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1.
Food Chem ; 399: 134000, 2023 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-36037689

RESUMO

A novel cross-linked enzyme aggregates (CLEAs) catalyst was produced by precipitation and cross-linking sucrose isomerase (SIase) for isomaltulose production. The effects of precipitants and cross-linkers on the catalytic performance of the CLEAs were first evaluated. Then, bovine serum albumin (BSA) was used as additive and two immobilized enzymes, cross-linked SIase aggregates (CLSIAs) and CLSIAs-BSA were obtained. All the immobilized preparations exhibited superior thermal stability, pH tolerance, and storage stability compared to the soluble SIase, and showed excellent reusability. These samples still retained more than 61% of their initial activity after ten reuse cycles, with CLSIAs-BSA retaining up to 91.7%. The conversion ratios of sucrose into isomaltulose using CLSIAs-BSA reached 88.4 and 81.2% with sucrose and sugar cane juice as substrate, respectively. Therefore, CLSIAs are a highly effective biocatalyst for the preparation of isomaltulose with great potential for industrial applications.


Assuntos
Glucosiltransferases , Isomaltose , Reagentes de Ligações Cruzadas , Estabilidade Enzimática , Enzimas Imobilizadas/metabolismo , Glucosiltransferases/metabolismo , Isomaltose/análogos & derivados , Sacarose
2.
Sci Total Environ ; 857(Pt 2): 159471, 2023 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-36265634

RESUMO

The source, vertical distribution and migration behavior of plutonium in five soil profiles (from forest, grassland and desert areas) in northern China were investigated. The average 240Pu/239Pu atomic ratio of 0.184 ± 0.022 observed in these samples is in good agreement with the reported value of global fallout, suggesting that the global fallout is the major source of plutonium in northern China. The 239,240Pu inventories in five soil profiles ranges from 43.3 Bq/m2 to 175 Bq/m2, lying in the reported range for global fallout in the similar latitude band. The effective convection velocity (0.04-0.16 cm/y) and effective dispersion coefficient (0.13-0.41cm2/y) of plutonium in different soil profiles derived using the CDE model varies significantly, attributed to multi-factors including location, topography, climate and soil types. The results showed that the migration of plutonium in grassland soil is significantly slow compared to other type of soil, especially desert soil.


Assuntos
Plutônio , Monitoramento de Radiação , Cinza Radioativa , Poluentes Radioativos do Solo , Plutônio/análise , Cinza Radioativa/análise , Poluentes Radioativos do Solo/análise , Solo , Monitoramento de Radiação/métodos , China
3.
Sci Total Environ ; 856(Pt 2): 159199, 2023 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-36198352

RESUMO

The quantitative analysis of biomass is essential for the research and application of moving bed biofilm reactors (MBBRs). However, the difficulty in measuring the attached growing biomass hinders the quantitative analysis of biofilm processes. In this study, a pilot-scale MBBR system was established to investigate biofilm evolution. The quantity of active heterotrophic and autotrophic biomass was measured throughout the entire culturing process. The total active biomass reached 250 mg COD/m2 when the biofilm attachment and detachment were balanced, and the corresponding autotrophic biomass contributes to as high as 17 % of the total biomass. Furthermore, quantitative image analysis was performed to obtain the thickness and morphological data of the biofilm evolution. Multivariate regression models were constructed based on the morphological data, which provided satisfactory prediction accuracy for the biofilm thickness and maturation. The most suitable carrier spots for biomass quantification and biofilm maturation were suggested. This work provided the life-cycle information of biofilm quantity and morphology of the MBBR, which contributes to the quantitative understanding of biofilm evolution at MBBRs.


