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1.
Adv Mater ; : e2201555, 2022 Apr 27.
Artigo em Inglês | MEDLINE | ID: mdl-35475585

RESUMO

Lithium-sulfur (Li-S) batteries promise great potential as high-energy-density energy storage devices due to their ultrahigh theoretical energy density of 2600 Wh kg-1 . Evaluation and analysis on practical Li-S pouch cells are highly essential for achieving actual high energy density under working conditions and affording developing directions for practical applications. This review aims to afford a comprehensive overview of high-energy-density Li-S pouch cells regarding seven years of development and to point out further research directions. Key design parameters to achieve actual high energy density are firstly addressed to define the research boundaries distinguished from coin-cell-level evaluation. Systematical analysis on the published literatures and cutting-edge performances are then conducted to demonstrate the achieved progresses and the gap towards practical applications. Following that, failure analysis as well as promotion strategies at the pouch cell level is respectively discussed to reveal the unique working and failure mechanism that shall be accordingly addressed. Finally, perspectives towards high-performance Li-S pouch cells are presented regarding the challenges and opportunities of this field. This article is protected by copyright. All rights reserved.

2.
J Orthop Res ; 2022 Jan 09.
Artigo em Inglês | MEDLINE | ID: mdl-35005809

RESUMO

Diabetes mellitus contributes to intervertebral disc degeneration. Nucleus pulposus cell senescence plays an important role in intervertebral disc degeneration. However, the effects of hyperglycemia on human nucleus pulposus cells and the underlying process remains poorly understood. In the current study, we evaluated the effects of high glucose levels on human nucleus pulposus cell senescence in vitro and the effects of hyperglycemia on rat nucleus pulposus aging in vivo. Human nucleus pulposus cells were cultured in high-glucose medium (200 mM glucose) for 48 h. Senescence-associated ß-galactosidase staining, western blot analysis, and enzyme-linked immunosorbent assays were performed to evaluate human nucleus pulposus cell senescence. Flow cytometry and enzyme-linked immunosorbent assays were used to evaluate reactive oxygen species and advanced glycation end-product levels. Transcriptome sequencing followed by bioinformatics analysis was used to understand the abnormal biological processes of nucleus pulposus cells cultured in high-glucose medium. Diabetes mellitus rat models were established and histopathological and immunohistochemical analysis was conducted to examine nucleus pulposus tissue senescence in vivo. Exposure to a high glucose concentration promoted human nucleus pulposus cell senescence and increased the senescence-related secretion phenotype in human nucleus pulposus cells in vitro and in rat nucleus pulposus tissue in vivo. Bioinformatics analysis showed that hub genes were involved in nucleus pulposus cell cycle activities and cell senescence. The results suggest that appropriate blood glucose control may be key to preventing intervertebral disc degeneration in diabetic patients.

3.
BMC Cardiovasc Disord ; 22(1): 20, 2022 01 29.
Artigo em Inglês | MEDLINE | ID: mdl-35090397

RESUMO

BACKGROUND: Dextrocardia is a rare congenital condition (1/10,000-12,000) and AF is uncommon (1-2%). Therefore, the occurrence of the two conditions is rare. Percutaneous left atrial appendage occlusion (LAAO) is a treatment to prevent atrial fibrillation (AF)-associated thromboembolic events. CASE PRESENTATION: An 85-year-old female with known situs inversus totalis, persistent AF, and stroke was treated with oral anticoagulation, but she was suffering from constant gingival bleeding. Her CHA2DS2VASc score was 6 points (abnormal, ≥ 2), and her HAS-BLED score was 4 points (abnormal, ≥ 3). The transthoracic echocardiography (TTE) demonstrated left atrial (LA) enlargement (46 mm) and 50% of ejection fraction. She underwent percutaneous LAAO for stroke recurrence prevention using a Watchman occluder. The operation was successful but with technical differences compared with a standard case because of the dextrocardia. CONCLUSION: This is the first reported case of a percutaneous LAAO in situs inversus dextrocardia. This case indicates the feasibility of LAAO in congenital cardiac malposition combined with AF.


