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1.
IEEE Trans Vis Comput Graph ; 26(1): 811-821, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31443003

RESUMO

OD bundling is a promising method to identify key origin-destination (OD) patterns, but the bundling can mislead the interpretation of actual trajectories traveled. We present OD Morphing, an interactive OD bundling technique that improves geographical faithfulness to actual trajectories while preserving visual simplicity for OD patterns. OD Morphing iteratively identifies critical waypoints from the actual trajectory network with a min-cut algorithm and transitions OD bundles to pass through the identified waypoints with a smooth morphing method. Furthermore, we extend OD Morphing to support bundling at interaction speeds to enable users to interactively transition between degrees of faithfulness to aid sensemaking. We introduce metrics for faithfulness and simplicity to evaluate their trade-off achieved by OD morphed bundling. We demonstrate OD Morphing on real-world city-scale taxi trajectory and USA domestic planned flight datasets.

2.
Front Biosci (Landmark Ed) ; 25: 452-462, 2020 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-31585896

RESUMO

Gastric cancer is the fourth most common malignancy world-wide that bears a high mortality by invasiveness and metastases. To this end, we examined the role of miR-1 in mobility and migration of gastric cancer cells. miR-1 was down-regulated and Sorcin, which supports invasion, was highly expressed in gastric cancer cell lines as compared to the control. The overexpression of miR-1 significantly inhibited the mobility and migration of gastric cancer cells, while, its knockdown exerted an oppoiste effect. In addition, while overexpression of miR-1 suppressed the expression of Sorcin, the siRNA knockdown of Sorcin significantly counteracted the effect of miR-1 inhibitor on cell invasion and migration of gastric cancer cells. A miR-1 mimic decreased while its inhibitor increased the MMP-7 and VEGF required for invasion. Taken together, the findings support the view that miR-1 controls the mobility and migration of gastric cancer cells and might be a therapeutic target for blocking gastric cancer invasion.

3.
Behav Sleep Med ; : 1-14, 2019 Oct 31.
Artigo em Inglês | MEDLINE | ID: mdl-31672062

RESUMO

Objective: Poor sleep quality is common in nursing staff. This meta-analysis aimed to examine the pooled prevalence of poor sleep quality in nursing staff.Methods: A systematic search in PubMed, EMBASE, PsycINFO, and Web of Science databases was performed. Studies that reported sleep quality measured by the Pittsburgh Sleep Quality Index (PSQI) were synthesized using a random-effects model.Results: Fifty-three studies were analyzed. The pooled prevalence of poor sleep quality was 61.0% (95% CI: 55.8-66.1%). The pooled total PSQI score was 7.13 ± 0.18 (95% CI: 6.78-7.50). The pooled component scores were 1.47 ± 0.20 (95% CI of mean score: 1.08-1.85) in sleep latency, 0.91 ± 0.15 (95% CI of mean score: 0.61-1.21) in sleep duration, 1.59 ± 0.13 (95% CI of mean score: 1.35-1.84) in overall sleep disturbances, 0.33 ± 0.18 (95% CI of mean score: 0-0.67) in sleeping medication, 1.21 ± 1.20 (95% CI of mean score: 0.83-1.60) in daytime dysfunction, 1.39 ± 0.14 (95% CI of mean score: 1.11-1.67) in subjective sleep quality, and 0.66 ± 0.11 (95% CI of mean score: 0.44-0.87) in habitual sleep efficiency. Subgroup and meta-regression analyses found that PSQI cutoff values, mean age, body mass index (BMI), sample size, study quality, and work experience moderated the prevalence of poor sleep quality.Conclusions: Poor sleep quality appears to be common in nursing staff. Considering its negative impact on health, effective measures should be taken to improve poor sleep quality in this population. Longitudinal studies should be conducted to examine the contributing factors of nurses' poor sleep quality.

