Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 102
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Artigo em Inglês | MEDLINE | ID: mdl-32060687

RESUMO

Adjuvant cytokine-induced killer (CIK) cell immunotherapy has shown potential in improving the prognosis of hepatocellular carcinoma (HCC) patients after curative resection. However, whether an individual could obtain survival benefit from CIK cell treatment remains unknown. In the present study, we focused on the characteristics of CIK cells and aimed to identify the best predictive biomarker for adjuvant CIK cell treatment in patients with HCC after surgery. This study included 48 patients with HCC treated with postoperative adjuvant CIK cell immunotherapy. The phenotype activity and cytotoxic activity of CIK cells were determined by flow cytometry and xCELLigence™ Real-Time Cell Analysis (RTCA) system, respectively. Correlation analysis revealed that the cytotoxic activity of CIK cells was significantly negative correlated with the percentage of CD3+ CD4+ cell subsets, but significantly positive correlated with CD3-CD56+ and CD3+ CD56+ cell subsets. Survival analysis showed that there were no significant associations between patients' prognosis and the phenotype of CIK cells. By contrast, there was statistically significant improvement in recurrence-free survival (RFS) and overall survival (OS) for patients with high cytotoxic activity of CIK cells as compared with those with low cytotoxic activity of CIK cells. Univariate and multivariate analyses indicated that CIK cell cytotoxicity was an independent prognostic factor for RFS and OS. In conclusion, a high cytotoxic activity of CIK cells can serve as a valuable biomarker for adjuvant CIK cell immunotherapy of HCC patients after surgery.

2.
Reprod Biol Endocrinol ; 18(1): 1, 2020 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-31924215

RESUMO

BACKGROUND: Controlled ovarian stimulation (COS) has a negative effect on the endometrial receptivity compared with natural menstrual cycle. Whether it's necessary to postpone the first frozen embryo transfer (FET) following a freeze-all strategy in order to avoid any residual effect on endometrial receptivity consequent to COS was inconclusive. OBJECTIVE: The purpose of this retrospective study was to explore whether the delayed FET improve the live birth rate and neonatal outcomes stratified by COS protocols after a freeze-all strategy. METHODS: A total of 4404 patients who underwent the first FET cycle were enrolled in this study between April 2014 to December 2017, and were divided into immediate (within the first menstrual cycle following withdrawal bleeding) or delayed FET (waiting for at least one menstrual cycle and the transferred embryos were cryopreserved for less than 6 months). Furthermore, each group was further divided into two subgroups according to COS protocols, and the pregnancy and neonatal outcomes were analyzed between the immediate and delayed FET following the same COS protocol. RESULTS: When FET cycles following the same COS protocol, there was no significant difference regarding the rates of live birth, implantation, clinical pregnancy, multiple pregnancy, early miscarriage, premature birth and stillbirth between immediate and delayed FET groups. Similarly, no significant differences were found for the mean gestational age, the mean birth weight, and rates of low birth weight and very low birth weight between the immediate and delayed FET groups. The sex ratio (male/female) and the congenital anomalies rate also did not differ significantly between the two FET groups stratified by COS protocols. CONCLUSION: Regardless of COS protocols, FET could be performed immediately after a freeze-all strategy for delaying FET failed to improve reproductive and neonatal outcomes.

3.
Arch Gynecol Obstet ; 2020 Jan 04.
Artigo em Inglês | MEDLINE | ID: mdl-31903500

RESUMO

PURPOSE: To identify the optimal time for the frozen embryo transfer (FET) after oocyte retrieval in freeze-all cycles. METHODS: A retrospective analysis of 977 patients was performed. Implantation, clinical pregnancy and live birth rates were analyzed. RESULTS: No significant difference was found between the first FET performed in the first menstrual cycle group and performed within the subsequent menstrual cycle group in terms of implantation, pregnancy and live birth rates. To rule out the effect of endometrial thickness, a hierarchical analysis was performed. There were no differences between groups for pregnancy, multiple pregnancy and live birth rates for all ranges of endometrial thickness. CONCLUSIONS: The first FET should be performed once the endometrial thickness has been prepared well rather than delaying until the subsequent menstrual cycles.

