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1.
Int J Biol Sci ; 16(4): 611-619, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32025209

RESUMO

Triple-negative breast cancer (TNBC) is one of the most malignant breast cancers lacking targeted therapeutics currently. We recently reported that mifepristone (MIF), a drug regularly used for abortion, suppresses TNBC cell growth by inhibiting KLF5 expression via inducing miR-153. However, its anticancer efficacy is only modest at high dose. In order to enhance the anticancer activities, a focused compound library containing 17 compounds by altering the sensitive metabolic region of mifepristone has been designed and synthesized. We first tested the cell growth inhibitory effects of these compounds in TNBC cell lines. Among them, FZU-00,003 displayed the most potent efficiency. FZU-00,003 suppresses TNBC cell growth, cell cycle progression and induces apoptosis more effectively than MIF does. Consistently, FZU-00,003 induces miR-153 expression and suppressed KLF5 expression at much lower dosages than MIF does. Furthermore, FZU-00,003 inhibits tumor growth more potently than MIF does. Taken together, the MIF derivative, FZU-00,003 may serve as a better therapeutic compound for TNBC than MIF.

2.
Bioresour Technol ; : 122933, 2020 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-32037192

RESUMO

The aim of this work was to study sequential batch fermentation of glucose with a biological consortium amended with nine different biochars or with an activated carbon. The glucose fermentation was enhanced by carbon amendment, with activated carbon being more effective than biochars as cell carriers and electron conductors between functional species. The volatile fatty acid distributions were shifted in the consumption of the produced H2 and CO2. The types of biochars were irrelevant to glucose glycolysis and the subsequent H2 and CO2 consumption reactions. Biofilm growth affects the detailed mechanisms occurred in fermentation broth to the yielded volatile fatty acid distributions.

3.
Bioresour Technol ; 303: 122921, 2020 Jan 29.
Artigo em Inglês | MEDLINE | ID: mdl-32028217

RESUMO

Effects of adding biochars on dark fermentation production of volatile fatty acids (VFAs) from glucose were investigated. Nine biochars were synthesized and applied, together with an activated carbon, as the testing amendment to enhance preferable fermentation. Biochars were porous materials with internal pores and excess surface functional groups, which would lead to enrichment of acetate over butyrate in the VFA production. Biochar coconut and biochar longan shell showed excess functional groups and high bulk internal crystallinity, presented 109.6% and 71.8% enrichments of acetate production, respectively. The syntrophic growth of fermentative bacteria and homoacetogens on biochar surfaces via direct interspecies electron transfer mechanism was assumed to interpret the noted enhanced acetate production. The excess functional groups on biochar surface to facilitate biofilm development and the high crystallinity of biochar bulk to ease electron transfer favored the production of acetate.

4.
Environ Int ; 136: 105503, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32006760

RESUMO

Anaerobic digestion (AD) of organics is a challenging task under high-strength sulfate (SO42-) conditions. The generation of toxic sulfides by SO42--reducing bacteria (SRB) causes low methane (CH4) production. This study investigated the feasibility of alleviating sulfide inhibition and enhancing CH4 production by using an anaerobic reactor with built-in microbial electrolysis cell (MEC), namely ME-AD reactor. Compared to AD reactor, unionized H2S in the ME-AD reactor was sufficiently converted into ionized HS- due to the weak alkaline condition created via cathodic H2 production, which relieved the toxicity of unionized H2S to methanogenesis. Correspondingly, the CH4 production in the ME-AD system was 1.56 times higher than that in the AD reactor with alkaline-pH control and 3.03 times higher than that in the AD reactors (no external voltage and no electrodes) without alkaline-pH control. MEC increased the amount of substrates available for CH4-producing bacteria (MPB) to generate more CH4. Microbial community analysis indicated that hydrogentrophic MPB (e.g. Methanosphaera) and acetotrophic MPB (e.g. Methanosaeta) participated in the two major pathways of CH4 formation were successfully enriched in the cathode biofilm and suspended sludge of the ME-AD system. Economic revenue from increased CH4 production totally covered the cost of input electricity. Integration of MEC with AD could be an attractive technology to alleviate sulfide inhibition and enhance CH4 production from AD of organics under SO42--rich condition.

