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1.
Exp Ther Med ; 18(6): 4820-4828, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31772647

RESUMO

Dexmedetomidine (DEX) is widely used in perioperative settings for analgesia and sedation; however, little is known about its effects on the hypoxia-induced progression of tumor cells. In the present study, the effects of DEX on hypoxia-induced growth and metastasis of lung cancer cells and colorectal cancer cells was examined. A549 cells and HCT116 cells were treated with normoxia, hypoxia, co-treatment of hypoxia and DEX, and atipamezole (an α2 adrenoceptor antagonist) for 4 h. The proliferation rate of cells was determined by MTT assays. Cell metastatic potential was evaluated by Transwell assays. Survivin and hypoxia inducible factor (HIF)-1α were detected by western blotting. Matrix metalloproteinase (MMP)-2 and MMP-9 were measured using reverse transcription-quantitative PCR. It was demonstrated that hypoxia treatment promoted the proliferation and may promote the metastasis of the two cancer cell lines. DEX substantially contributed to the survival and aggressiveness of the two cancer cell lines following hypoxia. Furthermore, DEX upregulated the expression of survivin, MMP-2, MMP-9 and HIF-1α in the two cancer cell lines in response to hypoxia. Finally, the effects of DEX on the hypoxia-induced growth and metastatic potential of cancer cells were reversed by atipamezole. Collectively, DEX enhances the hypoxia-induced progression of lung cancer cells and colorectal cancer cells by regulating HIF-1α signaling, which may be associated with the α2 adrenoceptor pathway.

2.
Zhongguo Gu Shang ; 32(7): 641-646, 2019 Jul 25.
Artigo em Chinês | MEDLINE | ID: mdl-31382723

RESUMO

OBJECTIVE: To explore the clinical effect of operative reduction and internal fixation in treating atypical unstable Hangman fracture in elderly osteoporotic patients. METHODS: The clinical data of 9 elderly osteoporotic patients with atypical unstable Hangman fracture treated from December 2012 to December 2017 were retrospectively analyzed. There were 5 males and 4 females with an average age of 72.7 years (range 65 to 79) old. The fracture line was located on bilateral inferior articular surface or lamina with anterior dislocation of axis in 3 cases (similar to Levine-Edwards type II); one side of the fracture line was located on the lower articular surface and opposite side involved on the upper articular surface and the body of axis with atlantoaxial lateral mass dislocation in 4 cases; the fracture line was located at the pedicle of the axis, transverse foramen and posterior inferior wall of the vertebral body, accompanying by anterior and posterior longitudinal ligaments and C2-C3 intervertebral disc injury resulted in C2-C3 intervertebral instability in 2 cases. According to ASIA grade of spinal cord injury, 2 cases were grade D and 7 cases were grade E. Preoperative JOA scores were 9 to 11 points with an average of 9.8 points. All patients underwent routinely skull traction for reduction. Three patients with anterior dislocation of axis were treated with stage I anterior-posterior internal fixation and 6 patients with simple posterior pedicle screw fixation. Postoperative JOA score, ASIA system and the imaging data were used to evaluate clinical effects. RESULTS: All patients were followed up from 12 to 20 months with an average of 18 months. The neck pain disappeared after operation and cervical spine movement was well in all patients. The improvement rate of JOA at 3 months after operation was 75% to 87.5%. Two cases of ASIA grade D fully recovered to grade E. All fractures healed at 6 to 12 months after operation. Except one case occurred superior laryngeal nerve injury and had a complete recovery after 3 months, the other patients had no complications like spinal cord and vertebral artery injury, plate screw loosening and wound infection. CONCLUSIONS: According to the type of atypical unstable Hangman fracture in elderly osteoporotic patients, choosing a reasonable and personalized surgical plan can achieve immediate cervical stability and well reduction, which is beneficial for early ambulation and quick rehabilitation.