4.
Ecology ; 100(11): e02828, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31323118

RESUMO

Elucidating the variation of allocation pattern of ecosystem net primary productivity (NPP) and its underlying mechanisms is critically important for understanding the changes of aboveground and belowground ecosystem functions. Under optimal partitioning theory, plants should allocate more NPP to the organ that acquires the most limiting resource, and this expectation has been widely used to explain and predict NPP allocation under changing precipitation. However, confirmatory evidence for this theory has mostly come from observed spatial variation in the relationship between precipitation and NPP allocation across ecosystems, rather than directly from the influences of changing precipitation on NPP allocation within systems. We performed a 6-yr five-level precipitation manipulation experiment in a semiarid steppe to test whether changes in NPP allocation can be explained by the optimal partitioning theory, and how water requirement of plant community is maintained if NPP allocation is unaltered. The 30 precipitation levels (5 levels × 6 yr) were divided into dry, nominal, and wet precipitation ranges, relative to historical precipitation variation over the past six decades. We found that NPP in both aboveground (ANPP) and belowground (BNPP) increased nonlinearly as precipitation increased, while the allocation of NPP to BNPP (fBNPP ) showed a concave quadratic relationship with precipitation. The declined fBNPP as precipitation increased in the dry range supported the optimal partitioning theory. However, in the nominal range, NPP allocation was not influenced by the changed precipitation; instead, BNPP was distributed more in the surface soil horizon (0-10 cm) as precipitation increased, and conversely more in the deeper soil layers (10-30 cm) as precipitation decreased. This response in root foraging appears to be a strategy to satisfy plant water requirements and partially explains the stable NPP allocation patterns. Overall, our results suggest that plants can adjust their vertical BNPP distribution in response to drought stress, and that only under extreme drought does the optimal partitioning theory strictly apply, highlighting the context dependency of the adaption and growth of plants under changing precipitation.


Assuntos
Ecossistema , Chuva , Biomassa , Plantas , Solo
5.
Hum Mutat ; 40(12): 2221-2229, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31286593

RESUMO

Hemoglobinopathies are the most common monogenic disorders worldwide. Substantial effort has been made to establish databases to record complete mutation spectra causing or modifying this group of diseases. We present a variant database which couples an online auxiliary diagnosis and at-risk assessment system for hemoglobinopathies (DASH). The database was integrated into the Leiden Open Variation Database (LOVD), in which we included all reported variants focusing on a Chinese population by literature peer review-curation and existing databases, such as HbVar and IthaGenes. In addition, comprehensive mutation data generated by high-throughput sequencing of 2,087 hemoglobinopathy patients and 20,222 general individuals from southern China were also incorporated into the database. These sequencing data enabled us to observe disease-causing and modifier variants responsible for hemoglobinopathies in bulk. Currently, 371 unique variants have been recorded; 265 of 371 were described as disease-causing variants, whereas 106 were defined as modifier variants, including 34 functional variants identified by a quantitative trait association study of this high-throughput sequencing data. Due to the availability of a comprehensive phenotype-genotype data set, DASH has been established to automatically provide accurate suggestions on diagnosis and genetic counseling of hemoglobinopathies. LOVD-DASH will inspire us to deal with clinical genotyping and molecular screening for other Mendelian disorders.

6.
Med Sci Monit ; 25: 5375-5388, 2019 Jul 20.
Artigo em Inglês | MEDLINE | ID: mdl-31325292

RESUMO

BACKGROUND Oxymatrine (OMT), a quinolizidine alkaloid derived from the traditional Chinese herb Radix Sophorae flavescentis, has widely reported pharmacological efficacy in treating cardiovascular dysfunction-related diseases. However, the underlying mechanism has been unclear. Here, we investigated the potential inhibitory effects and mechanism of OMT on transdifferentiation of cardiac fibroblast to myofibroblasts induced by aldosterone in vitro. MATERIAL AND METHODS The cardiac fibroblasts (CFBs) proliferation and migration capacity were evaluated by MTT assay, cell cycle assay, and scratch analysis, respectively. The protein expression of the Nrf2/Keap1 signal pathway, FN, Collagen I, Collagen III, alpha-SMA, CTGF, and mineralocorticoid receptor (MR) protein was detected by Western blot analysis. The mRNA expression of Nrf2 was detected by qRT-PCR. Immunofluorescence staining was used to observe the expression of alpha-SMA protein. Nrf2 siRNA was used to explore the role of Nrf2 in OMT-treated CFBs. GSH, SOD, and MDA levels and hydroxyproline content were measured by colorimetric assay with commercial kits. The DCFH-DA fluorescent probe was used to assess cellular ROS levels. RESULTS OMT and Curcumin (an Nrf2 agonist) attenuated aldosterone (ALD)-induced proliferation and migration in CFBs, as well as the fibrosis-associated protein expression levels. Moreover, OMT activated Nrf2 and promoted the nucleus translocation of Nrf2. OMT alleviated the elevated levels of alpha-SMA, Collagen I, Collagen III, and CTGF, which were abrogated by the Nrf2 siRNA transfection. We also found that OMT decreased oxidative stress levels. CONCLUSIONS Our results confirm that OMT alleviates transdifferentiation of cardiac fibroblasts to myofibroblasts induced by aldosterone via activating the Nrf2/Keap1 pathway in vitro.