5.
J Appl Microbiol ; 2020 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-32026569

RESUMO

AIMS: Diseases caused by pathogenic fungi was a major constrain in increasing productivity and improving quality of Panax notoginseng. The aim of the present research was to evaluate the inhibitory activity of essential oils (EOs) from Asteraceae family, Chrysanthemum indicum and Laggera pterodonta, against pathogenic fungi of P. notoginseng. METHODS AND RESULTS: The antifungal activity was investigated using multiple methods, disclosing that the EOs from C. indicum and L. pterodonta are active against hypha growth of different fungi but with different degrees of potency. Checkerboard testing indicated that the combination of EOs with hymexazol had synergistic effect against Pythium aphanidermatum, and exhibited additive effects against bulk of targeted pathogenic fungi. Besides, we found that the baseline sensitivity of Fusarium oxysporum to L. pterodonta EOs was higher than those of C. indicum by means of mycelium growth rate method. Finally, the practicability of those EOs as plant pesticide was confirmed by in vivo model showing that EOs can significantly inhibit the occurrence of root rot of P. notoginseng caused by F. oxysporum. CONCLUSION: Those study suggests that the EOs from Chrysanthemum indicum and Laggera pterodonta had the potential to develop into new pollution-free pesticides for the protection of precious Chinese herbal medicines. SIGNIFICANCE AND IMPACT OF STUDY: This study provided a new way of biological control for overcoming the frequent diseases occurrence of P. notoginseng.

6.
Sci Rep ; 10(1): 3118, 2020 Feb 20.
Artigo em Inglês | MEDLINE | ID: mdl-32080330

RESUMO

Patients with chronic obstructive pulmonary disease (COPD) repeat acute exacerbations (AE). Global Initiative for Chronic Obstructive Lung Disease (GOLD) is only available for patients in stable phase. Currently, there is a lack of assessment and prediction methods for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients during hospitalization. To enhance the monitoring and treatment of AECOPD patients, we develop a novel C5.0 decision tree classifier to predict the prognosis of AECOPD hospitalized patients with objective clinical indicators. The medical records of 410 hospitalized AECOPD patients are collected and 28 features including vital signs, medical history, comorbidities and various inflammatory indicators are selected. The overall accuracy of the proposed C5.0 decision tree classifier is 80.3% (65 out of 81 participants) with 95% Confidence Interval (CI):(0.6991, 0.8827) and Kappa 0.6054. In addition, the performance of the model constructed by C5.0 exceeds the C4.5, classification and regression tree (CART) model and the iterative dichotomiser 3 (ID3) model. The C5.0 decision tree classifier helps respiratory physicians to assess the severity of the patient early, thereby guiding the treatment strategy and improving the prognosis of patients.

7.
Chin J Traumatol ; 2020 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-32081450

RESUMO

PURPOSE: The purpose of this study was to review the microsurgical anatomy and clipping of ruptured anterior communicating artery (AComA) aneurysms and to plan and avoid complications before operation. METHODS: A total of 523 cases of cerebral aneurysms admitted to the neurosurgery department of the Third Affiliated Hospital of Sun Yat-Sen University from September 2010 to October 2018 were analyzed retrospectively. Among them, 85 patients had ruptured AComA aneurysms. This study was limited to 85 of these cases, whose satisfactory preoperative angiographic diagnostic films can be retrieved from the hospital database system because of the need for detailed review. RESULTS: We performed supraorbital eyebrow keyhole approach (SOEK) craniotomy in 85 patients to clip 85 AComA aneurysms, in the setting of subarachnoid hemorrhage (SAH). Patients' mean age was 52.69 ± 9.94 years (range, 28-78 years). The proportions of small, medium and large aneurysms were 83.5%, 15.3%, and 1.2%, respectively. The average size of the aneurysms was 5.07 ± 2.36 mm. There were 77.8% of patients with inferior aneurysms and 81.3% of patients with superior aneurysms achieved good results. There was a significant correlation between A1 dominance and operation method (p ≤ 0.001). There was no significant relationship between surgical approach and aneurysm projection or A2 plane (p = 0.157 &p = 0.318). CONCLUSION: Regardless of whether the A2 plane is open or closed, the A1 dominant side is still a better choice for accessing AComA aneurysms to avoid dangerous premature bleeding.

8.
Artif Intell Med ; 102: 101780, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31980086

RESUMO

The general public's attitudes, demands, and expectations regarding medical AI could provide guidance for the future development of medical AI to satisfy the increasing needs of doctors and patients. The objective of this study is to investigate public perceptions, receptivity, and demands regarding the implementation of medical AI. An online questionnaire was designed to investigate the perceptions, receptivity, and demands of general public regarding medical AI between October 13 and October 30, 2018. The distributions of the current achievements, public perceptions, receptivity, and demands among individuals in different lines of work (i.e., healthcare vs non-healthcare) and different age groups were assessed by performing descriptive statistics. The factors associated with public receptivity of medical AI were assessed using a linear regression model. In total, 2,780 participants from 22 provinces were enrolled. Healthcare workers accounted for 54.3 % of all participants. There was no significant difference between the healthcare workers and non-healthcare workers in the high proportion (99 %) of participants expressing acceptance of AI (p = 0.8568), but remarkable distributional differences were observed in demands (p < 0.001 for both demands for AI assistance and the desire for AI improvements) and perceptions (p < 0.001 for safety, validity, trust, and expectations). High levels of receptivity (approximately 100 %), demands (approximately 80 %), and expectations (100 %) were expressed among different age groups. The receptivity of medical AI among the non-healthcare workers was associated with gender, educational qualifications, and demands and perceptions of AI. There was a very large gap between current availability of and public demands for intelligence services (p < 0.001). More than 90 % of healthcare workers expressed a willingness to devote time to learning about AI and participating in AI research. The public exhibits a high level of receptivity regarding the implementation of medical AI. To date, the achievements have been rewarding, and further advancements are required to satisfy public demands. There is a strong demand for intelligent assistance in many medical areas, including imaging and pathology departments, outpatient services, and surgery. More contributions are imperative to facilitate integrated and advantageous implementation in medical AI.

9.
EBioMedicine ; 51: 102621, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31901869

RESUMO

BACKGROUND: Approximately 1 in 33 newborns is affected by congenital anomalies worldwide. We aimed to develop a practical model for identifying infants with a high risk of congenital cataracts (CCs), which is the leading cause of avoidable childhood blindness. METHODS: This case-control study was performed in the Zhongshan Ophthalmic Center and involved 2005 subjects, including 1274 children with CCs and 731 healthy controls. The CC identification models were established based on birth conditions, family medical history, and family environmental factors using the random forest (RF) and adaptive boosting methods (trained by 1129 CC cases and 609 healthy controls), which were tested by internal 4-fold cross-validation and external validation (145 CC cases and 122 healthy controls). The models were also tested using 4 datasets with gradually reduced proportions of CC patients (bilateral cases) to validate their performance in an approximate simulation of a clinical environment with a relatively low disease prevalence. FINDINGS: The CC identification models showed high discrimination in both the 4-fold cross validation (area under the curve (AUC)=0.91 [95% confidence interval: 0.88-0.94] in bilateral cases; 0.82 [0.77-0.89] in unilateral cases) and external validation (AUC=0.93±0.05 in bilateral cases; 0.86±0.01 in unilateral cases), and achieved stable performance in the clinical tests (AUC=0.94-0.96 in the four subgroups by RF). Furthermore, family history of CC, low parental education level, and comorbidity were identified as the top three most relevant factors to both bilateral and unilateral CC diagnosis. INTERPRETATION: Our CC identification models can accurately discriminate CC patients from healthy children and have the potential to serve as a complementary screening procedure, especially in undeveloped and remote areas.

