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2.
Adv Mater ; : e2004553, 2020 Oct 13.
Artigo em Inglês | MEDLINE | ID: mdl-33048428

RESUMO

Halogen redox couples offer several advantages for energy storage such as low cost, high solubility in water, and high redox potential. However, the operational complexity of storing halogens at the oxidation state via liquid-phase media hampers their widespread application in energy-storage devices. Herein, an aqueous zinc-dual-halogen battery system taking the advantages of redox flow batteries (inherent scalability) and intercalation chemistry (high capacity) is designed and fabricated. To enhance specific energy, the designed cell exploits both bromine and chlorine as the cathode redox couples that are present as halozinc complexes in a newly developed molten hydrate electrolyte, which is distinctive to the conventional zinc-bromine batteries. Benefiting from the reversible uptake of halogens at the graphite cathode, exclusive reliance on earth-abundant elements, and membrane-free and possible flow-through configuration, the proposed battery can potentially realize high-performance massive electric energy storage at a reasonable cost.

3.
J Transl Med ; 18(1): 378, 2020 10 07.
Artigo em Inglês | MEDLINE | ID: mdl-33028341

RESUMO

BACKGROUND: Molecular classification has laid the framework for exploring glioma biology and treatment strategies. Pro-neural to mesenchymal transition (PMT) of glioma is known to be associated with aggressive phenotypes, unfavorable prognosis, and treatment resistance. Recent studies have highlighted that long non-coding RNAs (lncRNAs) are key mediators in cancer mesenchymal transition. However, the relationship between lncRNAs and PMT in glioma has not been systematically investigated. METHODS: Gene expression profiles from The Cancer Genome Atlas (TCGA), the Chinese Glioma Genome Atlas (CGGA), GSE16011, and Rembrandt with available clinical and genomic information were used for analyses. Bioinformatics methods such as weighted gene co-expression network analysis (WGCNA), gene set enrichment analysis (GSEA), Cox analysis, and least absolute shrinkage and selection operator (LASSO) analysis were performed. RESULTS: According to PMT scores, we confirmed that PMT status was positively associated with risky behaviors and poor prognosis in glioma. The 149 PMT-related lncRNAs were identified by WGCNA analysis, among which 10 (LINC01057, TP73-AS1, AP000695.4, LINC01503, CRNDE, OSMR-AS1, SNHG18, AC145343.2, RP11-25K21.6, RP11-38L15.2) with significant prognostic value were further screened to construct a PMT-related lncRNA risk signature, which could divide cases into two groups with distinct prognoses. Multivariate Cox regression analyses indicated that the signature was an independent prognostic factor for high-grade glioma. High-risk cases were more likely to be classified as the mesenchymal subtype, which confers enhanced immunosuppressive status by recruiting macrophages, neutrophils, and regulatory T cells. Moreover, six lncRNAs of the signature could act as competing endogenous RNAs to promote PMT in glioblastoma. CONCLUSIONS: We profiled PMT status in glioma and established a PMT-related 10-lncRNA signature for glioma that could independently predict glioma survival and trigger PMT, which enhanced immunosuppression.

4.
Neural Plast ; 2020: 8880543, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33082779

RESUMO

Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting side effect caused by chemotherapy drugs, and its existence seriously affects the quality of life of patients. We first established an oxaliplatin-induced peripheral neuropathy (OIPN) model and then measured and evaluated mechanical hyperalgesia, thermal nociception, cold allodynia, and intraepidermal nerve fiber (IENF) density to determine Siwei Jianbu Decoction's role in preventing OIPN. Then, we conducted a systematic pharmacological study that revealed important roles for the MAPK signaling pathway and proinflammatory immune pathway and confirmed these roles by western blot, immunofluorescence, and qPCR. The data show that Siwei Jianbu Decoction can effectively prevent oxaliplatin-induced neuroinflammation by inhibiting an increase in NF-κB expression via downregulation of p-ERK1/2 and p-p38. The present study showed that SWJB may be beneficial in preventing oxaliplatin-induced peripheral neuropathy.

