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1.
Platelets ; : 1-4, 2019 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-31509040

RESUMO

Avian influenza A (H7N9) is a serve zoonosis with a high mortality rate. Timely and effective diagnosis and early warning is crucial for the clinical treatment of H7N9 patients. The previous studies indicated that thrombocytopenia was associated with the prognosis of influenza cases, but the related evidence of platelet change within the course of the disease remains largely insufficient. A total of 130 laboratory-confirmed H7N9 cases and their corresponding medical records from August 2013 to March 2015 were collected from 23 hospitals of 13 cities in Guangdong, China. The results indicated that there was a significant difference between the outcome of H7N9 cases and their average platelet count (PC) including maximum, minimum, range, admission and discharge/death of the PC value. Furthermore, we built a classification and regression tree (CART) model to predict the fatality rate which varied with average PC. There was a 7% chance for a mortality from H7N9 if PC was over 207.0 × 10^9/L, while there was a 46.3% chance of a mortality from H7N9 when PC was between 123.9 × 10^9/L and 207.0 × 10^9/L, and 81.3% chance of a mortality from H7N9 when PC was less than 123.9 × 10^9/L. This study demonstrates that using platelet count to predict the fatality of H7N9 is significant, and lower platelet counts of H7N9 patients were associated with higher risk of mortality of H7N9 patients, which may need to be taken into consideration when planning clinical treatment.

2.
World Neurosurg ; 2019 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-31493609

RESUMO

OBJECTION: Delayed postoperative hemorrhage (DPOH) was a severe postoperative complication after intracranial epidermoid cyst (EC) surgery. This study was designed to investigate possible clinical data and image features related to DPOH in EC patients. MATERIAL AND METHODS: We retrospectively investigated 186 cases of EC and eight cases presented an appearance of DPOH. Preoperative magnetic resonance imaging(MRI)and clinical data (age, sex, chief surgeon, tumor size, tumor location and degree of resection) were reviewed and analyzed. Student's t-test and chi-square test were used and statistical significance was defined as P < 0.05. RESULTS: A total of eight patients suffered from DPOH. Seven patients (87.5%) with DPOH showed atypical mixed signal intensity on preoperative T1 MRI, compared with typical low-intensity in another DPOH case. Only one case of mixed signal intensity on T1 MRI was found in 178 patients without DPOH. The mixed signal intensity in preoperative T1 MRI was highly related to DPOH and mortality (both P < 0.001). There is no significant difference in other relative clinical data between patients with or without DPOH. CONCLUSION: Mixed signal intensity on preoperative T1 MRI might be associated with DPOH in patients with EC. The surgeon should pay more attention to this rarely atypical imaging before surgery. Further observations are necessary to illustrate the relationship of mixed signal intensity and DPOH in EC and to guide reasonable therapy.

3.
Sci Rep ; 9(1): 11152, 2019 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-31371769

RESUMO

Despite the growing attentions dedicated to the harvesting of acoustic energy that is a clean and renewable yet usually wasted energy source, the long wavelength of airborne sound still poses fundamental limits on the miniaturization of harvester devices and hinders practical applications. Here we present an ultrathin and planar acoustic energy harvester with rigidity. We propose a distinctive metasurface-based mechanism that reduces the effective wavelength to produce extraordinarily strong local energy within deep-subwavelength dimension and enable high-efficiently harvesting energy of incident airborne sound with considerably long wavelength. Our design idea is implemented by a foldy-structured metasurface capable of confining low-frequency energy within narrow channel at resonance, with a piezoelectric plate judiciously placed to converse acoustic to electric energy. The resulting device is downscaled to as thin as λ/63 while keeping flat shape and mechanical rigidity. We analytically derive the effective acoustical parameter of the unit cell, and verify the theoretical predictions via numerical simulations which shows the generation of the maximum output power at the prescribed working frequency. Our design with compactness and rigidity makes an important step towards the miniaturization and integration of acoustic energy harvesters and may have far-reaching implication in diverse applications ranging from microelectronic device design to wireless and self-powered active sensing.

4.
Environ Res ; 177: 108610, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31376629

RESUMO

BACKGROUND: Heatwaves affect human health and global heatwave-related disease burden will continue to rise as climate change proceeds, but the effects of heatwaves on cardiovascular and respiratory diseases have not yet been investigated globally and nationally. OBJECTIVES: This systematic review and meta-analysis aim to quantify heatwave effects on four major health outcomes: cardiovascular and respiratory morbidity and mortality. METHODS: We searched PubMed, Scopus, Embase, and Web of Science for relevant studies from database inception to November 2018. Categories of morbidity included hospital admissions, emergency department visits, and ambulance attendances/call-outs. A random-effects meta-analysis model was used to pool previous estimates of heatwave effects on mortality and morbidity due to cardiovascular and respiratory diseases. Subgroup analyses by gender, age, and disease cause were conducted. Sensitivity analyses were performed by the categories of morbidity, heatwave definitions, study design, and using a leave-one-out cross validation approach. This study is registered with PROSPERO (number: CRD42018101964). RESULTS: We identified 54 studies conducted in 20 countries. In total, there were significant associations between heatwaves and cardiovascular mortality (risk estimates (RE): 1.149, 95% confidence interval (CI): 1.090, 1.210) and respiratory mortality (RE: 1.183, 95%CI: 1.092, 1.282), but the magnitude of these associations varied across countries and studies. Heatwaves appeared to be marginally associated with cardiovascular and respiratory morbidities (RE: 0.999, 95%CI: 0.996, 1.002, p-value = 0.61 for cardiovascular morbidity; RE: 1.043, 95%CI: 0.995, 1.093; p-value = 0.08 for respiratory morbidity). For mortality, significant associations were observed for the elderly, ischemic heart disease, stroke, heart failure, and chronic obstructive pulmonary disease. Sensitivity analyses suggested that these findings were robust. CONCLUSION: Mortality of cardiovascular and respiratory diseases appeared to be more vulnerable to heatwaves in comparison to morbidity. Considering high heterogeneity detected between studies and limited investigations into subpopulations, more research are required to provide a clearer picture of how heatwaves affect cardiovascular and respiratory diseases in different settings.

5.
Artigo em Inglês | MEDLINE | ID: mdl-31425078

RESUMO

Multi-view visual classification methods have been widely applied to use discriminative information of different views. This strategy has been proven very effective by many researchers. On the one hand, images are often treated independently without fully considering their visual and semantic correlations. On the other hand, view consistency is often ignored. To solve these problems, in this paper, we propose a novel multi-view image classification method with visual, semantic and view consistency (VSVC). For each image, we linearly combine multi-view information for image classification. The combination parameters are determined by considering both the classification loss and the visual, semantic and view consistency. Visual consistency is imposed by ensuring that visually similar images of the same view are predicted to have similar values. For semantic consistency, we impose the locality constraint that nearby images should be predicted to have the same class by multiview combination. View consistency is also used to ensure that similar images have consistent multi-view combination parameters. An alternative optimization strategy is used to learn the combination parameters. To evaluate the effectiveness of VSVC, we perform image classification experiments on several public datasets. The experimental results on these datasets show the effectiveness of the proposed VSVC method.

6.
Autoimmunity ; 52(4): 161-167, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31394943

RESUMO

Background: Semaphorin-3A (Sema3A) and Semaphorin-7A (Sema7A) play crucial roles in immune system by inhibiting T cell proliferation and leading to the secretion of pro-inflammatory cytokines. Increasing evidence suggest that Sema3A and Sema7A may link to the development and pathogenesis of systemic lupus erythematosus (SLE). Objective: This study aims to evaluate the association of Sema3A, Sema7A gene single-nucleotide polymorphisms (SNPs) with susceptibility to SLE. Methods: There were 495 SLE patients and 493 healthy controls in the study. Sema3A gene and Sema7A gene were genotyped by improved multiple ligase detection reaction (iMLDR), their plasma expression levels were detected by enzyme-linked immunosorbent assay (ELISA). Results: No differences in genotype and allele frequencies of these SNPs were observed between SLE patients and healthy controls. However, analysing Sema3A and Sema7A SNPs with clinical manifestations of SLE indicated that, in Sema3A, the A allele frequencies of rs7804122 polymorphism was higher in patients with oral ulcers. In Sema7A, there were differences in allele frequencies of the rs2075589 and rs28362930 polymorphisms between SLE patients with haematological disorder and those without. The GG genotype and G allele frequencies of rs28362930 and the CC genotype, and C allele frequencies of rs741761 were both related to discoid rash in SLE patients. The allele frequency of G (rs28362930) was higher in SLE patients with renal disorder. There were differences in the genotype frequencies and allele frequencies of rs741761 between SLE patients with and without arthritis. No differences in plasma Sema3A and Sema7A levels were detected in SLE patients of different genotypes. Conclusions: Sema3A and Sema7A gene polymorphisms are not related to SLE genetic susceptibility, but may link to several clinical features of SLE.

7.
Ying Yong Sheng Tai Xue Bao ; 30(6): 1919-1926, 2019 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-31257764

RESUMO

Microbial oxidation is the only biological sink of atmospheric methane (CH4). It is essential to understand the variation of CH4 fluxes among different grassland use types for developing low-emission management system. Here, we measured the CH4 flux and the soil methane-oxidizing bacteria abundance in a typical steppe under grazing, mowing and fencing management in central Inner Mongolia, with the aims to determine the effects of these grassland use types on CH4 flux, and to test the hypothesis that pmoA functional gene abundance regulates CH4 fluxes. The measurements were conducted on the experimental grassland that had experienced four grassland use treatments over five years. The treatments were whole growing season grazing from May to September (T1), spring and summer grazing (twice in May and July)(T2), autumn mowing (T3) and enclosure (T0). We measured CH4 flux using static chamber method, and quantified the abundance of pmoA functional genes using molecular techniques. Moreover, we measured plant biomass and soil physicochemical properties. The results showed that moderate grazing significantly enhanced CH4 uptake rate and the methane-oxidizing bacteria abundance (i.e., the pmoA gene copy number per gram of dry soil). The pmoA gene copy number ranged from 6.9×104 to 3.9×105 per gram of dry soil in growing season. The CH4 uptake rate was (68.21±3.01) µg·m-2·h-1 under T1, which was 22.1%, 37.5% and 30.9% higher than that under T2, T3 or T0 , respectively. The CH4 uptake rate was positively correlated with abundance of CH4 oxidizing bacteria and soil sand content, but negatively correlated with soil silt content, soil moisture, NH4+-N and NO3--N content, and plant biomass. These results suggested that the steppe ecosystem is a CH4 sink under all land-use types in central Inner Mongolia, and that moderate grazing would enhance methane-oxidizing bacteria abundance and CH4 uptake by improving soil sand content, reducing soil mineral nitrogen content and plant production in the typical steppe ecosystem. These results were of significance for the development of low-emission grassland management system.


Assuntos
Ecossistema , Metano/análise , Methylococcaceae/fisiologia , China , Solo
8.
IEEE Trans Cybern ; 2019 Jul 11.
Artigo em Inglês | MEDLINE | ID: mdl-31295131

RESUMO

We develop a novel method for measuring the similarity between complete weighted graphs, which are probed by means of the discrete-time quantum walks. Directly probing complete graphs using discrete-time quantum walks is intractable due to the cost of simulating the quantum walk. We overcome this problem by extracting a commute time minimum spanning tree from the complete weighted graph. The spanning tree is probed by a discrete-time quantum walk which is initialized using a weighted version of the Perron-Frobenius operator. This naturally encapsulates the edge weight information for the spanning tree extracted from the original graph. For each pair of complete weighted graphs to be compared, we simulate a discrete-time quantum walk on each of the corresponding commute time minimum spanning trees and, then, compute the associated density matrices for the quantum walks. The probability of the walk visiting each edge of the spanning tree is given by the diagonal elements of the density matrices. The similarity between each pair of graphs is then computed using either: 1) the inner product or 2) the negative exponential of the Jensen-Shannon divergence between the probability distributions. We show that in both cases the resulting similarity measure is positive definite and, therefore, corresponds to a kernel on the graphs. We perform a series of experiments on publicly available graph datasets from a variety of different domains, together with time-varying financial networks extracted from data for the New York Stock Exchange. Our experiments demonstrate the effectiveness of the proposed similarity measures.

9.
Am J Pathol ; 189(8): 1637-1653, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31345467

RESUMO

Cholangiocarcinoma (CCA) is a malignant cancer that is associated with high mortality rates. The relationship between laminin γ 2 chain gene (LAMC2) and epidermal growth factor receptor (EGFR) has been previously documented in gastric cancer and oral squamous cell carcinoma. This study investigates the role of LAMC2 in epithelial-mesenchymal transition (EMT) and angiogenesis in CCA and explores the underlying mechanism(s). Differentially expressed genes related to CCA were initially screened using a microarray analysis, and the interaction between LAMC2 and the EGFR signaling pathway was identified. To determine the regulatory effects of LAMC2 on CCA progression, LAMC2 was silenced or overexpressed and the EGFR signaling pathway was activated or blocked. Subsequently, the regulation effects of LAMC2 were evaluated on the expression of EMT markers, invasion and migration of CCA cells, as well as microvessel density in nude mice. Microarray analysis demonstrated that highly expressed LAMC2 is linked to CCA development, which involves the EGFR signaling pathway. When LAMC2 expression was increased, the EGFR signaling pathway and EMT were activated in CCA tissues. Silencing of LAMC2 as well as EGFR signaling pathway inhibition led to suppression of EMT, cell invasion, and migration abilities in vitro, as well as angiogenesis in vivo. This study demonstrates that LAMC2 silencing suppresses the activity of the EGFR signaling pathway, thus functioning as a tumor suppressor in CCA.

10.
Br J Neurosurg ; : 1-2, 2019 Jul 10.
Artigo em Inglês | MEDLINE | ID: mdl-31290349

RESUMO

Massive cerebellar hemorrhage from hemangioblastomas in children has never been described to our knowledge. We reported a 10-year-old child who presented with a large hematoma in the left cerebellar hemisphere. Hemangioblastomas was not expected preoperatively to be the cause. An emergency suboccipital craniotomy was performed. Histopathological examination confirmed the diagnosis of hemangioblastoma with massive hemorrhage.

11.
Adv Mater ; 31(35): e1902930, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31267581

RESUMO

Biological materials with hierarchical architectures (e.g., a macroscopic hollow structure and a microscopic cellular structure) offer unique inspiration for designing and manufacturing advanced biomimetic materials with outstanding mechanical performance and low density. Most conventional biomimetic materials only benefit from bioinspired architecture at a single length scale (e.g., microscopic material structure), which largely limits the mechanical performance of the resulting materials. There exists great potential to maxime the mechanical performance of biomimetic materials by leveraging a bioinspired hierarchical structure. An ink-based three-dimensional (3D) printing strategy to manufacture an ultralight biomimetic hierarchical graphene material (BHGMs) with exceptionally high stiffness and resilience is demonstrated. By simultaneously engineering 3D-printed macroscopic hollow structures and constructing an ice-crystal-induced cellular microstructure, BHGMs can achieve ultrahigh elasticity and stability at compressive strains up to 95%. Multiscale finite element analyses indicate that the hierarchical structures of BHGMs effectively reduce the macroscopic strain and transform the microscopic compressive deformation into the rotation and bending of the interconnected graphene flakes. This 3D printing strategy demonstrates the great potential that exists for the assembly of other functional materials into hierarchical cellular structures for various applications where high stiffness and resilience at low density are simultaneously required.

12.
Artigo em Inglês | MEDLINE | ID: mdl-31154587

RESUMO

Accurate prediction of risk-states in Serious Mental Illnesses (SMIs) is critical for reducing their massive societal burden. Risk-state assessments are notably inaccurate. Recent innovations, including widely available and inexpensive mobile technologies for ambulatory "biobehavioral" data, can reshape risk assessment. To help understand and accelerate clinician involvement, we surveyed 90 multi-disciplinary clinicians serving SMI populations in various settings to evaluate how risk assessment is conducted and can improve. Clinicians reported considerable variability in conducting risk assessment, and few clinicians explicated their procedures beyond tying it to broader mental status examinations or interviews. Very few clinicians endorsed using currently-available standardized risk measures, and most reported low confidence in their utility. Clinicians also reported spending approximately half the time conducting individual risk assessments than optimally needed. When asked about improvement, virtually no clinicians acknowledged biobehavioral, objective technologies, or ambulatory recording. Overall, clinicians seemed unaware of meaningful ways to improve risk assessment.

13.
Org Lett ; 21(13): 5051-5054, 2019 Jul 05.
Artigo em Inglês | MEDLINE | ID: mdl-31199154

RESUMO

Ochrocephalamines B-D (1-3), composed of fused quinolizidine and octahydroquinoline rings, were isolated from Oxytropis ochrocephala Bunge. Ochrocephalamine B (1) has a unique bridged tetracyclic ring skeleton fused with a lactam ring. The structures of 1-3 were elucidated using spectroscopic and computational approaches. Ochrocephalamine C (2) and D (3) demonstrated potent anti-HBV activities and are more potent against the secretion of HBeAg than that of HBsAg.

14.
Environ Health Perspect ; 127(5): 57012, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31148503

RESUMO

BACKGROUND: Prenatal exposure to air pollution has been associated with childhood respiratory disease and other adverse outcomes. Epigenetics is a suggested link between exposures and health outcomes. OBJECTIVES: We aimed to investigate associations between prenatal exposure to particulate matter (PM) with diameter [Formula: see text] ([Formula: see text]) or [Formula: see text] ([Formula: see text]) and DNA methylation in newborns and children. METHODS: We meta-analyzed associations between exposure to [Formula: see text] ([Formula: see text]) and [Formula: see text] ([Formula: see text]) at maternal home addresses during pregnancy and newborn DNA methylation assessed by Illumina Infinium HumanMethylation450K BeadChip in nine European and American studies, with replication in 688 independent newborns and look-up analyses in 2,118 older children. We used two approaches, one focusing on single cytosine-phosphate-guanine (CpG) sites and another on differentially methylated regions (DMRs). We also related PM exposures to blood mRNA expression. RESULTS: Six CpGs were significantly associated [false discovery rate (FDR) [Formula: see text]] with prenatal [Formula: see text] and 14 with [Formula: see text] exposure. Two of the [Formula: see text] CpGs mapped to FAM13A (cg00905156) and NOTCH4 (cg06849931) previously associated with lung function and asthma. Although these associations did not replicate in the smaller newborn sample, both CpGs were significant ([Formula: see text]) in 7- to 9-y-olds. For cg06849931, however, the direction of the association was inconsistent. Concurrent [Formula: see text] exposure was associated with a significantly higher NOTCH4 expression at age 16 y. We also identified several DMRs associated with either prenatal [Formula: see text] and or [Formula: see text] exposure, of which two [Formula: see text] DMRs, including H19 and MARCH11, replicated in newborns. CONCLUSIONS: Several differentially methylated CpGs and DMRs associated with prenatal PM exposure were identified in newborns, with annotation to genes previously implicated in lung-related outcomes. https://doi.org/10.1289/EHP4522.

15.
Psychiatry Res ; 273: 767-769, 2019 03.
Artigo em Inglês | MEDLINE | ID: mdl-31207864

RESUMO

Evaluating patients' verbal fluency by counting the number of unique words (e.g., animals) produced in a short-period (e.g., 1-3 min) is one of the most widely employed cognitive tests in psychiatric research. We introduce new methods to analyze fluency output that leverage modern computational language technology. This enables moving beyond simple word counts to charting the temporal dynamics of speech and objectively quantifying the semantic relationship of the utterances. These metrics can greatly expand the current psychiatric research toolkit and can help refine clinical theories regarding the nature of putative language differences in patients.

16.
Cancer Lett ; 459: 156-167, 2019 Sep 10.
Artigo em Inglês | MEDLINE | ID: mdl-31181320

RESUMO

The overexpression of the MDM2 oncoprotein frequently occurs in hepatocellular carcinoma (HCC). Small molecules that inhibit MDM2-p53 binding show efficacy against p53 wild-type HCC, but most patients have p53-mutant tumors and intrinsic resistance to such MDM2 inhibitors. We have recently discovered that the NFAT1 transcription factor upregulates MDM2 expression, but the role of NFAT1 in HCC is not fully understood. The present study was designed to develop a dual-targeting (MDM2 and NFAT1) strategy for the treatment of HCC. We herein demonstrate that high expression levels of NFAT1 and MDM2 are independent predictors of a poor prognosis in patients with HCC. We have also identified a MDM2 and NFAT1 dual inhibitor (termed MA242) that induces MDM2 auto-ubiquitination and degradation and represses NFAT1-mediated MDM2 transcription. MA242 profoundly inhibits the growth and metastasis of HCC cells in vitro and in vivo, independent of p53. The present efficacy and mechanistic studies provide proof-of-principle data to support the therapeutic value of this dual targeting strategy in future drug discovery.

17.
Medicine (Baltimore) ; 98(18): e15167, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31045760

RESUMO

Patients with persistent or recurrent trigeminal neuralgia (TN) after microvascular decompression (MVD) are frequently difficult to manage. This study aimed to analyze the safety and efficiency of repeat MVD, with the main focus on prognostic factors and long-term outcomes.We performed a retrospective study of 41 TN patients (19 men, 22 women) who underwent repeat MVD due to persistent or recurrent pain from January 2008 to January 2016. These patients were followed up from 12 to 96 months (mean, 42 ±â€Š17.3 months). Univariate analysis by Spearman's rank correlation coefficient was used for analysis of prognostic factors.During the repeat MVD, compression of the trigeminal nerve was noted by an artery in 15 patients (36.6%), vein in 6 patients (14.6%), Teflon in 8 patients (19.5%), and no compression in 12 patients (29.3%). Twenty-one patients (51.2%) had already undergone 1 or more previous ablative procedures, either before the first MVD or between the surgeries. The complete pain relief rates of repeat MVD were 87.8% immediately after surgery and 75% at last follow-up. Thirteen patients (31.7%) had new or increased facial numbness after repeat surgery. Univariate analysis revealed 2 prognostic factors, negative finding during reoperation (P = .021) and no pain relief after the initial surgery (P = .038), that showed a negative influence on success rates after repeat MVD.Repeat MVD can still achieve an excellent outcome in patients with persistent or recurrent pain. However, the risk of facial numbness is increased. Surgeons should be selective in performing repeat MVD, priority should be given to patients who have a pain-free interval after initial MVD or show demonstrable compression on imaging studies.


Assuntos
Cirurgia de Descompressão Microvascular/efeitos adversos , Reoperação/estatística & dados numéricos , Neuralgia do Trigêmeo/diagnóstico , Neuralgia do Trigêmeo/cirurgia , Adulto , Idoso , Feminino , Humanos , Hipestesia/etiologia , Masculino , Cirurgia de Descompressão Microvascular/métodos , Pessoa de Meia-Idade , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Prognóstico , Recidiva , Reoperação/efeitos adversos , Estudos Retrospectivos , Resultado do Tratamento , Neuralgia do Trigêmeo/etiologia , Neuralgia do Trigêmeo/patologia
18.
J Cell Mol Med ; 23(8): 5340-5348, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31124601

RESUMO

The aim of our study was to assess the associations of HSP90AB1 copy number variations (CNVs) with systemic lupus erythematosus (SLE) risk and glucocorticoids (GCs) efficacy, as well as the relationship between HSP90AB1 single-nucleotide polymorphisms (SNPs) and GCs efficacy. HSP90AB1 CNVs and SLE risk were analysed in 519 patients and 538 controls. Patients treated with GCs were followed up for 12 weeks and were divided into sensitive and insensitive groups to investigate the effects of CNVs (419 patients) and SNPs (457 patients) on the efficacy of GCs. Health-related quality of life (HRQoL) was also measured by SF-36 at baseline and week 12 to explore the relationship between CNVs/SNPs and HRQoL improvements in Chinese SLE patients. Our results indicated a statistically significant association between HSP90AB1 CNVs and SLE (PBH  = 0.039), and this association was more pronounced in the female subgroup (PBH  = 0.039). However, we did not detect association of HSP90AB1 CNVs/SNPs with efficacy of GCs. But we found a marginal association between SNP rs13296 and improvement in Role-emotional, while this association was not strong enough to survive in the multiple testing corrections. Collectively, our findings suggest that the copy number of HSP90AB1 is associated with SLE susceptibility. But copy number and polymorphisms of HSP90AB1 may not be associated with efficacy of GCs.

19.
Sci Total Environ ; 682: 514-522, 2019 Sep 10.
Artigo em Inglês | MEDLINE | ID: mdl-31129539

RESUMO

OBJECTIVES: Air pollution is an important trigger of cardiovascular disease worldwide, but few studies have determined the cardiovascular disease, health, and economic burdens attributable to ambient carbon monoxide (CO). This study aimed to examine the association between CO and CVD hospitalizations, and quantified the attributable CVD hospitalizations, associated hospital stays and hospitalization costs for CO in Lanzhou, one of the most air-polluted Chinese cities historically. METHODS: Daily data on CVD hospitalizations, air pollutants, and weather records from 2013 to 2017 were obtained for Lanzhou, China. Generalized additive model with a quasi-Poisson link was used to model the association between CO and CVD hospitalizations, after controlling for other air pollutants, weather conditions, day of week, long-term trend, influenza and pneumonia incidence. The effects of CO on hospital stays and hospitalization expenses from CVD were also quantified. RESULTS: CO concentrations below the current Chinese ambient air quality standard had a significant impact on CVD hospitalizations. Each 1 mg/m3 increase in CO concentration on the present day and previous 4 days (lag 0-4) was associated with an 11% (95% confidence interval: 3%-20%) increase in total CVD hospitalizations. During the study period, CO was responsible for 11.74% of total CVD hospitalizations, equating to 62,792 inpatient days and 149 million RMB. Each adult patient on average spent approximately 5% of annual salary on medicine from CO-related CVD treatment during hospitalization. Maintaining the historical CO concentration within 1 to 3 mg/m3 could avert hundreds of total CVD hospitalizations and save millions of RMB annually in Lanzhou, China. CONCLUSIONS: Exposure to low-level ambient CO concentration increased the risk of CVD hospitalizations and resulted in substantial health and economic burdens in Lanzhou, China. Our findings can be used for evidence-based practice and policy making to assess the cost-effectiveness of prevention measures.


Assuntos
Poluentes Atmosféricos/análise , Poluição do Ar/estatística & dados numéricos , Monóxido de Carbono/análise , Doenças Cardiovasculares/epidemiologia , Exposição Ambiental/estatística & dados numéricos , Política Ambiental , Adulto , China/epidemiologia , Hospitalização , Humanos
20.
Med Phys ; 46(6): 2696-2708, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30994186

RESUMO

PURPOSE: Dual-head positron emission tomography (PET) scanners have increasingly attracted the attention of many researchers. However, with the compact geometry, the depth-of-interaction blurring will reduce the image resolution considerably. Monte Carlo (MC)-based system response matrix (SRM) is able to describe the physical process of PET imaging accurately and improve reconstruction quality significantly. The MC-based SRM is large and precomputed, which leads to a longer image reconstruction time with indexing and retrieving precomputed system matrix elements. In this study, we proposed a GPU acceleration algorithm to accelerate the iterative reconstruction. METHODS: It has been demonstrated that the line-of-response (LOR)-based symmetry and the Graphics Processing Unit (GPU) technology can accelerate the reconstruction tremendously. LOR-based symmetry is suitable for the forward projection calculation, but not for the backprojection. In this study, we proposed a GPU acceleration algorithm that combined the LOR-based symmetry and voxel-based symmetry together, in which the LOR-based symmetry is responsible for the forward projection, and the voxel-based symmetry is used for the backprojection. RESULTS: Simulation and real experiments verify the efficiency of the algorithm. Compared with the CPU-based calculation, the acceleration ratios of the forward projection and the backprojection operation are 130 and 110, respectively. The total acceleration ratio is 113×. In order to compare the acceleration effect of the different symmetries, we realized the reconstruction with the voxel-based symmetry and the LOR-based symmetry strategies. Compared with the LOR-based GPU reconstruction, the acceleration ratio is 3.5×. Compared with the voxel-based GPU reconstruction, the acceleration ratio is 12×. CONCLUSION: We have proposed a new acceleration algorithm for the dual-head PET system, in which both the forward and backprojection operations are accelerated by GPU.

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