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1.
Spectrochim Acta A Mol Biomol Spectrosc ; 224: 117362, 2020 Jan 05.
Artigo em Inglês | MEDLINE | ID: mdl-31352140

RESUMO

In this work, a novel strategy for perfluorooctane sulfonic acid (PFOS) detection was established by using a ratiometric nanosensor with the combination of fluorescence and second-order scattering (SOS). The practical ratiometric nanosensor was synthesized simply by mixing fluorescent dye ethidium bromide (EB) and nitrogen doped carbon dots (N-CDs) which was synthesized by a one-step hydrothermal method with Victoria Blue B, possessing three emission peaks at 472 nm, 560 nm and 600 nm under a single wavelength excitation of 280 nm, respectively. The EB served as the reference signal label, and the N-CDs, having response to the analytes, acted as the response signal label. To achieve ratiometric detection, the fluorescence emission of the N-CDs was turned off and the SOS emission was turned on with the addition of the target PFOS. To achieve colorimetric detection, with the help of EB, the fluorescence of the system changed from green to orange. Under the optimal conditions, the difference of F472/I568 of the nanosensor had good linearity against the concentrations of PFOS within a linear range of 0-2.0 µM. The limit of detection was as low as 27.8 nM, which was low enough for the detection of PFOS in water samples. The proposed method has been successfully applied to the detection of PFOS with RSD <1.67%. The results show that the as-prepared N-CDs/EB ratiometric nanosensor has potential application for the detection of PFOS in environmental monitoring.

2.
Opt Express ; 27(20): 27862-27872, 2019 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-31684547

RESUMO

Three-dimensional (3D) imaging can be reconstructed by a computational ghost imaging system with single pixel detectors based on a photometric stereo, but the requirement of large measurements and long imaging times are obstacles to its development. Also, the compressibility of the target's surface normals has not been fully studied, which causes the waste in sampling efficiency in single-pixel imaging. In this paper, we propose a method to adaptively measure the object's 3D information based on surface normals. In the proposed method, the regions of object's surface are illuminated by patterns of different spatial resolutions according to the variation of surface normals. The experimental results demonstrate that our proposed scheme can reduce measurements and preserve the quality of the formed 3D image.

3.
Opt Express ; 27(20): A1601-A1614, 2019 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-31684591

RESUMO

Optical polarization characteristics and light extraction behavior of deep-ultraviolet (DUV) light-emitting diode (LED) flip-chip with full-spatial omnidirectional reflector (FSODR) have been investigated. FSODR is fabricated to be simultaneously covered on the whole flip-chip, except the sapphire surface. It is found that the FSODR greatly enhance both transverse-electric (TE) and transverse-magnetic (TM) mode light extraction at every space angle, resulting in total enhancement of 73.1% and 79.8%, respectively. Moreover, the four individual ODR structures separated from FSODR, which are covered on the surface of n-AlGaN, the interface of p-GaN/p-AlGaN, the sidewall of mesa and the sidewall of n-AlGaN/AlN, respectively, show considerably different optical polarization characteristics and extraction behaviors between each other. The achievements of FSODR cannot be obtained by any separated ODR, and all of the individual ODRs can contribute to the FSODR. Especially, the synergy effect of TM extraction behavior obviously exists in FSODR. As a result, the light extraction efficiency (LEE) enhancement of FSODR is approximately 60% at a high current density of 140A/cm2. This study is significant for understanding and modulating the extraction behavior of polarized light to realize high efficiency AlGaN-based DUV LEDs.

