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Sci Rep ; 11(1): 14640, 2021 07 19.
Artigo em Inglês | MEDLINE | ID: mdl-34282234


Many efforts have been devoted to investigating the effect of the interaction between the serotonin transporter gene (5-HTTLPR) and environment (G × E) on depression, but they yield mixed results. The inconsistency has suggested that G × E effects may be more complex than originally conceptualized, and further study is warranted. This study explored the association among 5-HTTLPR, peer victimization and depressive symptoms and the underlying mediating role of inhibitory control in this association. A total of 871 Chinese Han adolescents (Mage = 15.32 years, 50.3% girls) participated and provided saliva samples from which the 5-HTTLPR was genotyped. This study found that 5-HTTLPR interacted with peer victimization in predicting depressive symptoms. Adolescents carrying L allele reported more depressive symptoms than SS carriers when exposed to higher level of peer victimization. Furthermore, adolescents' inhibitory control deficits mediated the association between 5-HTTLPR × peer victimization and depressive symptoms. These findings suggested that one pathway in which G × E may confer vulnerability to depressive symptoms is through disruptions to adolescents' inhibitory control system.

J Youth Adolesc ; 50(10): 2079-2095, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34259955


Ample evidence suggested that parental responsiveness, demandingness, and autonomy granting protect adolescents from depressive symptoms. However, what is less well understood is how parenting practices reduce the risk of depressive symptoms. This study tested the protective effects of parenting practices and inhibitory control on depressive symptoms, along with the mediating role of inhibitory control and the moderating role of the COMT gene in linking parenting practices to depressive symptoms. The study utilized cross-sectional data from a community sample of Chinese Han adolescents (N = 943, Mage = 15.25 years, SD = 0.70 years; 51.9% girls). Results showed that parental responsiveness and autonomy granting promoted higher inhibitory control, which in turn was associated with lower depressive symptoms. Further, the mediation effects were moderated by the COMT gene. For adolescents with ValVal homozygotes, both responsiveness and autonomy granting were related to higher levels of inhibitory control, which reduced risk for depressive symptoms, but the mediation effects were not observed among Met allele carriers. The mediating role of inhibitory control did not hold in the parental demandingness model. Findings support the cognitive theory that inhibitory control is a proximal factor linking parenting practices to depressive symptoms exclusively in ValVal homozygotes. These results also suggested that differentiating different dimensions of parenting practices may help to further clarify the processes by which parenting practices eventuate depressive symptoms.

Catecol O-Metiltransferase , Poder Familiar , Adolescente , Catecol O-Metiltransferase/genética , Criança , Educação Infantil , Estudos Transversais , Depressão/genética , Feminino , Humanos , Masculino
Front Psychol ; 11: 60, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32132943


Effortful control (EC) plays a crucial role in psychopathology disorders. Emerging studies have paid attention to the effects of G × E interaction on EC. The present study investigated interactions between monoamine oxidase A (MAOA) T941G polymorphism with parenting practices on EC in a sample of 1,531 Chinese adolescents. The adolescents completed the Early Adolescent Temperament Questionnaire-Revised (EATQ-R) EC scale and the Parenting Style Index provided during the study to assess EC and parenting practices, respectively. MAOA T941G polymorphism exerted no effect on adolescent EC; however, results revealed that the MAOA gene interacted with parental acceptance/involvement in their associations with EC among boys. Specifically, although increased levels of parental acceptance/involvement benefited all adolescents, boys with G alleles of the MAOA gene exhibited higher sensitivity to parental acceptance/involvement, compared with T carriers; this interaction was not significant among girls. This study is the first to identify MAOA × parenting interaction on adolescent EC, further contributing to the literature in MAOA gene-EC.

J Youth Adolesc ; 47(11): 2468-2480, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30242586


Behavioral genetics studies and new empirical evidence suggest that depression cannot simply be explained by the influence of single genes but that gene-gene-environment interactions are important to better understanding the etiology of depression. The present study investigated the main and interactive effects of COMT gene Val158Met polymorphism, DAT1 gene rs27072 polymorphism, and peer relationships (i.e., peer acceptance and rejection) on adolescent depressive symptoms. In a sample of 1045 Chinese Han adolescents (Mage = 12.34 ± 0.47 years, 50.1% girls), saliva samples, self-reported depressive symptoms and within-classroom peer nominations were collected. After controlling for gender, age, and SES, the three-way interaction of COMT, DAT1, and peer acceptance significantly concurrently predicted adolescent depressive symptoms. Adolescents with ValVal genotype of COMT and CC genotype of DAT1 were more sensitive to acceptance, compared to their counterparts carrying other combined genotypes. However, a similar three-way interaction was not significant in the case of peer rejection. Additionally, the split-half validation generally replicated these findings. More importantly, this study underscores complex polygenic underpinnings of depression and lends support for the gene-gene-environment interactions implicated in the etiology of depressive symptoms.