4.
Artigo em Inglês | MEDLINE | ID: mdl-31686297

RESUMO

Cumulative reports comparing the efficacy and safety outcomes between uninterrupted NOACs and vitamin K antagonists (VKA) in AF ablation had been freshly published. This meta-analysis aimed at offering a more comprehensive evaluation between these two anticoagulants in uninterrupted strategy. We searched in PUBMED, EMBASE, and Cochrane Library (inception to June 10, 2019) for eligible studies. Fixed-effects model was preferred in pooled analysis if I2 < 50%. Publication bias was also evaluated. A total of 23 studies involving 12,725 individuals were analyzed in this literature. There were no difference between uninterrupted NOACs and VKA groups in incidence of Stroke/TIA (RR 0.98, 95% CI 0.54-1.77, P = 0.93, I2 = 0%), silent cerebral embolism (RR 1.09, 95% CI 0.82-1.43, P = 0.56, I2 = 0%), minor bleeding complication (RR 0.97, 95% CI 0.83-1.14, P = 0.73, I2 = 0%), cardiac tamponade (RR 0.95, 95% CI 0.63-1.42, P = 0.80, I2 = 0%). Uninterrupted NOACs was associated with significantly lower major bleeding incidence (RR 0.67, 95% CI 0.49-0.92, P = 0.01, I2 = 0%), pericardial effusion (RR 0.75, 95% CI 0.56-1.00, P = 0.048, I2 = 9%). In sub-analysis, no difference was found in all sub-analyses for Stroke/TIA while significant major bleeding risk reduction in uninterrupted NOACs was identified in the subgroup of CHA2DS2-VASc score ≥ 2 and target activated clotting time (ACT) > 300 s. In conclusions, uninterrupted NOACs was more effective than uninterrupted VKA in reducing major bleeding and pericardial effusion risk without increasing thromboembolism risk, and the benefits of uninterrupted NOACs on major bleeding complication could be more pronounced if CHA2DS2-VASc score ≥ 2 or target ACT > 300 s.

5.
Kardiol Pol ; 2019 Nov 05.
Artigo em Inglês | MEDLINE | ID: mdl-31688837

RESUMO

BACKGROUND: Clinical outcomes of catheter ablation for persistent atrial fibrillation (PerAF) remain discouraging. AIM: This meta-analysis aims to compare the role of cryoballoon ablation (CBA) with radiofrequency ablation (RFA) in PerAF. METHODS: Systematic searches of the PubMed, EMBASE, and Cochrane Library databases were performed for studies comparing the outcomes between CBA and RFA. A total of seven trials containing 934 patients were analyzed. RESULTS: No differences between groups were found for freedom from atrial arrhythmia (RR: 1.04, 95% CI: 0.93-1.15, P = 0.52, I2 = 0%), procedural complications (RR: 0.91, 95% CI: 0.52-1.59, P = 0.74, I2 = 0%), AF/AT relapse during the blanking period (RR: 0.73, 95% CI: 0.50-1.06, P = 0.1, I2 = 9%), repeat ablation (RR: 0.74, 95% CI: 0.45-1.21, P = 0.23, I2 = 62%), and vascular complications (RR: 0.98, 95% CI: 0.42-2.27, P = 0.97, I2 = 0%). CBA improved the incidence of conversion to sinus rhythm during ablation (RR: 1.69, 95% CI: 1.01-2.83, P = 0.046, I2 = 0%) and phrenic nerve palsy (PNP, RR: 3.05, 95% CI: 0.95-9.80, P = 0.06, I2 = 0%). RFA increased the cardiac tamponade risk (RR: 0.27, 95% CI: 0.06-1.25, P = 0.09, I2 = 0%). During sub-analyses, lower incidence of recurrent atrial arrhythmia and repeat ablation were found during CBA without touch-up RFA in pulmonary vein isolation. CONCLUSIONS: CBA provides an alternative technique for PerAF ablation and might reduce repeat ablation and cardiac tamponade risk and increase the PNP risk.

