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1.
Chemistry ; 24(8): 1998-2003, 2018 Feb 06.
Artigo em Inglês | MEDLINE | ID: mdl-29243864

RESUMO

The largest known polyoxometalate (POM)-templated silver-alkynyl cluster, [(EuW10 O36 )2 @Ag72 (tBuC≡C)48 Cl2 ⋅4 BF4 ] (SD/Ag20), was isolated under solvothermal conditions and structurally characterized. It was confirmed by single-crystal X-ray diffraction (SCXRD) as a {EuW10 }2 -in-{Ag72 } clusters-in-cluster rod-like compound. The high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) shows that such a double anion-templated cluster is assembled from a crucial single anion-templated Ag42 intermediate in the solution. The crystallization of Ag42 species (SD/Ag21), followed by SCXRD, gave an important clue about the assembly route of SD/Ag20 in solution: the Ag42 cluster eliminates six silver atoms laterally, then fuses together at the vacant face to form the final Ag72 cluster (elimination-fusion mechanism). The characteristic emission of [EuW10 O36 ]9- is well maintained in SD/Ag20. This work not only provides a new method for the synthesis of larger silver clusters as well as the functional integration of the silver cluster and POMs, but also gives deep insights about the high-nuclear silver cluster assembly mechanism.

2.
Dalton Trans ; 43(43): 16515-21, 2014 Nov 21.
Artigo em Inglês | MEDLINE | ID: mdl-25260091

RESUMO

Two new metal-organic frameworks (1-2) were ionothermally obtained by the reaction of a biphenyltetracarboxylic sodium (Na4BPTC) ligand and M(OOCCH3)2 (M = Co(1) and Mn(2)). Crystal structure analysis reveals that 1 is a Co3Na6 unit-based three dimensional heterometallic MOF, while 2 exhibits a {Mn(COO)n} chain-based three-dimensional framework. Furthermore, the magnetic measurement shows that both of them have anti-ferromagnetic properties. A combination of Density Functional Theory (DFT) and Quantum Monte Carlo (QMC) simulation uncovers that in 2 the coupling parameters between two adjacent Mn(II) ions are J1 = -2.0 cm(-1) and J2 = -1.6 cm(-1), and the magnetism mainly originates from the propagation of Mn(II) ions by the super-exchange of carboxylates. Interestingly, the superexchange modes of J1 and J2 are different. Two spin nets of -/+/- dominate in the coupling for J1, while for J2 there are two spin nets of -/+/- and one spin net of +/-/+.

3.
Acta Crystallogr C ; 69(Pt 1): 5-7, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23282902

RESUMO

In the title metal-organic framework (MOF), [La(C(8)H(8)N(2)O(6))(C(2)O(4))(0.5)(H(2)O)](n), the La(III) cation is coordinated by eight O atoms in a square antiprismatic configuration. Each La(III) cation is connected to adjacent La(III) cations by bridging 2,5-dioxopiperazine-1,4-diacetate (PODC(2-)) and oxalate (lying about an inversion centre) ligands, generating two-dimensional grid layers. The layers are further linked via the carboxylate groups of the PODC(2-) ligands in syn-syn and syn-anti modes, resulting in a three-dimensional framework with a short Schläfli vertex notation of {4(7).6(3)}{4(7).6(7).8}.

4.
Int J Med Mushrooms ; 13(1): 51-60, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-22135904

RESUMO

This study examines the effects of various fructose concentrations in media on the production and quality of bioactive exopolysaccharides (EPS) from Bitter medicinal mushroom, Antrodia camphorata in submerged cultures. The fructose in media of submerged cultures of A. camphorata significantly affected the production, average molecular weight (Mn), and antioxidant activity of exopolysaccharides. The specific growth rate decreased monotonically from 0.33 to 0.25 1/day as the fructose concentration increased from 10 to 60 g/L; however, maximum production and productivity for EPS increased from 75.23 to 164.87 mg/L and 6.27 to 9.70 mg/L/day, respectively. In addition, the fed-batch culture used in this study significantly improved the production of EPS (2.43-fold enhancement, from 75.23 to 182.99 mg/L), number average molecular weights of EPS (1.47-fold enhancement, from 5.44 x 10, to 7.98 x 10(5) Da), protein/exopolysaccharide ratios (1.63-fold enhancement, from 16% to 26%), and antioxidant activity of EPS (1.32-fold enhancement, from 60% to 79%), as compared with corresponding properties of batch fermentation at 10 g/L fructose in an air-lift bioreactor. The antioxidant activity of EPS was highly correlated with number average molecular weights (R2 = 0.90) and protein/exopolysaccharide ratios (R2 = 0.96). The positive results of this research have successfully verified the promotion efficiency on the production and quality of EPS from the medicinal mushroom A. camphorata.