7.
Hemoglobin ; 43(1): 7-11, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31084366

RESUMO

Hemoglobinopathies are caused by genetic defects on the globin genes. To date, more than 900 ß-globin variants have been recorded worldwide. These gene alterations often cause either a decrease in ß-globin synthesis or completely block synthesis, leading to a hemoglobinopathy. While most of these causative mutations are inherited, de novo mutations are quite rare. Here, we investigated three hemoglobinopathy cases. These patients developed severe hemolytic anemia at 3-5 months of age and were transfusion-dependent. In patient 1, a novel ß variant, Hb Zunyi [ß147(HC3)Stop→Gln; HBB: c.442T>C] was identified. This de novo mutation results in a stop codon substitution to a glutamine residue at codon 147 of the ß-globin gene, and leads to severe thalassemia. In patient 2, we discovered the rare Hb Southampton mutation [ß106(G8)Leu→Pro; HBB: c.320T>C], while in patient 3, the rare Hb Alesha mutation [ß67(E11)Val→Met (GTG>ATG); HBB: c.202G>A] was detected. The identification of the novel ß variant, Hb Zunyi, has added to the human globin database and will shed light on future diagnosis of hemoglobinopathy/thalassemia and genetic counseling.


Assuntos
Substituição de Aminoácidos , Hemoglobinas Anormais/genética , Mutação , Globinas beta/genética , Talassemia beta/diagnóstico , Talassemia beta/genética , Alelos , Sequência de Aminoácidos , Biomarcadores , Criança , Pré-Escolar , Códon , Análise Mutacional de DNA , Índices de Eritrócitos , Genótipo , Humanos , Masculino , Fenótipo , Índice de Gravidade de Doença
8.
J Clin Lab Anal ; 33(4): e22845, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30809867

RESUMO

OBJECTIVES: Thalassemia is a highly prevalent monogenic inherited disease in southern China. It is important to collect epidemiological data comprehensively for proper prevention and treatment. METHODS: In this study, blood samples collected from 15 807 residents of Chenzhou were primarily screened by hematological tests. A total of 3973 samples of suspected thalassemia carriers were further characterized by combined next-generation sequencing (NGS) and Gap-PCR. RESULTS: In total, 1704 subjects were diagnosed as thalassemia carriers with a total prevalence rate of 10.78%, including 943 α-thalassemia carriers, 708 ß-thalassemia carriers, and 53 composite α and ß-thalassemia carriers. The prevalence rates of α-thalassemia, ß-thalassemia, and composite α and ß-thalassemia were 5.97%, 4.48%, and 0.34%, respectively. Meanwhile, we characterized 19 α-thalassemia variations and 21 ß-thalassemia variations in thalassemia carriers. Approximately 2.88% of thalassemia carriers would be missed by traditional genetic analysis. In addition, four novel thalassemia mutations and one novel abnormal hemoglobin mutation were identified. CONCLUSIONS: Our data suggest a high prevalence of thalassemia and a diverse spectrum of thalassemia-associated variations in Chenzhou. Also, combined NGS and Gap-PCR is an effective thalassemia screening method. Our findings might be helpful for prevention and treatment of thalassemia in this region.


