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1.
Environ Int ; 147: 106318, 2021 02.
Artigo em Inglês | MEDLINE | ID: mdl-33387882

RESUMO

Several studies suggest that organochlorine exposure can affect male reproductive functions, causing poor semen quality, endocrine disruption, or dysregulation of thyroid hormones. This study uses multiple linear regression (MLR) models to analyze the correlation between male reproductive functions and polychlorinated biphenyl (PCBs) congeners or p,p'-DDE levels in serum, semen, and indoor dust samples. Multiple comparisons were all adjusted using the false discovery rate (FDR). The results revealed that the PCB congener levels in seminal plasma were significantly associated with the quality parameters of human semen (i.e., sperm count, morphology, and motility) and thyroid hormones after adjusting for covariates, e.g., associations of the sperm concentration with levels of CB105 (ß = -0.323, 95% CI: -0.561, -0.085, p = 0.009), CB44 (ß = 0.585, 95% CI: 0.290, 0.880, p < 0.001), and CB66 (ß = -0.435, 95% CI: -0.728, -0.143, p = 0.004) in the seminal plasma were observed. Correlations between serum pollutants levels and the semen quality, reproductive hormones, or thyroid hormones were also observed. Moreover, our results demonstrate that the quantification of PCBs in seminal plasma can better describe male reproductive disorders than that in serum or dust. Organochlorine exposure measured in serum or dust, especially in seminal plasma, was associated with semen quality, as well as reproductive and thyroid hormones, thus suggesting that the impacts of persistent pollutants on male reproductive health require further investigation.


Assuntos
Resíduo Eletrônico , Poluentes Ambientais , Bifenilos Policlorados , China , Diclorodifenil Dicloroetileno , Exposição Ambiental/efeitos adversos , Poluentes Ambientais/toxicidade , Humanos , Masculino , Bifenilos Policlorados/toxicidade , Análise do Sêmen
2.
Environ Pollut ; 263(Pt B): 114440, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32244121

RESUMO

Tetrabromobisphenol-A (TBBPA) is an emerging organic pollutant and a commonly used brominated flame retardant that has received much attention owing to its toxicity. Although TBBPA is ubiquitously detected in atmospheric particulate matter and dust, few studies have investigated the sub-chronic inhalation exposure to TBBPA. To further understand the excretion characteristics and tissue accumulation of TBBPA after inhalation exposure, we used the rat model to conduct a sub-chronic inhalation exposure study. Male rats were administered with different doses of aerosol TBBPA (12.9, 54.6, 121.6, and 455.0 mg/m3). TBBPA was found in the excretion (feces and urine) and all the target tissues (lung, liver, heart, thymus gland, spleen, testicles, muscles, kidneys, brain and serum). Feces were the main route of excretion, which contributed 19.18% to 72.54% (urine <0.10%). TBBPA excretion through feces following inhalation administration was much higher than that following oral and dermal exposure, thereby indicating lower bioavailability of TBBPA under inhalation exposure. Liver and serum showed higher levels of TBBPA compared with those of other tissues, thereby suggesting tissue-specific accumulation of TBBPA in rats. Owing to the relative non-invasiveness of serum sampling and greatest TBBPA concentration among the tissues, serum is a suitable matrix for estimation of TBBPA bioaccumulation after inhalation exposure.


Assuntos
Líquidos Corporais/química , Retardadores de Chama , Bifenil Polibromatos/análise , Animais , Disponibilidade Biológica , Fezes/química , Exposição por Inalação , Masculino , Ratos
3.
Environ Int ; 138: 105666, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-32203811

RESUMO

Typical halogenated persistent organic pollutants (Hal-POPs), including polybrominated diphenyl ethers (PBDEs), polybrominated biphenyls (PBBs), polychlorinated biphenyls (PCBs), and dichlorodiphenyltrichloroethane (DDT), are a group of ubiquitous organic pollutants with an endocrine disrupting effect. This study evaluated the accumulation and congener profiles of Hal-POPs in the bodies of men who live/work in areas of South China where electronic wastes are collected and managed, especially in their semen samples. The results show that the detection frequency and serum concentrations of Hal-POP congeners within the high-exposure group (HEG) were higher than those of the low-exposure group (LEG). Furthermore, an identical trend was observed for the seminal plasma concentrations of Hal-POPs. The distribution characteristics, such as their mean, median, and discrete values, of PBDE congeners in serum and semen samples from the same subjects were consistent with each other. However, the distribution characteristics of PCB congeners in serum samples were different from those in semen samples. BDE153 was one of the most abundant congeners found in the serum and semen samples; hence, it can be identified as an indicator PBDE congener. Further research is needed to explore the mechanism of Hal-POPs distribution in human semen and serum samples.