Assuntos
Antrodia/metabolismo , Carbono/metabolismo , Meios de Cultura/química , Microbiologia Industrial/métodos , Polissacarídeos/biossíntese , Antioxidantes/metabolismo , Antrodia/química , Antrodia/crescimento & desenvolvimento , Técnicas de Cultura Celular por Lotes , Biomassa , Reatores Biológicos , Fermentação , Frutose/metabolismo , Peso Molecular , Polissacarídeos/química , Polissacarídeos/isolamento & purificação , Temperatura
5.
Chem Commun (Camb) ; 47(43): 11933-5, 2011 Nov 21.
Artigo em Inglês | MEDLINE | ID: mdl-21975950

RESUMO

A 3D metal-organic framework, featuring three kinds of cation channels, was obtained through an ionothermal reaction. Investigation on its temperature-dependent conductivity indicates the contribution of order and disorder of the Emim(+) (Emim(+) = 1-ethyl-3-methyl imidazolium bromide) in the channel to its conductivity.

6.
Dalton Trans ; 40(39): 10237-41, 2011 Oct 21.
Artigo em Inglês | MEDLINE | ID: mdl-21894331

RESUMO

Three metal-organic frameworks, [M(3)(ip)(4)][EMIm](2) (M = Co 1, Ni 2, Mn 3, H(2)ip = isophthalic acid, EMIm = 1-ethyl-3-methyl imidazolium) were prepared from an ionic liquid medium. All the compounds feature the same (4(24))(6(4)) topology based on linear trinuclear clusters as eight-connected nodes. Compounds 1 and 2 are isostructural, while compound 3 exhibits a different structure due to the slight difference in the arrangement of M(3)(OOCR)(8) SBUs. Magnetic property measurements reveal that all the compounds display anti-ferromagnetic coupling, where compounds 2 and 3 show isotropic exchange interactions of -0.10 cm(-1) for 2 and -1.6 cm(-1) for 3. Investigation of the thermal diffusivity shows that the thermal diffusivity of 1 is higher than that of 3, while that of 3 is higher than that of 2.

7.
Inorg Chem ; 50(9): 3843-5, 2011 May 02.
Artigo em Inglês | MEDLINE | ID: mdl-21456535

RESUMO

Two three-dimensional 2p-3d-4f heterometallic frameworks featuring a nanosized Ln(6)Cu(24)Na(12) (Ln = Gd, Dy) cluster as a node have been obtained under microwave irradiation conditions through the reaction of H(2)ANMA (H(2)ANMA = L-alanine-N-monoacetic acid), Cu(NO(3))(2), and Ln(NO(3))(3) (Ln = Gd for 1, Dy for 2) with NaOH in deionized water. Investigations on the magnetic properties show that 1 exhibits ferrimagnetic behavior. The electrical conductivity measurements reveal that 1 behaves as a proton conductor.

8.
Artigo em Chinês | MEDLINE | ID: mdl-19957658

RESUMO

OBJECTIVE: To prepare a decellularized whole laryngeal scaffold by utilizing a perfusion-decellularized technique, reseed cells on it, and construct decellularized laryngeal muscles. METHODS: Perfusion decellularized larynxes were obtained by common carotid arterious perfusion with detergents. Then they were performed by macroscopic view, histological examination, scanning electron microscopy (SEM) and cartilage viability. Decellularized laryngeal scaffold were then reseeded with inducted mesenchymal stem cells (MSCs). Composites were transferred into greater omentums of rabbits after one day's adherence and harvested after eight weeks. Macroscopic view, histological examination and immunohistochemistry were performed. RESULTS: Perfusion larynxes became transparent after two hours. Histology and SEM indicated that perfusion method showed better decullularized effect. More vintages and collagen fibers but no intact cell or nuclei were retained in the decellularized matrix. Porosity measured by Image pro plus 6.0 was 80.4% +/- 3.2% (x +/- s). Chondrocyte vitality assay indicated chondrocyte vitality rate in the perfusion group was 86.9% +/- 1.5%. After eight weeks, vascularization formed and integrated cartilage frameworks still remained. Histological examination could clearly show the presence of muscle bundles and vessels. Immunohistochemical examination indicated that sarcomeric-alpha actin expressed positively in corresponding areas. CONCLUSIONS: It is feasible to reseed MSCs into the decellularized laryngeal muscle matrix for constructing tissue-engineered laryngeal muscles. This in vivo maturation into the omentum could be the first step before in situ implantation of the construct.