Assuntos
Apêndice Atrial/cirurgia , Fibrilação Atrial/cirurgia , Cateterismo Cardíaco/métodos , Procedimentos Cirúrgicos Cardíacos/métodos , Dextrocardia/complicações , Dispositivo para Oclusão Septal , Acidente Vascular Cerebral/prevenção & controle , Idoso de 80 Anos ou mais , Apêndice Atrial/diagnóstico por imagem , Fibrilação Atrial/complicações , Fibrilação Atrial/diagnóstico , Fibrilação Atrial/fisiopatologia , Dextrocardia/diagnóstico , Ecocardiografia , Eletrocardiografia , Feminino , Humanos
4.
Adv Sci (Weinh) ; 9(2): e2103910, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34784102

RESUMO

Lithium-sulfur (Li-S) battery is identified as one of the most promising next-generation energy storage systems due to its ultra-high theoretical energy density up to 2600 Wh kg-1 . However, Li metal anode suffers from dramatic volume change during cycling, continuous corrosion by polysulfide electrolyte, and dendrite formation, rendering limited cycling lifespan. Considering Li metal anode as a double-edged sword that contributes to ultrahigh energy density as well as limited cycling lifespan, it is necessary to evaluate Li-based alloy as anode materials to substitute Li metal for high-performance Li-S batteries. In this contribution, the authors systematically evaluate the potential and feasibility of using Li metal or Li-based alloys to construct Li-S batteries with an actual energy density of 500 Wh kg-1 . A quantitative analysis method is proposed by evaluating the required amount of electrolyte for a targeted energy density. Based on a three-level (ideal material level, practical electrode level, and pouch cell level) analysis, highly lithiated lithium-magnesium (Li-Mg) alloy is capable to achieve 500 Wh kg-1 Li-S batteries besides Li metal. Accordingly, research on Li-Mg and other Li-based alloys are reviewed to inspire a promising pathway to realize high-energy-density and long-cycling Li-S batteries.

5.
J Endovasc Ther ; 29(1): 117-131, 2022 02.
Artigo em Inglês | MEDLINE | ID: mdl-34355606

RESUMO

OBJECTIVE: Smooth muscle cell (SMC) phenotypic switching is associated with development of a variety of occlusive vascular diseases. Paeonol has been reported to be involved in suppressing SMC proliferation. However, it is still unknown whether paeonol can regulate SMC phenotypic switching, and which eventually result in suppressing vasculogenesis. METHODS: Murine left common carotid artery was injured by completely ligation, and paeonol was administrated by intraperitoneal injection. Hematoxylin and eosin (H&E) staining was performed to visualize vascular neointima formation. Rat aortic SMCs were used to determine whether paeonol suppresses cell proliferation and migration. And murine hind limb ischemia model was performed to confirm the function role of paeonol in suppressing vasculogenesis. RESULTS: Complete ligation of murine common carotid artery successfully induced neointima formation. Paeonol treatment dramatically reduced the size of injury-induced neointima. Using rat aortic primary SMC, we identified that paeonol strongly suppressed cell proliferation, migration, and decreased extracellular matrix deposition. And paeonol treatment dramatically suppressed vasculogenesis after hind limb ischemia injury. CONCLUSION: Paeonol could regulate SMC phenotypic switching through inhibiting proliferation and migration of SMC, which results in inhibiting ischemia-induced vasculogenesis.


Assuntos
Lesões das Artérias Carótidas , Músculo Liso Vascular , Acetofenonas , Animais , Lesões das Artérias Carótidas/tratamento farmacológico , Células Cultivadas , Camundongos , Neointima , Ratos , Resultado do Tratamento
6.
J Am Chem Soc ; 143(47): 19865-19872, 2021 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-34761937

RESUMO

Lithium-sulfur (Li-S) batteries constitute promising next-generation energy storage devices due to the ultrahigh theoretical energy density of 2600 Wh kg-1. However, the multiphase sulfur redox reactions with sophisticated homogeneous and heterogeneous electrochemical processes are sluggish in kinetics, thus requiring targeted and high-efficient electrocatalysts. Herein, a semi-immobilized molecular electrocatalyst is designed to tailor the characters of the sulfur redox reactions in working Li-S batteries. Specifically, porphyrin active sites are covalently grafted onto conductive and flexible polypyrrole linkers on graphene current collectors. The electrocatalyst with the semi-immobilized active sites exhibits homogeneous and heterogeneous functions simultaneously, performing enhanced redox kinetics and a regulated phase transition mode. The efficiency of the semi-immobilizing strategy is further verified in practical Li-S batteries that realize superior rate performances and long lifespan as well as a 343 Wh kg-1 high-energy-density Li-S pouch cell. This contribution not only proposes an efficient semi-immobilizing electrocatalyst design strategy to promote the Li-S battery performances but also inspires electrocatalyst development facing analogous multiphase electrochemical energy processes.

7.
ESC Heart Fail ; 8(6): 5560-5564, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-34612024

RESUMO

Myocardial fibrosis detected by cardiac magnetic resonance (CMR) has been reported in patients with desmin-related myopathy, although its characteristics remain unclear. Here, we describe a case of desmin-related restrictive cardiomyopathy wherein CMR imaging revealed myocardial oedema, ischaemia, and fibrosis in the left ventricle; the different types and processes of myocardial injury were detected by CMR. Middle wall left ventricular enhancement may be a feature of late gadolinium enhancement, and the lateral wall is often involved in cases of myocardial injury. CMR is useful for the early detection of cardiac involvement and the prediction of prognosis in patients diagnosed with desmin-related myopathy.


Assuntos
Cardiomiopatias/diagnóstico , Cardiomiopatia Restritiva , Distrofias Musculares/diagnóstico , Cardiomiopatia Restritiva/diagnóstico , Meios de Contraste , Desmina , Feminino , Gadolínio , Humanos , Imagem Cinética por Ressonância Magnética , Espectroscopia de Ressonância Magnética , Adulto Jovem
8.
J Int Med Res ; 49(9): 3000605211041269, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34525883

RESUMO

Oesophageal liposarcomas are particularly rare, accounting for 1.2-1.5% of all gastrointestinal liposarcomas. Surgical resection is the usual treatment. Endoscopic resection is minimally invasive but still controversial. This current case report describes a rare case of a large oesophageal liposarcoma in a 52-year-old male that presented with 10-year history of dysphagia for dry and solid food that was exacerbated by a recent common cold. Thoracoscopic and laparoscopic oesophagectomy was performed. He did not have any dysphagia or dyspnoea 1 week postoperatively. The excised specimen consisted of a polypoid mass measuring 21.0 cm × 5.1 cm. Histological examination confirmed that it was an oesophageal liposarcoma. At 1-year postoperatively, there was no sign of recurrence. Thoracoscopy and laparoscopy can be used to treat large oesophageal masses. Long-term follow-up is required as oesophageal liposarcomas tend to recur.


Assuntos
Neoplasias Esofágicas , Laparoscopia , Lipossarcoma , Neoplasias Esofágicas/diagnóstico por imagem , Neoplasias Esofágicas/cirurgia , Esofagectomia , Humanos , Lipossarcoma/diagnóstico por imagem , Lipossarcoma/cirurgia , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia
9.
Lab Invest ; 101(9): 1238-1253, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-34059758

RESUMO

Spinal cord injury (SCI) is one common neurological condition which involves primary injury and secondary injury. Neuron inflammation and apoptosis after SCI is the most important pathological process of this disease. Here, we tried to explore the influence and mechanism of miRNAs on the neuron inflammatory response and apoptosis after SCI. First, by re-analysis of Gene Expression Omnibus dataset (accession GSE19890), miR-182 was selected for further study because of its suppressive effects on the inflammatory response in the various types of injuries. Functional experiments demonstrated that miR-182 overexpression promoted functional recovery, reduced histopathological changes, and alleviated spinal cord edema in mice. It was also observed that miR-182 overexpression reduced apoptosis and attenuated the inflammatory response in spinal cord tissue, as evidenced by the reduction of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1ß, and the induction of IL-10. Using a lipopolysaccharide (LPS)-induced SCI model in BV-2 cells, we found that miR-182 was downregulated in the BV-2 cells following LPS stimulation, and upregulation of miR-182 improved LPS-induced cell damage, as reflected by the inhibition of apoptosis and the inflammatory response. IκB kinase ß (IKKß), an upstream target of the NF-κB pathway, was directly targeted by miR-182 and miR-182 suppressed its translation. Further experiments revealed that overexpression of IKKß reversed the anti-apoptosis and anti-inflammatory effects of miR-182 in LPS stimulated BV-2 cells. Finally, we found that miR-182 overexpression blocked the activation of the NF-κB signaling pathway in vitro and in vivo, as demonstrated by the downregulation of phosphorylated (p­) IκB-α and nuclear p-p65. Taken together, these data indicate that miR-182 improved SCI-induced secondary injury through inhibiting apoptosis and the inflammatory response by blocking the IKKß/NF-κB pathway. Our findings suggest that upregulation of miR-182 may be a novel therapeutic target for SCI.


Assuntos
Apoptose/efeitos dos fármacos , Inflamação/metabolismo , MicroRNAs/farmacologia , Traumatismos da Medula Espinal/metabolismo , Animais , Modelos Animais de Doenças , Feminino , Quinase I-kappa B/metabolismo , Camundongos , Camundongos Endogâmicos C57BL , NF-kappa B/metabolismo , Transdução de Sinais/efeitos dos fármacos
10.
Front Cell Neurosci ; 15: 646788, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34054430

RESUMO

A secondary injury induced by a spinal cord injury (SCI) remains the main cause of devastating neural dysfunction; therefore, it has been the subject of focused research for many years. Long noncoding RNA (lncRNA) has been found to participate in the SCI process, and this finding presents a high potential for diagnosis and treatment; however, the role of lncRNA in a secondary injury induced by SCI remains unclear. The aim of this study was to investigate the regulatory effect of lncRNA growth arrest-specific transcript 5 (GAS5) in secondary injury during SCI. The SCI mice model and hypoxic cellular model were established to research the roles of lncRNA GAS5 during SCI. Reverse transcription quantitative polymerase chain reaction (qRT-PCR) was conducted to determine the expression levels of microR-93 (miR-93) and lncRNA GAS5. Western blot analysis of the apoptosis regulator protein and terminal deoxynucleotidyl transferase dUTP nick end labeling assay was conducted to evaluate neuron cell apoptosis. Basso, Beattie, and Bresnahan (BBB) scores were calculated to assess neurological function. Flow cytometry was used to determine neuron cell apoptosis. The associations among GAS5, miR-93, and the phosphatase and tensin homolog (PTEN) were disclosed using RNA immunoprecipitation (RIP) assay, RNA pulldown assay, and dual-luciferase reporter assay. QRT-PCR demonstrated that GAS5 was significantly upregulated in both the SCI mice and hypoxic cellular models. GAS5 knockdown suppressed neuron cell apoptosis and inflammatory response in the SCI mice model. Further studies have indicated that GAS5 functions as a competing endogenous RNA (ceRNA) by sponging miR-93 in neuronal cells. In addition, PTEN was a target of miR-93, and GAS5 knockdown exhibited its anti-apoptotic and anti-inflammatory effects through the miR-93/PTEN axis. These findings suggest that the GAS5/miR-93/PTEN axis may be a promising therapeutic target for SCI.

11.
Global Spine J ; : 21925682211001813, 2021 Apr 26.
Artigo em Inglês | MEDLINE | ID: mdl-33896208

RESUMO

STUDY DESIGN: Retrospective study. OBJECTIVE: Lumbar magnetic resonance imaging (MRI) findings are believed to be associated with low back pain (LBP). This study sought to develop a new predictive classification system for low back pain. METHOD: Normal subjects with repeated lumbar MRI scans were retrospectively enrolled. A new classification system, based on the radiological features on MRI, was developed using an unsupervised clustering method. RESULTS: One hundred and fifty-nine subjects were included. Three distinguishable clusters were identified with unsupervised clustering that were significantly correlated with LBP (P = .017). The incidence of LBP was highest in cluster 3 (57.14%), nearly twice the incidence in cluster 1 (30.11%). There were obvious differences in the sagittal parameters among the 3 clusters. Cluster 3 had the smallest intervertebral height. Based on follow-up findings, 27% of subjects changed clusters. More subjects changed from cluster 1 to clusters 2 or 3 (14.5%) than changed from cluster 2 or cluster 3 to cluster 1 (5%). Participation in sport was more frequent in subjects who changed from cluster 3 to cluster 1. CONCLUSION: Using an unsupervised clustering method, we developed a new classification system comprising 3 clusters, which were significantly correlated with LBP. The prediction of LBP is independent of age and better than that based on individual sagittal parameters derived from MRI. A change in cluster during follow-up may partially predict lumbar degeneration. This study provides a new system for the prediction of LBP that should be useful for its diagnosis and treatment.