Assuntos
Talassemia alfa/epidemiologia , Talassemia alfa/genética , Talassemia beta/epidemiologia , Talassemia beta/genética , Adolescente , Adulto , Criança , Pré-Escolar , China/epidemiologia , Feminino , Triagem de Portadores Genéticos , Hemoglobinas Anormais/genética , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Epidemiologia Molecular , Mutação , Reação em Cadeia da Polimerase/métodos , Adulto Jovem
9.
Dermatology ; 234(3-4): 105-111, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30041183

RESUMO

BACKGROUND: No optimal regimen exists for the LPNYL (long-pulsed 1,064-nm neodymium:yttrium-aluminum-garnet laser) for treating onychomycosis. OBJECTIVE: To establish an optimal LPNYL treatment regimen for onychomycosis caused by Trichophyton rubrum (OCTr). PATIENTS AND METHODS: First, 511 infected nails of 177 patients were treated using LPNYL with orthogonally designed regimens according to various energy densities, spot sizes, pulse widths, and treatment times. The optimal treatment regimen was established by multivariate analysis. Next, 69 patients with 221 infected nails were randomized to receive oral itraconazole (drug group) and the optimal regimen of LPNYL treatment (laser group). The clinical efficacy (CE) and mycological efficacy (ME) were evaluated at 6 and 12 months following the start of treatment, and adverse reactions were recorded in both groups. RESULTS: Both CE and ME were significantly correlated with the energy density (p < 0.05) and treatment times (p < 0.05), but not with the spot size (0.071 < p < 0.083) or pulse width (0.051 < p < 0.060), at 6 or 12 months. There were no significant differences at 6 or 12 months (p > 0.05), and no significant difference was observed in CE at 12 months between the two groups (p > 0.05). At 6 months, the CE in the laser group was significantly higher than that in the drug group (p < 0.001). CONCLUSIONS: LPNYL is effective and safe for treating OCTr. The energy density and treatment times are the main factors that affect the efficacy. The optimal regimen for LPNYL is an energy density of 45 J/cm2, pulse width of 35 ms, spot size of 4 mm, frequency of 1 Hz, and 6 treatments with 1-week intervals. Laser treatment has rapid clinical recovery.


Assuntos
Dermatoses do Pé/radioterapia , Lasers de Estado Sólido/uso terapêutico , Terapia com Luz de Baixa Intensidade/métodos , Onicomicose/radioterapia , Trichophyton/isolamento & purificação , Adolescente , Adulto , Antifúngicos/uso terapêutico , Feminino , Humanos , Itraconazol/uso terapêutico , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento , Adulto Jovem
10.
Comput Intell Neurosci ; 2018: 1838639, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29955226

RESUMO

The knowledge characteristics weighting plays an extremely important role in effectively and accurately classifying knowledge. Most of the existing characteristics weighting methods always rely heavily on the experts' a priori knowledge, while rough set weighting method does not rely on experts' a priori knowledge and can meet the need of objectivity. However, the current rough set weighting methods could not obtain a balanced redundant characteristic set. Too much redundancy might cause inaccuracy, and less redundancy might cause ineffectiveness. In this paper, a new method based on rough set and knowledge granulation theories is proposed to ascertain the characteristics weight. Experimental results on several UCI data sets demonstrate that the weighting method can effectively avoid subjective arbitrariness and avoid taking the nonredundant characteristics as redundant characteristics.


Assuntos
Armazenamento e Recuperação da Informação/métodos , Diabetes Mellitus/fisiopatologia , Humanos , Teoria da Informação , Conhecimento , Análise de Componente Principal
11.
Fertil Steril ; 109(6): 1044-1050, 2018 06.
Artigo em Inglês | MEDLINE | ID: mdl-29871792

RESUMO

OBJECTIVE: To identify the incidence and risk factors associated with IVF-conceived monozygotic twinning (MZT). DESIGN: Retrospective study. SETTING: Academic hospital. PATIENT(S): A total of 3,463 women with clinical pregnancies between January 2014 and February 2015 were analyzed. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The measures were the incidence of MZT based on the number of embryos that were replaced, type of insemination method (conventional IVF or intracytoplasmic sperm injection [ICSI]), with or without the use of assisted hatching (AH), and day of embryo transferred in fresh and frozen cycles. RESULT(S): Ninety-three women (2.69%) with MZT were observed. No statistically significant differences were observed in the cycle parameters of fresh or frozen cycles between MZT and other non-MZT pregnancies. Specific IVF procedures or techniques, such as the number of embryo replaced, zona pellucida manipulation (ICSI and AH), and freeze-thaw procedure, did not significantly increase the rate of MZT, except for the day of embryo transferred. Compared with day 3 transferred, day 4 and 5/6 transferred showed an increased probability of MZT (odds ratio [OR], 2.73; 95% confidence interval [CI], 1.16-6.42 for day 4 transferred and OR, 3.68; 95% CI, 2.29-5.93 for day 5/6 transferred). CONCLUSION(S): Extended culture (advanced embryo stage) in fresh and frozen cycles appeared to be associated with increased rates of MZT. The effect of the number of embryos transferred, ICSI and AH, and freeze-thaw procedures on the risk for MZT was not demonstrated.