4.
Mol Plant ; 2019 Oct 31.
Artigo em Inglês | MEDLINE | ID: mdl-31678614

RESUMO

Dietary anthocyanins are important health-promoting antioxidants that make a major contribution to the quality of fruits. It is intriguing that most tomato cultivars do not produce anthocyanins in fruit. However, the purple tomato variety Indigo Rose, which combines the dominant Aft locus and the recessive atv locus from wild tomato species, exhibits light-dependent anthocyanin accumulation in the skin. Here, we report that whereas Aft encodes a functional allele of an anthocyanin activator named SlAN2-like, atv encodes a non-functional allele of the anthocyanin repressor SlMYBATV. The expression of SlAN2-like is responsive to light and a functional SlAN2-like can activate both anthocyanin biosynthetic genes and their regulatory genes, suggesting that SlAN2-like acts as a master regulator and plays a critical role for the activation of anthocyanin biosynthesis. Our results reveal that cultivated tomatoes contain a non-functional allele of this master regulator and therefore fail to produce anthocyanins. Indeed, expression of a functional SlAN2-like in a tomato cultivar led to the activation of the entire anthocyanin biosynthesis pathway and high levels of anthocyanin accumulation in both peel and flesh. Our study exemplifies that efficient engineering of complex metabolic pathways could be achieved through tissue-specific expression of master transcriptional regulators.

5.
J Cell Biochem ; 2019 Nov 03.
Artigo em Inglês | MEDLINE | ID: mdl-31680322

RESUMO

Synovial mesenchymal stem cells (SMSCs) with high proliferation and multi differentiation ability, and low immunogenicity have attracted research attention for their potential application in tissue engineering. Once their ability of osteogenesis is strengthened, it will be of practical value to apply the SMSCs in the field of bone regeneration. The current study aimed to investigate the osteogenic characteristics of SMSCs induced by bone morphogenetic protein 9 (BMP9) both in vitro and in vivo and to elucidate the mechanism underlying these characteristics. Specifically, different BMPs were assessed to determine the protein that would be the most favorable for stimulating osteogenic differentiation of SMSCs following their separation. The BMP9-enhanced osteogenesis of SMSCs was fully investigated in vitro and in vivo, and the c-Jun N-terminal kinase (JNK)/Smad2/3 signaling pathway stimulated by BMP9 was further explored. Our data suggested that BMP9 could significantly promote gene and protein expression of runt-related transcription factor 2, alkaline phosphatase, osteopontin, and osteocalcin, and SP600125, a JNK-specific inhibitor, could effectively decrease this tendency. Similar results were also confirmed in rats with cranial defects. In conclusion, our study indicated that BMP9 promotes bone formation both in vitro and in vivo possibly by activating the JNK/Smad2/3 signaling pathway.

6.
Appl Opt ; 58(28): 7733-7740, 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31674455

RESUMO

In the research on scattering polarimetry, a scattering mechanism is described by an internal degree of freedom called rotation invariant parameter α. Traditionally, α is calculated by the diagonal scattering matrix of the single scatterer. However, when the research object is a scatterer with complicated surface and microstructure, the traditional calculation of parameter α is biased, since the corresponding scattering matrix is a nondiagonal matrix. To address this problem, this paper proposes a scientific model based on Cameron decomposition to raise the accuracy of parameter α in the complicated scatterer. The rotation invariant parameter with higher accuracy is renamed as a nondiagonal rotation invariant angle. In the verified experiments, the experimental values of each nondiagonal rotation invariant angle are compared with the referenced values calculated by optical constant and incident angle. The results demonstrate that fewer residuals are achieved than by the traditional method. Based on the presented calculating model, the scattering mechanism difference interval between two different materials is proposed as a judging area to distinguish the differences between scattering mechanisms in application.

7.
Appl Opt ; 58(28): 7741-7748, 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31674456

RESUMO

A four-quadrant detector is a kind of photoelectric detector that can quickly and accurately measure the incident angle of light. However, its ability to measure in a large field of view (FOV) is limited by its hardware structure and its calculation principle. To solve these problems, this paper proposes an improved algorithm that can extend the measurement linear range without reducing its measurement accuracy. After that, through simulation and experiment, we compare it with many other location algorithms, including the most widely used classical algorithm and the logarithmic algorithm suitable for large FOVs. Finally, the following conclusions can be drawn from both theoretical data and experimental data: the improved algorithm can significantly improve the measurement accuracy over 50% in the same FOV condition, and the measurable range can be expanded over 25% in the same accuracy requirement. At the same time, the robustness of noise does not decrease; when the root mean square error of the classical algorithm fluctuates at 0.1° in different SNR conditions, the improved algorithm is also 0.1°, while the logarithmic algorithm can reach 1.7°, and other algorithms are around 0.25°. In addition, the improved algorithm is more stable in measuring a certain direction and can effectively avoid the influence from the offset of incident light in another axis.

8.
Biochim Biophys Acta Mol Basis Dis ; : 165583, 2019 Oct 29.
Artigo em Inglês | MEDLINE | ID: mdl-31676378

RESUMO

Acetaminophen (APAP) is one of the most commonly used drugs worldwide, and APAP-induced liver injury is the most frequent cause of acute liver failure in developed countries. However, the mechanisms of APAP-induced hepatotoxicity are not well understood, and treatment options for the disorder are very limited. Here, we show that TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is a major mediator of APAP-induced liver injury in mice, and its blockade markedly ameliorates the liver failure. In APAP-treated mice, TRAIL was expressed in the liver, spleen, and peripheral blood primarily by CD11b+Gr1+ neutrophils. The concentration of soluble TRAIL in the blood, and the frequencies of TRAIL+ leukocytes in the spleen and liver positively correlated with the severity of liver injury. APAP sensitized hepatocytes to TRAIL-induced apoptosis by upregulating the expression of the TRAIL receptor DR5 (death receptor 5), presumably through its transcription factor CHOP (C/EBP homologous protein). Importantly, blocking TRAIL with a soluble DR5-Fc fusion protein (sDR5-Fc) significantly attenuated APAP-induced liver injury, the hepatic infiltration of leukocytes, the levels of inflammatory cytokines, and the mortality of mice. When administered alongside N-acetylcysteine, sDR5-Fc further protected against APAP-induced acute liver injury. Thus, the TRAIL-DR5 signaling pathway plays a key role in APAP-induced liver inflammation and failure, and its blockade represents an effective new strategy to treat the liver disease.

9.
Dev Sci ; : e12910, 2019 Oct 10.
Artigo em Inglês | MEDLINE | ID: mdl-31599035

RESUMO

Studies have shown that numerosity-based arithmetic training can promote arithmetic learning in typically developing children as well as children with developmental dyscalculia (DD), but the cognitive mechanism underlying this training effect remains unclear. The main aim of the current study was to examine the role of visual form perception in arithmetic improvement through an eight-day numerosity training for DD children. Eighty DD children were selected from four Chinese primary schools. They were randomly divided into the intervention and control groups. The intervention group received training on an apple-collecting game, whereas the control group received an English dictation task. Children's cognitive and arithmetic performance was assessed before and after training. The results showed that the intervention group showed a significant improvement in arithmetic performance, ANS acuity, and visual form perception, but not in spatial processing and sentence comprehension. The control group showed no significant improvement in any cognitive ability. Mediation analysis further showed that training-related improvement in arithmetic performance was fully mediated by the improvement in visual form perception. The results suggest that short-term numerosity training enhances the arithmetic performance of DD children by improving their visual form perception.