Assuntos
Parafusos Pediculares , Fraturas da Coluna Vertebral , Idoso , Descompressão Cirúrgica , Feminino , Fixação Interna de Fraturas , Humanos , Masculino , Estudos Retrospectivos , Resultado do Tratamento
3.
Zookeys ; (778): 1-95, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30104914

RESUMO

The genus Chromoteleia Ashmead is revised. Twenty-seven species are recognized, of which six species are redescribed: C.congoana (Risbec), C.connectens Kieffer, C.fuscicornis Kieffer, C.longitarsis Kieffer, C.semicyanea Ashmead, C.tricarinata Kieffer; and twenty-one species are described as new: C.aequalis Chen & Johnson, sp. n., C.alternata Chen & Johnson, sp. n., C.bidens Chen & Masner, sp. n., C.copiosa Chen & Johnson, sp. n., C.cuneus Chen & Johnson, sp. n., C.curta Chen & Johnson, sp. n., C.depilis Chen & Johnson, sp. n., C.dispar Chen & Masner, sp. n., C.feng Chen & Johnson, sp. n., C.fossa Chen & Johnson, sp. n., C.ingens Chen & Masner, sp. n., C.levitas Chen & Johnson, sp. n., C.longa Chen & Johnson, sp. n., C.maura Chen & Masner, sp. n., C.parvitas Chen & Johnson, sp. n., C.pilus Chen & Johnson, sp. n., C.plana Chen & Johnson, sp. n., C.rara Chen & Johnson, sp. n., C.robusta Chen & Johnson, sp. n., C.semilutea Chen & Johnson, sp. n., C.sparsa Chen & Johnson, sp. n.Chromoteleiarufithorax Kieffer remains a valid species, but its identity and status are unclear. All species are known only from the Neotropical region except for Chromoteleiacongoana (Resbec) which only occurs in Africa.

5.
Mol Phylogenet Evol ; 124: 1-9, 2018 07.
Artigo em Inglês | MEDLINE | ID: mdl-29510236

RESUMO

The Apoidea represent a large and common superfamily of the Hymenoptera including the bees and sphecid wasps. A robust phylogenetic tree is essential to understanding the diversity, taxonomy and evolution of the Apoidea. In this study, features of apoid mitochondrial genomes were used to reconstruct phylogenetic relationships. Twelve apoid mitochondrial genomes were newly sequenced, representing six families and nine subfamilies. Gene rearrangement events have occurred in all apoid mitochondrial genomes sequenced to date. Sphecid wasps have both tRNA and protein-coding gene rearrangements in 5 of 8 species. In bees, the only rearranged genes are tRNAs; long-tongued bees (Apidae + Megachilidae) are characterized by movement of trnA to the trnI-trnQ-trnM tRNA cluster. Phylogenetic analyses of mitochondrial gene sequences support the known paraphyly of sphecid wasps, with bees nested within this clade. The Ampulicidae is sister to the remaining Apoidea. Crabronidae is paraphyletic, split into Crabronidae s.s. and Philanthidae, with the latter group a sister clade to bees. The monophyletic bees are either classified into two clades, long-tongued bees (Apidae + Megachilidae) and short-tongued bees (Andrenidae + Halictidae + Colletidae + Melitidae), or three groups with the Melitidae sister to the other bees. Our study showed that both gene sequences and arrangements provide information on the phylogeny of apoid families.


Assuntos
Abelhas/genética , Ordem dos Genes , Genoma Mitocondrial , Filogenia , Vespas/genética , Animais , Sequência de Bases , Teorema de Bayes , Rearranjo Gênico , Funções Verossimilhança , Análise de Sequência de DNA
6.
Zookeys ; (730): 87-122, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29416398

RESUMO

The genus Habroteleia Kieffer is revised. Seven species are recognized, three are redescribed: H. flavipes Kieffer, H. persimilis (Kozlov & Kononova), H. ruficoxa (Kieffer); and four species are described as new: H. mutabilis Chen & Talamas, sp. n., H. salebra Chen & Talamas, sp. n., H. soa Chen & Talamas, sp. n., and H. spinosa Chen & Johnson, sp. n. Four species are treated as junior synonyms of Habroteleia flavipes Kieffer: Chrestoteleia bakeri Kieffer, syn. n., Habroteleia bharatensis Saraswat, syn. n., Habroteleia browni Crawford, syn. n., and Habroteleia kotturensis (Sharma), syn. n.Habroteleia dagavia (Kozlov & Lê), syn. n. is treated as junior synonym of Habroteleia persimilis (Kozlov & Kononova). Baryconus vindhiensis (Sharma), comb. n. is transferred out of Habroteleia Kieffer. Habroteleia impressa (Kieffer) and H. scapularis (Kieffer) remain valid species but their identity and status are unclear.

