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1.
Biol Trace Elem Res ; 200(1): 426-436, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33644828

RESUMO

Vegetables are important contributors to a healthy diet, and their adequate daily intake can help prevent some of the major illnesses. The aim of the study was to examine the content of the major and trace elements in selected organically grown (OG) and conventionally grown (CG) vegetables (cabbage, kohlrabi, Brussels sprout, beetroot, carrot, potato, and onion), taken from city green markets. Multi-elemental analysis was carried out by inductively coupled plasma method with optical emission spectrometry (ICP-OES). Nutritional quality evaluation in comparison to nutritional reference values was done. In studied vegetables, Al, Ca, K, Fe (with the exception of organic kohlrabi), Mg, Na, P, S, and Zn were quantified in all samples, whereas As, Cd, Co, Hg, Se, and V were below the limit of detection for these elements. Macroelements and trace elements were found at higher concentrations in OG and CG vegetables, respectively. Differences in concentrations of studied elements between the same vegetable species produced in two agricultural systems were significant, except for beetroot (p ≤ 0.05). Principal component analysis and hierarchical cluster analysis results showed that the botanical origin had higher influence on sample differentiation than the agronomic practice, which was in accordance with the results obtained by Mann-Whitney U test. Good quality of both OG and CG vegetables in respect of nutritionally beneficial elements was observed.


Assuntos
Brassica , Oligoelementos , Avaliação Nutricional , Análise Espectral , Oligoelementos/análise , Verduras
2.
Physiol Mol Biol Plants ; 27(10): 2201-2214, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34744361

RESUMO

Cost-effective exogenous application of some antioxidant, viz. salicylic acid (SA) and ascorbic acid (AA), and essential micronutrient elements like Zn might alleviate the harmful impacts of drought stress. Here, we evaluated the interaction of foliar-sprayed SA (1 mM), AA (10 mM), and Zn (3 g L-1) and irrigation regime (normal irrigation, moderate water stress, and severe water stress) by assaying an array of agronomic, physiological, analytical and biochemical parameters of Moldavian balm (Dracocephalum moldavica L.). Accordingly, the SA and AA treatments reduced the harmful effects of moderate and severe drought stress. Well-watered plants applied with Zn had the highest biomass yield (4642.5 kg ha-1). Severe water stress decreased plant biomass, essential oil (EO) content, EO yield, relative water content, and chlorophyll a content by 37.6%, 23.3%, 47.5%, 35.3%, and 53%, respectively, relative to normal irrigation. Plants treated with Zn under moderate drought stress had the highest EO content. Moderate and severe water stress increased enzymatic antioxidant (catalase, superoxide dismutase, and peroxidase) activities and total soluble sugars and proline contents. In terms of EO composition, SA-treated plants under moderate water stress contained the most geraniol (22.8%) and geranial (26.3%), while Zn-treated plants under severe water stress contained the most geranyl acetate (48.2%). This study demonstrated that foliar application of Zn and SA significantly improves EO productivity and quality in Moldavian balm under moderate water stress. The relevant findings were supported by heatmap clustering, revealing that irrigation regime had main effect on the essential oil compounds and biochemical and physiological parameters. Supplementary Information: The online version contains supplementary material available at 10.1007/s12298-021-01084-1.

4.
Front Surg ; 8: 704902, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34497827

RESUMO

Background: The T1 substaging of bladder cancer (BCa) potentially impacts disease progression. The objective of the study was to compare the prognostic accuracy of two substaging systems on the recurrence and progression of primary pathologic T1 (pT1) BCa and to test a nomogram based on pT1 substaging for predicting recurrence-free survival (RFS) and progression-free survival (PFS). Methods: The medical records of 204 patients affected by pT1 BCa were retrospectively reviewed. Substaging was defined according to the depth of lamina propria invasion in T1a-c and the extension of the lamina propria invasion to T1-microinvasive (T1m) or T1-extensive (T1e). Uni- and multivariable Cox regression models evaluated the independent variables correlated with recurrence and progression. The predictive accuracies of the two substaging systems were compared by Harrell's C index. Multivariate Cox regression models for the RFS and PFS were also depicted by a nomogram. Results: The 5-year RFS was 47.5% with a significant difference between T1c and T1a (p = 0.02) and between T1e and T1m (p < 0.001). The 5-year PFS was 75.9% with a significant difference between T1c and T1a (p = 0.011) and between T1e and T1m (p < 0.001). Model T1m-e showed a higher predictive power than T1a-c for predicting RFS and PFS. In the univariate and multivariate model subcategory T1e, the diameter, location, and number of tumors were confirmed as factors influencing recurrence and progression after adjusting for the other variables. The nomogram incorporating the T1m-e model showed a satisfactory agreement between model predictions at 5 years and actual observations. Conclusions: Substaging is significantly associated with RFS and PFS for patients affected by T1 BCa and should be included in innovative prognostic nomograms.