Assuntos
Criopreservação/métodos , Técnicas de Cultura Embrionária/métodos , Gravidez de Gêmeos/estatística & dados numéricos , Técnicas de Reprodução Assistida/estatística & dados numéricos , Gemelaridade Monozigótica , Zona Pelúcida/patologia , Adulto , Técnicas de Cultura Embrionária/estatística & dados numéricos , Transferência Embrionária/métodos , Transferência Embrionária/estatística & dados numéricos , Feminino , Congelamento , Humanos , Incidência , Recém-Nascido , Gravidez , Estudos Retrospectivos , Injeções de Esperma Intracitoplásmicas/métodos , Injeções de Esperma Intracitoplásmicas/estatística & dados numéricos , Fatores de Tempo
12.
Reprod Biol Endocrinol ; 16(1): 36, 2018 Apr 10.
Artigo em Inglês | MEDLINE | ID: mdl-29636081

RESUMO

BACKGROUND: Overweight/obese women with polycystic ovary syndrome (PCOS) are at increased risk of subfertility and complications of pregnancy, compared with normal-weight women. To implement controlled ovarian hyperstimulation (COH), the improved efficacy of the gonadotrophin-releasing hormone antagonist (GnRH-ant) protocol has been demonstrated, as well as frozen embryo transfer (FET). OBJECTIVE: This retrospective study evaluated the pregnancy outcomes after combined GnRH-ant protocol and FET in overweight/obese women with PCOS, with reference to that of normal-weight women with PCOS. METHODS: Women with PCOS (n = 398) who underwent the GnRH-ant protocol for COH followed by FET, were stratified as normal-weight (BMI < 24 kg/m2) or overweight/obese (BMI ≥24 kg/m2). The outcomes of pregnancy were compared. RESULTS: The overweight/obese patients had significantly lower rates of embryo implantation (47.7%), live birth (47.8%), and live births of twins (10.9%) compared with the normal-weight group (58.4%, 60.8%, and 30.0%, respectively; P = 0.006, 0.015, and 0.000), while the rate of late abortion was significantly higher (11.0% cf. 3.8%, P = 0.030). BMI was the only significant factor affecting the probability of live birth. CONCLUSION: The pregnancy outcomes of overweight/obese women with PCOS after COH via the GnRH-ant protocol and FET remained at a significant deficit compared with that of normal-weight women with PCOS.


Assuntos
Transferência Embrionária , Obesidade/complicações , Indução da Ovulação , Resultado da Gravidez , Feminino , Hormônio Liberador de Gonadotropina/antagonistas & inibidores , Humanos , Sobrepeso , Gravidez , Estudos Retrospectivos
13.
Proc Natl Acad Sci U S A ; 115(16): 4027-4032, 2018 04 17.
Artigo em Inglês | MEDLINE | ID: mdl-29666315

RESUMO

Despite evidence from experimental grasslands that plant diversity increases biomass production and soil organic carbon (SOC) storage, it remains unclear whether this is true in natural ecosystems, especially under climatic variations and human disturbances. Based on field observations from 6,098 forest, shrubland, and grassland sites across China and predictions from an integrative model combining multiple theories, we systematically examined the direct effects of climate, soils, and human impacts on SOC storage versus the indirect effects mediated by species richness (SR), aboveground net primary productivity (ANPP), and belowground biomass (BB). We found that favorable climates (high temperature and precipitation) had a consistent negative effect on SOC storage in forests and shrublands, but not in grasslands. Climate favorability, particularly high precipitation, was associated with both higher SR and higher BB, which had consistent positive effects on SOC storage, thus offsetting the direct negative effect of favorable climate on SOC. The indirect effects of climate on SOC storage depended on the relationships of SR with ANPP and BB, which were consistently positive in all biome types. In addition, human disturbance and soil pH had both direct and indirect effects on SOC storage, with the indirect effects mediated by changes in SR, ANPP, and BB. High soil pH had a consistently negative effect on SOC storage. Our findings have important implications for improving global carbon cycling models and ecosystem management: Maintaining high levels of diversity can enhance soil carbon sequestration and help sustain the benefits of plant diversity and productivity.


