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1.
Cancer Biomark ; 28(2): 193-199, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32224525

RESUMO

BACKGROUND: Clinically non-functioning Pituitary Adenomas (NFPA) are among the most common neoplasms of the sellar region. They usually present with compressive symptoms such as headache and visual field defects and not infrequently, are found incidentally. NFPA are classified as gonadotropinomas, null cell adenomas, according to their immunohistochemical phenotype. The molecular alterations responsible for the development of these lesions are incompletely understood, and there is scarce information regarding the molecular alterations and markers. OBJECTIVE: We carried out an in-silico analysis aimed at identifying the molecular alterations in NFPA and to discover new molecular markers. METHODS: Twenty-three microarray libraries were analyzed. Fourteen correspond to NFPA and 9 to control tissue gland. They were analyzed using Partek Genomic Suite to identify differentially expressed genes and WebGestalt and Metascape to understand the meaning behind the gene lists. RESULTS: Pituitary adenomas showed a markedly different transcriptome compared to the non-tumoral gland, regardless of their putative immunophenotype. Genes related to calcium metabolism such as CACNA2D4, immune-related CXCR4, and stem cell-related KLF8 and PITX2 were altered. CONCLUSIONS: Differentially expressed calcium metabolism and immune-related genes in NFPA represent attractive molecular markers and potential therapeutic targets.

2.
Int J Mol Sci ; 21(6)2020 Mar 14.
Artigo em Inglês | MEDLINE | ID: mdl-32183254

RESUMO

One of the characteristics of the cerebral aging process is the presence of chronic inflammation through glial cells, which is particularly significant in neurodegeneration. On the other hand, it has been demonstrated that the aryl hydrocarbon receptor (AHR) participates in the inflammatory response. Currently, evidence in animal models shows that the hallmarks of aging are associated with changes in the AHR levels. However, there is no information concerning the behavior and participation of AHR in the human aging brain or in Alzheimer's disease (AD). We evaluated the expression of AHR in human hippocampal post-mortem tissue and its association with reactive astrocytes by immunohistochemistry. Besides this, we analyzed through ELISA the AHR levels in blood serum from young and elder participants, and from AD patients. The levels of AHR and glial fibrillar acid protein were higher in elder than in young post-mortem brain samples. AHR was localized mainly in the cytosol of astrocytes and displayed a pattern that resembles extracellular vesicles; this latter feature was more conspicuous in AD subjects. We found higher serum levels of AHR in AD patients than in the other participants. These results suggest that AHR participates in the aging process, and probably in the development of neurodegenerative diseases like AD.

3.
Arch Med Res ; 50(7): 428-436, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31783305

RESUMO

AIMS: Gynaecological malignancies such as breast, ovarian and cervical cancers have become an important public health problem. Detection of molecular alterations in cancer research is fundamental since it can reveal specific pathogenic patterns and genes that could serve as markers. Our aim was to characterize common genomic and transcriptomic signatures for the three gynaecologic malignancies with the highest incidence and mortality to try to identify new molecular markers, therapeutic targets and molecular signatures. METHODS: Here we analysed a total of 723 microarray libraries corresponding to equal number of breast, ovary and cervical cancer and non-cancer patient samples. Copy number variation (CNV) was carried out using 428 libraries and transcriptomic analysis using the 295 remaining samples. RESULTS: Our results showed that breast, ovary and cervical malignancies are characterized by gain of 1q chromosome. At transcriptomic level, they share 351 coding and non-coding genes, which could represent core transcriptome of gynaecological malignancies. Pathway analysis from the resulting gene lists from CNV and expression showed participation in cell cycle, metabolism, and cell adhesion molecules among others. CONCLUSIONS: Chromosome 1q characterize the gynaecological malignancies, which could harbour a richness of genetic repertoire to mine for molecular markers and targets, particular gynaecologic expression profile, containing FANCI, FH and MIR155HG among others, could represent part of the transcriptomic core for diagnostic test and attractive therapeutic targets. It may not be long before every human cancer sample is profiled for a detections test to ascertain a molecular diagnosis and prognosis and to define an optimal and precise treatment strategy.