5.
Plants (Basel) ; 10(7)2021 Jul 02.
Artigo em Inglês | MEDLINE | ID: mdl-34371555

RESUMO

The essentiality of selenium (Se) and iodine (I) to human beings and the widespread areas of selenium and iodine deficiency determine the high significance of functional food production with high levels of these elements. In this respect, joint biofortification of agricultural crops with Se and I is especially attractive. Nevertheless, in practice this topic has raised many problems connected with the possible utilization of many Se and I chemical forms, different doses and biofortification methods, and the existence of wide species and varietal differences. The limited reports relevant to this subject and the multiplicity of unsolved questions urge the need for an adequate evaluation of the results obtained up-to-date, useful for developing further future investigations. The present review discusses the outcome of joint plant Se-I biofortification, as well as factors affecting Se and I accumulation in plants, paying special attention to unsolved issues. A particular focus has been given to the prospects of herb sprouts production enriched with Se and I, as well as the interactions between the latter microelements and arbuscular-mycorrhizal fungi (AMF).

6.
PeerJ ; 9: e11463, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34141469

RESUMO

Many agricultural regions in arid and semiarid climate zone need to deal with increased soil salinity. Legumes are classified as salt-sensitive crops. A field experiment was performed to examine the application of phosphorus (P) fertilizer source and rate on growth, chlorophylls and carotenoid content, DNA and RNA content and ion accumulation in common bean (Phaseolus vulgaris L.) cultivated under salinity stress. An experimental design was split-plot with three replicates. The main plots included two P sources, namely single superphosphate (SP) and urea phosphate (UP). The sub-plots covered four P rates, i.e., 0.0, 17.5, 35.0, and 52.5 kg P ha-1. All applied P fertilization rates, in both forms, increased plant height, leaf area, dry weight of shoots and roots per plant, and total dry weight (TDW) in t ha-1. The highest accumulation of N, P, K+, Mg2+, Mn2+, Zn2+, and Cu2+ was determined in the shoot and root of common bean, while 35 kg of P per ha-1 was used compared to the other levels of P fertilizer. The highest P rate (52.5 kg ha-1) resulted in a significant reduction in Na+ in shoot and root of common bean. The response curve of TDW (t ha-1) to different rates of P (kg ha-1) proved that the quadratic model fit better than the linear model for both P sources. Under SP, the expected TDW was 1.675 t ha-1 if P was applied at 51.5 kg ha-1, while under UP, the maximum expected TDW was 1.875 t ha-1 if P was supplied at 42.5 kg ha-1. In conclusion, the 35.0 kg P ha-1 could be considered the best effective P level imposed. The application of P fertilizer as urea phosphate is generally more effective than single superphosphate in enhancing plant growth and alleviating common bean plants against salinity stress.

7.
R Soc Open Sci ; 8(3): 202064, 2021 Mar 03.
Artigo em Inglês | MEDLINE | ID: mdl-33959359

RESUMO

Rosehip (pseudo-fruit) of dog rose (Rosa canina L.) is highly valued, and owing to nutritional and sensory properties it has a significant place in the food industry. This work represents an innovative report focusing on the evaluation of the phytochemical composition of rosehips (hypanthium and seed) grown in different locations in Serbia, using Raman microspectroscopy combined with multivariate data analysis. Some significant differences arose between the analysed rosehip samples with regard to the chemical profile of both hypanthium parenchyma cells and seed, although no evident discrimination was recorded between the samples of wild and cultivated rosehip. The differences between the hypanthium samples compared were mainly determined by the content of carotenoids, phenolic compounds and polysaccharides, whereas phenolics, polysaccharides (pectin, cellulose and hemicellulose) and lipids (to a lower extent) contributed to the seed sample discrimination. The differences observed between the rosehip samples may be attributed to abiotic factors (growing, ripening and storage conditions), which had a significant impact on the carotenoid and polyphenols biosynthesis.