Assuntos
Biofilmes , Reatores Biológicos , Biomassa , Eliminação de Resíduos Líquidos/métodos
4.
Nat Commun ; 13(1): 7192, 2022 Nov 23.
Artigo em Inglês | MEDLINE | ID: mdl-36418311

RESUMO

Actinide diatomic molecules are ideal models to study elusive actinide multiple bonds, but most of these diatomic molecules have so far only been studied in solid inert gas matrices. Herein, we report a charged U≡N diatomic species captured in fullerene cages and stabilized by the U-fullerene coordination interaction. Two diatomic clusterfullerenes, viz. UN@Cs(6)-C82 and UN@C2(5)-C82, were successfully synthesized and characterized. Crystallographic analysis reveals U-N bond lengths of 1.760(7) and 1.760(20) Å in UN@Cs(6)-C82 and UN@C2(5)-C82. Moreover, U≡N was found to be immobilized and coordinated to the fullerene cages at 100 K but it rotates inside the cage at 273 K. Quantum-chemical calculations show a (UN)2+@(C82)2- electronic structure with formal +5 oxidation state (f1) of U and unambiguously demonstrate the presence of a U≡N bond in the clusterfullerenes. This study constitutes an approach to stabilize fundamentally important actinide multiply bonded species.

5.
Chem Sci ; 13(44): 12980-12986, 2022 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-36425487

RESUMO

Synthesis of the first thorium-containing clusterfullerenes, ThC2@C s (6)-C82 and ThC2@C2(5)-C82, is reported. These two novel actinide fullerene compounds were characterized by mass spectrometry, single-crystal X-ray diffraction crystallography, UV-vis-NIR spectroscopy, and theoretical calculations. Crystallographic studies reveal that the encapsulated ThC2 clusters in both C s (6)-C82 and C2(5)-C82 feature a novel bonding structure with one thorium metal center connected by a C[triple bond, length as m-dash]C unit, forming an isosceles triangular configuration, which has not been hitherto observed for endohedral fullerenes or for solid phase thorium carbides. Electronic structure calculations assign a formal electronic structure of [Th4+(C2)2-]2+@[C82]2-, with pronounced donation bonding from (C2)2- to Th4+, secondary backbonding from the fullerene to thorium and Th-C double bond character in both compounds. This work presents a new family of endohedral fullerenes, MC2@C2n-2, being unexpected isomers of MC2n , and provides broader understanding of thorium bonding.

6.
Patterns (N Y) ; 3(11): 100609, 2022 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-36419453

RESUMO

Why are the transition temperatures (T c) of superconducting materials so different? The answer to this question is not only of great significance in revealing the mechanism of high-T c superconductivity but also can be used as a guide for the design of new superconductors. However, so far, it is still challenging to identify the governing factors affecting the T c. In this work, with the aid of machine learning and first-principles calculations, we found a close relevance between the upper limit of the T c and the energy-level distribution of valence electrons. It implies that some additional inter-orbital electron-electron interaction should be considered in the interpretation of high-T c superconductivity.

7.
Arch Public Health ; 80(1): 238, 2022 Nov 19.
Artigo em Inglês | MEDLINE | ID: mdl-36403065

RESUMO

BACKGROUND: Injury is an important cause of death in China. In the present study, we systematically analyzed the epidemiological characteristics and trends of injury death in Xi'an residents from 2005 to 2020. METHODS: Data on injury deaths from 2005 to 2020 were obtained from the "Xi'an Center for Disease Control and Prevention", injury deaths were classified according to the International Classification Disease-10th Revision (ICD-10). The data were stratified by gender, age groups, injury types, and then overall and type-specific injury mortality rates were estimated. Joinpoint regression analysis was conducted to estimate annual percent change (APC). The grey interval predicting method was used to predict the future characteristics of injury deaths in Xi'an city. RESULTS: From 2005 to 2020, injury caused 32,596 deaths (5.79% of all deaths; 35.71/100000 population). Injury mortality rates were higher among males than females. Motor vehicle traffic accidents were the commonest injury type. The highest injury mortality rates were in those aged 85 years or older. Overall, Joinpoint regression analysis revealed that injury mortality had significantly (p < 0.05) decreasing trends. GM (1,1) model estimated that injury mortality will be on a declining curve. CONCLUSIONS: Motor vehicle traffic accidents, transport accidents other than motor vehicles, unintentional falls, suicide, and accidental poisoning are the main causes of injury. The injury death rate is projected to decline over the next decade.