Assuntos
Biomarcadores/metabolismo , Perfilação da Expressão Gênica/métodos , Neoplasias dos Genitais Femininos/economia , Neoplasias dos Genitais Femininos/genética , Genômica/métodos , Medicina de Precisão/métodos , Transcriptoma/genética , Feminino , Humanos , Prognóstico
4.
Case Rep Pathol ; 2016: 6749590, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27313933

RESUMO

Haemangioblastomas are neoplasms of uncertain histogenesis with cellular and reticular variants advocated in current lore. Herein we describe an intriguing cerebellar specimen with unusual traits including spindle cell morphology and CD34 positivity. A thirty-nine-year old man had an infratentorial tumour discovered incidentally and resected three times. In all the instances, histopathological diagnosis was haemangioblastoma; nonetheless, he had neither physical stigmata nor family history of von Hippel-Lindau disease. By histology, the lesion was composed of areas of conventional stromal cells admixed with territories populated by short-spindled cells packed in lobules, sometimes giving the appearance of gomitoli. Immunoperoxidase-coupled reactions confirmed the expression of inhibin A, neuron-specific enolase (NSE), PS100, and CD57 but also revealed focal immunolabeling for CD34, CD99, and FXIIIa. This case highlights the potential phenotypical diversity that can be found within these neoplasms. Rather than uncertain histogenesis, it may in fact reflect multiple lines of differentiation-histomimesis-prone to adopt unusual morpho- and immunophenotypes in a subset of haemangioblastomas.

5.
J Pathol Transl Med ; 49(4): 325-30, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-26081826

RESUMO

We report a 50-year-old woman with no relevant clinical history who presented with headache and loss of memory. Magnetic resonance imaging showed a left parieto-temporal mass with annular enhancement after contrast media administration, rendering a radiological diagnosis of high-grade astrocytic neoplasm. Tumour sampling was performed but the patient ultimately died as a result of disease. Microscopically, the lesion had areas of glioblastoma mixed with a benign mesenchymal constituent; the former showed hypercellularity, endothelial proliferation, high mitotic activity and necrosis, while the latter showed fascicles of long spindle cells surrounded by collagen and reticulin fibers. With approximately 40 previously reported cases, gliofibroma is a rare neoplasm defined as either glio-desmoplastic or glial/benign mesenchymal. As shown in our case, its prognosis is apparently determined by the degree of anaplasia of the glial component.

6.
J Pathol Transl Med ; 49(5): 403-8, 2015 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26081827

RESUMO

We report a unique case of a 4-year-old girl with an intriguing fibrohistiocytic tumour. Magnetic resonance imaging scans showed a dural mass of variegated intensity compressing the left occipital pole and apparently extending toward the superior sagittal sinus. Grossly, the cut surface of the surgical specimen was yellow, pale, and soft with reddish kernel-like crusts. Histologically, the yellow areas resembled cholesterol granulomas with widespread coagulative necrosis, cholesterol clefts, powdery calcification, foreign body-type giant cells, and foamy macrophages, while the scattered red spots contained numerous multinucleated giant cells of foreign-body and Touton types, the former with amphophilic to slightly eosinophilic cytoplasm. Immunoperoxidase reactions confirmed the expression of histiocytic markers and vimentin. As far as we know, no tumour displaying these peculiar morphological features has yet been described.

7.
PLoS One ; 7(7): e40070, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22808091

RESUMO

Ample animal studies demonstrate that neuropeptides NPY and α-MSH expressed in Arcuate Nucleus and Nucleus of the Tractus Solitarius, modulate glucose homeostasis and food intake. In contrast is the absence of data validating these observations for human disease. Here we compare the post mortem immunoreactivity of the metabolic neuropeptides NPY, αMSH and VGF in the infundibular nucleus, and brainstem of 11 type-2 diabetic and 11 non-diabetic individuals. α-MSH, NPY and tyrosine hydroxylase in human brain are localized in the same areas as in rodent brain. The similar distribution of NPY, α-MSH and VGF indicated that these neurons in the human brain may share similar functionality as in the rodent brain. The number of NPY and VGF immuno positive cells was increased in the infundibular nucleus of diabetic subjects in comparison to non-diabetic controls. In contrast, NPY and VGF were down regulated in the Nucleus of the Tractus Solitarius of diabetic patients. These results suggest an activation of NPY producing neurons in the arcuate nucleus, which, according to animal experimental studies, is related to a catabolic state and might be the basis for increased hepatic glucose production in type-2 diabetes.