7.
Cancer Invest ; 36(1): 1-9, 2018 Jan 02.
Artigo em Inglês | MEDLINE | ID: mdl-29303365

RESUMO

Abnormal expression and dysfunction of microRNAs are correlated with osteosarcoma (OS). This study demonstrated that the miR-187 level in OS tissues and cell lines was decreased. The proliferation and metastatic abilities of U-2OS cells were inhibited by miR-187 overexpression and promoted by miR-187 knockdown. Moreover, miR-187 also inhibited growth and metastasis of OS cells in vivo. Furthermore, we revealed that miR-187 could interact with S100A4 3'-UTR and inhibit S100A4 expression in OS cells. In summary, miR-187 inhibits growth and metastasis of OS cells by downregulating S100A4, which might be a potential biomarker and therapeutic target of OS.


Assuntos
Neoplasias Ósseas/genética , Proliferação de Células/genética , Regulação para Baixo/genética , MicroRNAs/genética , Metástase Neoplásica/genética , Osteossarcoma/genética , Proteína A4 de Ligação a Cálcio da Família S100/genética , Regiões 3' não Traduzidas/genética , Neoplasias Ósseas/patologia , Linhagem Celular Tumoral , Movimento Celular/genética , Regulação Neoplásica da Expressão Gênica/genética , Humanos , Metástase Neoplásica/patologia , Osteossarcoma/patologia
8.
Zookeys ; (648): 1-136, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28325969

RESUMO

The genus Calliscelio Ashmead is presumed to be a diverse group of parasitoids of the eggs of crickets (Orthoptera: Gryllidae). A least one species has been found to be an important factor in depressing cricket pest populations. The New World species of Calliscelio are revised. Forty-two species are recognized, 3 are redescribed: Calliscelio bisulcatus (Kieffer), Calliscelio laticinctus Ashmead, Calliscelio rubriclavus (Ashmead), comb. n.; and 38 are described as new: Calliscelio absconditum Chen & Johnson, sp. n., Calliscelio absum Chen & Johnson, sp. n., Calliscelio alcoa Chen & Masner, sp. n., Calliscelio amadoi Chen & Johnson, sp. n., Calliscelio armila Chen & Masner, sp. n., Calliscelio bidens Chen & Masner, sp. n., Calliscelio brachys Chen & Johnson, sp. n., Calliscelio brevinotaulus Chen & Johnson, sp. n., Calliscelio brevitas Chen & Johnson, sp. n., Calliscelio carinigena Chen & Johnson, sp. n., Calliscelio crater Chen & Johnson, sp. n., Calliscelio crena Chen & Johnson, sp. n., Calliscelio eboris Chen & Johnson, sp. n., Calliscelio extenuatus Chen & Johnson, sp. n., Calliscelio flavicauda Chen & Johnson, sp. n., Calliscelio foveolatus Chen & Johnson, sp. n., Calliscelio gatineau Chen & Johnson, sp. n., Calliscelio glaber Chen & Masner, sp. n., Calliscelio granulatus Chen & Masner, sp. n., Calliscelio latifrons Chen & Johnson, sp. n., Calliscelio levis Chen & Johnson, sp. n., Calliscelio longius Chen & Johnson, sp. n., Calliscelio magnificus Chen & Masner, sp. n., Calliscelio migma Chen & Johnson, sp. n., Calliscelio minutia Chen & Johnson, sp. n., Calliscelio paraglaber Chen & Johnson, sp. n., Calliscelio pararemigio Chen & Masner, sp. n., Calliscelio prolixus Chen & Johnson, sp. n., Calliscelio punctatifrons Chen & Johnson, sp. n., Calliscelio remigio Chen & Masner, sp. n., Calliscelio ruga Chen & Johnson, sp. n., Calliscelio rugicoxa Chen & Masner, sp. n., Calliscelio sfina Chen & Johnson, sp. n., Calliscelio storea Chen & Johnson, sp. n., Calliscelio suni Chen & Johnson, sp. n., Calliscelio telum Chen & Johnson, sp. n., Calliscelio torqueo Chen & Johnson, sp. n., Calliscelio virga Chen & Johnson, sp. n. Four species are treated as junior synonyms of Calliscelio rubriclavus (Ashmead): Anteris nigriceps Ashmead, syn. n., Caloteleia marlattii Ashmead, syn. n., Caloteleia grenadensis Ashmead, syn. n., and Macroteleia ruskini Girault, syn. n.