13.
Front Cardiovasc Med ; 8: 783872, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-35127859

RESUMO

INTRODUCTION: Pathological vascular remodeling is a hallmark of various vascular diseases. Smooth muscle cell (SMC) phenotypic switching plays a pivotal role during pathological vascular remodeling. The mechanism of how to regulate SMC phenotypic switching still needs to be defined. This study aims to investigate the effect of Andrographolide, a key principle isolated from Andrographis paniculate, on pathological vascular remodeling and its underlying mechanism. METHODS: A C57/BL6 mouse left carotid artery complete ligation model and rat SMCs were used to determine whether Andrographolide is critical in regulating SMC phenotypic switching. Quantitative real-time PCR, a CCK8 cell proliferation assay, BRDU incorporation assay, Boyden chamber migration assay, and spheroid sprouting assay were performed to evaluate whether Andrographolide suppresses SMC proliferation and migration. Immunohistochemistry staining, immunofluorescence staining, and protein co-immunoprecipitation were used to observe the interaction between EDNRA, EDNRB, and Myocardin-SRF. RESULTS: Andrographolide inhibits neointimal hyperplasia in the left carotid artery complete ligation model. Andrographolide regulates SMC phenotypic switching characterized by suppressing proliferation and migration. Andrographolide activates the endothelin signaling pathway exhibited by dramatically inducing EDNRA and EDNRB expression. The interaction between EDNRA/EDNRB and Myocardin-SRF resulted in promoting SMC differentiation marker gene expression. CONCLUSION: Andrographolide plays a critical role in regulating pathological vascular remodeling.

14.
J Cardiol Cases ; 22(6): 283-285, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33304422

RESUMO

The purpose of this case report is to describe the multimodal cardiac magnetic resonance (CMR) imaging features of an invasive thymoma extending into the superior vena cava and right atrium. This unusual case indicates that multimodal CMR can not only reveal the morphological features of thymoma but also enable the identification of histological types, which provides a reasonable surgical plan in the perioperative management. .

15.
Med Sci Monit ; 26: e927107, 2020 Nov 05.
Artigo em Inglês | MEDLINE | ID: mdl-33149108

RESUMO

BACKGROUND Spinal cord injury (SCI) is a serious nervous system condition that can cause lifelong disability. The aim of this study was to identify potential molecular mechanisms and therapeutic targets for SCI. MATERIAL AND METHODS We constructed a weighted gene coexpression network and predicted which hub genes are involved in SCI. A compression model of SCI was established in 45 Sprague-Dawley rats, which were divided into 5 groups (n=9 per group): a sham operation group, and 1, 3, 5, and 7 days post-SCI groups. The spinal cord tissue on the injured site was harvested on 1, 3, 5, and 7 days after SCI and 3 days after surgery in the sham operation group. High-throughput sequencing was applied to investigate the expression profile of the mRNA in all samples. Differentially expressed genes were screened and included in weighted gene coexpression network analysis (WGCNA). Co-expressed modules and hub genes were identified by WGCNA. The biological functions of each module were investigated using the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases. RESULTS According to the RNA-seq data, a total of 1965 differentially expressed genes were screened, and WGCNA identified 10 coexpression modules and 5 hub genes. Module function analysis revealed that SCI was associated with immune response, cell division, neuron projection development, and collagen fibril organization. CONCLUSIONS Our study revealed dynamic changes in a variety of biological processes following SCI and identified 5 hub genes via WGCNA. These results provide insights into the molecular mechanisms and therapeutic targets of SCI.


Assuntos
Biologia Computacional , Redes Reguladoras de Genes , Transdução de Sinais/genética , Compressão da Medula Espinal/complicações , Compressão da Medula Espinal/genética , Traumatismos da Medula Espinal/complicações , Traumatismos da Medula Espinal/genética , Animais , Modelos Animais de Doenças , Perfilação da Expressão Gênica , Regulação da Expressão Gênica , Ontologia Genética , Masculino , Ratos Sprague-Dawley , Compressão da Medula Espinal/patologia , Traumatismos da Medula Espinal/patologia
16.
J Orthop Surg Res ; 15(1): 314, 2020 Aug 12.
Artigo em Inglês | MEDLINE | ID: mdl-32787876

RESUMO

OBJECTIVE: To compare the spinal stability with different fixation methods after thoracic TES using finite element analysis METHODS: The spinal finite element model was established from a healthy volunteer, and the validity was verified. The models of T8 thoracic total en bloc spondylectomy (TES) with and without artificial vertebral body were established combination with different fixation methods: the first was long segment fixation with fixed segments T5-7, T9-11; the second was short segment fixation with fixed segments T6-7, T9-10; the third was modified short segment with a pair of vertebral body screws on T7 and T9 added on the basis of short segment fixation. The motions of each model in standing state were simulated in software. The range of motion (ROM) and internal fixation stress changes were analyzed. RESULTS: When anterior support was effective, the three fixation methods could effectively maintain the stability of the spine. However, when anterior support failed, the ROM of the long segment fixation group and the short segment fixation group in the flexion-extension directions was significantly higher than that of when the anterior support existed, while the modified short segment fixation group had no significant changes. Meanwhile, the stress of internal fixation in the long segment fixation group and the short segment fixation group were greatly increased. However, there were no significant changes in modified short segment fixation group. CONCLUSION: After TES, the presence of the thoracic cage gives partial anterior stabilization. When the anterior support failed, the modified short segment fixation method can provide better stability.


