0.05 level. RESULTS: In relation to R0, a significant increase (p = 0.001) was observed for the distensibility, when compared to values of pre- (0.3273 mm) and immediately post- (0.3795 mm) resource application which feature a greater distensibility. Related to R2 values, a significant increase (p = .001) of the gross elasticity at pre- (0.8419) and post- (0.8884) therapeutic ultrasound application was found. CONCLUSIONS: Therapeutic ultrasound promotes significant alterations of the biomechanical characteristics of the skin. TRIAL REGISTRATION:, 1111-1146-7342.

Breast Cancer Res Treat ; 127(3): 697-704, 2011 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-21445573


The aim of this study was to evaluate the arterial and venous blood flow in women who underwent upper limb axillary dissection surgery for the treatment of breast cancer. Sixty women were divided into two groups: group 1 (G1)--30 women who underwent breast surgery with axillary dissection level II or III (55.6 ± 8.6 years); group 2 (G2)--control, 30 women with no breast cancer (57.4 ± 7.0 years). Blood flow profile was evaluated by a continuous wave ultrasound Doppler device (Nicolet Vascular Versalab SE) with an 8 MHz probe. Axillary, brachial arteries and veins, arm circumference, volumes, and the ankle-brachial index (ABI) were examined. Wilcoxon test and Mann-Whitney tests were applied to analyze blood flow velocity intra-group and between G1 and G2, respectively. The G1 results showed no lymphedema and no peripheral arterial disease (ABI > 0.9). Moreover, the mean blood flow velocity of the vessels ipsilateral to the surgery was significantly higher than the contralateral ones for all vessels examined (P < 0.05). The mean velocity of blood flow of the vessels contralateral to surgery was significantly higher than the axillary artery in G2 (P < 0.05). It can be concluded that women who underwent axillary dissection due to breast cancer showed probable stenosis in the arterial and venous axillary and brachial vessels of the upper limb ipsilateral to the surgery, confirmed by the increase of blood flow velocity, and such obstruction might affect the limb contralateral to the operation site.

Neoplasias da Mama/irrigação sanguínea , Neoplasias da Mama/fisiopatologia , Extremidade Superior/irrigação sanguínea , Adulto , Idoso , Idoso de 80 Anos ou mais , Artéria Axilar/cirurgia , Veia Axilar/cirurgia , Velocidade do Fluxo Sanguíneo , Artéria Braquial , Veias Braquiocefálicas , Neoplasias da Mama/cirurgia , Feminino , Humanos , Linfedema/cirurgia , Mastectomia/efeitos adversos , Pessoa de Meia-Idade , Doença Arterial Periférica/etiologia , Ultrassonografia Doppler , Extremidade Superior/cirurgia