9.
Biosens Bioelectron ; 91: 328-333, 2017 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-28040665

RESUMO

5-hydroxymethylcytosine (5hmC) is the sixth base of DNA. It is involved in active DNA demethylation and can be a marker of diseases such as cancer. In this study, we developed a simple and sensitive 2-(4-boronophenyl)quinoline-4-carboxylic acid modified poly (glycidyl methacrylate (PBAQA-PGMA) fluorescent probe to detect the 5hmC content of genomic DNA based on T4 ß-glucosyltransferase-catalyzed glucosylation of 5hmC. The fluorescence-enhanced intensity recorded from the DNA sample was proportional to its 5-hydroxymethylcytosine content and could be quantified by fluorescence spectrophotometry. The developed probe showed good detection sensitivity and selectivity and a good linear relationship between the fluorescence intensity and the concentration of 5 hmC within a 0-100nM range. Compared with other fluorescence detection methods, this method not only could determine trace amounts of 5 hmC from genomic DNA but also could eliminate the interference of fluorescent dyes and the need for purification. It also could avoid multiple labeling. Because the PBAQA-PGMA probe could enrich the content of glycosyl-5-hydroxymethyl-2-deoxycytidine from a complex ground substance, it will broaden the linear detection range and improve sensitivity. The limit of detection was calculated to be 0.167nM after enrichment. Furthermore, the method was successfully used to detect 5-hydroxymethylcytosine from mouse tissues.


Assuntos
5-Metilcitosina/análogos & derivados , Ácidos Bóricos/química , DNA/química , Corantes Fluorescentes/química , Ácidos Polimetacrílicos/química , Espectrometria de Fluorescência/métodos , 5-Metilcitosina/análise , Animais , Química Encefálica , Fígado/química , Camundongos , Miocárdio/química , Quinolinas/química
10.
Zookeys ; (612): 113-23, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27667925

RESUMO

A new species of the stephanid genus Foenatopus Smith, Foenatopus weii sp. n., is described and illustrated from Yunnan Province, China. A modified section of the identification key to species of Foenatopus is added to include the new species. The male of Parastephanellus brevicoxalis Hong, van Achterberg & Xu, 2011 from Guangdong Province, China is also described and illustrated for the first time.

11.
Zookeys ; (601): 119-25, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27551191

RESUMO

A new species of the genus Pseudomegischus van Achterberg, Pseudomegischus yunnanensis sp. n., is described and illustrated from Yunnan Province, China. This is the second species of the genus reported from China. A modified section of the identification key to species of Pseudomegischus is added to include the new species.

12.
Zookeys ; (587): 77-124, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27408528

RESUMO

The Chinese Aulacidae are revised, keyed and illustrated for the first time. In total twenty-five species are recorded from China, included within two genera Aulacus Jurine, 1807 and Pristaulacus Kieffer, 1900, with five and twenty species respectively. Among the treated species, six are newly described for science: Aulacus magnus sp. n., Pristaulacus calidus sp. n., Pristaulacus centralis sp. n., Pristaulacus fopingi sp. n., Pristaulacus obscurus sp. n., and Pristaulacus pseudoiosephi sp. n. Three species are newly recorded from China: Pristaulacus excisus Turner, 1922, Pristaulacus iosephi Turrisi & Madl, 2013, and Pristaulacus rufobalteatus Cameron, 1907.