10.
Chem Soc Rev ; 2020 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-31999286

RESUMO

Since the first attempt that was made to obtain direct circularly polarized (CP) light from OLEDs by Meijer et al. in 1997, considerable efforts have been devoted to the development of circularly polarized organic light-emitting diodes (CP-OLEDs), particularly in the recent years. Circularly polarized electroluminescence (CPEL) based on OLEDs has attracted increasing interest for its efficient ability to generate CP light directly and wide potential applications in 3D displays, optical data storage, and optical spintronics. In this review, we systematically summarize the recent progress in chiral emitter based OLEDs with CPEL properties including CPEL based on chiral conjugated polymers, CPEL based on chiral metal complexes, and CPEL based on chiral simple organic molecules, especially chiral thermally activated delayed fluorescence (TADF) molecules. We believe that this review will provide a promising perspective of chiral emitter based OLEDs with CPEL properties for a broad range of scientists in different disciplinary areas and attract a growing number of researchers to this fast-growing research field.

11.
Commun Biol ; 3(1): 15, 2020 Jan 08.
Artigo em Inglês | MEDLINE | ID: mdl-31925315

RESUMO

Retinal detachment can lead to severe visual loss if not treated timely. The early diagnosis of retinal detachment can improve the rate of successful reattachment and the visual results, especially before macular involvement. Manual retinal detachment screening is time-consuming and labour-intensive, which is difficult for large-scale clinical applications. In this study, we developed a cascaded deep learning system based on the ultra-widefield fundus images for automated retinal detachment detection and macula-on/off retinal detachment discerning. The performance of this system is reliable and comparable to an experienced ophthalmologist. In addition, this system can automatically provide guidance to patients regarding appropriate preoperative posturing to reduce retinal detachment progression and the urgency of retinal detachment repair. The implementation of this system on a global scale may drastically reduce the extent of vision impairment resulting from retinal detachment by providing timely identification and referral.

12.
Science ; 367(6477): 580-586, 2020 01 31.
Artigo em Inglês | MEDLINE | ID: mdl-31949099

RESUMO

N 6-methyladenosine (m6A) regulates stability and translation of messenger RNA (mRNA) in various biological processes. In this work, we show that knockout of the m6A writer Mettl3 or the nuclear reader Ythdc1 in mouse embryonic stem cells increases chromatin accessibility and activates transcription in an m6A-dependent manner. We found that METTL3 deposits m6A modifications on chromosome-associated regulatory RNAs (carRNAs), including promoter-associated RNAs, enhancer RNAs, and repeat RNAs. YTHDC1 facilitates the decay of a subset of these m6A-modified RNAs, especially elements of the long interspersed element-1 family, through the nuclear exosome targeting-mediated nuclear degradation. Reducing m6A methylation by METTL3 depletion or site-specific m6A demethylation of selected carRNAs elevates the levels of carRNAs and promotes open chromatin state and downstream transcription. Collectively, our results reveal that m6A on carRNAs can globally tune chromatin state and transcription.

13.
Mol Cell Biol ; 2020 Jan 27.
Artigo em Inglês | MEDLINE | ID: mdl-31988105

RESUMO

Fibrosis is recognized as the major pathological change in adipose tissue during the development of obesity. However, the detailed mechanisms governing the interactions between the fibrotic components and their modifiers remain largely unclear. Here, we reported that matrix metalloproteinase 14 (MMP14), a key pericellular collagenase, is dramatically upregulated in obese adipose tissue. We generated a doxycycline (Dox)-inducible adipose tissue-specific MMP14 overexpression model to study its regulatory function. We found that overexpression of MMP14 in the established obese adipose tissue leads to enlarged adipocytes and increased body weights in the transgenic mice. Furthermore, the mice exhibited decreased energy expenditure, impaired lipid metabolism and insulin resistance. Mechanistically, we found that MMP14 digests collagen 6α3 to produce endotrophin, a potent co-stimulator of fibrosis and inflammation. Unexpectedly, when overexpressing MMP14 in the early stage obese adipose tissue, the transgenic mice showed a healthier metabolic profile, including ameliorated fibrosis and inflammation as well as improved lipid and glucose metabolism. This unique metabolic phenotype is likely due to digestion/modification of the dense adipose tissue extracellular matrix by MMP14, thereby releasing the mechanical stress to allow for its healthy expansion. Understanding these dichotomous impacts of MMP14 provides novel insights into strategies to treat obesity-related metabolic disorders.