10.
Endocrinology ; 2019 Oct 10.
Artigo em Inglês | MEDLINE | ID: mdl-31599935

RESUMO

A growing body of evidence implied a pivotal role of Sirt1 in chondrocyte function and homeostasis, however, its underlying mechanisms mediating chondrogenesis which is an essential process for physiological skeletal growth, are still poorly understood. In the present study, we generated TamCartSirt1-/-(Sirt1 cKO) mice to explore the role of Sirt1 during postnatal endochondral ossification. Compared with control mice, cKO mice exhibited growth retardation associated with inhibited chondrocyte proliferation and hypertrophy, as well as activated apoptosis. These effects were regulated by hyperactivation of mammalian target of rapamycin complex 1(mTORC1) signaling, and thereby inhibition of autophagy and induction of ER stress in growth plate chondrocytes. Intraperitoneal injection of mTORC1 inhibitor, rapamycin, to mice with Sirt1 deletion, partially neutralized such inhibitory effects of Sirt1 ablation on longitudinal bone growth, indicating the causative link between SIRT1 and mTORC1 signaling in the growth plate. Mechanistically, SIRT1 interacted with tuberous sclerosis complex 2 (TSC2), a key upstream negative regulator of mTORC1 signaling, and loss of Sirt1 inhibited TSC2 expression, resulting in hyperactivated mTORC1 signaling in chondrocytes. In conclusion, our findings suggest that loss of Sirt1 may trigger mTORC1 signaling in growth plate chondrocytes and contributes to growth retardation, thus indicating that SIRT1 is an important regulator during chondrogenesis and providing new insights into the clinical potential of SIRT1 in bone development.

11.
Chem Soc Rev ; 2019 Oct 07.
Artigo em Inglês | MEDLINE | ID: mdl-31589233

RESUMO

Cancer immunotherapy by educating or stimulating patients' own immune systems to attack cancer cells has demonstrated promising therapeutic responses in the clinic. However, although the number of approved immunotherapeutics is rapidly increasing, key challenges such as limited clinical response rate and significant autoimmunity-related adverse effects remain to be resolved. Recently, it has been discovered that a diverse range of biomaterials-assisted local treatment methods including localized radiotherapy, chemotherapy or phototherapy are able to stimulate the immune systems, often by inducing immunogenic cell death (ICD). The triggered tumor-specific immunological responses after such local treatments, especially in combination with immune checkpoint blockade (ICB) therapy, can achieve a significant abscopal effect to attack whole-body spreading metastatic cancer cells, and later on result in immune memory to inhibit tumor recurrence. Moreover, local delivery of immunomodulatory therapeutics with biomaterials has also been demonstrated to be an alternative strategy to improve the therapeutic responses and reduce side effects of cancer immunotherapy. In this review, we would like to summarize the latest advances, challenges and opportunities in utilizing biomaterials-assisted local treatment strategies for enhancing anticancer immunity, and discuss further prospects in this field together with how this strategy may possibly be translated into clinical use.

12.
J Org Chem ; 2019 Oct 25.
Artigo em Inglês | MEDLINE | ID: mdl-31622097

RESUMO

A direct and practical metal-free N-H phosphorylation has been achieved via the TBHP/NH4I-mediated cross-dehydrogenative coupling (CDC) reactions between imines/imidates and P(O)H compounds. This transformation provides an efficient synthetic route to the construction of P-N bonds with good functional group compatibility, leading to the formation of N-phosphorylimines and N-phosphorylimidates in up to 95% yield (33 examples) under mild conditions.

13.
BMC Musculoskelet Disord ; 20(1): 461, 2019 Oct 22.
Artigo em Inglês | MEDLINE | ID: mdl-31638954

RESUMO

BACKGROUND: Cervical spinal manipulation therapy is a common non-invasive treatment for neck pain and stiffness, and has been widely used in the population. However, most people do not pay attention to the potential risks of neck manipulation, such as ligament damage, fractures, and spinal cord injuries. Epidural hematoma is a disease in which blood accumulates in the epidural space of the vertebral body. This disease is usually caused by trauma or iatrogenic surgery, and may be associated with blood coagulopathies, neoplasms, or degenerative spinal disease. Reports of epidural hematoma caused by cervical spinal manipulation are rare. CASE PRESENTATION: We present the case of a patient with tetraplegia and spinal shock after neck manipulation. A physical examination of the patient on admission found tenderness in the neck and increased muscle tension in both upper limbs. The superficial sensation of the upper limb disappeared, but the deep sensation still remained. The lower extremity had 0/5 power on both sides. The sensation below the T2 level completely disappeared. A cervical magnetic resonance imaging scan showed an acute posterior epidural hematoma from the C3-T3 vertebrae. Ultimately, the patient underwent emergency hematoma removal and showed partial improvement in symptoms of paralysis during follow-up. CONCLUSIONS: Although spinal manipulation is simple and neck pain is common and recurrent in the general population, the basic condition and disease history of patients should be determined before manipulation. For high-risk patients, caution should be applied for cervical spinal manipulation or it should be prohibited. For a suspected hematoma, MRI should be used at an early stage to diagnose and locate the hematoma.

14.
World Neurosurg ; 2019 Oct 21.
Artigo em Inglês | MEDLINE | ID: mdl-31648055

RESUMO

OBJECTIVE: Ultra-early hematoma growth(uHG), the black hole sign, and the blend sign are common predictors of hematoma enlargement(HE). This study aimed to develop a new diagnostic criterion for predicting HE using uHG and to compare the accuracy of uHG, the black hole sign, and the blend sign in predicting HE in patients with spontaneous intracerebral hemorrhage(sICH). METHODS: We retrospectively analyzed data of 920 patients with sICH from August 2013 to January 2018. Receiver operating characteristic curves were plotted to determine the optimal threshold values of uHG to predict HE. The effects of the black hole sign, blend sign, and uHG on HE were assessed using univariate and multivariate logistic regression models, and their prediction accuracies were analyzed using receiver operator analyses. RESULTS: The black hole sign was identified in 131 patients, the blend sign in 163 patients, and uHG> 6.46mL/h in 441 patients. Logistic analysis showed that the black hole sign, blend sign, and uHG> 6.46mL/h were independent predictors of HE. The sensitivity values of uHG> 6.46mL/h, the black hole sign, and the blend sign were 70.43%, 24.19%, and 36.56%, respectively, and specificity values were 57.77%, 88.28%, and 87.06%, respectively. uHG had the greatest area under the curve. The black hole and blend signs were more commonly found in patients with uHG> 6.46mL/h(P < 0.001). CONCLUSION: uHG> 6.46mL/h was the optimal predictor used for identifying patients at high risk of developing HE. A higher uHG value was associated with an increased prevalence of the black hole and blend signs.

15.
Am J Reprod Immunol ; : e13202, 2019 Oct 24.
Artigo em Inglês | MEDLINE | ID: mdl-31646704

RESUMO

PROBLEM: The complement system plays a key role in normal placentation, and delicate regulation of complement system activation is critical for successful pregnancy. Therefore, establishing a normal range of complement components during pregnancy is important for clinical evaluation and research. METHODS: We performed a prospective study to investigate the normal range of complement components in circulation during different stages of pregnancy. Plasma concentrations of complement factor B (CFB), C1q, complement factor H (CFH), C3, C3c, and C4 were measured using an immunoturbidimetric assay; mannan-binding lectin (MBL), C3a, C5a, and soluble C5b-9 (sC5b-9) levels at different time points of pregnancy were determined by enzyme-linked immunosorbent assay (ELISA). RESULTS: A total of 733 plasma samples were collected from 362 women with a normal pregnancy and 65 samples from nonpregnant women. In the first trimester of pregnancy, the levels of CFB, CFH, MBL, C3c, C4, and C3a were 414.5±85.9 mg/L (95%CI for mean: 402.4-426.6 mg/L), 381.0±89.0 mg/L (95%CI for mean: 368.5-393.6 mg/L), 4274.5±2752 ng/mL (95%CI for mean: 3881.1-4656.4 ng/mL), 1346.9±419.8 mg/L (95%CI for mean: 1287.7-1406.0 mg/L), 357.4±101.8 mg/L (95%CI for mean: 343.0-371.7 mg/L), and 182.5±150.0 ng/ml (95%CI for mean: 186.9-229.1 ng/mL), respectively. The levels of C3 and C4 increased gradually throughout pregnancy. The levels of C1q, C5a and sC5b-9 in the first and second trimesters were nearly the same as those in non-pregnant women. CONCLUSIONS: The results of this study show that pregnancy itself may influence the plasma levels of complement system components.

16.
Nucleic Acids Res ; 2019 Oct 23.
Artigo em Inglês | MEDLINE | ID: mdl-31642496

RESUMO

De novo mutations (DNMs) significantly contribute to sporadic diseases, particularly in neuropsychiatric disorders. Whole-exome sequencing (WES) and whole-genome sequencing (WGS) provide effective methods for detecting DNMs and prioritizing candidate genes. However, it remains a challenge for scientists, clinicians, and biologists to conveniently access and analyse data regarding DNMs and candidate genes from scattered publications. To fill the unmet need, we integrated 580 799 DNMs, including 30 060 coding DNMs detected by WES/WGS from 23 951 individuals across 24 phenotypes and prioritized a list of candidate genes with different degrees of statistical evidence, including 346 genes with false discovery rates <0.05. We then developed a database called Gene4Denovo (http://www.genemed.tech/gene4denovo/), which allowed these genetic data to be conveniently catalogued, searched, browsed, and analysed. In addition, Gene4Denovo integrated data from >60 genomic sources to provide comprehensive variant-level and gene-level annotation and information regarding the DNMs and candidate genes. Furthermore, Gene4Denovo provides end-users with limited bioinformatics skills to analyse their own genetic data, perform comprehensive annotation, and prioritize candidate genes using custom parameters. In conclusion, Gene4Denovo conveniently allows for the accelerated interpretation of DNM pathogenicity and the clinical implication of DNMs in humans.

17.
J Agric Food Chem ; 67(42): 11796-11804, 2019 Oct 23.
Artigo em Inglês | MEDLINE | ID: mdl-31589426

RESUMO

High molecular weight glutenin subunits (HMW-GSs) are important components of wheat (Triticum aestivum L.) gluten proteins that affect the processing quality of wheat dough. However, the contributions of individual HMW-GS to sponge cake quality still remain unclear. To investigate the effects of 1Bx7 and 1By9 at Glu-B1 on wheat gluten properties and sponge cake quality, we screened an ethylmethanesulfonate (EMS)-mutagenized wheat population and obtained two independent mutants that lack 1Bx7 and another two mutants that lack 1By9. The absence of 1Bx7 or 1By9 significantly affects the accumulation levels of gluten proteins and the formation of a gluten network. Quality testing indicated that the lack of 1Bx7 or 1By9 leads to weaker dough strength and inferior sponge cake performance. These results demonstrate that 1Bx7 and 1By9 make important contributions to gluten functionality and sponge cake quality.


Assuntos
Pão/análise , Glutens/química , Triticum/química , Culinária , Glutens/genética , Peso Molecular , Subunidades Proteicas/química , Subunidades Proteicas/genética , Triticum/genética
18.
Life Sci ; 238: 116976, 2019 Oct 18.
Artigo em Inglês | MEDLINE | ID: mdl-31634464

RESUMO

AIM: The purpose of the present study was to elucidate the protective effect of histone deacetylase 6 inhibitor ACY1215 on autophagy pathway in acute liver failure (ALF). MAIN METHODS: Lipopolysaccharide (LPS) and d-galactosamine (D-Gal) were used to induce ALF model in C57BL/6 mice. D-Gal and tumor necrosis factor alpha (TNF-α) were applied in L02 cell. Autophagy inhibitor 3-MA and ACY1215 were conducted to induce 3-MA group, ACY1215 group and ACY1215+3-MA group. RESULTS: ACY1215 improved liver histological and functional changes in ALF mice model, whereas the autophagy inhibitor 3-MA aggravated liver tissue pathological and functional damage in ALF mice model group. The apoptotic levels (including apoptotic index/rate and apoptotic proteins) in ALF mice and L02 cell were ameliorated with treatment ACY1215. 3-MA accentuated the apoptotic levels in ACY1215 group. D-Gal/TNF-α could reduce L02 cell mitochondrial membrane potential (ΔΨm) in control group. ACY1215 increased the ΔΨm in ALF model. 3-MA also further reduced the ΔΨm in ACY1215 group. ACY1215 could induce autophagy in ALF mice and cell model group accompanied with an increase in expression of LC3-II and beclin-1 proteins and down-regulation of p62 protein. Moreover, the expression of LC3-II and beclin1 proteins were greatly reduced and the expression of p62 protein was ascended after intervention with 3-MA in ACY1215 group. SIGNIFICANCE: Histone deacetylase 6 inhibitor ACY1215 could protect acute liver failure mice and L02 cell by inhibiting apoptosis pathway through enhancing autophagy way.

19.
Br J Radiol ; : 20190480, 2019 Oct 16.
Artigo em Inglês | MEDLINE | ID: mdl-31596123

RESUMO

OBJECTIVE: To evaluate the diagnostic accuracy of multiparametric MRI (mpMRI) for detecting extracapsular extension (ECE) in patients with prostate cancer (PCa). METHODS AND MATERIALS: We searched MEDLINE, PubMed, Embase and the Cochrane library up to December 2018. We included studies that used mpMRI to differentiate ECE from organ-confined PCa with a combination of T2 weighted imaging (T2WI), diffusion-weighted imaging, and dynamic contrast-enhanced MRI. All studies included had pathological diagnosis with radical prostatectomy. Two reviewers independently assessed the methodological quality of included studies by using Quality Assessment of Diagnostic Accuracy Studies 2 tool. We calculated pooled sensitivity, specificity, positive and negative predictive values, diagnostic odds ratios and receiver operating characteristic curve for mpMRI from 2 × 2 tables. RESULTS: A total of 17 studies that comprised 3374 participants were included. The pooled data showed a sensitivity of 0.55 (95% confidence interval 0.43, 0.66]) and specificity of 0.87 (95% confidence interval 0.82, 0.91) for extracapsular extension detection in PCa. CONCLUSION: First, our meta-analysis shows moderate sensitivity and high specificity for mpMRI to differentiate ECE from organ-confined prostate cancer before surgery. Second, our meta-analysis shows that mpMRI had no significant differences in performance compared with the former meta-analysis with use of T2WI alone or with additional functional MRI. ADVANCES IN KNOWLEDGE: It is the first meta-analysis to evaluate the accuracy of mpMRI in combination of TWI, diffusion-weighted imaging and dynamiccontrast-enhanced-MRI for extracapsular extension detection.

20.
Chemosphere ; 241: 125005, 2019 Sep 28.
Artigo em Inglês | MEDLINE | ID: mdl-31605994

RESUMO

Iron dipicolinamide (Fedpa), as an efficient Fenton-like catalyst, was fabricated to excite hydrogen peroxide (H2O2) for the removal of 2,4-dichlorophenol (2,4-DCP). The unique structures and the electronic properties of Fedpa were contributed to its excellent catalytic performance in alkaline Fenton process. Fe was chelated with dpa by four Fe-N bonds leaved two labile sites, which reduced the oxidation potential of dpa[FeIII/FeII], dpa[FeV/FeIII] or dpa[FeIV/FeII] to 0.316 V and 1.189 V respectively, and made it easily be bound with H2O2 to initiate the reaction. The results showed that 99.5% removal rate of 2,4-DCP (0.58 mM) was achieved by using 0.027 g/L Fedpa and 5.8 mM H2O2 in 60 min at pH 9.9. The coordination between Fe and dpa enhanced the catalytic efficiency of FeII. The active species generated in Fedpa/H2O2 system contained the iron-oxo species (dpaFeV = O or dpaIV = O), O2- and HO. The iron-oxo species was the main non-radical reactive species for the degradation of 2,4-DCP and some degradation intermediates were detected by GC-QTOF. Furthermore, the influence of factors, such as Fedpa loading, solution pH, temperature and anions (F-, Cl-, SO42-, NO3- and PO43-) on the catalytic performance of Fedpa were also discussed. This process of complexation between Fe and dpa combined with a green oxidant H2O2 presents a new insight for the use of Fenton-like system in the degradation of refractory organics.

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