Assuntos
Núcleo Arqueado do Hipotálamo/metabolismo , Diabetes Mellitus Tipo 2/genética , Fatores de Crescimento Neural/genética , Neurônios/metabolismo , Neuropeptídeo Y/genética , Núcleo Solitário/metabolismo , Adulto , Idoso , Núcleo Arqueado do Hipotálamo/patologia , Autopsia , Estudos de Casos e Controles , Diabetes Mellitus Tipo 2/metabolismo , Diabetes Mellitus Tipo 2/patologia , Feminino , Regulação da Expressão Gênica , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Fatores de Crescimento Neural/metabolismo , Neurônios/patologia , Neuropeptídeo Y/metabolismo , Núcleo Solitário/patologia , alfa-MSH/genética , alfa-MSH/metabolismo
8.
Radiographics ; 30(6): 1705-19, 2010 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-21071384

RESUMO

Neurocysticercosis is a neurologic parasitic disease caused by the encysted larva of the tapeworm Taenia solium and is the most important parasitic disease of the human central nervous system. It is the most common cause of acquired epilepsy in endemic settings and constitutes a public health challenge for most of the developing world. Nowadays, however, as a result of globalization, neurocysticercosis is being seen more frequently in developed countries as well. Neurocysticercosis is acquired through fecal-oral contamination, and the disease course is complex, with two intermediate hosts (ie, pigs and humans) and a definitive host (humans). Traditionally, it has been classified into active and nonactive forms according to disease location. Radiologists must be aware of its imaging appearance, which is quite variable, as is the differential diagnosis. Imaging findings depend on several factors, including the stage of the life cycle of T solium at presentation; the number and location (ie, subarachnoid, cisternal, or intraventricular) of parasites; and associated complications such as vascular involvement (ie, arteritis with or without infarction), inflammatory response (ie, edema, gliosis, or arachnoiditis), and, in ventricular forms, degree of obstruction. Thus, the diagnostic approach, management, and prognosis for neurocysticercosis differ widely depending on the type of infection.


Assuntos
Diagnóstico por Imagem , Neurocisticercose/diagnóstico , Animais , Anti-Helmínticos/uso terapêutico , Diagnóstico Diferencial , Humanos , Estágios do Ciclo de Vida , Neurocisticercose/tratamento farmacológico , Neurocisticercose/epidemiologia , Neurocisticercose/fisiopatologia , Taenia solium/crescimento & desenvolvimento , Taenia solium/fisiologia
9.
Acta Neuropathol ; 116(5): 507-15, 2008 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-18810470

RESUMO

In recent years, we have used a variety of tau immunological markers combined with the dye thiazin red (TR), an accurate marker to differentiate the fibrillar from the nonfibrillar state of both amyloid-beta and tau in Alzheimer's disease (AD). In this study, we used TR as a potential diagnostic marker of AD in frozen-thawed (F-T) brain tissue and imprint cytology. Control experiments included the use of Thioflavin-S staining, fixed tissue, and some double-labeled material with TR and selected tau markers, including AT100, MC1, Alz-50, TG-3, Tau-C3, and S396. Our results indicate that TR retains its strong affinity for both tangles and plaques in unfixed F-T tissue and imprint cytology. This information provides a potential use of TR as an accurate diagnostic tool for the rapid postmortem diagnosis of AD neuropathology. This study shows the advantages of TR on cytology mainly because tools for the fast postmortem diagnosis of AD are practically nonexistent. In addition, we observed Tau-C3 immunoreactivity in extracellular tangles, suggesting that the Tau-C3 epitope is characteristically stable. Moreover, this study demonstrates that chemical fixation is not necessarily required for tau immunoreactivity on histological sections.


Assuntos
Doença de Alzheimer/diagnóstico , Encéfalo/patologia , Neurônios/patologia , Placa Amiloide/patologia , Idoso , Idoso de 80 Anos ou mais , Doença de Alzheimer/metabolismo , Peptídeos beta-Amiloides/metabolismo , Benzotiazóis , Encéfalo/metabolismo , Feminino , Imunofluorescência/métodos , Humanos , Imuno-Histoquímica , Masculino , Microscopia Confocal , Pessoa de Meia-Idade , Emaranhados Neurofibrilares/metabolismo , Emaranhados Neurofibrilares/patologia , Neurônios/metabolismo , Compostos Orgânicos/metabolismo , Placa Amiloide/metabolismo , Mudanças Depois da Morte , Coloração pela Prata/métodos , Tiazóis/metabolismo , Proteínas tau/metabolismo
10.
J Alzheimers Dis ; 12(4): 365-75, 2007 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-18198423