8.
Molecules ; 26(4)2021 Feb 20.
Artigo em Inglês | MEDLINE | ID: mdl-33672486

RESUMO

Medicinal plants and their derived compounds have drawn the attention of researchers due to their considerable impact on human health. Among medicinal plants, mint (Mentha species) exhibits multiple health beneficial properties, such as prevention from cancer development and anti-obesity, antimicrobial, anti-inflammatory, anti-diabetic, and cardioprotective effects, as a result of its antioxidant potential, combined with low toxicity and high efficacy. Mentha species are widely used in savory dishes, food, beverages, and confectionary products. Phytochemicals derived from mint also showed anticancer activity against different types of human cancers such as cervix, lung, breast and many others. Mint essential oils show a great cytotoxicity potential, by modulating MAPK and PI3k/Akt pathways; they also induce apoptosis, suppress invasion and migration potential of cancer cells lines along with cell cycle arrest, upregulation of Bax and p53 genes, modulation of TNF, IL-6, IFN-γ, IL-8, and induction of senescence phenotype. Essential oils from mint have also been found to exert antibacterial activities against Bacillus subtilis, Streptococcus aureus, Pseudomonas aeruginosa, and many others. The current review highlights the antimicrobial role of mint-derived compounds and essential oils with a special emphasis on anticancer activities, clinical data and adverse effects displayed by such versatile plants.


Assuntos
Antibacterianos/farmacologia , Antineoplásicos Fitogênicos/farmacologia , Antioxidantes/farmacologia , Mentha/química , Óleos Voláteis/farmacologia , Compostos Fitoquímicos/farmacologia , Antibacterianos/química , Antibacterianos/isolamento & purificação , Antineoplásicos Fitogênicos/química , Antineoplásicos Fitogênicos/isolamento & purificação , Antioxidantes/química , Antioxidantes/isolamento & purificação , Bactérias/efeitos dos fármacos , Compostos de Bifenilo/antagonistas & inibidores , Proliferação de Células/efeitos dos fármacos , Humanos , Óleos Voláteis/química , Óleos Voláteis/isolamento & purificação , Compostos Fitoquímicos/química , Compostos Fitoquímicos/isolamento & purificação , Picratos/antagonistas & inibidores
9.
Ann Ital Chir ; 102021 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-33480867

RESUMO

BACKGROUND: Pancreatic neuroendocrine tumors (PNETs) are uncommon, representing <5% of all pancreatic neoplasms, divided into functioning PNETs with secreted hormone cause of specific symptoms, and non-functioning PNETs (nf- PNETs) characterized by delayed diagnosis with metastases and clinical manifestations of compressive effects. Surgical approach is recommended for functioning and nf-PNETs >2 cm in diameter. CASE REPORT: A 76-year-old woman was admitted to the UOC-University-Surgery Hospital "A. Fiorini" in Terracina for nausea and pain in the upper abdominal quadrants with dorso-lumbar irradiation, arising after the evening meal. After the haematochemistry tests and the instrumental investigations, the diagnosis of acute, severe halitiasic pancreatitis was made. Conventional US, CCT, CE-MRI and EUS showed a 2.8cm diameter lesion in the head-body junction of the pancreas. FNA-cytological examination did not found the presence of atypical pancreatic cells. Total-body scintigraphy with Octreoscan® documented a pathological hypercaptation area located in correspondence with the neoformation. The patient underwent a body-tail spleno-pancreatectomy. The histological examination showed an intermediate grade (G2) nf-PNET infiltrating the lienal vein and stenosing the Wirsung duct, with perilesional pancreatitis. Immunohistochemistry showed CAM 5.2, Synaptophysin (>95%) and Chromogranin (60%) positive immunophenotype, with negative intratumoral Somatostatin expression. CONCLUSION: Although rarely, nf-PNETS may be the cause of severe non-biliary acute pancreatitis from pancreatic ductal system compression. In cases where PET/CT68Ga cannot be performed, total-body scintigraphy with Octreoscan® remains the most widely used method for the diagnosis of PNETs and the identification of extra-pancreatic lesions. Chromogranin and Synaptophysin are confirmed as specific markers of neuroendocrine differentiation. KEY WORDS: Acute pancreatitis, Chromogranin, Pancreatic neuroendocrine tumor, Synaptophysin, Somatostatin.