13.
Acta Pharmacol Sin ; 36(9): 1137-44, 2015 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26256403

RESUMO

AIM: Ca(2+)-release-activated Ca(2+) (CRAC) channel, a subfamily of store-operated channels, is formed by calcium release-activated calcium modulator 1 (ORAI1), and gated by stromal interaction molecule 1 (STIM1). CRAC channel may be a novel target for the treatment of immune disorders and allergy. The aim of this study was to identify novel small molecule CRAC channel inhibitors. METHODS: HEK293 cells stably co-expressing both ORAI1 and STIM1 were used for high-throughput screening. A hit, 1-phenyl-3-(1-phenylethyl)urea, was identified that inhibited CRAC channels by targeting ORAI1. Five series of its derivatives were designed and synthesized, and their primary structure-activity relationships (SARs) were analyzed. All derivatives were assessed for their effects on Ca(2+) influx through CRAC channels on HEK293 cells, cytotoxicity in Jurkat cells, and IL-2 production in Jurkat cells expressing ORAI1-SS-eGFP. RESULTS: A total of 19 hits were discovered in libraries containing 32 000 compounds using the high-throughput screening. 1-Phenyl-3-(1-phenylethyl)urea inhibited Ca(2+) influx with IC50 of 3.25±0.17 µmol/L. SAR study on its derivatives showed that the alkyl substituent on the α-position of the left-side benzylic amine (R1) was essential for Ca(2+) influx inhibition and that the S-configuration was better than the R-configuration. The derivatives in which the right-side R3 was substituted by an electron-donating group showed more potent inhibitory activity than those that were substituted by electron-withdrawing groups. Furthermore, the free N-H of urea was not necessary to maintain the high potency of Ca(2+) influx inhibition. The N,N'-disubstituted or N'-substituted derivatives showed relatively low cytotoxicity but maintained the ability to inhibit IL-2 production. Among them, compound 5b showed an improved inhibition of IL-2 production and low cytotoxicity. CONCLUSION: 1-Phenyl-3-(1-phenylethyl)urea is a novel CRAC channel inhibitor that specifically targets ORAI1. This study provides a new chemical scaffold for design and development of CRAC channel inhibitors with improved Ca(2+) influx inhibition, immune inhibition and low cytotoxicity.


Assuntos
Bloqueadores dos Canais de Cálcio/química , Bloqueadores dos Canais de Cálcio/farmacologia , Canais de Cálcio/metabolismo , Ureia/análogos & derivados , Ureia/farmacologia , Cálcio/metabolismo , Desenho de Drogas , Células HEK293 , Humanos , Células Jurkat , Proteínas de Membrana/metabolismo , Proteínas de Neoplasias/metabolismo , Proteína ORAI1 , Molécula 1 de Interação Estromal , Relação Estrutura-Atividade
14.
Zookeys ; (385): 1-207, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24624023

RESUMO

The Chinese fauna of the family Trigonalyidae Cresson, 1887, is revised, keyed and fully illustrated for the first time. Eight genera of this family (Bakeronymus Rohwer, 1922, Bareogonalos Schulz, 1907, Jezonogonalos Tsuneki, 1991, re-instated, Lycogaster Shuckard, 1841, Orthogonalys Schulz, 1905, Pseudogonalos Schulz, 1906, Taeniogonalos Schulz, 1906 and Teranishia Tsuneki, 1991) are recorded from China. The genus Ischnogonalos Schulz, 1907, is synonymized with Taeniogonalos Schulz, 1906. In total 40 valid species are recognized. Twenty species are new for science: Jezonogonalos elliptifera sp. n., J. jiangliae sp. n., J. luteata sp. n., J. nigrata sp. n., Lycogaster angustula sp. n., L. flavonigrata sp. n., L. nigralva sp. n., Orthogonalys cheni sp. n., O. clypeata sp. n., O. robusta sp. n., Pseudogonalos angusta sp. n., Taeniogonalos bucarinata sp. n., T. cordata sp. n., T. geminata sp. n., T. sculpturata sp. n., T. triangulata sp. n., T. tricolorisoma sp. n., T. uncifera sp. n., Teranishia crenulata sp. n. and T. glabrata sp. n. Two species are reported new for China: Orthogonalys elongata Teranishi, 1929 and Nanogonalos flavocincta Teranishi, 1929 (renamed to Taeniogonalos subtruncata nom. n.). Seven new synonyms are proposed: Poecilogonalos yuasai Teranishi, 1938, and P. maga taiwana Tsuneki, 1991, of Taeniogonalos taihorina (Bischoff, 1914); Taiwanogonalos minima Tsuneki, 1991, and T. similis Tsuneki, 1991, of Taeniogonalos alticola (Tsuneki, 1991); P. intermedia Chen, 1949, and P. unifasciata Chen, 1949, of Taeniogonalos formosana (Bischoff, 1913). Six taxa are recognised as valid species: Bakeronymus seidakka Yamane & Terayama, 1983, Jezonogonalos laeviceps (Tsuneki, 1991), J. satoi (Tsuneki, 1991), Taeniogonalos alticola (Tsuneki, 1991), T. flavoscutellata (Chen, 1949) and T. gestroi (Schulz, 1908). Five new combinations are made: Jezonogonalos laeviceps (Tsuneki, 1991), comb. n., J. satoi (Tsuneki, 1991), comb. n., Taeniogonalos flavoscutellata (Chen, 1949), comb. n., T. gestroi (Schulz, 1908), comb. n. and T. lachrymosa (Westwood, 1874), comb. n. Lectotypes are designated for Lycogaster violaceipennis Chen, 1949, Poecilogonalos flavoscutellata Chen, 1949, P. rufofasciata Chen, 1949, and P. tricolor Chen, 1949.