6.
Liver Transpl ; 2019 Nov 12.
Artigo em Inglês | MEDLINE | ID: mdl-31715655

RESUMO

Image evaluation of the vascular architecture is essential before living donor liver transplantation (LDLT). However, the use of contrast-enhanced study in recipients with impaired renal function is limited due to risk of acute kidney injury and nephrogenic systemic fibrosis. Therefore, a contrast medium-free method is both valuable and necessary for preoperative vascular evaluation. Recent literature reported Inflow sensitive inversion recovery (IFIR) Magnetic resonance angiography (MRA) without use of contrast medium to be a reproducible and noninvasive tool to assess hepatic vasculature with adequate to good image quality. The purpose of this study is to clinically apply IFIR MRA preoperatively in LDLT recipients. We retrospectively reviewed 31 LDLT recipients with renal function impairment from March 2013 to August 2018 who received IFIR MRA as pre-transplant vascular architecture evaluation and underwent subsequent LDLT. The image findings were assessed for subjective image quality and compared to intra-operative findings. Our result shows the pre-transplant vascular anatomy was well correlated with intraoperative findings in all recipients. Successful ratings with image quality score ≥ 2 for proper hepatic arteries (PHA), portal veins and inferior vena cava (IVC) were 100.0%, 96.8% and 93.5%, respectively. Readable ratings with imaging quality score ≥ 1 for left and right hepatic arteries, and gastroepiploic arteries were 83.9%, 96.7% and 22.6%, respectively. We also found recipients with higher MELD scores (>23) had lower image quality scores in PHA and IVC (p<0.05). Despite the above, images were still satisfactory for pre-liver transplant vascular evaluation. CONCLUSION: In pre-liver transplant recipients with impaired renal function, IFIR MRA is a feasible and reproducible image modality.

7.
BMC Health Serv Res ; 19(1): 807, 2019 Nov 06.
Artigo em Inglês | MEDLINE | ID: mdl-31694620

RESUMO

BACKGROUND: General practice clinics are the main primary care institutions providing ambulatory care in the rural areas of Beijing, rational use of medicines is crucial for the rural primary care system. This study investigated the prescribing patterns of general practice clinics in rural Beijing to provide a baseline for monitoring and promoting the rational use of medicines. METHODS: We performed a cross-sectional study at 14 rural community health service centers in 6 non-central districts of Beijing sampled through a multistage approach, 85 general practitioners were selected from the 14 centers. Total 8500 prescriptions were derived by recording 100 consecutive patients of each the general practitioner. The World Health Organization drug use indicators and an additional indicator were adopted to assess the prescribing patterns. RESULTS: The median number of medicines per encounter was 2.0 (1.0, 2.0); the percentage of generics and essential medicines prescribed were 97.0 and 58.2%, respectively; the percentage of encounters with antibiotics prescribed was 15.1%; the percentage of encounters with injections prescribed was 3.7%; the percentage of encounters with traditional Chinese patent medicines prescribed was 52.5%; the median duration of consultation time was 6.0 (4.0, 10.0) minutes. The most frequently prescribed medicine was aspirin (low dose, 4.6%). The prescribing indicators were influenced by different patient characteristics, patients with new cooperative rural medical scheme were less likely to be prescribed with ≥3 medicines (OR 0.865), essential medicines (OR 0.812) and traditional Chinese patent medicines (OR 0.631), but were more likely to be prescribed with injections (OR 1.551) in the encounter. Patients with ≥3 problems were more likely to be prescribed with ≥3 medicines (OR 6.753), antibiotics (OR 2.875) and traditional Chinese patent medicines (OR 2.926) in the encounter. CONCLUSIONS: Most indicators in this study showed similar or fair performance in comparison with World Health Organization and domestic reports, except the percentage of medicines prescribed from the essential medicine list. Regular monitoring on the prescription quality of general practice clinics in rural Beijing should be maintained.