Assuntos
Tumores Neuroendócrinos , Neoplasias Pancreáticas , Pancreatite , Doença Aguda , Idoso , Feminino , Humanos , Tumores Neuroendócrinos/complicações , Tumores Neuroendócrinos/diagnóstico , Tumores Neuroendócrinos/cirurgia , Pancreatectomia , Neoplasias Pancreáticas/complicações , Neoplasias Pancreáticas/diagnóstico , Neoplasias Pancreáticas/cirurgia , Pancreatite/diagnóstico , Pancreatite/etiologia , Pancreatite/cirurgia
10.
Plants (Basel) ; 9(8)2020 Aug 18.
Artigo em Inglês | MEDLINE | ID: mdl-32824850

RESUMO

Tomato is considered one of the most important crops worldwide from nutritional and economic standpoints, and, in this respect, sustainable production should be a prime objective, particularly in terms of fertilization and irrigation management. The aim of this study is to compare the effects of two fertilization types (chemical or organic) and two irrigation regimes (67% or 100% of evapotranspiration replenishment) on biometrical, biochemical, and yield parameters of three indeterminate cultivars of tomato grown in a greenhouse. The results showed that the effect of organic fertilization was better compared to chemical fertilization for lycopene accumulation and antioxidant activity, as well as for the lower concentrations of any of the macroelements in the tomato fruits; therefore, organic fertilization can be used as an alternative to chemical fertilization in sustainable horticulture. In each cultivar under the same fertilization type, the effect of irrigation was significant on yield and the number of fruits, but the 100% evapotranspiration restoration did not enhance the fruit concentration of all the macroelements and microelements compared to 67% irrigation regime. Higher concentrations of macro- and microelements in the chemically fertilized fruits compared to the organic ones, regardless of the cultivar and the irrigation regime, suggest that the inorganic substances are more easily absorbed by plants under a protected environment. Organic fertilization positively affected the lycopene and antioxidant activities of tomato fruits, thus proving to be a valuable alternative to chemical fertilization in sustainable agriculture, although the product premium quality also depends on the cultivar used.

11.
Plants (Basel) ; 9(7)2020 Jun 27.
Artigo em Inglês | MEDLINE | ID: mdl-32604987

RESUMO

The essentiality of selenium (Se) and iodine (I) for the human organism and the relationship between these two trace elements in mammal metabolism highlight the importance of the joint Se-I biofortification to vegetable crops in the frame of sustainable farming management. A research study was carried out in southern Italy to determine the effects of the combined inoculation with arbuscular mycorrhizal fungi (AMF) and biofortification with Se and I on plant growth, seed yield, quality, and antioxidant and elemental status, as well as residual biomass chemical composition of chickpea grown in two different planting times (14 January and 28 February). The AMF application improved the intensity of I and Se accumulation both in single and joint supply of these elements, resulting in higher seed yield and number as well as dry weight, and was also beneficial for increasing the content of antioxidants, protein, and macro- and microelements. Earlier planting time resulted in higher values of seed yield, as well as Se, I, N, P, Ca, protein, and antioxidant levels. Se and I showed a synergistic effect, stimulating the accumulation of each other in chickpea seeds. The AMF inoculation elicited a higher protein and cellulose synthesis, as well as glucose production in the residual biomass, compared to the single iodine application and the untreated control. From the present research, it can be inferred that the plant biostimulation through the soil inoculation with AMF and the biofortification with Se and I, applied singly or jointly, proved to be effective sustainable farming tools for improving the chickpea seed yield and/or quality, as well as the residual biomass chemical composition for energy production or beneficial metabolite extraction.

12.
Plants (Basel) ; 9(8)2020 Jul 23.
Artigo em Inglês | MEDLINE | ID: mdl-32718004

RESUMO

Shading nets have been increasingly drawing research interest, as they allow us to improve the environmental conditions for greenhouse-grown crops. The effects of two shading nets (50% and 79% shading degree), plus an unshaded control, on yield, mineral composition and antioxidants of perennial wall rocket (Diplotaxis tenuifolia L.-D.C.) grown under tunnels in southern Italy were determined. The shading application resulted in a yield decrease, compared to the unshaded control, except for the highest production under 50% shading in July. The highest yield was recorded in the April-May and May-June and the lowest in July. Similar trends were recorded for plant dry weight, leaf number per rosette and mean weight, but the latter showed the highest value under 79% light extinction in July. The rocket leaves were brighter in the summer cycles than in the spring ones. Leaf nitrate was highest in spring and under 79% shading. Potassium, phosphorus, calcium and magnesium showed the highest values in spring and in the unshaded control. The lipophilic antioxidant activity showed the highest values under the 79% shading net in the spring cropping seasons, whereas in July it did not significantly differ from 50% light extinction. The hydrophilic antioxidant activity always attained the highest values in the unshaded control. The unshaded leaves had the highest total phenol accumulation when grown in April-May and the lowest in July. The total ascorbic acid content was always highest in the unshaded control leaves compared to the shading treatments. Fifty percent crop shading is, therefore, an effective sustainable tool for increasing the yield of perennial wall rocket leaves in July, when the light intensity under the plastic tunnel exceeds the plant requirements, also resulting in a mineral composition that is not significantly different from that of the unshaded crops.