14.
Drug Alcohol Depend ; 208: 107851, 2020 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-31954951

RESUMO

BACKGROUND: The present study aims to (i) identify patterns in the changes of endorsed positive alcohol expectancies (AEs) through early adolescence and (ii) examine associated childhood social context predictors of such profiles. METHODS: We used three waves of longitudinal data from the Alcohol-Related Experiences among Children. The baseline sample comprised 928 6th graders from 17 elementary schools in northern Taiwan (response rate = 60 %); subsequent follow-up was conducted at 7th and 8th grade (follow-up rate = 88 %). Data concerning three domains of positive AEs (i.e., global positive transformation, enhancing social behaviors, and promoting relaxation), social context, and alcohol drinking were collected by self-administered questionnaires. Longitudinal latent profile and survey multinomial logistic regression analyses were used to evaluate the association estimates, stratified by childhood alcohol initiation. RESULTS: Three distinct profiles (decreasing, stable, and increasing) of positive AEs were identified for the alcohol-naïve children (n = 466); observing paternal drinking and watching TV more than two hours per day at baseline were strongly linked with the stable and increasing AE profiles (aOR = 1.96-4.80). For the alcohol-experienced children, four profiles (low decreasing, low increasing, high decreasing, and high increasing) emerged; observing maternal drinking was predictive for the high-increasing profile (aOR = 2.94). Regardless of childhood alcohol initiation, recent alcohol use appeared to be the strongest predictor for the increasing profiles of positive AEs. CONCLUSIONS: Strategies addressing pro-alcohol social contexts that facilitate a prominent increase in positive AEs should be considered when devising preventive programs targeting underage drinking behaviors and problems.

15.
Neural Netw ; 123: 412-419, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31945620

RESUMO

In this paper, we derive a new fixed-time stability theorem based on definite integral, variable substitution and some inequality techniques. The fixed-time stability criterion and the upper bound estimate formula for the settling time are different from those in the existing fixed-time stability theorems. Based on the new fixed-time stability theorem, the fixed-time synchronization of neural networks is investigated by designing feedback controller, and sufficient conditions are derived to guarantee the fixed-time synchronization of neural networks. To show the usability and superiority of the obtained theoretical results, we propose a secure communication scheme based on the fixed-time synchronization of neural networks. Numerical simulations illustrate that the new upper bound estimate formula for the settling time is much tighter than those in the existing fixed-time stability theorems. Moreover, the plaintext signals can be recovered according to the new fixed-time stability theorem, while the plaintext signals cannot be recovered according to the existing fixed-time stability theorems.

16.
Bioconjug Chem ; 31(2): 276-292, 2020 Feb 19.
Artigo em Inglês | MEDLINE | ID: mdl-31935072

RESUMO

The greatest advantage of activatable fluorescence probes (AFPs) is the inherent responsiveness to manipulate spectroscopic properties by chemical/physical interactions with the biological analytes/microenvironmental factors. As alternatives to "always-on" fluorescence probes, AFPs in the first near-infrared (NIR-I) window expanded dramatically over the past decade and served as powerful tools in fluorescence biosensing and bioimaging. Benefiting from the deep tissue penetration, minimal tissue damage, and negligible background signal within longer wavelength, recent progress of fluorescent materials in the second near-infrared (NIR-II) window has been creating vast new opportunities in developing AFPs. Here, we review the current role of AFPs in biosensing and bioimaging, with emphasis on NIR-II AFPs developed for biomedical applications. The challenges and prospects of AFPs are also discussed by considering the clinical translation from bench to bedside.

17.
Chem Commun (Camb) ; 56(12): 1863-1866, 2020 Feb 11.
Artigo em Inglês | MEDLINE | ID: mdl-31950934

RESUMO

Sign inversions of circularly polarized luminescence (CPL) for the hydro[5]helicene and [5]helicene derivatives were discovered and studied experimentally and theoretically. The inverted CPL signs from the hydro[5]helicene to [5]helicene derivatives were realized by one-step oxidation. The introduction of triphenylamine (TPA) subunits into the helical skeletons also led to the sign inversion of CPL only when there existed an enhanced intramolecular charge-transfer state with a small enough Egap.