Assuntos
Biodiversidade , Sequestro de Carbono , Carbono/análise , Ecossistema , Plantas/metabolismo , Solo/química , Biomassa , China , Conservação dos Recursos Naturais , Conjuntos de Dados como Assunto , Fazendas , Florestas , Pradaria , Atividades Humanas , Humanos , Concentração de Íons de Hidrogênio , Nitrogênio/análise , Dispersão Vegetal , Plantas/química , Plantas/classificação , Chuva , Temperatura Ambiente
14.
Sci Total Environ ; 635: 423-431, 2018 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-29677668

RESUMO

Soil is the largest organic carbon (C) pool in terrestrial ecosystems. Periodic changes in environmental temperature occur diurnally and seasonally; yet, the response of soil organic matter (SOM) decomposition to varying temperatures remains unclear. In this study, we conducted a modified incubation experiment using soils from 16 forest ecosystems in China with periodically and continuously varying incubation temperature to investigate how heterotrophic respiration (Rh) responds to different temperature patterns (both warming and cooling temperature ranging between 5 and 30°C). Our results showed a pronounced asymmetric response of Rh to temperature warming and cooling among the soils of all forest ecosystems, with Rh increasing more rapidly during the warming phase compared to the cooling phase. This asymmetric response of Rh to warming and cooling temperatures was widespread in all soils. In addition, the amplitude of this asymmetric response differed among different forest ecosystems, with subtropical and warm-temperate forest ecosystems exhibiting greater asymmetric responses. Path analyses showed that soil pH and the microbial community explained most of the variation in this asymmetric response. Furthermore, the widespread asymmetric response of Rh to warming and cooling temperatures suggests that accumulated SOM decomposition might be overestimated on average by 20% for warming alone when compared with admix warming and cooling. These findings provide new insights on the responses of Rh to natural shifts in temperature, emphasizing the need to consider this widespread asymmetric response of Rh to warming and cooling phases to predict C-climate feedback with great accuracy, especially under future non-uniform warming scenarios.

17.
World Neurosurg ; 105: 115-121, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28578110

RESUMO

OBJECTIVE: Recurrent chronic subdural hematoma (CSDH) is not rare. Some studies have demonstrated the role of dexamethasone in the medical management of chronic subdural hematoma. However, no systematic study in the treatment of recurrent CSDH has been published. The aim of our study is to evaluate the efficacy and safety of dexamethasone in patients with recurrent CSDH. METHODS: We retrospectively reviewed medical records of consecutive patients from July 2010 to September 2014. A total of 27 patients with symptomatic recurrent CSDH were included in the analysis. Follow-up for each patient consisted of computed tomography or magnetic resonance imaging every 28 days from admission to the resolution of hematoma. Data were collected on hematoma volume, complications, and outcome. RESULTS: Among the 27 patients, 3 patients with recurrent CSDH were only treated by burr hole surgery. Of the other 24 patients who primarily underwent dexamethasone treatment, 17 (70.8%) patients were treated successfully with medical treatment, whereas 7 patients required reoperation. Complications were noted in 3 (12.5%) patients (1 hyperglycemia, 1 urinary tract infection, and 1 pneumonia). There was 1 mortality (4.2%) for massive brain infarction. Twenty-one of the 24 patients (87.5%) recovered to their previous functional levels. There was no statistical significance in Fisher text between surgery and dexamethasone regarding success, complication, and functional recovery rate. CONCLUSIONS: Patients with recurrent CSDH can be treated successfully and safely with the nonsurgical medical treatment of dexamethasone. By use of this method, reoperation may be avoided.


