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1.
Echocardiography ; 37(2): 270-275, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31955465

RESUMO

AIMS: Isometric indexation of cardiac structures fails in patients with overweight. The aim of the study was to evaluate the LA indexed volume (LAVOL), left ventricular end-diastolic diameter (LVEDD), left ventricular mass index (LVMI), and the aortic sinus diameter (AOSD) in healthy subjects with normal and high BMI and find the allometric correction exponent. METHODS: Four hundred and thirty patients without cardiac pathology were analyzed. Patients were divided into groups: Group I BMI < 24.9 187 patients, Group II BMI 25-29.9 154 patients, Group III BMI 30-34.9 63 patients, and Group IV 35-39.9 26 patients. A Doppler echocardiogram was performed. The parameters indexed were compared between groups. When allometric growth was verified, the allometric coefficient was calculated. RESULTS: Male sex 242 p (56%), mean age: 44.87 ± 13.10 years, better correlation: LAVOL, LV mass, and AOSD with body surface area (BSA) (LAVOL R: .74, R2 .55, LV mass R: .73, R2 : 0.53, AOSD R: .57, R2 : .35), LVEDD with high (R: .63, R2 : .39) were observed. A significant increase was observed in LAVOL and LVMI in the groups with increased BMI. We observed a decrease in the indexed AOSD and a marginal difference between groups in LVEDD. The allometric correction exponent calculated was as follows: LAVOL: 0.96 and for LVMI: 0.97. CONCLUSIONS: Allometric correction is superior to isometric indexation to assess LAVOL and LVMI in obese and overweight patients. Allometric correction would allow differentiating deviations from VOLAI and IMVI attributable to obesity from those attributable to an associated pathology.

2.
Echocardiography ; 35(10): 1557-1563, 2018 10.
Artigo em Inglês | MEDLINE | ID: mdl-30044512

RESUMO

AIMS: Evaluate the ability of right atrial (RA) strain to predict systolic pulmonary artery pressure (SPAP). METHODS AND RESULTS: A total of 102 patients were prospectively enrolled. Conventional echocardiographic measures were performed. RA volume was calculated. Mean maximum right ventricle (RV) strain and lateral RA strain were obtained. Pearson's correlation test was used. A multivariate analysis was performed to compare SPAP with RA strain, RV strain, and baseline characteristics of the patients. RA strain was compared between patients with SPAP ≤ 37 mm Hg with those with SPAP > 37 mm Hg. A receiver operating characteristic (ROC) curve was constructed. A P < 0.01 value was considered statistically significant. AGE: 58.7 ± 15.7 years. Male: 46 (45.1%). The correlation coefficient between SPAP and RA strain was -0.64 (P < 0.01, 95% confidence interval (CI): -0.75 to -0.50). Quadratic R2 coefficient = 0.52. In the multivariate analysis, RA strain was independently associated with SPAP level. There were significant differences in RA strain between patients with SPAP ≤ 37 mm Hg (63.3 ± 13.3%; 95% CI: 59.4%-65.1%) and >37 mm Hg (32.7 ± 11.1%; 95% CI: 26.5%-38.39%) (P < 0.01). RA strain < 42.5% was capable to predict a SPAP > 37 mm Hg with 93% sensitivity and 94% specificity, area under the curve (AUC) of 98% (95% CI: 94%-100%). CONCLUSIONS: Right atrial strain is independently associated with SPAP level. RA strain lower than 42.5% can predict a SPAP > 37 mm Hg with high sensitivity and specificity.


