In-situ fabrication of bimetallic FeCo2O4-FeCo2S4 heterostructure for high-efficient alkaline freshwater/seawater electrolysis.

Rational construction of bifunctional electrocatalysts with long-term stability and high electrocatalytic activity is of great importance, but it is challenging to obtain highly efficient non-precious metal-based catalysts for overall seawater electrolysis. Herein, a nickel foam (NF) self-supporting CoFe-layered double hydroxide (CoFe-LDH/NF) was directly converted into FeCo2O4-FeCo2S4 heterostructure via hydrothermal method in 50 mM Na2S solution, instead of FeCo2O4@FeCo2S4 core-shell structure. The FeCo2O4-FeCo2S4 heterojunction shows nanosheets structure with rough surface (the thickness of âˆ¼ 198.9 nm), which provides rich oxide/sulfide interfaces, high electrochemical active area, a large number of active sites, as well as fast charge and mass transfer. In 1.0 M KOH solution, 1.0 M KOH + 0.5 M NaCl, and alkaline natural seawater, the FeCo2O4-FeCo2S4 heterojunction exhibits eminently electrocatalytic performance, with overpotentials of η-100 = 225 mV, η-100 = 233 mV, and η-100 = 238 mV for OER, as well as η-100 = 271 mV, η-100 = 273 mV, and η-100 = 277 mV for HER, respectively. Furthermore, self-supporting FeCo2O4-FeCo2S4 electrode (FeCo2O4-FeCo2S4/NF) as the cathode and anode of an electrolyzer exhibits a lower cell voltage of E-100 = 1.75 V in alkaline seawater than those of FeCo2S4/NF (1.77 V), CoFe-LDH/NF (1.87 V), and FeCo2O4/NF (1.91 V). Specifically, FeCo2O4-FeCo2S4 electrolyzer can stably produce hydrogen for over 48 h in alkaline freshwater/seawater electrolyte. These outstanding electrocatalytic performances and corrosion resistance to salty-water can be attributed to the surface reconstruction behavior of the FeCo2O4-FeCo2S4/NF catalyst during OER, which leads to the in-situ formation of metal oxyhydroxides. In particular, the FeCo2O4-FeCo2S4 heterojunction is also very competitive among most state-of-the-art non-noble metal-based catalysts, whether in KOH or alkaline salty-water electrolytes.

Exposed {110} facets of BiOBr anchored to marigold-like MnCo2O4 with abundant interfacial electron transfer bridges and efficient activation of peroxymonosulfate.

Precise charge transfer modification and efficient activation of peroxymonosulfate are effective methods for increasing photocatalytic efficiency. Here, BiOBr/MnCo2O4 photocatalysts with abundant Mn-Br bonds were generated by immobilizing the exposed {110} facets of BiOBr in the marigold-like MnCo2O4. The prepared BiOBr/MnCo2O4 retained the marigold-like morphology of MnCo2O4 while exhibiting good adsorption properties and interface contact effects. More importantly, the interfacial Mn-Br bond between MnCo2O4 and BiOBr functioned as charge transport bridges, allowing for a directional transfer channel and lowering the potential energy barrier for interfacial charge transfer. In addition, the exposure of the {110} facets exhibited more Mn atom-anchored sites for easy anchoring of BiOBr, significantly solving the stability problem of the bismuth material. Compared to MnCo2O4 + BiOBr, which did not form Mn-Br bonds, the MnCo2O4/BiOBr heterojunction had more efficient photocatalytic activity (1.3 times) and stability. This suggested that using electronic bridges for directional charge transfer was an efficient way to improve photocatalytic efficiency.

Hydrological reduction and control effect evaluation of sponge city construction based on one-way coupling model of SWMM-FVCOM: A case in university campus.