8.
Comput Math Methods Med ; 2022: 1718143, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36404910

RESUMO

Objective. This study is aimed at screening out effective active compounds of Qizhen capsule (QZC) and exploring the underlying mechanisms against gastric cancer (GACA) by combining both bioinformatic analysis and experimental approaches. Weighted gene coexpression network analysis (WGCNA), network pharmacology, molecular docking simulation, survival analysis, and data-based differential gene and protein expression analysis were employed to predict QZC's potential targets and explore the underlying mechanisms. Subsequently, multiple experiments, including cell viability, apoptosis, and protein expression analyses, were conducted to validate the bioinformatics-predicted therapeutic targets. The results indicated that luteolin, rutin, quercetin, and kaempferol were vital active compounds, and TP53, MAPK1, and AKT1 were key targets. Molecular docking simulation showed that the four abovementioned active compounds had high binding affinities to the three main targets. Enrichment analysis showed that vital active compounds exerted therapeutic effects on GACA through regulating the TP53 pathway, MAPK pathway, and PI3K/AKT pathway. Furthermore, data-based gene expression analysis revealed that TP53 and JUN genes were not only differentially expressed between normal and GACA tissues but also correlated with clinical stages. In parallel, in vitro experimental results suggested that QZC exerted therapeutic effects on GACA by decreasing IC50 values, downregulating AKT expression, upregulating TP53 and MAPK expression, and increasing apoptosis of SGC-7901 cells. This study highlights the potential candidate biomarkers, therapeutic targets, and basic mechanisms of QZC in treating GACA, providing a foundation for new drug development, target mining, and related animal studies in GACA.


Assuntos
Biologia Computacional , Neoplasias Gástricas , Animais , Neoplasias Gástricas/tratamento farmacológico , Neoplasias Gástricas/genética , Simulação de Acoplamento Molecular , Proteínas Proto-Oncogênicas c-akt , Farmacologia em Rede , Fosfatidilinositol 3-Quinases
9.
Diabetes Metab Syndr Obes ; 15: 3459-3468, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36353667

RESUMO

Objective: To evaluate associations of obesity indices with bone mineral densities (BMD) and risk of osteoporosis in T2DM patients totally and stratified across presence of any diabetic cardiovascular complications. Methods: Cross-sectional analyses of baseline information on a cohort of 250 T2DM patients were conducted in Xiamen, China. Obesity indices included body weight, height, body mass index (BMI), waist and waist hip ratio (WHR). BMD was measured using dual-energy X-ray absorptiometry at three different sites, and osteoporosis was defined based on the minimum T-scores of BMD. Presence of any diabetic vascular complications was confirmed by checking their medical records histories. Results: Among the 250 T2DM patients, 50 (20.0%) were defined as osteoporosis. Multivariable linear regression and multivariable logistic regression analyses showed that igher obesity indices, including body weight, BMI and waist, but neither body height nor waist hip ratio, were positively associated with the minimum T-scores of BMD and had significantly decreased risk of osteoporosis. Stratified analyses across presence of any of diabetic vascular complications showed similar results for those with any of diabetic vascular complications, while no significant association between obesity indices and minimum T-scores of BMD was found for those without. Postmenopausal women (vs men) and ever drinking were significantly associated with increased risk of osteoporosis, and the adjusted odds ratios (95% CIs) were 5.165 (1.762-15.138, p = 0.003) and 3.789 (1.087-13.214, p = 0.037), respectively. None of metabolic profiles, including systolic and diastolic blood pressure, triglyceride, total cholesterol, high-density lipoprotein cholesterol, HbA1c and blood uric acid, was significantly associated with either minimum T-scores of BMD or risk of osteoporosis. Conclusion: Associations of obesity indices with either BMD or risk of osteoporosis in T2DM patients varied by presence of any diabetic vascular complication and should be not interpreted as causal without considering the often-unmeasured effect modification by health status.

10.
Vaccine ; 40(50): 7219-7229, 2022 Nov 28.
Artigo em Inglês | MEDLINE | ID: mdl-36328881

RESUMO

Classical swine fever virus (CSFV) is the etiological agent of classical swine fever, a highly contagious disease that causes significant economic losses to the swine industry. Systemic prophylactic immunization with the live attenuated vaccine, the C-strain vaccine, is one of the effective measures for CSF control. However, one of the limitations of the C-strain vaccine is that the field strains-infected animals cannot be differentiated from the C-strain vaccinated herds by serological tests (DIVA). This constraint hampers the practical usage of the C-strain vaccine to eradicate the CSF in China. In the current study, a novel CSF modified live marker vaccine candidate was constructed based on the attenuation of the prevalent 2.1 genotype strain by the deletion of two virulence associated functional residues in the CSFV Erns, H79, and C171. Meanwhile, four residues S14, G22, E24, and E25 were identified specifically for the 6B8 mAb binding to the CSFV E2 as the novel conformational epitope. Then four substitutions of S14K, G22A, E24R, and G25D were further incorporated in the double deletion construct as a negative serological marker. Finally, the double-deletion marker MLV candidate GD18-ddErnHC-KARD was rescued, and its safety and efficacy profiles were evaluated in piglets. The safety study results indicated that the candidate did not induce fever, clinical signs, or pathological lesions with a high dose of 105.0 TCID50, and in addition, no virus shedding was detected until 21 days post-inoculation. Meanwhile, the efficacy study results demonstrated that at a low dose of 103.0 TCID50, it conferred complete clinical protection and no virus shedding was detected after the challenge with a highly virulent Shimen strain. Importantly, the infected animals were differentiated using the accompanied DIVA ELISA. These results constitute a proof-of-concept for rationally designing a CSF antigenically marked modified live vaccine candidate.


Assuntos
Vírus da Febre Suína Clássica , Peste Suína Clássica , Vacinas Atenuadas , Animais , Biomarcadores , Peste Suína Clássica/prevenção & controle , Vírus da Febre Suína Clássica/genética , Estudos de Viabilidade , Suínos , Vacinas Atenuadas/efeitos adversos , Vacinas Marcadoras
11.
Nanomaterials (Basel) ; 12(22)2022 Nov 17.
Artigo em Inglês | MEDLINE | ID: mdl-36432344

RESUMO

Silver nanoparticles (Ag NPs), a commonly used antibacterial nanomaterial, exhibit broad-spectrum antibacterial activity to combat drug-resistant bacteria. However, the Ag NPs often causes a low availability and high toxicity to living bodies due to their easy aggregation and uncontrolled release of Ag+ in the bacterial microenvironment. Here, we report a porous metal-organic framework (MOF)-based Zr-2-amin-1,4-NH2-benzenedicarboxylate@Ag (denoted as UiO-66-NH2-Ag) nanocomposite using an in-situ immobilization strategy where Ag NPs were fixed on the UiO-66-NH2 for improving the dispersion and utilization of Ag NPs. As a result, the reduced use dose of Ag NPs largely improves the biosafety of the UiO-66-NH2-Ag. Meanwhile, after activation by the Ag NPs, the UiO-66-NH2-Ag can act as nanozyme with high peroxidase (POD)-like activity to efficiently catalyze the decomposition of H2O2 to extremely toxic hydroxyl radicals (·OH) in the bacterial microenvironment. Simultaneously, the high POD-like activity synergies with the controllable Ag+ release leads to enhanced reactive oxygen species (ROS) generation, facilitating the death of resistant bacteria. This synergistic antibacterial strategy enables the low concentration (12 µg/mL) of UiO-66-NH2-Ag to achieve highly efficient inactivation of ampicillin-resistant Escherichia coli (AmprE. coli) and endospore-forming Bacillus subtilis (B. subtilis). In vivo results illustrate that the UiO-66-NH2-Ag nanozyme has a safe and accelerated bacteria-infected wound healing.