5.
Nanoscale ; 2020 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-33057564

RESUMO

The development of highly efficient and robust biomimetic catalysts is an essential and feasible strategy to overcome the intrinsic drawbacks of natural enzymes. Inspired by the synthetic strategy of covalent organic frameworks, we adopted a covalent-bond-driven strategy to prepare polyoxometalate (POM) based open frameworks (NKPOM-OFs = Nankai University POM-OFs) with abundant Mo[double bond, length as m-dash]O groups that can mimic the active center of sulfite oxidase. Four 2-dimensional (2D) NKPOM-OFs were designed and synthesized via the condensation reaction of linear amino-containing POMs with planar tetra-aldehyde monomers. Benefitting from the high crystallinity, the structures of 2D POM-OFs can be successfully determined from structural simulations. The results unveiled that NKPOM-OFs possessed 2D staggered stacking layered structures with the sql topology. All these NKPOM-OFs exhibited high crystallinity and stability and demonstrated outstanding performance to serve as biomimetic catalysts of sulfite oxidase with good recyclability. Notably, exfoliation of NKPOM-OFs under ultrasonic treatment can significantly boost the catalytic activity with almost two times faster reaction rates. This study not only enriches the facile and versatile synthesis strategy for POM-OFs but also provides new biomimetic platforms for biocatalysis.

6.
Ann Hum Biol ; : 1-16, 2020 Oct 16.
Artigo em Inglês | MEDLINE | ID: mdl-33059477

RESUMO

BACKGROUND: Mongolian populations are widely distributed geographically, showing abundant ethnic diversity with geographic and tribal differences. AIM: To infer the genetic substructure, admixture and ancient genetic sources of Mongolians together with Kazakhs. SUBJECTS AND METHODS: We genotyped more than 690,000 genome-wide SNPs from 33 Mongolian and Chinese Kazakh individuals s and compared these with both ancient and present-day Eurasian populations using Principal Component Analysis (PCA), ADMIXTURE, Refine-IBD, f statistics, qpWave and qpAdm. RESULTS: We found genetic substructures within Mongolians corresponding to Ölöd, Chahar, and Inner Mongolian clusters, which was consistent with tribe classifications. Mongolian and Kazakh groups derived about 6% to 40% of West Eurasian related ancestry, most likely from Bronze Age Steppe populations. The East Asian related ancestry in Mongolian and Kazakh groups was well represented by the Neolithic DevilsCave related nomadic lineage, comprising 42% to 64% of studied groups. We also detected 10% to 51% of Han Chinese related ancestry in Mongolian and Kazakh groups, especially in Inner Mongolians. The average admixture times for Inner Mongolian, Mongolian_Chahar, Mongolian_Ölöd and Chinese Kazakh were about 1381, 626, 635 and 632 years ago, respectively, with Han and French as the sources. CONCLUSIONS: The DevilsCave related ancestry was once widespread westwards covering a wide geographical range from Far East Russia to the Mongolia Plateau. The formation of present-day Mongolic and Turkic-speaking populations has also received genetic influence from agricultural expansion.

7.
Zhong Nan Da Xue Xue Bao Yi Xue Ban ; 45(9): 1142-1148, 2020.
Artigo em Inglês, Chinês | MEDLINE | ID: mdl-33051431

RESUMO

Somatic symptom disorder (SSD) is a somatic disorder characterized by excessive anxiety over various somatic symptoms for a long time, which makes patients feel very painful and the quality of personal life significantly decreased. Previous studies have shown that there is a connection between the clinical manifestations of SSD patients and their cultural background. The patient in this case report was highly affected by Chinese yin-yang culture, displaying obvious Chinese characteristics.We report a patient with SSD, whose clinical manifestations were mainly sexual dysfunction and mood symptoms which were closely related to the Traditional Chinese culture of Yin and Yang. In this case, Hamilton Anxiety Scale, Hamilton Depression Scale, and International Erectile Function Questionnaire were used to evaluate the patients' anxiety, depression, and sexual function, and the scores were 32, 33, and 9, respectively. The patient was treated with a combination of venlafaxine and mirtazapine. After 5 weeks of treatment, the patient's clinical symptoms improved significantly.The clinical manifestations of some Chinese SSD patients have obvious characteristic relevance to Chinese theory of Yin and Yang, making SSD easily to be misdiagnosed. Therefore, clinicians should pay atlention to this situation. In addition, the combination of venlafaxine and mirtazapine may have a better effect on SSD patients with chronic pain and sexual dysfunction.


Assuntos
Sintomas Inexplicáveis , Yin-Yang , Ansiedade , Transtornos de Ansiedade , China , Características Culturais , Humanos , Masculino , Medicina Tradicional Chinesa , Inquéritos e Questionários
8.
Artigo em Inglês | MEDLINE | ID: mdl-33078353

RESUMO

To date, research evidence suggests that extreme ambient temperatures may lead to preterm birth. Since the results of studies in subtropical humid monsoon climate are inconclusive, we investigated the association between extreme ambient temperatures and the risk of preterm birth in Xuzhou, China. We analyzed the association between the birth data of 103,876 singleton deliveries (from July 1, 2016 to June 30, 2019) and ambient temperature. We used a quasi-Poisson model with distributed lag nonlinear models (DLNM) to investigate the delay and nonlinear effects of temperature, taking into account the effects of air pollutants and relative humidity. During the study period, the number of hospitalizations for preterm birth was 4623. Taking the median temperature (16.8 °C) as a reference, the highest risk estimate at extreme cold temperature (- 2.8 °C, 1st percentile) was found at lag 0-1 days. Exposure to extreme cold (- 2.8 °C, 1st percentile), or moderate cold (6.8 °C, 25th percentile) were associated with 1.659 (95% confidence interval [CI] 1.177-2.338) and 1.456 (95% CI 1.183-1.790) increased risks of preterm birth, respectively. In the further stratified analysis of the age of pregnant women, we found that there were significant associations between cold temperatures and preterm birth in both groups (older group ≥ 35; younger group < 35). In a subtropical humid monsoon climate, low ambient temperatures may lead to preterm birth, suggesting that women should stay away from low temperatures during pregnancy.

9.
Am J Vet Res ; 81(11): 837-877, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-33107745

RESUMO

OBJECTIVE: To compare the pharmacokinetics of cefquinome sulfate in ducklings and goslings after IV or IM administration of a single dose. ANIMALS: 216 healthy Muscovy ducklings (Cairina moschata) and 216 healthy Sichuan white goslings (Anser cygnoides). PROCEDURES: Ducklings and goslings were each randomly assigned to 3 groups (n = 72/group) that received a single dose (2 mg/kg) of injectable cefquinome sulfate administered IV or IM or of injectable cefquinome sulfate suspension administered IM. Blood samples were collected at various points after drug administration (n = 6 birds/time point). Plasma cefquinome concentrations were measured by high-performance liquid chromatography with UV detection, and pharmacokinetic parameters were calculated with a 2-compartment model method. RESULTS: After IV injection, mean distribution half-life of cefquinome was longer in goslings (0.446 hours) than in ducklings (0.019 hours), whereas volume of distribution at steady state was greater (0.432 vs 0.042 L/kg) and elimination half-life was slower (1.737 vs 0.972 hours). After IM administration of injectable cefquinome sulfate, bioavailability of the drug was higher in goslings (113.9%) than in ducklings (67.5%). After IM administration of injectable cefquinome sulfate suspension, bioavailability was also higher in goslings (123.1%) than in ducklings (96.8%), whereas elimination half-life was slower (6.917 vs 1.895 hours, respectively). CONCLUSIONS AND CLINICAL RELEVANCE: In goslings, IV administration of cefquinome resulted in slower distribution and metabolism of the drug than in ducklings and IM administration resulted in higher bioavailability. The delayed-release effect of the injectable cefquinome sulfate suspension when administered IM was observed only in goslings.