Assuntos
Função do Átrio Direito , Ecocardiografia/métodos , Hipertensão Pulmonar/fisiopatologia , Artéria Pulmonar/fisiopatologia , Idoso , Feminino , Átrios do Coração/diagnóstico por imagem , Átrios do Coração/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Estudos Prospectivos , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
3.
Medicina (B.Aires) ; 73(1): 17-20, feb. 2013. tab
Artigo em Espanhol | LILACS | ID: lil-672021

RESUMO

La punción percutánea de la arteria radial para la realización de procedimientos por cateterismo ha ganado mayor aceptación en los últimos tiempos. Esto sucedió como consecuencia de haber alcanzado resultados similares a los obtenidos mediante el acceso femoral, con los beneficios de una menor tasa de complicaciones y mayor confort de los pacientes. Recientemente, su utilización tomó un impulso adicional, por estar asociada a mejor pronóstico en síndromes coronarios agudos. En el presente trabajo hemos evaluado si la factibilidad, resultados y ventajas relacionadas al acceso percutáneo de la arteria radial en procedimientos por cateterismo, se aplican también a quienes presentan disección previa de la arteria humeral. Sobre un total de 1 356 accesos radiales percutáneos, 53 fueron en pacientes con disección previa de la arteria humeral, obteniéndose éxito del acceso en el 96.2% (51/53) de las punciones. A través de estos accesos se realizaron 71 procedimientos por cateterismo, con 93.6% (44/47) de éxito del procedimiento en las intervenciones diagnósticas y 100% (24/24) en las terapéuticas. En este grupo no ocurrieron complicaciones mayores. Las complicaciones menores sucedieron en el 1.4% (1/71) de los casos y no se registraron nuevas complicaciones en el seguimiento a siete días. Si bien el grupo es pequeño, consideramos que resulta suficiente para mostrar que las punciones percutáneas de la arteria radial para la realización de procedimientos por cateterismo, en pacientes con disección previa de la arteria humeral, son factibles y permiten elevadas tasas de éxito con baja frecuencia de complicaciones.


The percutaneous punction of the radial artery for catheterization procedures has gained acceptance lately. This was a consequence of achieving results similar to the femoral approach, with the benefits of a lower rate of complications and increased comfort for the patients post procedure. Recently it has gained an additional impulse with the better prognosis obtained in acute coronary syndromes. In this trial we have evaluated if the feasibility, results and advantages related with the use of the radial artery percutaneous approach to perform catheterization procedures, continues when used in patients who have had a previous brachial artery cutdown. Out of a total of 1356 percutaneous radial accesses, 53 were in patients with previous brachial artery cutdown. Through this access 71 catheterization procedures were performed, achieving access success in 96.2% (51/53) of the punctions. Once the access success was obtained, 93.6% (44/47) of the diagnostic procedures and 100% (24/24) of the therapeutics procedures were successful. During hospitalization, in this group of patients, no major adverse cardiac events occurred and there was a 1.4% (1/71) rate of minor events. At seven days follow up, no new complications were recorded. Although this is a small group, we believe that it is enough to show that percutaneous punctions of the radial artery to perform catheterization procedures, in patients with previous brachial artery cutdown, are feasible, allowing high access and procedure success rates, with a low frequency of complications.


Assuntos
Humanos , Artéria Braquial/cirurgia , Cateterismo Cardíaco/métodos , Artéria Radial , Doenças Vasculares/cirurgia , Estudos de Viabilidade , Punções
4.
Medicina (B.Aires) ; 73(1): 17-20, feb. 2013. tab
Artigo em Espanhol | BINACIS | ID: bin-131132

RESUMO

La punción percutánea de la arteria radial para la realización de procedimientos por cateterismo ha ganado mayor aceptación en los últimos tiempos. Esto sucedió como consecuencia de haber alcanzado resultados similares a los obtenidos mediante el acceso femoral, con los beneficios de una menor tasa de complicaciones y mayor confort de los pacientes. Recientemente, su utilización tomó un impulso adicional, por estar asociada a mejor pronóstico en síndromes coronarios agudos. En el presente trabajo hemos evaluado si la factibilidad, resultados y ventajas relacionadas al acceso percutáneo de la arteria radial en procedimientos por cateterismo, se aplican también a quienes presentan disección previa de la arteria humeral. Sobre un total de 1 356 accesos radiales percutáneos, 53 fueron en pacientes con disección previa de la arteria humeral, obteniéndose éxito del acceso en el 96.2% (51/53) de las punciones. A través de estos accesos se realizaron 71 procedimientos por cateterismo, con 93.6% (44/47) de éxito del procedimiento en las intervenciones diagnósticas y 100% (24/24) en las terapéuticas. En este grupo no ocurrieron complicaciones mayores. Las complicaciones menores sucedieron en el 1.4% (1/71) de los casos y no se registraron nuevas complicaciones en el seguimiento a siete días. Si bien el grupo es pequeño, consideramos que resulta suficiente para mostrar que las punciones percutáneas de la arteria radial para la realización de procedimientos por cateterismo, en pacientes con disección previa de la arteria humeral, son factibles y permiten elevadas tasas de éxito con baja frecuencia de complicaciones.(AU)


The percutaneous punction of the radial artery for catheterization procedures has gained acceptance lately. This was a consequence of achieving results similar to the femoral approach, with the benefits of a lower rate of complications and increased comfort for the patients post procedure. Recently it has gained an additional impulse with the better prognosis obtained in acute coronary syndromes. In this trial we have evaluated if the feasibility, results and advantages related with the use of the radial artery percutaneous approach to perform catheterization procedures, continues when used in patients who have had a previous brachial artery cutdown. Out of a total of 1356 percutaneous radial accesses, 53 were in patients with previous brachial artery cutdown. Through this access 71 catheterization procedures were performed, achieving access success in 96.2% (51/53) of the punctions. Once the access success was obtained, 93.6% (44/47) of the diagnostic procedures and 100% (24/24) of the therapeutics procedures were successful. During hospitalization, in this group of patients, no major adverse cardiac events occurred and there was a 1.4% (1/71) rate of minor events. At seven days follow up, no new complications were recorded. Although this is a small group, we believe that it is enough to show that percutaneous punctions of the radial artery to perform catheterization procedures, in patients with previous brachial artery cutdown, are feasible, allowing high access and procedure success rates, with a low frequency of complications.(AU)


Assuntos
Humanos , Artéria Braquial/cirurgia , Cateterismo Cardíaco/métodos , Artéria Radial , Doenças Vasculares/cirurgia , Estudos de Viabilidade , Punções
5.
Medicina (B Aires) ; 73(1): 17-20, 2013.
Artigo em Espanhol | MEDLINE | ID: mdl-23335700

RESUMO

The percutaneous punction of the radial artery for catheterization procedures has gained acceptance lately. This was a consequence of achieving results similar to the femoral approach, with the benefits of a lower rate of complications and increased comfort for the patients post procedure. Recently it has gained an additional impulse with the better prognosis obtained in acute coronary syndromes. In this trial we have evaluated if the feasibility, results and advantages related with the use of the radial artery percutaneous approach to perform catheterization procedures, continues when used in patients who have had a previous brachial artery cutdown. Out of a total of 1356 percutaneous radial accesses, 53 were in patients with previous brachial artery cutdown. Through this access 71 catheterization procedures were performed, achieving access success in 96.2% (51/53) of the punctions. Once the access success was obtained, 93.6% (44/47) of the diagnostic procedures and 100% (24/24) of the therapeutics procedures were successful. During hospitalization, in this group of patients, no major adverse cardiac events occurred and there was a 1.4% (1/71) rate of minor events. At seven days follow up, no new complications were recorded. Although this is a small group, we believe that it is enough to show that percutaneous punctions of the radial artery to perform catheterization procedures, in patients with previous brachial artery cutdown, are feasible, allowing high access and procedure success rates, with a low frequency of complications.


Assuntos
Artéria Braquial/cirurgia , Cateterismo Cardíaco/métodos , Artéria Radial , Doenças Vasculares/cirurgia , Estudos de Viabilidade , Humanos , Punções
6.
Medicina (B.Aires) ; 73(1): 17-20, 2013.
Artigo em Espanhol | BINACIS | ID: bin-133229

RESUMO

The percutaneous punction of the radial artery for catheterization procedures has gained acceptance lately. This was a consequence of achieving results similar to the femoral approach, with the benefits of a lower rate of complications and increased comfort for the patients post procedure. Recently it has gained an additional impulse with the better prognosis obtained in acute coronary syndromes. In this trial we have evaluated if the feasibility, results and advantages related with the use of the radial artery percutaneous approach to perform catheterization procedures, continues when used in patients who have had a previous brachial artery cutdown. Out of a total of 1356 percutaneous radial accesses, 53 were in patients with previous brachial artery cutdown. Through this access 71 catheterization procedures were performed, achieving access success in 96.2


(51/53) of the punctions. Once the access success was obtained, 93.6


(44/47) of the diagnostic procedures and 100


(24/24) of the therapeutics procedures were successful. During hospitalization, in this group of patients, no major adverse cardiac events occurred and there was a 1.4


(1/71) rate of minor events. At seven days follow up, no new complications were recorded. Although this is a small group, we believe that it is enough to show that percutaneous punctions of the radial artery to perform catheterization procedures, in patients with previous brachial artery cutdown, are feasible, allowing high access and procedure success rates, with a low frequency of complications.


Assuntos
Artéria Braquial/cirurgia , Cateterismo Cardíaco/métodos , Artéria Radial , Doenças Vasculares/cirurgia , Estudos de Viabilidade , Humanos , Punções
7.
Rev. argent. cardiol ; 80(2): 114-120, abr. 2012. ilus, graf, tab
Artigo em Espanhol | LILACS-Express | ID: lil-657549

RESUMO

Introducción El 30% de los pacientes presentan antiagregación plaquetaria inadecuada con 100 mg/día de aspirina (AAS) luego de la cirugía de revascularización miocárdica (CRM), que podría deberse a una acción inhibitoria menor de esta dosificación de AAS a la mayor activación plaquetaria y al aumento del recambio plaquetario que ocurren en el posoperatorio. Objetivos Evaluar la relación entre el recuento plaquetario y el menor efecto antiagregante y determinar si dosis fragmentadas de AAS mejoran la antiagregación. Material y métodos Luego de la CRM con bypass cardiopulmonar (2,95 puentes en promedio), se aleatorizaron prospectivamente 50 pacientes a tres grupos: 18 pacientes (G100) a 100 mg/día, 14 (G300) a 300 mg/día y 18 (G100×3) a 100 mg 3 veces por día de AAS. En el preoperatorio todos recibieron 100 mg/día. La reactividad plaquetaria se midió mediante agregación en sangre entera con ácido araquidónico antes de la cirugía (T0), al primero (T1), tercero (T2) y séptimo días (T3) y al mes (T4) pos-CRM. Resultados En el preoperatorio todos los pacientes tenían valores óptimos de antiagregación (0 W). En el posoperatorio, los pacientes del G100×3 tuvieron mejores niveles de antiagregación (p < 0,05). Ningún paciente del G100×3 tuvo valores ≥ 6 W, correspondientes a los de personas sanas sin AAS, a diferencia de 5 pacientes (28%) del G100 y 4 pacientes (29%) del G300. Se observó una asociación estadísticamente significativa entre la antiagregación plaquetaria y el recambio del número de plaquetas (R2 = 0,57; p = 0,001). Un recambio diario > 20% se relacionó con valores de agregación plaquetaria ≥ 6 W con un OR = 2,1 (IC 1,8-4,21; p = 0,0028). Conclusiones En los pacientes sometidos a CRM, la menor respuesta antiagregante a la AAS se correlacionó con el recambio aumentado de plaquetas. El tratamiento podría fragmentarse con dosis bajas de AAS para obtener mejor antiagregación.


Thirty percent of patients do not achieve an adequate antiplatelet effect despite therapy with aspirin (ASA) 100 mg/d after coronary artery bypass-graft surgery (CABGS), probably due to reduced inhibitory effect of ASA, increased platelet activation and increased platelet turnover secondary to the surgical procedure. Objectives To evaluate the relation between platelet count and lower antiplatelet effect and to determine if antiaggregation improves by dividing the dose of ASA. Material and Methods A total of 50 patients undergoing CABGS (with an average of 2.95 grafts per surgery) were randomly assigned to three groups depending on the dose of ASA indicated: G100 (100 mg/d, n=18 patients), G300 (300 mg/d, n=14) and G100×3 (100 mg TID, n=18). All the patients received 100 mg/d before surgery. Platelet reactivity was assessed by whole blood impedance using arachidonic acid before surgery (T0), 24 h (T1), 72 h (T2), 7 days (T3), and one month post-CABG (T4). Results Before surgery, all patients had optimal values of antiaggregation (0 W). During the postoperative period, antiaggregation values were better in patients from G100×3 (p <0.05). No patients in G100×3 had values ≥6 W, which correspond to those of healthy subjects who do not receive ASA. This value was observed in 5 patients (28%) from G100 and 4 patients (29%) from G300. The association between antiaggregation and platelet turnover was statistically significant (R2=0.57; p=0.001). A daily turnover >20% was related with values of platelet aggregation ≥6 W; OR=2.1 (CI 1.8-4.21; p=0.0028). Conclusions In patients undergoing CABGS, the lowest antiplatelet effect of ASA was associated with the highest platelet turnover. A better antiaggregation might be achieved by dividing therapy in low dose of ASA.

8.
Rev. argent. cardiol ; 80(2): 114-120, abr. 2012. ilus, graf, tab
Artigo em Espanhol | BINACIS | ID: bin-129289

RESUMO

Introducción El 30% de los pacientes presentan antiagregación plaquetaria inadecuada con 100 mg/día de aspirina (AAS) luego de la cirugía de revascularización miocárdica (CRM), que podría deberse a una acción inhibitoria menor de esta dosificación de AAS a la mayor activación plaquetaria y al aumento del recambio plaquetario que ocurren en el posoperatorio. Objetivos Evaluar la relación entre el recuento plaquetario y el menor efecto antiagregante y determinar si dosis fragmentadas de AAS mejoran la antiagregación. Material y métodos Luego de la CRM con bypass cardiopulmonar (2,95 puentes en promedio), se aleatorizaron prospectivamente 50 pacientes a tres grupos: 18 pacientes (G100) a 100 mg/día, 14 (G300) a 300 mg/día y 18 (G100Î3) a 100 mg 3 veces por día de AAS. En el preoperatorio todos recibieron 100 mg/día. La reactividad plaquetaria se midió mediante agregación en sangre entera con ácido araquidónico antes de la cirugía (T0), al primero (T1), tercero (T2) y séptimo días (T3) y al mes (T4) pos-CRM. Resultados En el preoperatorio todos los pacientes tenían valores óptimos de antiagregación (0 W). En el posoperatorio, los pacientes del G100Î3 tuvieron mejores niveles de antiagregación (p < 0,05). Ningún paciente del G100Î3 tuvo valores ≥ 6 W, correspondientes a los de personas sanas sin AAS, a diferencia de 5 pacientes (28%) del G100 y 4 pacientes (29%) del G300. Se observó una asociación estadísticamente significativa entre la antiagregación plaquetaria y el recambio del número de plaquetas (R2 = 0,57; p = 0,001). Un recambio diario > 20% se relacionó con valores de agregación plaquetaria ≥ 6 W con un OR = 2,1 (IC 1,8-4,21; p = 0,0028). Conclusiones En los pacientes sometidos a CRM, la menor respuesta antiagregante a la AAS se correlacionó con el recambio aumentado de plaquetas. El tratamiento podría fragmentarse con dosis bajas de AAS para obtener mejor antiagregación.(AU)


Thirty percent of patients do not achieve an adequate antiplatelet effect despite therapy with aspirin (ASA) 100 mg/d after coronary artery bypass-graft surgery (CABGS), probably due to reduced inhibitory effect of ASA, increased platelet activation and increased platelet turnover secondary to the surgical procedure. Objectives To evaluate the relation between platelet count and lower antiplatelet effect and to determine if antiaggregation improves by dividing the dose of ASA. Material and Methods A total of 50 patients undergoing CABGS (with an average of 2.95 grafts per surgery) were randomly assigned to three groups depending on the dose of ASA indicated: G100 (100 mg/d, n=18 patients), G300 (300 mg/d, n=14) and G100Î3 (100 mg TID, n=18). All the patients received 100 mg/d before surgery. Platelet reactivity was assessed by whole blood impedance using arachidonic acid before surgery (T0), 24 h (T1), 72 h (T2), 7 days (T3), and one month post-CABG (T4). Results Before surgery, all patients had optimal values of antiaggregation (0 W). During the postoperative period, antiaggregation values were better in patients from G100Î3 (p <0.05). No patients in G100Î3 had values ≥6 W, which correspond to those of healthy subjects who do not receive ASA. This value was observed in 5 patients (28%) from G100 and 4 patients (29%) from G300. The association between antiaggregation and platelet turnover was statistically significant (R2=0.57; p=0.001). A daily turnover >20% was related with values of platelet aggregation ≥6 W; OR=2.1 (CI 1.8-4.21; p=0.0028). Conclusions In patients undergoing CABGS, the lowest antiplatelet effect of ASA was associated with the highest platelet turnover. A better antiaggregation might be achieved by dividing therapy in low dose of ASA.(AU)

9.
Medicina (B Aires) ; 71(5): 441-8, 2011.
Artigo em Espanhol | MEDLINE | ID: mdl-22057170

RESUMO

Contrast induced nephropathy (CIN) is one of the most frequent causes of acute renal failure in hospitalized patients. It is associated with an increase in morbidity and mortality in patients hospitalized for acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). Risk factors and prevention strategies are not well defined. The aim of this study was to assess the incidence and clinical risk factors associated to the development of contrast induced nephropathy in patients hospitalized for ACS. In a retrospective cohort we analyzed consecutive patients hospitalized for ACS undergoing urgent PCI within 72 hours from the admission. CIN was defined as a 25% increase of creatinine levels from baseline at 48 hours from the PCI. The inclusion period was from January 1, 2004 to June 30, 2010. A total of 125 patients were analyzed, and CIN occurred in 13 (10.4%) patients. An independent association was found between age (OR 1.05; 95% CI 1.004 to 1.11; p = 0.034), multiple vessel angioplasty (OR 2.2; 95% IC 1.07 to 4.8; p = 0.03) and the volume of contrast infused (OR 1.007; 95% CI 1.001 to 1.01; p = 0.014) with the development of CIN.


Assuntos
Síndrome Coronariana Aguda/diagnóstico , Lesão Renal Aguda/induzido quimicamente , Angioplastia , Meios de Contraste/efeitos adversos , Síndrome Coronariana Aguda/terapia , Fatores Etários , Argentina/epidemiologia , Creatinina/sangue , Feminino , Hospitalização/estatística & dados numéricos , Humanos , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Risco , Fatores de Tempo
10.
Medicina (B.Aires) ; 71(5): 441-448, oct. 2011. tab
Artigo em Espanhol | LILACS | ID: lil-633894

RESUMO

La nefropatía inducida por contraste (NIC) es una de las causas más frecuentes de insuficiencia renal en pacientes internados. En el síndrome coronario agudo (SCA), la presencia de NIC aumenta la morbimortalidad. Las medidas de profilaxis y los factores de riesgo intervinientes de NIC en SCA no han sido determinados con exactitud. El objetivo de este estudio fue evaluar la incidencia de NIC y los factores asociados a su desarrollo en pacientes ingresados en unidad coronaria con requerimiento de cinecoronariografía (CCG). Se realizó un estudio de cohorte retrospectivo. Se incluyeron pacientes consecutivos cursando SCA estudiados con CCG dentro de las 72 horas de su admisión. Se definió NIC al aumento del 25% del valor de creatinina a las 48 h sobre el nivel basal de ingreso. El período de inclusión fue entre el 1° de enero de 2004 hasta el 30 de junio de 2010. Se analizaron 125 casos. La incidencia de NIC fue del 10.4% (n = 13). En el análisis multivariado, los factores asociados independientemente a su desarrollo fueron la edad [OR 1.05 (IC 95% 1.004 - 1.11) p = 0.034], la angioplastia a múltiple vaso [OR 2.2 (IC 95% 1.07 - 4.8), p = 0.03] y el volumen de contraste utilizado [OR 1.007 (IC 95% 1.001 - 1.01), p = 0.014].


Contrast induced nephropathy (CIN) is one of the most frequent causes of acute renal failure in hospitalized patients. It is associated with an increase in morbidity and mortality in patients hospitalized for acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). Risk factors and prevention strategies are not well defined. The aim of this study was to assess the incidence and clinical risk factors associated to the development of contrast induced nephropathy in patients hospitalized for ACS. In a retrospective cohort we analyzed consecutive patients hospitalized for ACS undergoing urgent PCI within 72 hours from the admission. CIN was defined as a 25% increase of creatinine levels from baseline at 48 hours from the PCI. The inclusion period was from January 1°, 2004 to June 30, 2010. A total of 125 patients were analyzed, and CIN occurred in 13 (10.4%) patients. An independent association was found between age (OR 1.05; 95% CI 1.004 to 1.11; p = 0.034), multiple vessel angioplasty (OR 2.2; 95% IC 1.07 to 4.8; p = 0.03) and the volume of contrast infused (OR 1.007; 95% CI 1.001 to 1.01; p = 0.014) with the development of CIN.


Assuntos
Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Angioplastia , Síndrome Coronariana Aguda/diagnóstico , Lesão Renal Aguda/induzido quimicamente , Meios de Contraste/efeitos adversos , Fatores Etários , Síndrome Coronariana Aguda/terapia , Argentina/epidemiologia , Creatinina/sangue , Hospitalização/estatística & dados numéricos , Tempo de Internação , Estudos Retrospectivos , Fatores de Risco , Fatores de Tempo
11.
Rev. argent. cardiol ; 78(6): 492-498, nov.-dic. 2010. tab
Artigo em Espanhol | LILACS-Express | ID: lil-634221

RESUMO

Introducción El síndrome de respuesta inflamatoria sistémica es una complicación frecuente en el posoperatorio de cirugía cardíaca, que puede evolucionar con shock vasopléjico y los casos más graves pueden derivar en falla de uno o más órganos. Se describieron predictores en el preoperatorio y el perioperatorio asociados con esta complicación; sin embargo, un estado de inflamación subclínico en la etapa preoperatoria, no detectado por estudios de rutina, podría relacionarse con la respuesta inflamatoria desencadenada en el posoperatorio. Niveles elevados de proteína C reactiva (PCR), un parámetro de inflamación en diferentes escenarios clínicos y que se asocia con el pronóstico de diversas patologías cardiovasculares, podrían predecir el síndrome. Objetivo Evaluar la contribución de la elevación de los niveles preoperatorios de proteína C reactiva para predecir el síndrome de respuesta inflamatoria sistémica y sus complicaciones posoperatorias en cirugía cardíaca. Material y métodos Se incluyeron 169 pacientes consecutivos, prospectivos (77,3% hombres, edad 61,1 ± 15,9, Euroscore 9,46 [DE 12,7]) sometidos a cirugía cardíaca entre abril de 2007 y diciembre de 2008. Se determinó el nivel de PCR en todos los pacientes. El punto final combinado incluyó síndrome de respuesta inflamatoria sistémica y su asociación con fibrilación auricular, insuficiencia renal, shock o muerte. Resultados Ochenta y siete pacientes (54%) desarrollaron el síndrome de respuesta inflamatoria sistémica y 50 pacientes (31%) presentaron el punto final combinado. La mortalidad intrahospitalaria fue del 5,6% (9 pacientes). Ajustados por variables preoperatorias e intraoperatorias, los niveles preoperatorios de PCR ≥ 2 mg/dl se asociaron independientemente con el punto final combinado (OR 2,95, IC 95% 1,20-7,23; p < 0,018), con la evolución con síndrome de respuesta inflamatoria sistémica (SRIS) (OR 2,46, IC 95% 1,17-5,15; p < 0,000), SRIS combinado con insuficiencia renal (OR 5,10, IC 95% 1,48-17,58; p < 0,010), SRIS combinado con shock (OR 6,50, IC 95% 1,59-27,34; p < 0,005), SRIS combinado con fibrilación auricular (OR 3,51, IC 95% 1,14-10,79; p < 0,028), insuficiencia renal (OR 2,91, IC 95% 1,19-7,12; p < 0,019) y shock (OR 4,13, IC 95% 1,25-13,60; p < 0,020). Conclusiones Los niveles preoperatorios de PCR ≥ 2,0 mg/dl pueden predecir el síndrome de respuesta inflamatoria sistémica y el síndrome de respuesta inflamatoria sistémica con insuficiencia renal, fibrilación auricular, shock y muerte en el posoperatorio de cirugía cardíaca.


Background Systemic inflammatory response syndrome is a frequent postoperative complication of cardiovascular surgery that can develop vasoplegic shock and organ or multiorgan dysfunction in tlie most severe cases. Preoperative and postoperative predictors associated with this complication have been described; however, a subclinical preoperative inflammatory state, not detected by routine tests, might be related to the postoperative inflammatory response. Elevated C-reactive protein (CRP) levéis, a parameter of inflammation in different clinical scenarios that is associated with the prognosis of diverse cardiovascular diseases, might predict the syndrome. Objective To evalúate the valué of elevated C-reactive protein to predict systemic inflammatory response syndrome and its postoperative complications after cardiovascular surgery. Material and Methods A total of 169 consecutive patients (77.3% were men, age 61.1±15.9, Euroscore 9.46 [SD 12.7]) undergoing cardiovascular surgery were prospectively included between April 2007 and December 2008. CRP levéis were determined in all patients. The combined endpoint included the incidence of systemic inflammatory response syndrome and its association with atrial fibrillation, kidney failure, shock or death. Results Eighty seven patients (54%) developed systemic inflammatory response syndrome and 50 patients (31%) presented the combined endpoint. In-hospital mortality was 5.6% (9 patients). The preoperative levéis of CRP >2 mg/dl adjusted for preoperative and postoperative variables were independently associated with the combined endpoint (OR 2.95, 95% CI 1.20-7.23; p<0.018), with the development of systemic inflammatory response syndrome (SIRS) (OR 2.46, 95% CI 1.17-5.15; p<0.000), and with the combination of SIRS and kidney failure (OR 5.10, 95% CI 1.48-17.58; p<0.010), SIRS and shock (OR 6.50, 95% CI 1.59-27.34; p<0.005), and SIRS and atrial fibrillation (OR 3.51, 95% CI 1.14-10.79; p<0.028), kidney failure (OR 2.91, 95% CI 1.19-7.12; p<0.019) and shock (OR 4.13, 95% CI 1.25-13.60; p < 0.020). Conclusions Preoperative levéis of CRP >2.0 mg/dl may predict the systemic inflammatory response syndrome and the systemic inflammatory response syndrome with kidney failure, atrial fibrillation, shock and death in the postoperative period of cardiovascular surgery.

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