8.
Adv Mater ; : e1904914, 2019 Nov 07.
Artigo em Inglês | MEDLINE | ID: mdl-31696981

RESUMO

Immunogenic cell death (ICD) provides momentous theoretical principle for modern cancer immunotherapy. However, the currently available ICD inducers are still very limited and photosensitizer-based ones can hardly induce sufficient ICD to achieve satisfactory cancer immunotherapy by themselves. Herein, an organic photosensitizer (named TPE-DPA-TCyP) with a twisted molecular structure, strong aggregation-induced emission activity, and specific ability is reported for effectively inducing focused mitochondrial oxidative stress of cancer cells, which can serve as a much superior ICD inducer to the popularly used ones, including chlorin e6 (Ce6), pheophorbide A, and oxaliplatin. Furthermore, more effective in vivo ICD immunogenicity of TPE-DPA-TCyP than Ce6 is also demonstrated using a prophylactic tumor vaccination model. The underlying mechanism of the effectiveness and robustness of TPE-DPA-TCyP in inducing antitumor immunity and immune-memory effect in vivo is verified by immune cell analyses. This study thus reveals that inducing focused mitochondrial oxidative stress is a highly effective strategy to evoke abundant and large-scale ICD.

9.
World Neurosurg ; 2019 Nov 02.
Artigo em Inglês | MEDLINE | ID: mdl-31689567

RESUMO

BACKGROUND: Aneurysm wall enhancement (AWE) may predict rupture-prone intracranial aneurysms (IAs). However, the clinical and morphological risk factors related to AWE have not been well-described. Furthermore, the risk factors related to enhancement patterns have never been studied, especially in patients with anterior circulation aneurysms. Therefore, we aimed to investigate the risk factors related to wall enhancement and the enhancement patterns in anterior circulation unruptured aneurysms. METHODS: One-hundred patients (median age, 59 years; 68% female) with 113 anterior circulation unruptured aneurysms were included in this prospective study. Clinical and morphological risk factors related to wall enhancement and circumferential enhancement were analyzed using univariate and multivariate analyses. RESULTS: There were 33 (29.2%) symptomatic unruptured IAs and 50 (44.2%) IAs with AWE (partial [n=16], circumferential [n=34]). Univariate analysis showed that symptomatic IAs and morphological factors (irregular shape, size, width, dome depth, size ratio, aspect ratio, and bottleneck) correlated with wall enhancement. Furthermore, female sex, blood parameters (cholesterol, low-density lipoprotein), and morphological factors (size and dome depth) correlated with wall enhancement patterns (p<0.05). Multivariate analysis showed that size was the most important factor in wall enhancement (p=0.06; odds ratio, 3.758) and a trend for symptomatic IAs (p=0.033; odds ratio, 2.426). Female sex was the most important factor in circumferential enhancement (p=0.017; odds ratio, 7.276). CONCLUSIONS: AWE was strongly associated with aneurysm size and observed more frequently in symptomatic unruptured IAs. Sex hormones and atherosclerotic factors may be involved in circumferential enhancement. However, further studies should be performed to investigate the pathological mechanisms for pattern of enhancement.

10.
Nat Prod Res ; : 1-7, 2019 Nov 06.
Artigo em Inglês | MEDLINE | ID: mdl-31691585

RESUMO

One new ent-kauran diterpene, 7ß,16ß,17-trihydroxy ent-kauran 19-(6ß)-olide (1), along with eight known compounds were isolated from the seed of Ipomoea nil. Isolates caffeoylquinic acid derivatives 5-9 were found for the first time in this species. All structures were identified from various spectroscopic data. trans-Caffeic acid 3, phenylpropanoid 4, and caffeoylquinic acid derivatives 5-9 could inhibit ROS generations induced in human keratinocyte HaCaT cells with IC50 values of 0.94-28.40 µM. Compounds 3 and 5-9 also had DPPH free radical scavenging properties (IC50 values, 14.86-68.27 µM), however, isolate 4 did not show inhibition effect. Generally, I. nil and its secondary metabolites 3-9 could be further applied for oxidative stress damage resulted in skin disorders.

11.
Prenat Diagn ; 2019 Nov 07.
Artigo em Inglês | MEDLINE | ID: mdl-31697851

RESUMO

OBJECTIVE: This study aimed to validate the feasibility of haplotype-based noninvasive prenatal diagnosis (NIPD) of cobalamin C (cblC) deficiency. METHOD: This method includes three steps: First, targeted sequencing was performed on 21 families affected by cblC deficiency (including the couples and probands); Second, parental haplotypes linked with the pathogenic variant were determined using the genotypes of trios; Then, the fetal haplotypes were inferred through a parental haplotype assisted hidden Markov model (HMM). The NIPD results were confirmed by using the invasive procedures. RESULTS: 21 fetal genotypes were successfully inferred by NIPD including three compound heterozygotes with cblC deficiency, nine heterozygote carriers of cblC deficiency and nine normal fetuses. The NIPD results were confirmed using the invasive procedures with 100% concordant rate. CONCLUSION: This result has shown that haplotype-based NIPD of cblC deficiency has high concordant rate and indicated potential clinical utility as a pregnancy diagnosis method for high-risk carrier couples.

12.
Coron Artery Dis ; 2019 Nov 07.
Artigo em Inglês | MEDLINE | ID: mdl-31703014

RESUMO

BACKGROUND: Several studies have evaluated the long-term clinical outcomes of periprocedural myocardial injury for chronic total occlusions patients. However, the results of these studies were inconsistent. To determine whether the periprocedural myocardial injury has adverse effects on long-term clinical outcomes in chronic total occlusion patients undergoing percutaneous coronary intervention. METHODS: We searched Cochrane Library, PubMed, and Embase for eligible articles from their date of inception up to March 2019. Long-term clinical outcomes included major adverse cardiac events, all-cause death, cardiac death, myocardial infarction, and target vessel revascularization. Odds ratios with 95% confidence intervals were calculated as summary statistics by using Review Manager software. RESULTS: A total of 8 observational studies involving 5879 chronic total occlusions patients were included in this meta-analysis. These results of this meta-analysis indicated that periprocedural myocardial injury was associated with a higher risk of major adverse cardiac events (odds ratio, 1.94; 95% confidence interval, 1.22-3.08; P = 0.005), a higher risk of all-cause death (odds ratio, 1.30; 95% confidence interval, 1.02-1.64; P = 0.03), a higher risk of cardiac death (odds ratio, 2.59; 95% confidence interval, 1.41-4.78; P = 0.002), a higher risk of myocardial infarction (odds ratio, 3.07; 95% confidence interval, 1.90-4.98; P < 0.00001), and a higher risk of target vessel revascularization (odds ratio, 2.07; 95% confidence interval, 1.35-3.16; P=0.0008) than non-periprocedural myocardial injury. CONCLUSION: Periprocedural myocardial injury was associated with significantly increased risk of major adverse cardiac events, all-cause death, cardiac death, myocardial infarction, and target vessel revascularization in chronic total occlusion patients undergoing percutaneous coronary intervention at long-term follow-up.