18.
Water Res ; 172: 115475, 2020 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-31972413

RESUMO

Pharmaceutical and Personal Care Products (PPCPs) removal coupling with bioenergy production by microalgae has attracted growing attention. However, the biological interactions between PPCPs and microalgae are unclear during microalgal biosorption and biodegradation of PPCPs. In this study, an optimal ciprofloxacin (CIP) and sulfadiazine (SDZ) removal efficiency were achieved 100% and 54.53% with carbohydrate productivity of >1000 mg L-1 d-1 by Chlamydomonas sp. Tai-03, respectively. The elimination routes indicated that CIP removal was mainly achieved by biodegradation (65.05%) whereas SDZ was mainly removed by photolysis (35.60%). The visualization evidence of microscopic imaging Raman spectrometer supported the favorable biosorption of CIP due to its positive charge (+10.20 mV). Meanwhile, the tendency for gradual reduction of CIP in extracellular polymeric substances (EPS) indicated that suspended microalgal cell facilitated CIP uptake and biodegradation. Furthermore, photolysis and biodegradation pathways were thoroughly analyzed to demonstrate that intermediates were less toxic and had no adverse effect on the subsequent ethanol conversion. This study provides valuable information for the development of a novel microalgal PPCPs removal. These findings reveal the possible biological mechanisms of biosorption and biodegradation of PPCPs in microalgae, which could further enhance the feasibility of microalgal applications for simultaneous PPCPs remediation and alternative energy production.

19.
J Hazard Mater ; 386: 121657, 2020 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-31784129

RESUMO

A novel integrated autotrophic and heterotrophic denitrification- denitrifying sulfide removal (IAHD-DSR) process was established in this study for biogas desulfurization to simultaneously remove nitrogen in wastewater. The study demonstrated that the system could utilize methane and sulfide as co-electron donors to replace organic carbon source in IAHD process. Three batch tests (B1, B2 and B3) were set up with IAHD sludge to explore how the novel process works. According to mass balance in B2, methane oxidation and sulfide oxidation contributed 18.75 % and 71.25 % to nitrate removal, respectively; however, the contribution of methane oxidation to total nitrogen (TN) removal reached 84.36 %. Sulfide was mainly responsible for the reduction of nitrate to nitrite, while the methane was for nitrite to nitrogen gas in the presence of insufficient sulfide as electron donors. The TN removal in B2 was almost the same as in normal IAHD-DSR process B3-C. The functional genes mcrA and pmoA responsible for methane oxidation were detected in all three batches, with the abundance of 2.23 ×106 copies/(g dry soil) for mcrA in B1 being the highest in three batches. The sulfide addition in B2 increased the abundance of gene pmoA, indicating the enhancement of nitrite reduction coupled with methane oxidation.

20.
J Mater Chem B ; 8(1): 65-77, 2020 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-31768514

RESUMO

Gold nanostars (AuNSs), with unique physicochemical properties, are thought to be a promising agent for photothermal therapy (PTT). In this study, we prepared PEGylated gold nanostars (pAuNSs) using the HEPES-reduction method. The high photothermal conversion efficiency (∼80%) and photothermal stability of pAuNSs were demonstrated in vitro and in vivo. 111In-DTPA-pAuNSs were prepared as a radioactive surrogate for the biodistribution studies of pAuNSs. In both microSPECT/CT images and the biodistribution study, the tumor-to-muscle (T/M) ratio reached a maximum at 24 h post intravenous injection of 111In-DTPA-pAuNSs. The high linear correlation between the 111In radioactivity and the gold content in the tumors (R2 0.86-0.99) indicated that 111In-DTPA-pAuNSs were appropriate for noninvasively tracking pAuNSs in vivo after systemic administration. Histological examination after silver enhancement staining clearly illustrated that the accumulated pAuNSs in the tumors were mainly located on the luminal surface of vessels. The mice bearing a SKOV-3 xenograft exhibited remarkable therapeutic efficacy with negligible organ damage after receiving pAuNS-mediated photothermal therapy. Our findings suggested that pAuNSs, together with their radioactive surrogate 111In-DTPA-pAuNSs, are promising for applications in image-guided photothermal therapy.

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