13.
Plants (Basel) ; 9(7)2020 Jul 21.
Artigo em Inglês | MEDLINE | ID: mdl-32708158

RESUMO

Modern agriculture is facing many difficulties due to a rapidly changing climate, and environmental damage from agricultural production. The commitment of scientists and farmers to increase environmentally sustainable agricultural practices is one way to help mitigate environmental impacts. Among these practices, the use of biostimulants could be beneficial for increasing fertilizer efficiency and reducing excessive use in agriculture, and as plant growth regulators capable of increasing both production volume and quality of crops. In our study, rocket plants were grown in a greenhouse and treated with two biostimulants (protein hydrolysates or tropical plant extract), either individually or combined, to assess the effect on yield, dry biomass, mineral content, qualitative parameters as well as on economic profitability of foliar biostimulant applications. Total yield and dry biomass of the plants treated with the three biostimulant combinations on average increased by 48.1% and 37.2% respectively compared to untreated plants, without significant differences between treatments. Biostimulant application increased the content of chlorophyll, K, Mg and Ca, compared to the untreated plants. Furthermore, a biostimulant synergistic effect was detected concerning the content of total ascorbic acid. Our results confirmed that the biostimulants are eco-friendly products, able to boost plant growth and product quality and thus increase growers' profitability.

14.
Plants (Basel) ; 9(6)2020 May 30.
Artigo em Inglês | MEDLINE | ID: mdl-32486184

RESUMO

Increasing attention is being given to plant biostimulants as a sustainable farming practice aimed to enhance vegetable crop performance. This research was conducted on greenhouse-grown perennial wall rocket (Diplotaxis tenuifolia (L.) DC.), comparing three biostimulant treatments (legume-derived protein hydrolysates, Trichoderma harzianum T22, and protein hydrolysates + Trichoderma harzianum T22) plus an untreated control, in a factorial combination with three cropping seasons (autumn-winter, winter, winter-spring). Measurements were performed on leaf yield components, colorimetric indicators, mineral composition, bioactive compounds, and antioxidant activity. Leaf marketable yield and mean weight, as well as plant dry weight, showed the highest values in winter crop cycle. Biostimulant treatments resulted in 18.4% and 26.4% increase in leaf yield and number of leaves per rosette, respectively, compared to the untreated control. Protein hydrolysates led to the highest plant dry weight (+34.7% compared to the control). Soil plant analysis development (SPAD) index as well as NO3, PO4, SO4, and Ca contents were influenced more during the winter-spring season than the winter cropping season. The winter production season resulted in a 19.8% increase in the leaf lipophilic antioxidant activity, whereas the hydrophilic antioxidant activity was 34.9% higher during the winter-spring season. SPAD index was the highest with protein hydrolysates + Trichoderma applications, which also increased the colorimetric parameters compared to the untreated control. The treatment with protein hydrolysates + Trichoderma enhanced N, PO4, Mg, and Na contents, compared to both biostimulants applied singly and to the untreated control. Both biostimulants applied alone or the protein hydrolysates + Trichoderma combination led to the increase of the lipophilic and hydrophilic antioxidant activity, as well as ascorbic acid and chlorophyll b, compared to the untreated control. The present research revealed that protein hydrolysates and Trichoderma single applications, and even more their combination in the case of some nutrients content, represent an effective tool for enhancing the yield and the quality attributes of perennial wall rocket produced under the perspective of sustainable crop system.