Catecol O-Metiltransferase/genética , Depressão/genética , Proteínas da Membrana Plasmática de Transporte de Dopamina/genética , Adolescente , Grupo com Ancestrais do Continente Asiático/genética , Feminino , Interação Gene-Ambiente , Predisposição Genética para Doença , Genótipo , Humanos , Relações Interpessoais , Masculino , Grupo Associado , Polimorfismo Genético , Saliva
J Youth Adolesc ; 45(4): 812-29, 2016 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-26932718


To date, whether and how gene-environment (G × E) interactions operate differently across distinct subtypes of aggression remains untested. More recently, in contrast with the diathesis-stress hypothesis, an alternative hypothesis of differential susceptibility proposes that individuals could be differentially susceptible to environments depending on their genotypes in a "for better and for worse" manner. The current study examined interactions between monoamine oxidase A (MAOA) T941G and catechol-O-methyltransferase (COMT) Val158Met polymorphisms with maternal parenting on two types of aggression: reactive and proactive. Moreover, whether these potential G × E interactions would be consistent with the diathesis-stress versus the differential susceptibility hypothesis was tested. Within the sample of 1399 Chinese Han adolescents (47.2 % girls, M age = 12.32 years, SD = 0.50), MAOA and COMT genes both interacted with positive parenting in their associations with reactive but not proactive aggression. Adolescents with T alleles/TT homozygotes of MAOA gene or Met alleles of COMT gene exhibited more reactive aggression when exposed to low positive parenting, but less reactive aggression when exposed to high positive parenting. These findings provide the first evidence for distinct G × E interaction effects on reactive versus proactive aggression and lend further support for the differential susceptibility hypothesis.

Agressão/fisiologia , Catecol O-Metiltransferase/genética , Interação Gene-Ambiente , Comportamento Materno/psicologia , Monoaminoxidase/genética , Polimorfismo Genético , Agressão/psicologia , Alelos , Criança , Feminino , Genótipo , Humanos , Masculino , Comportamento Materno/etnologia
J Youth Adolesc ; 44(7): 1428-40, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-25941120


Most gene-environment interaction research on depression has largely focused on negative environment and to a lesser extent on positive environment. Moreover, to date few studies have directly examined G × E at different periods in development, particularly during early adolescence. The present study addressed these issues by examining the concurrent and prospective longitudinal effects of maternal parenting, DRD2 TaqIA polymorphism, and their interaction on adolescent depressive symptoms in a sample of 1026 Chinese adolescents (Mage = 11.33 ± 0.47 years at T1, 50.3% girls) in a three-wave longitudinal study from age 11 to 13. Results indicated that maternal positive and negative parenting significantly concurrently predicted adolescent depressive symptoms at all three waves, whereas TaqIA polymorphism had no main effect on depressive symptoms. TaqIA polymorphism interacted with negative parenting in predicting concurrent depressive symptoms at age 11 and 12. A1 carriers were more susceptible to negative parenting compared to A2A2 homozygotes, such that adolescents carrying A1 alleles experiencing high negative parenting reported more depressive symptoms but fared better when experiencing low negative parenting. However, the interaction became nonsignificant at age 13, indicating the interaction of TaqIA polymorphism and maternal parenting may vary with development. Also, there was no G × E effect on longitudinal change in depression. The findings provided evidence in support of the differential susceptibility hypothesis and shed light on the potential for dynamic change in gene-environment interactions over development.

Depressão/genética , Relações Pais-Filho , Polimorfismo Genético , Receptores de Dopamina D4/genética , Adolescente , China , Feminino , Estudos de Associação Genética , Predisposição Genética para Doença , Genótipo , Humanos , Estudos Longitudinais , Masculino , Estudos Prospectivos , Receptores de Dopamina D2/genética