Assuntos
Fusão Vertebral/métodos , Vértebras Torácicas/cirurgia , Fenômenos Biomecânicos , Análise de Elementos Finitos , Humanos , Masculino , Pessoa de Meia-Idade , Amplitude de Movimento Articular , Fusão Vertebral/instrumentação , Neoplasias da Coluna Vertebral/cirurgia
17.
Biomed Rep ; 13(2): 6, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32607235

RESUMO

The effect of Apocynum venetum leaf extract (AVLE) on the nervous system has been widely studied, but its effect on injured neurons is not fully understood. In the present study, the protective effect of AVLE on injured neurons was determined. H2O2 was used to induce oxidative stress in PC12 cells and cell viability assays were used to determine the optimum concentration range of AVLE and its protective effects against oxidative stress. A live-dead assay was performed to confirm the effects of AVLE on oxidative stress. Subsequently, expression of apoptotic proteins including Bax and cleaved-caspase-3 were evaluated to determine whether AVLE affected apoptosis, and reactive oxygen species (ROS) levels were detected to determine the role of AVLE in H2O2 exposure. Furthermore, expression of autophagic proteins including LC3-II and p62 were detected to evaluate the effects of AVLE on autophagic activity, and cells were treated with 3-methyladenine (3-MA), an autophagic inhibitor, to identify the underlying protective mechanism of AVLE. The results showed that the optimum conditions to induce oxidative stress were treatment with 40 µM H2O2 for 2 h, and the suitable range of AVLE concentrations was shown to be 1-100 µg/ml. AVLE improved cell viability in PC12 cells following treatment with H2O2. AVLE reduced the expression of Bax and cleaved-caspase-3, and decreased ROS production. Furthermore, AVLE upregulated LC3-II expression and downregulated p62 expression, whereas treatment with 3-MA increased the levels of ROS and apoptotic proteins. These results suggest that AVLE may protect injured neurons against oxidative stress-induced apoptosis, and this effect may be associated with the reduction of ROS by increasing autophagy.

18.
Nanomedicine (Lond) ; 15(15): 1487-1499, 2020 06.
Artigo em Inglês | MEDLINE | ID: mdl-32552485

RESUMO

Aim: To deliver syringic acid (SA) with a nanocarrier and enhance its function. Materials & methods: mPEG-PLGA-PLL (PEAL) nanoparticles were used to deliver SA. The characterization, storage stability, drug release, blood-compatibility and biocompatibility of SA-PEAL were detected by in vitro and in vivo assays. Cellular phenotypic experiments and rat sciatic nerve injury models were used to evaluate the function of SA-PEALs. Results: SA-PEAL had good storage stability, blood-compatibility and biocompatibility and could slowly release SA. SA-PEAL significantly enhanced the proliferation and migration ability of Schwann cells and function recovery of injured sciatic nerves. Conclusion: Our study provides an effective nano-delivery system for enhancing the neural repair function of SA and promoting further applications of SA.


Assuntos
Nanopartículas , Poliésteres , Animais , Ácido Gálico/análogos & derivados , Regeneração Nervosa , Polietilenoglicóis , Ratos , Nervo Isquiático
20.
Clin Imaging ; 63: 7-9, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32120312

RESUMO

The purpose of this case report is to describe the imaging and associated clinical features of an asymptomatic novel coronavirus pneumonia (COVID-19) patient outside Wuhan, China. The principle findings are that in this patient with laboratory-confirmed COVID-19, CT findings preceded symptoms and included bilateral pleural effusions, previously not reported in association with COVID-19. The role of this case report is promotion of potential recognition amongst radiologists of this new disease, which has been declared a global health emergency by the World Health Organization (WHO).


Assuntos
Infecções Assintomáticas , Infecções por Coronavirus/diagnóstico por imagem , Derrame Pleural/virologia , Pneumonia Viral/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Betacoronavirus , COVID-19 , China , Humanos , Masculino , Pessoa de Meia-Idade , Pandemias , SARS-CoV-2
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