13.
BMC Med Genomics ; 12(1): 157, 2019 11 07.
Artigo em Inglês | MEDLINE | ID: mdl-31699113

RESUMO

BACKGROUND: Preimplantation genetic testing for monogenic defects (PGT-M) has been available in clinical practice. This study aimed to validate the applicability of targeted capture sequencing in developing personalized PGT-M assay. METHODS: One couple at risk of transmitting Usher Syndrome to their offspring was recruited to this study. Customized capture probe targeted at USH2A gene and 350 kb flanking region were designed for PGT-M. Eleven blastocysts were biopsied and amplified by using multiple displacement amplification (MDA) and capture sequencing. A hidden Markov model (HMM) assisted haplotype analysis was performed to deduce embryo's genotype by using single nucleotide polymorphisms (SNPs) identified in each sample. The embryo without paternal rare variant was implanted and validated by conventional prenatal or postnatal diagnostic means. RESULTS: Four embryos were diagnosed as free of father's rare variant, two were transferred and one achieved a successful pregnancy. The fetal genotype was confirmed by Sanger sequencing of fetal genomic DNA obtained by amniocentesis. The PGT-M and prenatal diagnosis results were further confirmed by the molecular diagnosis of the baby's genomic DNA sample. The auditory test showed that the hearing was normal. CONCLUSIONS: Targeted capture sequencing is an effective and convenient strategy to develop customized PGT-M assay.

14.
Mikrochim Acta ; 186(12): 784, 2019 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-31732809

RESUMO

It is demonstrated that vanadium tetrasulfide (VS4) exhibits peroxidase (POx)-like activity which follows Michaelis-Menten kinetics when using H2O2 as a co-substrate. Electron spin resonance spectroscopy was use to analyze the catalytic mechanism. It suggests that the enzyme mimicking activity is caused by decomposing H2O2 into hydroxyl radicals. The method was used to quantify H2O2 by using 3,3',5,5'-tetramethylbenzidine as the substrate which results in the formation of a blue coloration (with an absorption peak at 652 nm). H2O2 can be detected in the 50 to 300 µM concentration range, and the detection limit is 5.0 µM. The assay for L-cysteine (L-cys) is based on the capability of oxTMB to oxidize L-cys to form L-cystine. The colorimetric L-cys assay has a linear response in the 5 to 100 µM concentration range and a 2.5 µM detection limit. Graphical abstractSchematic representation of the enzyme mimicking activity of vanadium tetrasulfide (VS4) submicrospheres originated from the decomposition of hydrogen peroxide (H2O2) to generate reactive hydroxyl radical (·OH) and the colorimetric detection of L-cysteine.

15.
BMC Urol ; 19(1): 119, 2019 Nov 21.
Artigo em Inglês | MEDLINE | ID: mdl-31752806

RESUMO

BACKGROUND: Metabolic syndrome (MetS) and serum prostate-specific antigen (PSA) levels are correlated. To investigate the underlying effect of MetS on PSA levels, the relationship between the major pathogenic factors of MetS and serum PSA levels was studied. METHODS: A total of 506 ostensibly healthy men who underwent routine health check-ups were recruited to this study. We evaluated the effect of the major pathogenic factors of MetS, which included insulin resistance, a subclinical inflammatory state and sexual hormone changes, on serum PSA levels by using linear regression analysis and multivariate analysis after adjusting for age, BMI and prostate volume. RESULTS: When simultaneously adjusting for age, BMI, prostate volume and high-density lipoprotein cholesterol, serum insulin levels and SHBG levels were inversely correlated with serum PSA levels (P = 0.049 and P = 0.004, respectively), and testosterone levels were positively correlated with serum PSA levels (P = 0.039). In multivariate regression models, serum insulin levels and serum SHBG levels were significantly associated with serum PSA levels (both P < 0.001). CONCLUSIONS: Among the major pathogenic factors of metabolic syndrome, insulin resistance and sexual hormone changes may be the most significant contributors to the decline in serum PSA levels.