Assuntos
Músculos Laríngeos/fisiologia , Laringe Artificial , Regeneração , Engenharia Tecidual/métodos , Tecidos Suporte , Animais , Matriz Extracelular , Estudos de Viabilidade , Músculos Laríngeos/citologia , Coelhos
9.
Zhonghua Liu Xing Bing Xue Za Zhi ; 30(3): 243-6, 2009 Mar.
Artigo em Chinês | MEDLINE | ID: mdl-19642378

RESUMO

OBJECTIVE: To evaluate the effect of intervention on factors influencing the health service utility regarding Maternal and Child Health (MCH) under the 'Qinba Health Project' in Sichuan province. METHODS: 15 towns in 5 programmed counties were selected, using the method of 'random layer sampling' to be the trial group. With similar MCH status and comparable to the trial group, another 9 towns in 3 non-programmed counties were chosen as the control group, using the same sampling method. Indicators on MCH service utility were compared with that in the control group, and the influencing factors of MCH service utility analyzed by logistic model. RESULTS: The main characteristics of the two groups were quite similar at the baseline study, with the average annual family incomes and MCH service per 1000 people. Annual input on MCH services from the government had an distinct increase. The average annual rates of increase regarding the indicators as clean delivery, hospitalized delivery, systematic care on maternal and children, maternal and infant mortality rates were: 1.95%, 9.34%, 4.82%, 3.04%, -2.67%, -13.84% (P < 0.02) through chi2 trend tests. In the trial group, the changes seen in the 6 indicators were better in the control group than in the control group (P < 0.05). Data from the logistic regression model showed that the major influencing factors on the use of hospitalized delivery service were: age of the pregnant woman, average annual income of the family, health insurance status, number of pre-delivery visits, whether on poverty alleviate program, and on knowledge of MCH. CONCLUSION: The intervention project in this programmed area seemed effective and better than the non-programmed area, through an eight-year observation.


Assuntos
Serviços de Saúde da Criança/estatística & dados numéricos , Serviços de Saúde Materna/estatística & dados numéricos , Serviços de Saúde da Mulher/estatística & dados numéricos , Adulto , Criança , Serviços de Saúde da Criança/economia , Pré-Escolar , China , Feminino , Humanos , Lactente , Recém-Nascido , Modelos Logísticos , Serviços de Saúde Materna/economia , Áreas de Pobreza , Gravidez , Amostragem , Fatores Socioeconômicos , Serviços de Saúde da Mulher/economia
10.
Artigo em Chinês | MEDLINE | ID: mdl-19558883

RESUMO

OBJECTIVE: To explore the treatment of cervical tracheoesophageal fistula (TEF) with complicated or remnant laryngotracheal stenosis (LTS) and anterior neck defect (AND). METHODS: From 1980 to 2007, 14 patients were diagnosed as TEF. Among them, 9 patients had complicated or remnant LTS, 3 patients had complicated AND, and 2 patients had TEF which were induced by Nickel-Titanium alloy mesh stent for treating benign esophageal stricture. All these patients were retrospectively studied in Tangdu Hospital. Treatment consisted of conservative therapy of TEF, staged surgical repair of TEF and laryngotracheal reconstruction according to the dimension (small or large) of TEF and complications. RESULTS: Four patients with small TEF (2 - 3 mm length) complicated LTS underwent laryngotracheal reconstruction stented with silicone T tube and TEF was adopted conservative treatment. The TEF and LTS were healed. Six patients with larger TEF (10 - 25 mm length) were repaired by staged surgical repair of TEF and laryngotracheal reconstruction. Among them, 3 cases had complicated LTS and AND, 2 cases had recent LTS and 1 case had TEF without complication. Two patients had TEF and LTS, whose TEF healed before laryngotracheal reconstruction, the remnant LTS were reconstructed and healed. During the follow-up ranged from one to ten years, 12 patients were successfully treated without complications. One patient with TEF and LTS was treated only LTS because of a segment of esophagus was closed and treated with esophagogastrostomy in the department of thoracic surgery after LTS was successfully reconstructed and cured. One patient died of bleeding and asphyxia induced by the Nickel-Titanium alloy stent because of the stent had not been taken out. CONCLUSION: The small cervical TEF complicated or remnant LTS can be treated by laryngotracheal reconstruction and conservative treatment of TEF at the same time. A larger TEF complicated LTS should be treated by staged repair of TEF and LTS.