Assuntos
Resíduo Eletrônico , Poluentes Ambientais , Bifenilos Policlorados , China , Monitoramento Ambiental , Éteres Difenil Halogenados/análise , Humanos , Masculino , Bifenilos Policlorados/análise , Sêmen/química
4.
Ecotoxicol Environ Saf ; 178: 105-112, 2019 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-30999178

RESUMO

Human hair, flue gas and fly ash from a municipal solid waste incinerator (MSWI) in south China were collected and analyzed for polychlorinated dibenzo-p-dioxin (PCDD) and polychlorinated dibenzofuran (PCDF). The ΣPCDD/F level in hair from male workers were higher than those from residents. The Principal Component Analysis (PCA) suggested that ΣPCDD/F in flue gas is an external source of male workers' hair ΣPCDD/F. Results of daily intake of ΣPCDD/F by inhaling flue gas suggested that the inhalation exposure of ΣPCDD/F was at a slight health risk. For the male workers directly exposed to the MSWI power plant, ΣPCDD/F levels in their hair were significantly higher than those who were non-directly exposed. Moreover, a significantly positive relationship was obtained between ΣPCDD/F levels in male workers' hair and the working time. The result of correlation analysis suggested that 1,2,3,4,6,7,8-HpCDD and OCDD could be level indicator congeners to estimate ΣPCDD/F levels. In addition, 2,3,7,8-TCDD could be applied as TEQ indicator congener to characterize the hair of MSWI male workers.


Assuntos
Dibenzofuranos Policlorados/análise , Cabelo/química , Incineração , Exposição por Inalação/análise , Exposição Ocupacional/análise , Dibenzodioxinas Policloradas/análise , China , Cinza de Carvão/análise , Humanos , Masculino , Resíduos Sólidos/análise
5.
Chemosphere ; 198: 266-273, 2018 May.
Artigo em Inglês | MEDLINE | ID: mdl-29421738

RESUMO

Previous studies have confirmed that house dust is one of the main sources of polybrominated diphenyl ethers (PBDEs) exposure, and also indicated that PBDEs might affect human semen quality. The aim of this study was to explore the association between PBDEs concentration in house dust and the semen quality of male resident. Results showed that the semen qualities of the residents living around the e-waste dismantling workshops for a long time (3-17years) at the e-waste areas in South China significantly decreased, and the DNA damage of sperms were aggravated. The adjusted correlation analysed by multiple linear regression model showed that the sperm concentration and count both had negative correlation with BDE47 level in semen (ß = -0.295, 95%CI: -0.553∼-0.036; ß = -0.400, 95%CI: -0.708∼-0.092, respectively). In addition, the sperm progressive motility [(A+B)%] and sperm viability both had negative correlation with BDE100 level in dust (ß = -0.360, 95%CI: -0.680∼-0.040; ß = -0.114, 95% CI: -0.203∼-0.025, respectively). And there were significant linear positive correlation between PBDE congener (e.g. BDE28, 47, 153) concentrations in dust and in paired semen samples (rs = 0.367-0.547, p < 0.05). This study suggested that exposure to PBDEs from house dust might have adverse effects on human semen quality. But the results need to be confirmed in further studies with a large-scale sampling, and find out more direct and convincing evidence.


Assuntos
Poluição do Ar em Ambientes Fechados/análise , Poeira/análise , Resíduo Eletrônico/análise , Exposição Ambiental/análise , Éteres Difenil Halogenados/análise , Espermatozoides/efeitos dos fármacos , Adulto , Poluição do Ar em Ambientes Fechados/efeitos adversos , China , Dano ao DNA , Exposição Ambiental/efeitos adversos , Éteres Difenil Halogenados/toxicidade , Humanos , Masculino , Projetos Piloto , Análise do Sêmen , Espermatozoides/química , Inquéritos e Questionários
6.
Clin Rev Allergy Immunol ; 54(2): 234-243, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28717941

RESUMO

TNF inhibitors have been used in ankylosing spondylitis (AS). The efficacy of TNF inhibitors was already evaluated by meta-analysis of randomized controlled trials (RCTs). However, the safety of TNF inhibitors is still unclear. Therefore, we aimed to evaluate and update the safety data from RCTs of TNF inhibitors in patients treated for AS. A systematic literature search was conducted from 1990 through May 31, 2016. All studies included were randomized, double-blind, controlled trials of patients with ankylosing spondylitis that evaluated adalimumab, certolizumab pegol, etanercept, golimumab, or infliximab treatment. The overall serious adverse events, the risk of serious infection events, and the risk of malignancy and discontinuation rates were abstracted, and risk estimates were calculated by Peto odds ratios (ORs). Fourteen randomized controlled trials involving 2032 subjects receiving TNF inhibitors and 1030 subjects receiving placebo and/or traditional disease-modifying anti-rheumatic drugs (DMARDs) were included. The overall serious adverse events (OR, 1.34; 95% CI, 0.87-2.05), the risk of serious infection events (OR, 1.59; 95% CI, 0.63-4.01), the risk of malignancy (OR, 0.98; 95% CI, 0.25-3.85), and discontinuation due to adverse events (OR, 1.55; 95% CI, 0.95-2.54) in patients treated with TNF inhibitors as a group were not significantly different from those treated with placebo in the control group. TNF inhibitors were generally safe for treatment of ankylosing spondylitis. These data may help guide clinical comparative decision making in the management of AS.


Assuntos
Antirreumáticos/uso terapêutico , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/epidemiologia , Infecções/epidemiologia , Neoplasias/epidemiologia , Espondilite Anquilosante/tratamento farmacológico , Adalimumab/efeitos adversos , Adalimumab/uso terapêutico , Anticorpos Monoclonais/efeitos adversos , Anticorpos Monoclonais/uso terapêutico , Antirreumáticos/efeitos adversos , Certolizumab Pegol/efeitos adversos , Certolizumab Pegol/uso terapêutico , Tomada de Decisão Clínica , Etanercepte/efeitos adversos , Etanercepte/uso terapêutico , Humanos , Infliximab/uso terapêutico , Neoplasias/etiologia , Ensaios Clínicos Controlados Aleatórios como Assunto , Risco , Fator de Necrose Tumoral alfa/antagonistas & inibidores
7.
J Org Chem ; 79(11): 4973-83, 2014 Jun 06.
Artigo em Inglês | MEDLINE | ID: mdl-24784450

RESUMO

A series of picenes having methoxy groups was synthesized through Pd-catalyzed Suzuki-Miyaura couplings or Wittig reaction/intramolecular cyclization sequences, and their physicochemical properties and single-crystal structures were evaluated. The substitution position effects between the outer 1,12-, 2,11-, and 4,9-position and the inner 3,10-position are quite different; the former showed the same electronic structure as that of picene, but the latter results in a HOMO geometry different from those of picene and other methoxy picenes. In addition, crystal structures of four types of methoxy-substituted picenes 4a-c,e strongly depend on their substitution position and number of methoxy groups, which dramatically changes the structures from the fully anisotropic 1D π-stacked structure to a unique 3D herringbone structure due to steric hindrance of methoxy groups. The calculations of transfer integrals based on their single-crystal structures reveal that the methoxy picenes have intermolecular overlaps less effective than that of the parent nonsubstituted picene. These results are attributed not only to the packing structure but also to electronic structures such as the HOMO distribution. The preliminary OFET of the representative 4c,e showed hole mobilities significantly lower than that of picene due to their less effective intermolecular overlaps, as predicted by the calculated transfer integrals.

8.
Org Lett ; 15(14): 3558-61, 2013 Jul 19.
Artigo em Inglês | MEDLINE | ID: mdl-23815165

RESUMO

A novel and versatile synthetic method for picene derivatives is developed using the Pd-catalyzed intramolecular double cyclization of the corresponding 2,3-bis[(1Z)-2-phenylethenyl]-1,4-dichlorobenzenes, which are readily prepared by Suzuki-Miyaura cross-coupling reactions of polyhalobenzenes with (Z)-arylethenylboronates. The physical properties of the obtained picenes can be modified via introducing a variety of functional groups to the picene framework. All compounds are investigated by UV-vis and fluorescence spectroscopic measurements, CV, and DFT calculations as well as X-ray diffraction analysis.

9.
Huan Jing Ke Xue ; 34(12): 4642-8, 2013 Dec.
Artigo em Chinês | MEDLINE | ID: mdl-24640902

RESUMO

A series of experiments were conducted to study the occurrence and distribution of volatile organic compounds (VOCs) in conventional and advanced drinking water treatment processes of 3 water treatment plants in Lianyungang City. Results showed that 30 compounds of 3 classes were detected from 67 kinds of VOCs in all the samples collected. The concentrations of carbonyl compounds, halogenated hydrocarbons and benzenes detected were in the ranges of 0.04-61.27, 0.02-35.61 and 0.07-2.33 microg x L(-1) respectively. Comparing the changes of different VOCs in three drinking water treatment plants, conventional chlorination process could effectively remove benzenes but meanwhile produced trihalomethanes (THMs). Additional advanced treatment ozonation-biological activated carbon process could decrease the formation of THMs during pre-chlorination but produced new risky contaminants like carbonyl compounds. The changes of VOCs in tap water were also investigated. It was found that carbonyl compounds produced by ozonation could be further transformed to THMs with residual chlorine. However, the health risks of all detected compounds in tap water were at a low level, except that the carcinogenic risk of crotonaldehydes (9.3 x 10(-5)-2.2 x 10(-4)) was slightly higher than the US EPA threshold (10(-6)-10(-4)).


Assuntos
Água Potável/análise , Compostos Orgânicos Voláteis/análise , Purificação da Água/métodos , Carbono/análise , Cloro/análise , Halogenação , Compostos Orgânicos/análise , Trialometanos/análise
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