16.
Theranostics ; 9(26): 8312-8320, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31754398

RESUMO

Rationale: PEGylation of nanocarriers could extend blood circulation time and enhance tumor accumulation via the enhanced permeability and retention (EPR) effect. Unfortunately, the PEG moiety suppresses tumor cell internalization of nanocarriers, resulting in limited therapeutic efficiency (known as the PEG dilemma). Designing stimuli-responsive shell-detachable nanocarriers, which could detach the PEG corona from the nanocarriers in desired tumor tissues in response to the local environment, is an appealing approach to overcome the PEG dilemma, but nanocarrier applications are also limited by a lack of universal stimuli for PEG detachment. Methods: In this study, we synthesized red light-responsive, amphiphilic mPEG bridged to the photosensitizer Ce6 via a thioketal (TK) bond (mPEG-TK-Ce6), which was then used to achieve the PEGylation of polylactide (PLA)-based nanoparticles encapsulating the Pt(IV) prodrug. The therapeutic efficacy of the prepared nanoparticles was evaluated in vitro and in vivo. Results: We demonstrated that the amphiphilic mPEG-TK-Ce6 can realize the PEGylation of Pt(IV) prodrug-loaded PLA nanoparticles and consequently enhanced nanoparticle accumulation in tumor tissues. When the tumor tissues were subjected to 660 nm irradiation, reactive oxygen species (ROS) generated by Ce6 induced the rapid degradation of the adjacent TK bond, resulting in PEG detachment and enhanced tumor cell internalization. Therefore, mPEG-TK-Ce6 facilely achieved PEGylation and light-responsive dePEGylation of the nanocarrier for enhanced antitumor efficacy in nanomedicine. Conclusion: Such red light-responsive amphiphilic mPEG-TK-Ce6 facilely achieved PEGylation and dePEGylation of the nanocarrier, providing a facile strategy to overcome PEG dilemma.

17.
Clin Cardiol ; 2019 Nov 19.
Artigo em Inglês | MEDLINE | ID: mdl-31743474

RESUMO

BACKGROUND: The ThermoCool Smarttouch Surroundflow catheter (STSFc) is an advanced catheter, which integrating contact force sensing and surroundflow technology. However, comparative data between STSFc and contact force sensing catheter (Thermocool SmartTouch catheter [STc]) are limited. HYPOTHESIS: We thought that STSFc might bring more clinical benefits. The aim of this meta-analysis was to compare the safety and efficiency between the STSFc and the STc for treatment of atrial fibrillation (AF). METHODS: The Medline, PubMed, Embase, and Cochrane Library databases were searched for studies comparing STSFc and STc. RESULTS: Four trials involving 727 patients were included in the study. Pool-analyses demonstrated that, as compared STc ablation, STSFc ablation was more beneficial in terms of procedural times (standard mean difference [SMD]: -0.22; 95% confidence interval [CI], -0.37 to -0.07, P = .005) and irrigation fluid volume (SMD: -1.94; 95% CI, -2.65 to -1.22, P < .0001). There was no significant difference between STSFc and STc (risk ratio [RR]: 1.02; 95% CI: 0.86 to 1.21, P = .79) for free from AF. Evidence of complications were low and similar for both groups (RR: 0.83; 95% CI: 0.19-3.55, P = .80). Additionally, patients administered STSFc ablation tended to have shorter fluoroscopic times (SMD: -0.20; 95% CI, -0.63-0.23, P = .21). CONCLUSIONS: STSFc ablation was associated with reducing procedural times and irrigation fluid volume. Further, STSFc ablation tended to shorten fluoroscopic times. Therefore, STSFc ablation would be a better choice for AF patients especially in patients with heart failure.