Assuntos
Fístula Cutânea/cirurgia , Estenose Esofágica/cirurgia , Fístula Traqueoesofágica/cirurgia , Adolescente , Adulto , Criança , Pré-Escolar , Fístula Cutânea/complicações , Fístula Cutânea/diagnóstico , Estenose Esofágica/complicações , Estenose Esofágica/diagnóstico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fístula Traqueoesofágica/complicações , Fístula Traqueoesofágica/diagnóstico , Resultado do Tratamento , Adulto Jovem
11.
Zhonghua Yi Shi Za Zhi ; 39(6): 338-42, 2009 Nov.
Artigo em Chinês | MEDLINE | ID: mdl-20193441

RESUMO

There was considerable attention paid to the succour of poverty with widespread practice in China's history. Succour of poverty and medical assistance in rural areas were closely connected with famine relief carried out by the rulers. The mutual assistance of emotional and moral support long-term in rural communities is the most important form of medical assistance. A succour of poverty and medical assistance system in the modern sense should inherit and learn from the past consideration of poverty assistance and bring in the fine tradition of multiple forces to participate, in order to establish a succour of poverty and medical assistance system compatible with economic and social development. This is not only an important component of anti-poverty strategy in rural areas but also an inevitable requirement of historical development.


Assuntos
Pobreza , População Rural , China , Humanos , Mudança Social
13.
Sichuan Da Xue Xue Bao Yi Xue Ban ; 39(6): 1007-10, 2008 Nov.
Artigo em Chinês | MEDLINE | ID: mdl-19253848

RESUMO

OBJECTIVES: To evaluate the effectiveness of interventions taken by Qinba Health Project on the Maternal and Child Health (MCH) services in Sichuan province. METHODS: Stratified random sampling was undertaken to select participants for the evaluation. Eighty one villages in 27 towns in the nine project counties and 27 villages in nine towns in three non-project counties with similar social economic backgrounds were selected. A questionnaire survey was undertaken in all of the selected health facilities and 462 women who received maternal services during the project time. Multiple variable regression analysis was performed to identify determinants of the change of services. RESULTS: The project MCH services reached the expected targets. The project towns improved their MCH services more significantly than the non-project towns. The logistic regression analysis identified project intervention, maternal age, average family income, health insurance, numbers of pre-natal examinations, eligibility to poverty alleviation, and knowledge as key determinants of the improvement of MCH services. CONCLUSION: The project intervention is effective in improving MCH services. However, more attentions to poverty alleviation and health promotion need to be paid.


Assuntos
Cuidado da Criança/organização & administração , Serviços de Saúde Materna/organização & administração , Áreas de Pobreza , Cuidado Pré-Natal/organização & administração , Saúde da População Rural , Adolescente , Adulto , Criança , Pré-Escolar , China , Feminino , Humanos , Pessoa de Meia-Idade , Gravidez , Análise de Regressão , Inquéritos e Questionários , Adulto Jovem
14.
Zhonghua Er Bi Yan Hou Ke Za Zhi ; 39(4): 208-10, 2004 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-15283279