12.
Dalton Trans ; 2022 Nov 21.
Artigo em Inglês | MEDLINE | ID: mdl-36408804

RESUMO

The types and quantities of surface ligands used in the synthesis of nanomaterials play a dominant role in determining their physical and chemical properties, and this situation likewise occurs in metal-chalcogenide supertetrahedral clusters (MCSCs). The MCSCs are mainly categorized into ligand-fully-protected MCSCs and ligand-free ones according to the surface ligand situation. However, ligand-partially-protected MCSCs are rarely reported. In this study, a facile synthetic strategy was proposed to create ligand-partially-protected MCSCs through the pyrolysis of the S-S or Se-Se bond of disulfide organic ligands in a solvothermal procedure, and a series of Pn-type MCSCs with their surface partially protected by thiophenol ligands (ISC-24-MnSnS: 10(3,5-DMPH+)·[Mn4Sn4S17]10-·4H2O; ISC-25-MnSnS-SPh: 7(3,5-DMPH+)·Mn4Sn4S14(SPh)37-·H2O; ISC-26-MnSnSeCl-SePh: 5.2(3,5-DMPH+)·Mn4Sn4Se12.2Cl0.8(SePh)45.2-·0.8(3,5-DMP)·4H2O; ISC-26-MnSnSeS-SPh: 6(3,5-DMPH+)·Mn4Sn4Se12S(SPh)46-·(3,5-DMP)·4H2O) were obtained. This work could lay a foundation for the synthesis of ligand-partially-protected MCSCs and other partially-protected nanomaterials through the cleavage of disulfide bonds in organic ligands.

13.
Front Nutr ; 9: 982626, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36324622

RESUMO

Background: Diet and other lifestyle habits may have an increased effect on blood lipids in older people. This study aimed to examine the associations between diet (meat, fish, and egg), alcohol consumption and blood lipids. Methods: Surveillance data on chronic diseases and their risk factors were collected from Shanghai during 2017-2018. A Kish table was used for sampling 438 older adults, of whom 71 consumed alcohol. Logistic regression was used to test the relationships between diet, alcohol consumption and blood lipid levels in elderly individuals, and the marginal effects (MEs) were estimated. Results: Dyslipidaemia was more common among drinkers than among nondrinkers (P < 0.01). Alcohol consumption was associated with dyslipidaemia (OR = 2.667, P < 0.01 for TC; OR = 1.919, P < 0.05 for LDL; OR = 3.412, P < 0.01 for TG), and consumption of more than 50 g of meat per day showed similar associations (OR = 3.227, P < 0.01 for TC; OR = 3.263, P < 0.01, for LDL; OR = 2.329, P < 0.01 for TG). The MEs of alcohol drinking and excessive meat consumption on the rate of dyslipidaemia were 0.324 for TC (P < 0.01), 0.255 for LDL (P < 0.05), and 0.174 for TG (P < 0.01). Discussion: The risk of hyperlipidaemia was increased among elderly individuals with excessive meat and alcohol consumption, which also had an interactive effect.

14.
Artigo em Inglês | MEDLINE | ID: mdl-36322227

RESUMO

Air pollution was considered one of the main causes linked to increased morbidity and mortality around the world. This study aimed to estimate the effect of air pollutants on daily death in Baotou city of Inner Mongolia. Daily deaths data were provided by Baotou Centers for Disease Control and Prevention for the years 2015-2019 (Baotou CDC). The air pollutants, PM2.5, PM10, NO2, SO2, CO and maximum 8-h average concentrations of O3, came from the eight environmental monitoring stations in Baotou city. Time-series plots were used to exploit the trend of air pollutants at calendar time. Generalized additive model was used to estimate the effect of air pollutants on daily death. Restricted cubic spline was employed to investigate non-line relationships between air pollutants and daily death. After adjusting the meteorological factors, non-accidental daily deaths were related to PM2.5 (ER = 0.074%) and PM10 (ER = 0.023%), respectively. In stratified analysis, population aged over 65 years and females were more sensitive to air pollutants exposure and warm season might make people more susceptible to air pollutants compared with cold season. PM2.5 and PM10 increase the risk of non-accidental and cardiovascular daily death, but not respiratory daily death.

15.
Nutr Neurosci ; : 1-10, 2022 Nov 17.
Artigo em Inglês | MEDLINE | ID: mdl-36384436

RESUMO

PURPOSE: Migraine is a highly prevalent headache disorder, and intake of various nutrients and special diets may improve migraine symptoms. We aimed to clarify the association between nutritional status and migraine. PATIENTS AND METHODS: We collected the data of 1838/8953 (migraineurs/all participants) from the National Health and Nutrition Examination Survey (NHANES) 1999-2004 cycle. We used weighted multivariable linear or logistic regression analyses to study the association between the prognostic nutritional index (PNI) and the occurrence of severe headache or migraine. RESULTS: After adjusting for confounding variables, we found that mild (PNI 45-50) or moderate to severe (PNI <45) malnutrition were associated with higher prevalence of severe headache or migraine (odds ratio [OR] 1.06, 95% confidence interval [CI] 1.00-1.12, P = 0.004; OR 1.07, 95% CI 1.03-1.12, P < 0.001). In addition, we found that those with severe headache or migraine consumed less alcohol, dietary fiber, cholesterol, total folate, vitamin A, riboflavin, vitamin B6, vitamin B12, vitamin C, vitamin K, selenium, potassium, magnesium, and copper, and consumed more caffeine and theobromine than did those without severe headache or migraine. CONCLUSION: The PNI is associated with migraine prevalence, and may thus serve as a predictor of migraine risk and highlights the potential of nutrition-based strategies for migraine prevention and treatment.

16.
Micromachines (Basel) ; 13(10)2022 Sep 25.
Artigo em Inglês | MEDLINE | ID: mdl-36295944

RESUMO

The paper proposes a three-degrees-of-freedom flexible nano-positioning stage constructed from compliant flexures and piezoelectric thin-sheet actuators, featuring a compact size and fast dynamic responses, which can be extensively applied to the typical micro/nano-positioning applications. Meanwhile, the dynamic model of the flexible PZT nano-positioning with distributed parameter characteristics is established to distinctly reflect the piezoelectric-mechanical coupling relationship between the four flexible PZT actuators and the three outputs of such a system. Furthermore, the attitude decoupling control for the 3-DOF flexible piezoelectric nano-positioning stage is achieved by the Active Disturbance Rejection Control (ADRC) method to compensate for the positioning errors in the actual positioning process. After this, a real-time experimental apparatus with two Position-Sensitive Detectors (PSDs) is also proposed and fabricated to test the three outputs of the flexible piezoelectric thin-sheet (PZT-5A) nano-positioning stage and validate the effectiveness of the dynamic modeling method and attitude decoupling control in the piezoelectric nano-positioning stage ranges.

17.
Int J Biol Macromol ; 222(Pt A): 1314-1325, 2022 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-36195223

RESUMO

In this work, a facile and efficient strategy known as 'dynamic self-vulcanization of dual difunctional monomers' was reported to toughen poly(lactic acid) (PLA) with in-situ formed crosslinked bio-polyurethane (PCPUE) phase from plant oil-derived hydrogenated dimer diol (Pripol) and hexamethylene diisocyanate (HDI). By simply adjusting equivalent ratios (nNCO/nOH) of complementary functional groups between these two difunctional toughening monomers from 1.0 to 2.2 while fixing their total feeding content at 20 wt%, the notched impact strength (IS) and phase morphologies of PLA blends can be tailored in a broad range. When the ratio reached 1.6, the maximum IS value up to 87.1 kJ/m2 (about 28 times that of neat PLA) was achieved with an elongation-at-break of ~223 %. Based on the analysis on reaction mechanism and phase morphologies, the optimum interfacial compatibility between PLA and PCPUE phases in junction with the proper crosslinking density of rubbery PCPUE phase was considered to be responsible for such a remarkable improvement in impact toughness.


Assuntos
Poliésteres , Poliuretanos , Polímeros , Fenômenos Químicos
18.
Front Public Health ; 10: 984621, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36267989

RESUMO

Objective: The prevention of hypertension in primary care requires an effective and suitable hypertension risk assessment model. The aim of this study was to develop and compare the performances of three machine learning algorithms in predicting the risk of hypertension for residents in primary care in Shanghai, China. Methods: A dataset of 40,261 subjects over the age of 35 years was extracted from Electronic Healthcare Records of 47 community health centers from 2017 to 2019 in the Pudong district of Shanghai. Embedded methods were applied for feature selection. Machine learning algorithms, XGBoost, random forest, and logistic regression analyses were adopted in the process of model construction. The performance of models was evaluated by calculating the area under the receiver operating characteristic curve, sensitivity, specificity, positive predictive value, negative predictive value, accuracy and F1-score. Results: The XGBoost model outperformed the other two models and achieved an AUC of 0.765 in the testing set. Twenty features were selected to construct the model, including age, diabetes status, urinary protein level, BMI, elderly health self-assessment, creatinine level, systolic blood pressure measured on the upper right arm, waist circumference, smoking status, low-density lipoprotein cholesterol level, high-density lipoprotein cholesterol level, frequency of drinking, glucose level, urea nitrogen level, total cholesterol level, diastolic blood pressure measured on the upper right arm, exercise frequency, time spent engaged in exercise, high salt consumption, and triglyceride level. Conclusions: XGBoost outperformed random forest and logistic regression in predicting the risk of hypertension in primary care. The integration of this risk assessment model into primary care facilities may improve the prevention and management of hypertension in residents.