18.
BMJ Open ; 9(11): e032462, 2019 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-31727663

RESUMO

OBJECTIVE: This study aimed to assess household preparedness for emergency events and its determinants in China. DESIGN: A cross-sectional questionnaire survey was conducted on 3541 households in China in 2015. PARTICIPANTS: Households were selected using a stratified cluster sampling strategy, representing central, eastern, western and southern regions of China. The designed questionnaires were administered through face-to-face interviews. OUTCOME MEASURES: Household emergency preparedness was measured with 14 indicators, tapping into the supply of nine emergency necessities (food and water, extra batteries, battery-powered radio, battery-operated torch, first-aid kit, gas mask, fire extinguisher, escape ropes, whistle), coverage of accident insurance, knowledge of local emergency response systems (emergency numbers, exit routes and shelters) and availability of a household evacuation plan. If an individual acted on 9 of the 14 indicators, they were deemed well prepared. Logistic regression models were established to identify predictors of well preparedness based on 3541 returned questionnaires containing no missing values. RESULTS: Only 9.9% of households were well prepared for emergencies: 53.6% did not know what to do and 31.6% did not want to think about it. A higher level of preparedness was found in the respondents who have attained higher education (adjusted OR=0.826 compared with the higher level), participated in emergency training activities (adjusted OR=2.299), had better emergency knowledge (adjusted OR=2.043), reported less fate-submissiveness (adjusted OR=1.385) and more self-reliance (adjusted OR=1.349), prior exposure to emergency events (adjusted OR=1.280) and held more positive attitudes towards preparedness (adjusted OR=1.286). CONCLUSION: Household preparedness for emergency events is poor in China. Lack of motivation, negative attitude to preparedness and knowledge shortfall are major but remediable barriers for household preparedness.

19.
Artigo em Inglês | MEDLINE | ID: mdl-31729145

RESUMO

Constructing artificial solid electrolyte interface (SEI) is a highly effective approach to overcome the poor reversibility of lithium (Li) metal anodes. Herein, an adhesive and self-healable supramolecular copolymer, comprising of pendant poly(ethylene oxide) (PEO) segments and ureido-pyrimidinone (UPy) quadruple hydrogen bonding moieties, is developed as a new protection layer of Li anode by a simple drop-coating. The protection performance of in-situ formed LiPEO-UPy SEI layer is significantly enhanced owing to the strong binding and improved stability arising from a spontaneous reaction between UPy groups with Li metal. Remarkably, an ultrathin (~70 nm) LiPEO-UPy layer can contribute to stable and dendrite-free cycling at a high areal capacity of 10 mAh cm-2 at 5 mA cm-2 for 1000 h. Furthermore, the full cell with high utilization of Li shows a much enhanced cycle life. This facile coating together with the promising electrochemical performance offers a new strategy for the development of dendrite-free metal anodes.

20.
Cancer Imaging ; 19(1): 74, 2019 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-31730015

RESUMO

BACKGROUND: Tumor recurrence is the major risk factor affecting post-transplant survival. In this retrospective study, we evaluate the prognostic values of magnetic resonance (MR) diffusion-weighted imaging (DWI) in liver transplantation for hepatocellular carcinoma (HCC). METHODS: From April 2014 to September 2016, 106 HCC patients receiving living donor liver transplantation (LDLT) were enrolled. Nine patients were excluded due to postoperative death within 3 months and incomplete imaging data. The association between tumor recurrence, explant pathologic findings, and DWI parameters was analyzed (tumor-to-liver diffusion weighted imaging ratio, DWIT/L; apparent diffusion coefficients, ADC). The survival probability was calculated using the Kaplan-Meier method. RESULTS: Sixteen of 97 patients (16%) developed tumor recurrence during the follow-up period (median of 40.9 months; range 5.2-56.5). In those with no viable tumor (n = 65) on pretransplant imaging, recurrence occurred only in 5 (7.6%) patients. Low minimum ADC values (p = 0.001), unfavorable tumor histopathology (p <  0.001) and the presence of microvascular invasion (p <  0.001) were risk factors for tumor recurrence, while ADCmean (p = 0.111) and DWIT/L (p = 0.093) showed no significant difference between the groups. An ADCmin ≤ 0.88 × 10- 3 mm2/s was an independent factor associated with worse three-year recurrence-free survival (94.4% vs. 23.8%) and overall survival rates (100% vs. 38.6%). CONCLUSIONS: Quantitative measurement of ADCmin is a promising prognostic indicator for predicting tumor recurrence after liver transplantation.

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