Assuntos
Dexametasona/uso terapêutico , Hematoma Subdural Crônico/tratamento farmacológico , Adulto , Idoso , Idoso de 80 Anos ou mais , Dexametasona/efeitos adversos , Feminino , Hematoma Subdural Crônico/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva , Reoperação/métodos , Estudos Retrospectivos , Prevenção Secundária , Tomografia Computadorizada por Raios X/efeitos adversos , Resultado do Tratamento
18.
PLoS One ; 12(5): e0176359, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28472050

RESUMO

Since chaos systems generally have the intrinsic properties of sensitivity to initial conditions, topological mixing and density of periodic orbits, they may tactfully use the chaotic ergodic orbits to achieve the global optimum or their better approximation to given cost functions with high probability. During the past decade, they have increasingly received much attention from academic community and industry society throughout the world. To improve the performance of particle swarm optimization (PSO), we herein propose a chaotic proportional integral derivative (PID) controlling PSO algorithm by the hybridization of chaotic logistic dynamics and hierarchical inertia weight. The hierarchical inertia weight coefficients are determined in accordance with the present fitness values of the local best positions so as to adaptively expand the particles' search space. Moreover, the chaotic logistic map is not only used in the substitution of the two random parameters affecting the convergence behavior, but also used in the chaotic local search for the global best position so as to easily avoid the particles' premature behaviors via the whole search space. Thereafter, the convergent analysis of chaotic PID controlling PSO is under deep investigation. Empirical simulation results demonstrate that compared with other several chaotic PSO algorithms like chaotic PSO with the logistic map, chaotic PSO with the tent map and chaotic catfish PSO with the logistic map, chaotic PID controlling PSO exhibits much better search efficiency and quality when solving the optimization problems. Additionally, the parameter estimation of a nonlinear dynamic system also further clarifies its superiority to chaotic catfish PSO, genetic algorithm (GA) and PSO.


Assuntos
Modelos Teóricos , Dinâmica não Linear , Algoritmos , Pesquisa Empírica
19.
20.
Medicine (Baltimore) ; 96(13): e6495, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-28353597

RESUMO

The predictive value of anti-Müllerian hormone (AMH) in Chinese women undergoing in vitro fertilization (IVF) treatment is data deficient. To determine the attributes of AMH in IVF, oocyte yield, cycle cancellation, and pregnancy outcomes were analyzed. All patients initiating their first IVF cycle with gonadotropin-releasing hormone agonist treatment in our center from October 2013 through December 2014 were included, except patients diagnosed with polycystic ovarian syndrome. Serum samples collected prior to IVF treatment were used to determine serum AMH levels. A total of 4017 continuous cycles were analyzed. The AMH level was positively correlated with the number of oocytes retrieved. Overall, AMH was significantly correlated with risk of cycle cancellation, poor ovarian response (POR, 3, or fewer oocytes retrieved) and high response (>15 oocytes), with an area under the curve (AUC) of 0.83, 0.89, and 0.82 respectively. An AMH cutoff of 0.6 ng/mL had a sensitivity of 54.0% and a specificity of 90.0% for the prediction of cycle cancellation, and cutoff of 0.8 ng/mL with a sensitivity of 55.0% and a specificity of 94.0% for the prediction of POR. Compared with AMH >2.0 ng/mL, patients with AMH < 0.6 ng/mL had a 53.6-fold increased risk of cancellation (P < 0.001), and AMH <0.80 ng/mL were 17.5 times more likely to experience POR (P < 0.001). However, AMH was less predictive of pregnancy and live birth, with AUCs of 0.55 and 0.53, respectively. Clinical pregnancy rate, ongoing pregnancy rate, and live birth rate per retrieval according to the AMH level (≤0.40, 0.41-0.60, 0.61-0.80, 0.81-1.00, 1.01-1.50, 1.51-2.00, and >2.00 ng/mL) showed no significant differences. Even with AMH≤0.4 ng/mL, 50.0% of all the patients achieved pregnancy and 34.8% of patients achieved live birth after transfer. Our results suggested that AMH is a fairly robust metric for the prediction of cycle cancellation and oocyte yield for Chinese women, but it is a relatively poor test for prediction of pregnancy outcomes. Patients with low levels of AMH still can achieve reasonable treatment outcomes and low AMH levels in isolation do not represent an appropriate marker for withholding fertility treatment.


Assuntos
Hormônio Antimülleriano/sangue , Hormônio Foliculoestimulante/sangue , Indução da Ovulação/estatística & dados numéricos , Adulto , Feminino , Fertilização In Vitro , Humanos , Idade Materna , Gravidez , Taxa de Gravidez , Estudos Retrospectivos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA