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Virchows Arch ; 450(1): 109-13, 2007 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-17109152

RESUMO

The case of a 66-year-old male patient with a chronic myeloproliferative type polycythemia vera disorder, who after 2 years of evolution is developing a tumefactive extramedullary hematopoiesis (TEH) located in the synovial of the articulation in the right knee, is described. The tumor histologically consists of a relatively lax and edematous synovial structure diffusely infiltrated by mature and semimature hematopoietic cellular population. The simultaneous study of the bone marrow reveals medullar spaces full of hematopoietic cellularity, with a predominance of megakaryocytic and red series, and with the addition of severe reticulin fibrosis, facts that suggest a progression toward myelofibrosis. The TEH developed in tissues without a reticulum endothelial system is very uncommon. We provide data about the first case located in the synovial membrane and we review the literature regarding this pathologic entity.


Assuntos
Hematopoese Extramedular , Neoplasias de Tecido Conjuntivo/patologia , Policitemia Vera/complicações , Membrana Sinovial/patologia , Idoso , Humanos , Masculino , Mielofibrose Primária/etiologia , Mielofibrose Primária/patologia
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