15.
Plant Foods Hum Nutr ; 75(2): 292-297, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32350812

RESUMO

Functional food with high concentrations of monosaccharides and antioxidants is important for quick replenishment of energy reserves and rehabilitation after intensive oxidant stress. The effect of high temperature and humidity for manufacturing such products from parsnip roots of three cultivars (Zemchug, Krugly, Bely aist) compared to garlic bulbs from cultivar Demidovsky was investigated. The processed parsnip demonstrated higher antioxidant activity than 'black garlic': phenolics (22.6 compared to 13.3 mg-GAE/g d.w.), total antioxidant activity (26.1 compared to 18.1 mg-GAE/g d.w.) and radical scavenging activity (0.24 compared to 0.18 mcM TE/g d.w.). Monosaccharides concentration in parsnip roots increased from 6.5-8.0 to 36.2-42.5 g/100 g d.w., the latter range including the value relevant to the processed garlic (37.4 g/100 g d.w.). Parsnip roots showed concurrent monosaccharides increase and disaccharides decrease (from 33.75-37.2 to 1.25-6.72 g/100 g), whereas garlic displayed the enhancement of both mono- and disaccharide biosynthesis. Total acidity level in processed parsnip also increased by 3 to 5 times and was highly correlated with monosaccharides content (r = 0.99 at P ≤ 0.01). Thanks to its higher mineral content, 'black parsnip' proved to be suitable for quick energy and antioxidant replenishment after strong physical and/or oxidant stress.


Assuntos
Alho , Pastinaca , Antioxidantes , Umidade , Temperatura
16.
Plants (Basel) ; 9(4)2020 Apr 09.
Artigo em Inglês | MEDLINE | ID: mdl-32283805

RESUMO

Celery is one of the major nutraceutical vegetable species due to the high dietary and medicinal properties of all of its plant parts. Yield, growth and produce quality of six celery genotypes belonging to leafy (Elixir and Samurai), stalk (Atlant and Primus) or root (Egor and Dobrynya) types, as well as the distribution of biomass, sugars, mineral elements and antioxidants among the different plant parts, were assessed. Within the celery root type, cultivar Dobrynya resulted in higher yield than Egor, whereas the genotype did not significantly affect the marketable plant part production of leafy and stalk types. Leaf/petiole ratios relevant to biomass, total dissolved solids, sugars, ascorbic acid, flavonoids, antioxidant activity and ash, K, Zn, Fe, Mn, Cu and Se content were significantly affected by the celery type examined. Ash content was highest in the leaves and lowest in the roots. Celery antioxidant system was characterized by highly significant relationships between ascorbic acid, polyphenols, flavonoids, antioxidant activity and Zn. Among the celery types analyzed, the highest values of chlorophyll, Fe and Mn content as well as antioxidant activity were recorded in leaves from root genotypes, which suggests interesting nutraceutical prospects of the aforementioned plant parts for human utilization.

17.
Ann Ital Chir ; 91: 372-377, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32277068

RESUMO

AIM: To evaluate the incidence of SSI and systemic infectious complications in a consecutive series of patients undergoing thyroid surgery in the absence of prophylactic antibiotic (NO-AP). METHODS: Prospective observational study including 77 patients who underwent total thyroidectomy and completion of previous hemithyroidectomy in NO-AP. The surgical intervention was performed by surgeons who were experienced in the procedure, and involved the use of Ligasure Harmonic Ethicon®, absorbable hemostat in oxidized regenerated cellulose (Tabotamp®), and skin incision suture device Skin Stapler®. The following risk factors were assessed: gender, age, BMI, alcohol consumption, habitual smoking, co-morbidities, ASA score, indication to surgery, duration of anesthesia and procedure lenght, type of surgical procedure, fever, white blood cells count, dosage of the pre-operative C Reactive Protein in the five first post-operative day, and histological diagnosis. The data were collected and processed using IBM SPSS software v.23.0. RESULTS: No factors of increased infectious risk have been identified. No infectious surgical and systemic complications have been reported causes of prolongation of the length of the hospital stay. CONCLUSIONS: Fever, neutrophilic leukocytosis and increased PCR cannot be assessed as predictive factors of infectious complication in thyroid surgery. The cutaneous antisepsis of the operative field with chlorhexidine gluconate, the improvement of the surgical technique, the protection of the cutaneous margins of incision, the use of new devices, the accurate hemostasis and the reduction of surgery time lead to a lack of SSIs and systemic infection complications in all patients undergoing thyroid surgery in NO-AP. KEY WORDS: Antibiotic prophylaxis, Surgical site infections, Thyroid surgery, Thyroidectomy.