RESUMO

OBJECTIVE: To study the effect of anterior and posterior cricoid splitting interposition grafting for severe glottic and subglottic stenosis. METHODS: This is a retrospective study, from 1991 to 2001 years, 25 patients (male 15, female 10, aged 9 to 46 years) with severe glottic and subglottic stenosis were operated with anterior and posterior cricoid splitting interposition grafting method at Tangdu Hospital. All of 25 patients were tracheostomy dependent before reconstruction. 19 patients had previously undergone 1 to 7 (average 2) surgical procedures. The surgical technique consisted of laryngotracheostomy, cricoid lamina midline vertical incision; rib cartilage graft (17 cases), muscular fasciae, perichondrium or split-thickness skin graft (15 cases), pedicle arytenoid cartilage graft (2 cases) and thyroid cartilage graft (1 case) interposition and silicon T-tube stenting for 3 to 6 months. RESULTS: Twenty-four patients (96%) were successfully decannulated and got an effective phonation. One patient failed decannulation. The follow-up period ranged from 1 to 10 years. All of the 24 patients had a stable airway and effective phonation. CONCLUSIONS: The anteroposterior cricoid split interposition graft technique was a safe and effective method for the treatment of severe glottic and subglottic stenosis. Careful split of the cricoid, avoiding injury of esophageal musculature, careful hemostasis, a tight suture graft and using stent were the keys of successful operation.


Assuntos
Cartilagem Cricoide/transplante , Laringoestenose/cirurgia , Adolescente , Adulto , Criança , Cartilagem Cricoide/cirurgia , Feminino , Glote , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Transplante Autólogo
15.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi ; 20(3): 306-9, 2004 May.
Artigo em Chinês | MEDLINE | ID: mdl-15193224

RESUMO

AIM: To investigate the feasibility of human bone marrow mesenchymal stem cells(hMSCs) as the seed cells for bone and cartilage tissue engineering. METHODS: Purified hMSCs were cultured in-vitro and induced to differentiate into osteoblasts and chondrocytes. Cellular morphologies were observed under inverted and electron microscopes. The specific markers of the osteoblasts and chondrocytes were detected by histochemical staining, immunohistochemical staining, and RT-PCR. RESULTS: After the hMSCs were passaged for 15 generations, the choractenistic morphology and cell surface antigens of hMSCs remained unchanged. The level of alkaline phosphatase(ALP) in the culture supernatant of the osteoinduction groups was higher than those in the control groups (P<0.05). The morphology of the cells in the osteoinduction and chondroinduction groups changed from spindle-shaped cells into polygon-shaped cells. A large number of the dilated rough endoplasmic reticulua, Golgi apparatus and mitochondria could be seen under transmission electron microscope. Calcium deposition was detected on the surfaces of the hMSCs after osteoinduction. Collagen(COL)-like processes were detected under scanning electron microscope. The staining of the ALP, calcium nudis, COL-I and osteocalcin(OC) were positive, and expressions of the COL-I and OC mRNAs were detected after osteoinduction. The expression of COL-II was detected by immunohistochemical staining and RT-PCR and a lot of the metachromatic-staining matrix around the cells was observed with toluidine blue staining after chondroinduction. CONCLUSION: hMSCs from human bone marrow can be purified, expanded and differentiated into osteoblasts and chondrocytes in-vitro, providing an alternative source for bone and cartilage tissue engineering.


Assuntos
Células da Medula Óssea/citologia , Condrócitos/citologia , Células-Tronco Mesenquimais/citologia , Osteoblastos/citologia , Fosfatase Alcalina/metabolismo , Ácido Ascórbico/farmacologia , Células da Medula Óssea/ultraestrutura , Cálcio/metabolismo , Diferenciação Celular/efeitos dos fármacos , Divisão Celular/efeitos dos fármacos , Células Cultivadas , Condrócitos/metabolismo , Condrócitos/ultraestrutura , Colágeno Tipo I/biossíntese , Colágeno Tipo I/genética , Colágeno Tipo II/biossíntese , Colágeno Tipo II/genética , Dexametasona/farmacologia , Humanos , Células-Tronco Mesenquimais/ultraestrutura , Osteoblastos/metabolismo , Osteoblastos/ultraestrutura , Osteocalcina/biossíntese , Osteocalcina/genética , RNA Mensageiro/biossíntese , RNA Mensageiro/genética , Engenharia Tecidual , Fator de Crescimento Transformador beta/farmacologia , Fator de Crescimento Transformador beta1
16.
Di Yi Jun Yi Da Xue Xue Bao ; 23(8): 766-9, 773, 2003 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-12919892

RESUMO

OBJECTIVE: To investigate the feasibility of generating cartilage tissues from human bone marrow mesenchymal stem cells (MSCs) cultured and induced in vitro using tissue engineering technique. METHODS: Human bone marrow MSCs were isolated from the ribs of patients receiving chest surgeries and induced into cartilage cells in serum culture-free medium. The cells were then seeded on perchloroethylene (PCE) as the scaffold material for the formation of cell-PCE composite, which was implanted under the dorsal skin of nude mice. Specimens of the implants were harvested 6 weeks after implantation and subjected to gross morphological observation and histological examination. RESULTS: Gross observation showed subcutaneous lump with considerable tenacity, and histologically, large amount of cartilage cells in clusters were seen to have evolved, in the presence of some scaffold material failing to be degraded, indicating that cartilage formation from the MSCs occurred approximately 6 weeks after the implantation of the induced MSCs. CONCLUSION: Human MSCs can be induced into chondrocytes in vitro, and the MSC-PCE composite possesses the potential to develop into cartilage in nude mice. Human MSCs can therefore be used as the seed cells to construct tissue-engineered cartilage.


Assuntos
Células da Medula Óssea/fisiologia , Condrogênese , Células-Tronco Mesenquimais/fisiologia , Animais , Células Cultivadas , Humanos , Imuno-Histoquímica , Camundongos , Camundongos Nus , Engenharia Tecidual
17.
Aviat Space Environ Med ; 74(7): 707-10, 2003 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-12862323

RESUMO

BACKGROUND: Previous research has shown that the eustachian tube (ET) in animals and humans is lined with a substance that lowers surface tension and thus facilitates the opening of the eustachian tube and aeration of the middle ear. The aims of the present study were to observe the role of eustachian tube surfactant (ETS) on the opening of the ET and to explore the therapeutic effect of natural and artificial ETS on barotitis media (BOM). METHODS: BOM was successfully established in 50 guinea pigs by simulated ascent in an altitude chamber. Subsets of the affected ears were treated by flushing with natural ETS, artificial ETS, artificial phospholipid, or saline. The effects were evaluated by measuring eustachian tube pressure opening level (POL). Other animals with BOM were treated with artificial ETS on one side and saline in the other, after which the clinical signs were observed. RESULTS: The POL of the saline group remained unchanged. Natural ETS decreased the POL from 11.98 to 6.11 kPa (p < 0.01); artificial ETS reduced the POL from 11.91 to 6.67 kPa (p < 0.01); there was no significant difference between the two treatments. Artificial phospholipid was less effective, decreasing POL from 11.86 to 8.61 kPa (p < 0.05). Clinical observations showed that after 1 wk of treatment with artificial ETS, the congestion in the tympanic membrane was alleviated, the hearing threshold improved, and the effusion in tympanic cavity diminished. CONCLUSION: Artificial ETS was as effective as natural ETS in facilitating the opening of eustachian tube and had definite therapeutic effects on BOM in this model.


Assuntos
Barotrauma/tratamento farmacológico , Tuba Auditiva/metabolismo , Otite Média/tratamento farmacológico , Tensoativos/uso terapêutico , Animais , Orelha Média/efeitos dos fármacos , Cobaias , Cloreto de Sódio/administração & dosagem , Irrigação Terapêutica , Resultado do Tratamento
18.
Ann Otol Rhinol Laryngol ; 111(1): 93-5, 2002 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-11800377

RESUMO

In the past 8 years, 45 patients with laryngotracheal stenosis have undergone reconstruction with the sternohyoid myocutaneous rotary door flap (RDF) technique at Tang Du Teaching Hospital in Xi'an, China. All patients were tracheostomy-dependent before reconstruction. Thirty-six patients had previously undergone 2 to 7 surgical procedures. Forty-one of the 45 patients (91%) were successfully decannulated. Decannulation failed in the other 4 because of RDF prolapse into the tracheal lumen or because of hypertrophic scar in the operative region. The follow-up period ranged from 1 to 8 years. Forty of the 41 patients had a stable airway and effective voice, and 1 patient had restenosis 3 years after decannulation. The results demonstrate that the RDF technique is a relatively simple and effective way to treat patients with laryngotracheal stenosis.


Assuntos
Laringoestenose/cirurgia , Retalhos Cirúrgicos , Estenose Traqueal/cirurgia , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias
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