The exacerbation of global warming, the frequent incidence of extreme weather events, and the rapid urbanization have collectively contributed to the heightened prevalence of flooding in urban areas. As a result of this challenge, sponge city (SPC) has been adopted in China as an efficient means of preventing and controlling urban floods. To evaluate the hydrological reduction and control effect of sponge city construction (SPCC) within a university campus, a one-way coupled model integrating one-dimensional sewer hydrodynamic model (SWMM) and two-dimensional surface flow model (FVCOM), namely SWMM-FVCOM model, was established. The Nash-Sutcliffe efficiency (NSE) of the SWMM were greater than 0.75 under there rainfalls with different intensity, indicating the good reliability and stability of this model could be used in the subsequent simulation. An analysis of drainage capacity and the risk of urban flooding was conducted using this model before and after the implementation of SPCC, considering six rainfall scenarios. Implementing SPCC demonstrated an effective performance in mitigating surface runoff, regulating inspection well overflow, and reducing overflow volume in the study region. However, the efficacy of runoff control diminished proportionally with the escalation of rainfall return period. Simultaneously, the implementation of low impact development (LID) measures can significantly decrease the extent and magnitude of surface inundations. The reduction rate of SPCC on the area of waterlogging ranged from 55.84% to 72.50%. But the control rate decreased with increasing rainfall return periods, demonstrating that adopting SPCC can effectively mitigate the severity of urban flooding resulting from low rainfall return period events (Tr < 20 years). This study can provide scientific foundation for environment managers to evaluate the impact of urban flooding prevention and control on runoff pollution mitigation when adopting the implementation of SPCC.

Determinants of organophosphate esters exposure in pregnant women from East China.

Organophosphate esters (OPEs) have been broadly used in various industrial and consumer products, resulting in global distribution and human exposure. Gestational exposure to OPEs may adversely affect the health of both pregnant women and their offspring. To better understand OPE exposure in pregnant women, our study determined eight urinary metabolites of major OPEs in pregnant women (n = 733) recruited at 12-16 weeks of gestation from Shanghai, China, and explored the determinants of OPE exposure among various sociodemographic characteristics, lifestyles, and dietary factors. Urinary metabolites of OPEs, including bis (1,3-dichloro-2-propyl) phosphate (BDCPP), bis (2-chloroethyl) phosphate (BCEP), bis (1-chloro-2-propyl) phosphate (BCIPP), dicresyl phosphate (DCP), diphenyl phosphate (DPP), dibutyl phosphate (DBP), bis (2-ethylhexyl) phosphate (BEHP), and bis (2-butoxyethyl) phosphate (BBOEP), exhibited a detection rate ranging from 69.30% to 99.32%. Multivariate linear regression models indicated that pregnant women who were multiparous, had a higher family income per capita, worked in white-collar jobs, and took nutritional supplements such as milk powder and fish oil tended to have higher urinary OPE metabolite concentrations. Besides, independent of sociodemographic characteristics and lifestyle factors, consumption of more aquatic products, soy products, pork, and puffed food, as well as drinking of purified tap water versus tap water, were associated with increased urinary OPEs metabolite concentrations. Our study demonstrated that OPE exposure was ubiquitous in pregnant women from Shanghai, and provided new insights into the potential factors influencing OPE exposure during pregnancy.

Rapid and selective removal of aristolochic acid I in natural products by vinylene-linked iCOF resins.

Rapid, efficient, and selective removal of toxicants such as aristolochic acid I (AAI) from complex natural product systems is of great significance for the safe use of herbal medicines or medicine-food plants. Addressing this challenge, we develop a high-performance separation approach based on ionic covalent organic frameworks (iCOFs) to separate and remove AAI. Two vinylene-linked iCOFs (NKCOF-46-Br- and NKCOF-55-Br-) with high crystallinity are fabricated in a green and scalable fashion via a melt polymerization synthesis method. The resulting materials exhibit a uniform morphology, high stability, fast equilibrium time, and superior affinity and selectivity for AAI. Compared to conventional separation media, NKCOF-46-Br- and NKCOF-55-Br- achieve the record high adsorption capacities of 246.0 mg g-1 and 178.4 mg g-1, respectively. Various investigations reveal that the positively charged framework and favorable pore microenvironment of iCOFs contribute to their high selectivity and adsorption efficiency. Moreover, the iCOFs exhibit excellent biocompatibility by in vivo toxicity assays. This study paves a new avenue for the rapid, selective and efficient removal of toxicants from complex natural systems.

Effects of phytase/ethanol treatment on aroma characteristics of rapeseed protein isolates.

This study investigates enhancing the flavor of rapeseed protein isolate (RPI), a protein-rich substance with an unfavorable taste, through phytase/ethanol treatment. Comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC × GC-TOF-MS) analysis identified 268 volatile compounds in RPI. The study found that this treatment significantly altered the content of these compounds, reducing sourness and enhancing sweetness and fruitiness. The analysis also showed that the treatment notably increased the relative odor activity values (ROAVs) of key aroma compounds, improving RPI's flavor. Sensory evaluation confirmed the positive impact of the treatment, indicating its potential to make RPI a more acceptable ingredient in the food industry.

HER2-positive advanced biliary tract cancer responds to second-line pyrotinib therapy: a case report.

Biliary tract cancers are solid tumors with poor prognosis and over 70% of patients present in advanced stages. The efficacy of second-line treatment for patients who progressed on GC chemotherapy is limited. Median OS of these patients is less than 1 year with palliative treatment. Despite the success of anti-HER2 therapy in HER2-positive breast cancer, the targeted therapy of HER2 mutations in BTCs is still being explored. This case report is the first report suggesting a 15-month PFS and partial response of pyrotinib in HER2-positive BTC. We report a 64-year-old female with HER2-positive biliary tract cancer. She was diagnosed with AJCC clinical stage IV (cT3N1M1) intrahepatic biliary tract cancer and got PD after 3 cycles of systemic chemotherapy of gemcitabine plus cisplatin. Due to the HER2-positive signature, pyrotinib (400 mg daily in 21-day cycles), an oral irreversible pan-ErbB TKI was prescribed in September 2021, with her informed consent. The tumor shrank significantly after this treatment and imaging assessments conducted on 24 September 2022 showed PR. Until the writing of the case draft, the patient had achieved 15 months of PFS. The present case suggests that Pyrotinib might be a potential effective treatment for HER2-positive advanced BTC.

HIV-1 active and latent infections induce disparate chromatin reorganization and transcriptional regulation of mRNAs and lncRNAs in SupT1 cells.

IMPORTANCE: HIV-1 infection of T-lymphocytes depends on co-opting cellular transcriptional and translational machineries for viral replication. This requires significant changes in the cellular microenvironment. We have characterized and compared the changes in cellular chromatin structures as well as gene expression landscapes in T cells that are either actively or latently infected with HIV-1. Our results reveal that chromatin accessibility and expression of both protein-coding mRNAs and non-coding lncRNAs are uniquely regulated in HIV-1-infected T cells, depending on whether the virus is actively transcribing or remains in a transcriptionally silent, latent state. HIV-1 latent infection elicits more robust changes in the cellular chromatin organization than active viral infection. Our analysis also identifies the effects of such epigenomic changes on the cellular gene expression and subsequent biological pathways. This study comprehensively characterizes the cellular epigenomic and transcriptomic states that support active and latent HIV-1 infection in an in vitro model of SupT1 cells.

Comparison of Long-Term Effects Following Phacoemulsification Combined with Goniosynechialysis and Trabeculectomy in Patients with Primary Angle-Closure Glaucoma and Cataract.

INTRODUCTION: Goniosynechialysis (Phaco-GSL) is a logical therapeutic approach for patients with primary angle-closure glaucoma (PACG) and cataract. The aim of this study was to compare the long-term effectiveness and safety of Phaco-GSL and trabeculectomy (TRB) in the management of PACG with coexisting cataract. METHODS: A review was conducted on 96 Chinese patients (96 eyes) with PACG and cataract from Peking Union Medical College Hospital (PUMCH). Among them, 56 patients underwent Phaco-GSL, while 40 underwent TRB. Intraocular pressure (IOP), best corrected visual acuity (BCVA), use of supplemental antiglaucoma medical therapy, surgery success rates, and complications for both procedures were assessed. RESULTS: The average follow-up period was 50.3 ± 18.7 months in the Phaco-GSL group and 61.2 ± 15.1 months in the TRB group. At the final follow-up, IOP decreased from 27.0 ± 11.1 mmHg to 13.5 ± 2.1 mmHg in the Phaco-GSL group and in the TRB group IOP decreased from 27.1 ± 7.7 mmHg to 16.5 ± 5.5 mmHg. The long-term postoperative IOP in the Phaco-GSL group was significantly lower than that in the TRB group. There was a statistically significant reduction in medication usage in both groups, with the TRB group having a higher number of postoperative medications at the final follow-up. The incidence of postoperative complications was significantly higher in the TRB group compared to the Phaco-GSL group. CONCLUSIONS: Phaco-GSL is the recommended surgical approach for Chinese patients with primary angle-closure glaucoma (PACG) and cataract. Compared to traditional TRB, eyes undergoing Phaco-GSL show a reduced requirement for antiglaucomatous medications, improved management of IOP, decreased risk of complications, and higher long-term cumulative probability of treatment success for patients with PACG.

In Situ Study of the Magnetic Field Gradient Produced by a Miniature Bi-Planar Coil for Chip-Scale Atomic Devices.

The miniaturization of quantum sensors is a popular trend for the development of quantum technology. One of the key components of these sensors is a coil which is used for spin modulation and manipulation. The bi-planar coils have the advantage of producing three-dimensional magnetic fields with only two planes of current confinement, whereas the traditional Helmholtz coils require three-dimensional current distribution. Thus, the bi-planar coils are compatible with the current micro-fabrication process and are quite suitable for the compact design of the chip-scale atomic devices that require stable or modulated magnetic fields. This paper presents a design of a miniature bi-planar coil. Both the magnetic fields produced by the coils and their inhomogeneities were designed theoretically. The magnetic field gradient is a crucial parameter for the coils, especially for generating magnetic fields in very small areas. We used a NMR (Nuclear Magnetic Resonance) method based on the relaxation of 131Xe nuclear spins to measure the magnetic field gradient in situ. This is the first time that the field inhomogeneities of the field of such small bi-planar coils have been measured. Our results indicate that the designed gradient caused error is 0.08 for the By and the Bx coils, and the measured gradient caused error using the nuclear spin relaxation method is 0.09±0.02, suggesting that our method is suitable for measuring gradients. Due to the poor sensitivity of our magnetometer under a large Bz bias field, we could not measure the Bz magnetic field gradient. Our method also helps to improve the gradients of the miniature bi-planar coil design, which is critical for chip-scale atomic devices.

Exploration of porous imine-based covalent organic framework for solid-phase extraction of five trace sulfonamides in food samples.

In this article, a highly crystalline porous imine-based covalent organic framework was synthesized at room temperature and used as solid-phase extraction (SPE) adsorbent for the purification and enrichment of trace sulfonamides (SAs) from food samples. The structure of the obtained material was characterized and studied in detail. The extraction process was optimized and the final elution was determined by the ultra-high-performance liquid chromatography-quadrupole time of flight mass spectrometry method. Low limits of detection (0.02-0.19 µg/kg) were obtained under optimal conditions, with the recoveries ranging from 70.5% to 105.3% when spiked at different levels. The adsorption process of the material for SAs was fitted by the Langmuir and Freundlich adsorption isotherm model, and the extraction capacity for Nitrofuran metabolites from food samples was also investigated for comparison. The results demonstrated that the framework was a good candidate SPE adsorbent that can be used for the enrichment of drug residues in complex matrix, and the work may provide a systematic study method for the development of porous adsorbents.

Uncovering the complex regulatory network of spring bud sprouting in tea plants: insights from metabolic, hormonal, and oxidative stress pathways.

The sprouting process of tea buds is an essential determinant of tea quality and taste, thus profoundly impacting the tea industry. Buds spring sprouting is also a crucial biological process adapting to external environment for tea plants and regulated by complex transcriptional and metabolic networks. This study aimed to investigate the molecular basis of bud sprouting in tea plants firstly based on the comparisons of metabolic and transcriptional profiles of buds at different developmental stages. Results notably highlighted several essential processes involved in bud sprouting regulation, including the interaction of plant hormones, glucose metabolism, and reactive oxygen species scavenging. Particularly prior to bud sprouting, the accumulation of soluble sugar reserves and moderate oxidative stress may have served as crucial components facilitating the transition from dormancy to active growth in buds. Following the onset of sprouting, zeatin served as the central component in a multifaceted regulatory mechanism of plant hormones that activates a range of growth-related factors, ultimately leading to the promotion of bud growth. This process was accompanied by significant carbohydrate consumption. Moreover, related key genes and metabolites were further verified during the entire overwintering bud development or sprouting processes. A schematic diagram involving the regulatory mechanism of bud sprouting was ultimately proposed, which provides fundamental insights into the complex interactions involved in tea buds.

Exploring the mechanism of resistance to vincristine in breast cancer cells using transcriptome sequencing technology.

Breast cancer has replaced lung cancer as the leading cancer globally, but various chemotherapy drugs for breast cancer are prone to resistance, especially in patients with distant metastases who are susceptible to multiple chemotherapy drug resistance often leading to treatment failure. Vincristine (VCR) is an alkaloid extracted from Catharanthus roseus, and is often used in combination with other chemotherapy drugs to treat various types of cancer, including breast cancer. Research on the development of resistance to VCR has been carried out using transcriptome sequencing technology. Firstly, gradient increase of VCR concentration was used to produce a VCR-resistant breast cancer cell line. Mechanistically, RNA was extracted from the VCR-resistant breast cancer cell line, and the transcriptome was sequenced. Further analysis showed changes in the expression levels of various genes in the aforementioned VCR-resistant breast cancer cell line. Meanwhile, the analysis of splicing events also indicated a change in variable splicing events. Further validation showed that the expression levels of multiple genes, including interleukin-1ß, were altered in the VCR-resistant breast cancer cell line, and these gene expression changes were related to VCR resistance. The results of the present study provide a theoretical basis for exploring the mechanism of VCR resistance clinically.

A fixel-based analysis of white matter reductions early detects Parkinson disease with mild cognitive impairment.

BACKGROUND: White matter (WM) tract alterations are early signs of cognitive impairment in Parkinson disease (PD) patients. Fixel-based analysis (FBA) has advantages over traditional diffusion tensor imaging in managing complex and crossing fibers. We used FBA to measure fiber-specific changes in patients with PD mild cognitive impairment (PD-MCI) and PD normal cognition (PD-NC). METHODS: Seventy-one patients with PD without dementia were included: 39 PD-MCI and 32 PD-NC. All underwent diffusion-weighted imaging, clinical examinations, and tests to evaluate their cognitive function globally and in five cognitive domains. FBA was used to investigate fiber-tract alterations and compare PD-MCI with PD-NC subjects. Correlations with each cognitive test were analyzed. RESULTS: Patients with PD-MCI were significantly older (P = 0.044), had a higher male-to-female ratio (P = 0.006) and total Unified Parkinson's Disease Rating Scale score (P = 0.001). All fixel-based metrics were significantly reduced within the body of the corpus callosum and superior corona radiata in PD-MCI patients (family-wise error-corrected P value < 0.05) compared with PD-NC patients. The cingulum, superior longitudinal fasciculi, and thalamocortical circuit exhibited predominantly fiber-bundle cross-section (FC) changes. In regression analysis, reduced FC values in cerebellar circuits were associated with poor motor function in PD-MCI patients and poor picture-naming ability in PD-NC patients. CONCLUSIONS: PD-MCI patients have significant WM alterations compared with PD-NC patients. FBA revealed these changes in various bundle tracts, helping us to better understand specific WM changes that are functionally implicated in PD cognitive decline. FBA is potentially useful in detecting early cognitive decline in PD.

Skin-Integrated Wireless Odor Message Delivery Electronics for the Deaf-blind.

Deaf-blindness limits daily human activities, especially interactive modes of audio and visual perception. Although the developed standards have been verified as alternative communication methods, they are uncommon to the nondisabled due to the complicated learning process and inefficiency in terms of communicating distance and throughput. Therefore, the development of communication techniques employing innate sensory abilities including olfaction related to the cerebral limbic system processing emotions, memories, and recognition has been suggested for reducing the training level and increasing communication efficiency. Here, a skin-integrated and wireless olfactory interface system exploiting arrays of miniaturized odor generators (OGs) based on melting/solidifying odorous wax to release smell is introduced for establishing an advanced communication system between deaf-blind and non-deaf-blind. By optimizing the structure design of the OGs, each OG device is as small as 0.24 cm3 (length × width × height of 11 mm × 10 mm × 2.2 mm), enabling integration of up to 8 OGs on the epidermis between nose and lip for direct and rapid olfactory drive with a weight of only 24.56 g. By generating single or mixed odors, different linked messages could be delivered to a user within a short period in a wireless and programmable way. By adopting the olfactory interface message delivery system, the recognition rates for the messages have been improved 1.5 times that of the touch-based method, while the response times were immensely decreased 4 times. Thus, the presented wearable olfactory interface system exhibits great potential as an alternative message delivery method for the deaf-blind.

A Cre-dependent reporter mouse for quantitative real-time imaging of Protein Kinase A activity dynamics.

Intracellular signaling dynamics play a crucial role in cell function. Protein kinase A (PKA) is a key signaling molecule that has diverse functions, from regulating metabolism and brain activity to guiding development and cancer progression. We previously developed an optical reporter, FLIM-AKAR, that allows for quantitative imaging of PKA activity via fluorescence lifetime imaging microscopy and photometry. However, using viral infection or electroporation for the delivery of FLIM-AKAR is invasive, cannot easily target sparse or hard-to-transfect/infect cell types, and results in variable expression. Here, we developed a reporter mouse, FL-AK, which expresses FLIM-AKAR in a Cre-dependent manner from the ROSA26 locus. FL-AK provides robust and consistent expression of FLIM-AKAR over time. Functionally, the mouse line reports an increase in PKA activity in response to activation of both Gαs and Gαq-coupled receptors in brain slices. In vivo, FL-AK reports PKA phosphorylation in response to neuromodulator receptor activation. Thus, FL-AK provides a quantitative, robust, and flexible method to reveal the dynamics of PKA activity in diverse cell types.

Value of preoperative biliary drainage in pancreatic head cancer patients with severe obstructive jaundice: A multicenter retrospective study.

BACKGROUND: Pancreatic head cancer accompanied by obstructive jaundice is a common clinical situation. The aim of this study was to assess the impact of preoperative biliary drainage (PBD) on clinical outcomes in patients with severe obstructive jaundice. METHODS: Patients with a bilirubin level of ≥250 mmol/L at diagnosis who underwent PBD were included. The primary endpoints and secondary endpoints were the postoperative severe complications rates. Secondary endpoints were the degree of improvement in general condition, predictors of severe postoperative complications, and the impact of PBD on patients with bilirubin levels >300 mmol/L. RESULTS: In total, 289 patients were included, and 188 patients (65.1%) underwent PBD. The patients who met the American Society of Anesthesiologists (ASA) classification II-III stages decreased from 119 to 100 (P = 0.047) after PBD. The overall severe complications were significantly more frequent in the direct surgery (DS) group than in the PBD group (34.7% vs. 22.9%, P = 0.031), especially the postoperative hemorrhage (6/43 [14.0%] vs. 9/35 [25.7%], P = 0.038) and intra-abdominal infection (6/43 [14.0%] vs. 10/35 [28.6%], P = 0.018). The ASA classifications II-III (odds ratio [OR]=2.89, 95% confidence interval [CI]: 1.38-4.31), P = 0.01) and DS (OR = 3.65, 95% CI: 1.45-7.08; P = 0.003) were independently associated with severe postoperative complications. The occurrence rate of severe postoperative complications in patients with a bilirubin level >300 mmol/L who underwent PBD was significantly lower than in patients who underwent DS (25.6% vs. 40.6%, P = 0.028), but the benefit of PBD was not observed in patients who had a bilirubin level between 250 and 300 mmol/L. CONCLUSION: PBD is useful in reducing severe postoperative complications, especially in patients with bilirubin levels >300 mmol/L.

Isomers are more likely to cause collapse of Daphnia magna populations than Di-(2-ethylhexyl) phthalate (DEHP).

Di-(2-ethylhexyl) phthalate (DEHP) is the most commonly used phthalate and is ubiquitous in surface water. Based on its well-established toxicological profile, many countries and regions have adopted specific environmental quality standard (EQS) for DEHP. In China, the EQS value for DEHP is 8 µg/L. However, information on isomers structurally similar to DEHP is limited. Among the isomers of DEHP, di-isooctyl phthalate (DIOP) and di-n-octyl phthalate (DnOP) have received limited attention. The goal of this paper was to study effects and toxic potencies of DEHP, DIOP, and DnOP to individuals and predict effects on populations of female Daphnia magna (cladoceran crustacea) in media containing environmentally relevant concentrations of single PAEs for three consecutive generations (21 days for every generation). Exposure to all three PAEs resulted in reduced survival and reproduction and cause collapse of populations at the highest concentrations. DnOP was the most potent for causing adverse effects followed by DIOP, while DEHP was the least potent. 8 µg DnOP/L were found to reduce the population size by 37 % in the F2 generation. These findings demonstrate that PAE isomers other than DEHP can cause adverse effects.

Developing and evaluating the impact of a small group communication programme in improving the entrepreneurial competence and economic self-efficacy of smallholder farmers with art skills.

The researchers in Study 1 conducted interviews among experts and developed a small group communication programme to be delivered in 24 months. In Study 2, a quasi-experiment was conducted involving 540 smallholder farmers in Nigeria to test the impact of the developed programme. The result showed that smallholder farmers with art skills who received the small group communication programme reported a significant improvement in their entrepreneurial competence and economic self-efficacy compared to smallholder farmers who did not receive the programme. A follow-up assessment after two years revealed the steady effectiveness of the developed programme.

Fabrication of robust and cost-efficient Hoffmann-type MOF sensors for room temperature ammonia detection.

The development of fast-response sensors for detecting NH3 at room temperature remains a formidable challenge. Here, to address this challenge, two highly robust Hoffmann-type metal-organic frameworks are rationally applied as the NH3 sensing materials which possess ultra-high static adsorption capacity for NH3, only lower than the current benchmark material. The adsorption mechanism is in-depth unveiled by dynamic adsorption and simulation studies. The assembled interdigital electrode device exhibits low detection limit (25 ppb) and short response time (5 s) at room temperature, which set a record among all electrical signal sensors. Moreover, the sensor exhibits excellent selectivity towards NH3 in the presence of 13 other potential interfering gases. Prominently, the sensor can stably output signals for more than two months at room temperature and can be recovered by simply purging nitrogen at room temperature without heating. This study opens up a way for reasonably designing gas sensing materials for toxic gases.