15.
Zookeys ; (300): 1-98, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23794890

RESUMO

The genus Macroteleia Westwood (Hymenoptera: Platygastridaes. l., Scelioninae) from China is revised. Seventeen species are recognized based on 502 specimens, all of which are new records for China. Seven new species are described: Macroteleia carinigena sp. n. (China), Macroteleia flava sp. n. (China), Macroteleia gracilis sp. n. (China), Macroteleia salebrosa sp. n. (China), Macroteleia semicircula sp. n. (China), Macroteleia spinitibia sp. n. (China) and Macroteleia striatipleuron sp. n. (China). Ten species are redescribed: Macroteleia boriviliensis Saraswat (China, India, Thailand), Macroteleia crawfordi Kiefer, stat. n. (China, Philippines, Thailand, Vietnam), Macroteleia dolichopa Sharma (China, India, Vietnam), Macroteleia emarginata Dodd (China, Malaysia), Macroteleia indica Saraswat & Sharma (China, India, Vietnam), Macroteleia lamba Saraswat & Sharma (China, India, Thailand, Vietnam), Macroteleia livingstoni Saraswat (China, India), Macroteleia peliades Kozlov & Lê (China, Vietnam), Macroteleia rufa Szelényi (China, Egypt, Georgia, Russia, Thailand, Ukraine) and Macroteleia striativentris Crawford (China, Philippines, Thailand, Vietnam). The following five new synonyms are proposed: Macroteleia crates Kozlov & Lê syn. n. and Macroteleia demades Kozlov & Lê syn. n. of Macroteleia crawfordi Kieffer; Macroteleia cebes Kozlov & Lê syn. n. and Macroteleia dones Kozlov & Lê syn. n. of Macroteleia indica Saraswat & Sharma; Macroteleia dores Kozlov & Lê syn. n. of Macroteleia lamba Saraswat & Sharma. A key to the Chinese species of the genus is provided.

16.
Zookeys ; (108): 49-60, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-21852927

RESUMO

The Chinese species of the genus Ismarus Haliday, 1835, are revised for the first time. Three new species from the Oriental region of China and belonging to Ismarus halidayi-group are described and illustrated: Ismarus longussp. n., Ismarus nigritrochantersp. n. and Ismarus parvicellussp. n. Two species are newly reported for the Chinese fauna: Ismarus dorsiger (Haliday, 1831) and Ismarus halidayi Foerster, 1850. A key to the Chinese species of the genus is provided. The type specimens are deposited in the Hymenopteran Collection of South China Agricultural University, Guangzhou (SCAU).

17.
Zhongguo Gu Shang ; 21(8): 626-8, 2008 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-19108384

RESUMO

OBJECTIVE: To study the therapeutic effect of combined multifunctional external fixator for treatment of tibiofibular fracture. METHODS: From Oct 1999 to Apr 2006, 37 patients of tibiofibular fractures were treated with combined multifunctional external fixator. There were 28 males and 9 females with an average of 47.8 years (range,from 22 to 76 years). There were 7 cases with transverse fracture, 18 comminuted fracture, 8 spiral fracture and 4 oblique fracture;closed fracture was in 29 cases and open fracture was in 8. RESULTS: All the patients were followed up 6 to 13 months (mean,9 months)and achieved union of the fractures. CONCLUSION: Combined multifunctional external fixator for tibiofibular fracture has many advantages such as minimal invasion, convenient operation, reliable fixation and high union ratio of fracture. Moreover,the treatment has no influence on motion of knee and ankle joint, even patient can walk with external fixator without long-term bed rest.


Assuntos
Fixadores Externos , Fíbula/lesões , Fraturas da Tíbia/cirurgia , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
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