Assuntos
Hipertensão , Aprendizado de Máquina , Humanos , Idoso , Adulto , Creatinina , China/epidemiologia , Hipertensão/epidemiologia , Algoritmos , Nitrogênio , Lipoproteínas HDL , Lipoproteínas LDL , Triglicerídeos , Atenção Primária à Saúde , Colesterol , Glucose , Ureia
19.
J Neural Eng ; 19(5)2022 10 17.
Artigo em Inglês | MEDLINE | ID: mdl-36195065

RESUMO

Objective. Auditory attention decoding (AAD) determines which speaker the listener is focusing on by analyzing his/her EEG. Convolutional neural network (CNN) was adopted to extract spectro-spatial-feature (SSF) from short-time-interval of EEG to detect auditory spatial attention without stimuli. However, the following factors are not considered in SSF-CNN scheme. (a) Single-band frequency analysis cannot represent the EEG pattern precisely. (b) The power cannot represent the EEG feature related to the dynamic patterns of the attended auditory stimulus. (c) The temporal feature of EEG representing the relationship between EEG and attended stimulus is not extracted. To solve these problems, SSF-CNN scheme was modified.Approach. (a) Multiple-frequency bands, but not a single alpha frequency band, of EEG, were analyzed to represent the EEG pattern more precisely. (b) Differential entropy, but not power, was extracted from each frequency band to represent the disorder degree of EEG, which was related to the dynamic patterns of the attended auditory stimulus. (c) CNN and convolutional-long-short-term-memory (ConvLSTM) were combined to extract spectro-spatial-temporal features from the 3D descriptor sequence constructed based on the topographical activity maps of multiple-frequency bands.Main results. Experimental results on KUL, DTU, and PKU with 0.1 s, 1 s, 2 s, and 5 s decision windows demonstrated that: (a) The proposed model outperformed SSF-CNN and state-of-the-art AAD models. Specifically, when the auditory stimulus was unavailable, AAD accuracy could be enhanced by at least3.25%,3.96%and5.08%on KUL, DTU, and PKU, respectively, compared with the baselines. And, on KUL, the longer decision window corresponded to lower enhancement, while on both DTU and PKU, the longer decision window corresponded to higher enhancement, except for two cases when decision window length was 2 s on PKU or 5 s on DTU. (b) Each modification contributed to the performance enhancement.Significance. DE feature, multi-band frequency analysis, and ConvLSTM-based temporal analysis help to enhance AAD accuracy.


Assuntos
Eletroencefalografia , Redes Neurais de Computação , Eletroencefalografia/métodos , Feminino , Humanos , Masculino
20.
Sensors (Basel) ; 22(19)2022 Sep 22.
Artigo em Inglês | MEDLINE | ID: mdl-36236302

RESUMO

In industrial processes, the composition of raw material and the production environment are complex and changeable, which makes the production process have multiple steady states. In this situation, it is difficult for the traditional single-mode monitoring methods to accurately detect the process abnormalities. To this end, a multimode monitoring method based on the factor dynamic autoregressive hidden variable model (FDALM) for industrial processes is proposed in this paper. First, an improved affine propagation clustering algorithm to learn the model modal factors is adopted, and the FDALM is constructed by combining multiple high-order hidden state Markov chains through the factor modeling technology. Secondly, a fusion algorithm based on Bayesian filtering, smoothing, and expectation-maximization is adopted to identify model parameters. The Lagrange multiplier formula is additionally constructed to update the factor coefficients by using the factor constraints in the solving. Moreover, the online Bayesian inference is adopted to fuse the information of different factor modes and obtain the fault posterior probability, which can improve the overall monitoring effect of the model. Finally, the proposed method is applied in the sintering process of ternary cathode material. The results show that the fault detection rate and false alarm rate of this method are improved obviously compared with the traditional methods.

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