RESUMO

Neurofibrillary tangles (NFT) and dystrophic neurites represent dense cytoplasmic accumulations of abnormal polymers in the brain of patients with Alzheimer's disease (AD). These polymers are referred to as paired helical filaments (PHFs) whose main structural core is composed of tau protein. Tau processing has been associated with hyperphosphorylation and truncation that results in PHF assembly. Both molecular events appear to cause conformational change of tau molecules [11,17,32]. In this regard, in a previous work focused on the analysis of patterns of immunolabeling in pre-tangle cells, we found that regional changes precede the structural modifications in tau [32]. In the present study, we further analyzed the early stages of tau processing in pre-tangle cells by using a variety of immunological markers of specific N-terminus phosphorylation tau sites. We used AT100, TG-3, AT8, pT231, Alz-50, Tau-C3 and 423 antibodies that recognize different abnormal tau epitopes in AD brains. These antibodies were combined and analyzed using a confocal microscope. Our results indicate that the early stages of abnormal tau processing are characterized by a sequential appearance of specific phospho-dependent epitope. The cascade of appearance of the antibodies is: pT231 --> TG-3 --> AT8 -->AT100 --> Alz-50. In addition; truncation at Asp-421 of the C-terminus of tau protein, as detected by Tau-C3, is also an early molecular event in tau protein aggregation prior to PHF formation in AD.


Assuntos
Doença de Alzheimer/metabolismo , Doença de Alzheimer/patologia , Epitopos/metabolismo , Fosforilação , Proteínas tau/metabolismo , Idoso , Idoso de 80 Anos ou mais , Doença de Alzheimer/imunologia , Anticorpos/imunologia , Encéfalo/imunologia , Encéfalo/patologia , Humanos , Imuno-Histoquímica , Microscopia Confocal , Pessoa de Meia-Idade , Emaranhados Neurofibrilares/imunologia , Emaranhados Neurofibrilares/metabolismo , Emaranhados Neurofibrilares/patologia , Placa Amiloide/imunologia , Placa Amiloide/metabolismo , Placa Amiloide/patologia , Proteínas tau/imunologia
11.
J Alzheimers Dis ; 8(1): 29-41, 2005 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-16155347

RESUMO

Neurofibrillary tangles (NFTs) are the neuropathological hallmarks in Alzheimer's disease (AD). Densities of NFTs correlate with the dementia status. NFTs reflect the intracellular accumulation of abnormal paired helical filaments (PHFs) composed of the microtubule-associated protein tau. Hyperphosphorylation and truncation have been proposed as key events leading to the genesis of PHFs. A recent hypothesis involving conformational changes has been emerging. These structural modifications of the tau protein were detected by monoclonal antibodies (mAbs) recognizing discontinuous epitopes along the tau molecule such as Alz-50, Tau-66 and MC1. A new mAb, TG-3, detects an early pathology in AD. The epitope of mAb TG-3 maps to phosphorylated Thr231 when the tau molecule is conformationally altered. In the present study, we used confocal microscopy to analyze the state of tau molecule adopting the TG-3 conformation during tangle formation. We also compared mAb TG-3 immunoreactivity with that of mAb Alz-50. Immunoelectronmicroscopy was also performed. N- and C- termini markers evidenced that the tau molecule is intact when it adopts the TG-3 conformation. In addition to NFT, mAb TG-3 also recognized NFT-not bearing-neurons suggesting an early processing of tau prior to NFT formation. Ultrastructural analysis evidenced the presence of TG-3 and Alz-50 immunoreactive products on organelles including mitochondria and endoplasmic reticulum. Nuclear heterochromatin was densely immunolabelled. These results together with the fact that TG-3 immunoreactivity is related to intact tau suggest that the conformation recognized by TG-3 is early staged in the neuronal pathology of AD. In addition, we document that the earliest changes in tau occur closely associated with organelles and heterochromatin.


Assuntos
Doença de Alzheimer/patologia , Anticorpos Monoclonais , Antígenos/imunologia , Citoesqueleto/patologia , Proteínas do Tecido Nervoso/metabolismo , Emaranhados Neurofibrilares/patologia , Idoso , Idoso de 80 Anos ou mais , Especificidade de Anticorpos , Córtex Entorrinal/patologia , Feminino , Hipocampo/patologia , Humanos , Masculino , Microscopia Confocal , Microscopia Imunoeletrônica , Pessoa de Meia-Idade , Neurônios/patologia , Fosforilação , Conformação Proteica , Proteínas tau
13.
Rev. méd. Hosp. Gen. Méx ; 63(1): 12-7, ene.-mar. 2000. ilus, tab, CD-ROM
Artigo em Espanhol | LILACS | ID: lil-294887

RESUMO

Se informan cuatro casos de esclerosis tuberosa. Los hallazgos post mortem más frecuentes fueron hamartomas subependimarios y angiofibromas faciales. También se encontraron astrocitomas subependimarios de células gigantes, rabdomiomas cardiacos múltiples, riñones poliquísticos, fibromas subungueales, manchas hipopigmentadas y angiomiolipomas renales. La presentación clínica y morfológica de la esclerosis tuberosa es variada y heterogénea y en esta breve serie se revisan los aspectos patológicos más importantes para su diagnóstico.


Assuntos
Humanos , Masculino , Feminino , Pré-Escolar , Adulto , Angiofibroma/patologia , Angiofibroma/patologia , Esclerose Tuberosa/patologia
15.
Patología ; 35(4): 283-9, oct.-dic. 1997. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-214338

RESUMO

El sistema nervioso central puede ser afectado por diversos tipos de vasculitis, ya sea como parte de una afección sistémica o de manera aislada. Se informan cuatro casos de arteritis segmentarias y focales de arterias intracraneanas, todos los pacientes fueron jóvenes y no presentaron datos clínicos de afección, ni lesiones en arterias extracraneanas. La afección de las arterias cerebrales fue focal y segmentaria y produjo trombosis con el consiguiente infarto isquémico en el territorio irrigado por el vaso afectado. Se revisan los conceptos sobre patogenía y clasificación de las vasculitis que afectan al sistema nervioso central, con especial atención de aquellas producidas por complejos inmunes circulantes


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Arterite/diagnóstico , Autopsia , Infarto/complicações , Trombose
16.
Vet. Méx ; 28(4): 317-24, oct.-dic. 1997. ilus
Artigo em Espanhol | LILACS | ID: lil-227418

RESUMO

A partir de su descripción primaria, el origen de los distintos componente mesenquimatosos que caracterizan a los tumores mixtos de la glándula mamaria canina ha sido controvertido. La mayoría de los autores han encontrado, mediante diferentes métodos, evidencias importantes que señalan a las células mioepiteliales como responsables de lo anterior. En el presente trabajo se estudiaron 15 tumores mixtos caninos por medio de la técnica del complejo avidina-biotina-peroxidasa. Se utilizaron 7 marcadores (citoqueratinas, antígeno de membrana epitelia, antígeno carcinoembrionario, actina músculo-específica, vimetina, proteína S-100 y desmina) comerciales para humanos, previa determinación de su reacción en tejidos testigos de caninos, con el propósito de correlacionar la expresión de dichos antígenos con los cambios ultraestructurales que se presentan en los componentes tisulares en transición. La mayoría de los anticuerpos resultaron confiables en tejidos caninos, excepto la proteína S-100. Por su parte, la citoqueratina, actina múculo-específica y vimetina se expresaron de forma notable en elementos epiteliales, mioepiteliales y mesenquimatosos, respectivamente. Ultraestucturalmente se identificaron 6 tipos celulares principales, de éstos las denominadas células de transición (filamentosas, estelares y condroides) conservaban características específicas de células mioepiteliales como filamentos de actina (5 a 8 nm), demosomas y cuerpos densos. Dichos hallazgos por microscopia electrónica aunados a la expresión de antígenos de membrana y proteínas estructurales, manifiesta por inmunoperoxidasa, señalan a las células mioepiteliales o sus precursoras como responsables de la formación del componente mesenquimatoso heterólogo característico de estos tumores. Se considera también la posibilidad de que el componente epitelial se orine de células con capacidad de diferenciación divergente epimioepitelial, como aparentemente ocurre en los adenomas pleomorfos de la glándulas mamaria y salival del humano


Assuntos
Animais , Cães , Avidina , Neoplasias da Mama/patologia , Mama/patologia , Doenças do Cão/patologia , Mioepitelioma/patologia , Biomarcadores Tumorais , Tumor Mesodérmico Misto/patologia
17.
Patología ; 35(2): 121-5, abr.-jun. 1997. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-214328