Assuntos
Anti-Infecciosos Locais/uso terapêutico , Glândula Tireoide , Tireoidectomia , Antibioticoprofilaxia , Hemostasia Cirúrgica , Humanos , Estudos Prospectivos , Infecção da Ferida Cirúrgica/prevenção & controle , Tireoidectomia/efeitos adversos
18.
Plants (Basel) ; 9(3)2020 Mar 16.
Artigo em Inglês | MEDLINE | ID: mdl-32188104

RESUMO

In many regions of the world, the production of vegetable crops is limited by a deepening water crisis. Drought stress affects productivity and the chemical composition of crops. The variability of drought tolerance between species and cultivars of economically important crops, such as pepper (Capsicum species), requires specific investigations to understand the physiological and biochemical responses to the aftermath of drought. The fruits and leaves of four chilli pepper cultivars were investigated to elucidate the fruits' pungency (Scoville Heat Units, SHU), ascorbic acid content, DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity, polyphenol content, membrane lipid peroxidation and key protective antioxidant enzyme activity under drought stress (18-28% volumetric water content) as compared to the control (35-60%). Drought increased the chilli pepper fruits' pungency expressed in Scoville Heat Units (SHU) as well as ascorbic acid content, but this relationship was also dependent on genotype and stress duration. 'Jolokia' was marked as most sensitive to drought by increasing content of capsaicinoids and DPPH˙ scavenging activity under stress conditions. Capsaicinoids and Ascorbic acid (AsA) greatly influenced the antioxidant activity of highly pungent chilli pepper fruits, although total phenols played a significant role in the mildly pungent genotypes. Generally, the activities of antioxidant enzymes increased under drought in chilli pepper leaves and fruits, although the intensity of the reaction varied among the cultivars used in the current research. All the investigated biochemical parameters were involved in the drought response of chilli pepper plants, but their significance and effectiveness were highly cultivar-dependent.

19.
Plants (Basel) ; 9(3)2020 Mar 18.
Artigo em Inglês | MEDLINE | ID: mdl-32197463

RESUMO

Utilization of arbuscular mycorrhizal fungi (AMF) for enhancing growth and development as well as production of essential oil in aromatic plants has been increasingly drawing research interest. In order to assess the AMF effects on different aromatic species, an open-field experiment was carried out using Artemisia dracunculus (tarragon), Lavandula angustifolia (lavender) and Hyssopus officinalis (hyssop). AMF stimulated the growth of tarragon and lavender plants, whereas hyssop showed a slight developmental slowing; nonetheless, a significant increase in essential oil content in the three species was seen. AMF application increased the biomass of A. dracunculus and H. officinalis by 20-35%. No differences in antioxidant activity and phenolics content were recorded at harvest between the control and AMF-inoculated plants, but the latter showed a significant increase in antioxidant status upon storage at high temperature and humidity compared to the untreated control. The enhancement of abiotic stress resistance during storage in plants inoculated with AMF was the highest in A. dracunculus, and the lowest in H. officinalis, while the untreated control plants showed a significant decrease in phenolics, ascorbic acid and chlorophyll content, as well as antioxidant activity, upon the abiotic stress. AMF inoculation differentially affected the mineral composition, increasing the accumulation of Se, I and Zn in A. dracunculus, and decreasing the levels of heavy metals and Co, Fe, Li, Mn in H. officinalis. Based on the outcome of the present research, AMF inoculation resulted in a significant enhancement of the overall performances of A. dracunculus, L. angustifolia and H. officinalis, and also in the improvement of plant antioxidant status upon storage in stress conditions.

20.
Case Rep Endocrinol ; 2020: 4239679, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32082648

RESUMO

Insulinoma is an insulin-producing pancreatic neuroendocrine tumor that can be malignant in about 10% of cases. Locoregional invasion, lymph node metastases, or remote metastases are the main criteria of malignant insulinoma. Its incidence in patients with pre-existing diabetes mellitus (DM) is exceptionally rare. In this report, we describe a 66-year-old man with long-standing type 2 DM who presented with recurrent episodes of diaphoresis due to severe hypoglycemia despite the withdrawal of insulin therapy, hypercalcitoninemia, and biochemical and radiological findings suggestive of metastatic malignant insulinoma. Unfortunately, after few days of diazoxide treatment, edema, hypotension, oliguria, and water retention were observed, patient's clinical status deteriorated rapidly, and he died in our department from acute renal failure.

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