RESUMO

Se presentan los hallazgos clínico-pathológicos de diez casos de enfermedad de Devic. La enfermedad fue más frecuente en mujeres adultas y el tiempo de evolución promedio en esta serie fue de diez meses. Las manifestaciones por lesión de la médula espinal fueron las más sobresalientes y casi todos los enfermos murieron por complicaciones pulmonares. Los hallazgos neuropatológicos más importantes fueron desmielinización, infiltrado linfocitario perivascular y cavitación del quiasma óptico y de la médula espinal. Algunos autores consideran la enfermedad de Devic como una forma de esclerosis múltiple y otros como entidad aparte, pero se sabe que es una enfermedad desmielinizante primaria confinada a nervios, quiasma y bandeletas ópticos y a la médula espina, en que el grado de destrucción es mayor aún que en las placas más antiguas de la esclerosis múltiple


Assuntos
Humanos , Adulto , Pessoa de Meia-Idade , Nervo Óptico/patologia , Neuromielite Óptica/fisiopatologia , Neuromielite Óptica/patologia , Quiasma Óptico , Medula Espinal/patologia , Medula Espinal/fisiopatologia
18.
Patología ; 34(3): 203-7, jul.-sept. 1996. ilus
Artigo em Espanhol | LILACS | ID: lil-187943

RESUMO

Se presenta el estudio clínico-patológico de dos casos de carcinoma de plexos coroides. El primero es de una niña de tres años con padecimiento final de tres meses de evolución caracterizado por convulsiones tónico-clónicas y signos meníngeos debidos a un tumor en el ventrículo lateral derecho con dilatación del sistema ventricular. En la autopsia se corroboró la presencia del tumor, algunos implantes subaracnoideos fueron más grandes que la estructura en que se asentaron, en especial el del puente y los de la médula espinal. El carcinoma de plexos coroides estaba en continuidad con un teratoma maduro. El segundo caso es un niño de ocho meses con inicio de síntomas desde el nacimiento, se le practicó derivación ventrículo-peritoneal y craneotomía fronto-parietal derecha con resección parcial de un tumor en el ventrículo lateral derecho; falleció pocos días después de la cirugía por hemorragia intraventricular y úlceras agudas gástricas con hemmoragia masiva. En la autopsia se encontró muy poco tumor residual. Se discuten los criterios de diagnóstico anatomo-patológico


Assuntos
Humanos , Masculino , Feminino , Lactente , Autopsia , Neoplasias Encefálicas/diagnóstico , Neoplasias Encefálicas/patologia , Carcinoma/diagnóstico , Carcinoma/patologia , Microscopia , Ventrículos Cerebrais/patologia
19.
Patología ; 34(2): 95-8, abr.-jun. 1996. ilus
Artigo em Espanhol | LILACS | ID: lil-187934

RESUMO

Se informan cuatro casos de autopsia con enfermedad de Moschcowitz, una niña, un hombre y una mujer jovenes, y una de mediana edad. En todos hubo una evolución corta con somnolencia y pérdida del estado de despierto, dos enfermas presentaron crisis convulsivas, el hombre joven parestesias y alteración de funciones cerebrales superiores y otra enferma focalización con hemiplejia izquierda. En los dos primeros casos se encontraron hemorragias cerebrales pequeñas y en los otros dos casos no hubo datos macroscópicos relevantes. Los hallazgos microscópicos en todos fueron oclusión de vénulas y capilares cerebrales por trombos de fibrina y escaso infiltrado mononuclear perivascular. Esta es una entidad rara y poco entendida que médicos clínicos y patólogos deben conocer y diagnosticar


Assuntos
Lactente , Adulto , Pessoa de Meia-Idade , Humanos , Masculino , Feminino , Hemorragia Cerebral/etiologia , Hemorragia Cerebral/patologia , Púrpura Trombocitopênica Trombótica/diagnóstico , Púrpura Trombocitopênica Trombótica/patologia
20.
Patología ; 34(1): 23-5, ene.-mar. 1996. ilus
Artigo em Espanhol | LILACS | ID: lil-187930

RESUMO

Se presentan dos casos de Corea de Huntington con autopsia completa, en dos hombres de 70 y 43 años en quienes no se hizo el diagnóstico en vida. Los hallazgos macroscópicos son muy característicos en los dos encéfalos, con atrofia principalmente del caudado y en menor grado del putamen y el globus pallidus, que microscópicamente se corrobora por la presencia de pérdida neuronal, rarefacción y gliosis poco acentuada. Se comenta acerca del diagnóstico premortem y la hipótesis actual sobre el mecanismo de la enfermedad


Assuntos
Pessoa de Meia-Idade , Humanos , Masculino , Atrofia/patologia , Autopsia , Cérebro/patologia , Doença de Huntington/patologia , Núcleo Caudado/patologia
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