10.
Mol Med Rep ; 22(4): 2966-2972, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32945387

RESUMO

Multidrug resistance of non­small cell lung cancer (NSCLC) is a common clinical problem, which is one of the main reasons leading to the failure of chemotherapy. Therefore, how to overcome or prevent drug resistance has become a hot and difficult issue in clinical research. The present study was designed to investigate the expression patterns, functions and underlying mechanisms of MUC1 in regulating paclitaxel­resistant cell line A549/PR in NSCLC. RT­qPCR and western blot was performed to determine the mRNA and protein level, respectively. CCK­8 was conducted to determine the cell viability of A549/PR cells. Moreover, flow cytometry assay was applied to examine the apoptosis rate of A549/PR. Herein, the MUC1 was over­expressed in clinic NSCLC tissues and A549/PR cells. Silence of MUC1 could obviously suppress the proliferation and promote apoptosis of A549/PR cells in treatment of paclitaxel through up­regulating the expression of Bax and Caspase­3, and down­regulating the expression of Bcl­2, suggesting that chemotherapy combined with the modulation of MUC1 might be characterized as a promising therapeutic approach to overcome paclitaxel­resistance in NSCLC in the future.

11.
J Int Med Res ; 48(9): 300060520945500, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32962480

RESUMO

OBJECTIVE: To evaluate the clinical efficacy of an allogeneic bone cage (Biocage; Beijing Datsing Bio-Tech Co., Ltd., Beijing, China) for treatment of single-segment lumbar degenerative disease in patients with a high risk of non-fusion. METHODS: From January 2013 to December 2016, 67 patients who underwent lumbar fusion were divided into the Biocage group (n = 33) and polyether ether ketone (PEEK) group (n = 34). The patients were followed up for 24 to 48 months. The mean intervertebral height of the fusion level, fusion rate, height of the intervertebral foramen, visual analog scale score, and Oswestry disability index were compared. RESULTS: The PEEK group had a lower fusion rate than the Biocage group (88.24% vs. 90.91%), although the difference was not statistically significant. During follow-up, the height of the intervertebral space was similar between the Biocage and PEEK groups (12.88 ± 0.45 and 12.84 ± 1.01 mm, respectively). The height of the intervertebral foramen was larger in the Biocage than PEEK group (20.67 ± 1.34 vs. 20.00 ± 2.05 mm). Good clinical efficacy was achieved in both groups. CONCLUSION: The Biocage is efficient and safe for treatment of single-segment lumbar degenerative disease in patients with a high risk of non-fusion.

12.
Int J Cancer ; 147(11): 3139-3151, 2020 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-32875565

RESUMO

The evolutionary dynamics of human cancers has been investigated popularly and several bifurcated paths in cancer evolutionary trajectories are revealed to be with differential outcomes and phenotypes. However, whether such bifurcated paths exist in glioblastoma (GBM) remains unclear. In 385 GBM samples, through determining the clonal status of cancer driver events and inferring their temporal order, we constructed a temporal map of evolutionary trajectories at the patient population level. By investigating the differential impact on clinical outcome, we identified four key bifurcated paths, namely, "chromosome 10 copy number loss (ie, 10 loss) → chromosome 19 copy number gain (ie, 19 gain): 10 loss → 13q loss"; "10 loss → 19 gain: 10 loss → 15q loss"; "10 loss → 19 gain: 10 loss → 6q loss" and "10 loss → 19 gain: 10 loss → 16q loss". They formed a core multibranches path, with 10 loss being regarded as the common earliest event followed by 19 gain and four other departure events (13q loss, 15q loss, 6q loss and 16q loss), which may account for their difference in genome instability and patient survival time. Compared to "10 loss → 19 gain", the patients with "10 loss → 13q loss" had higher telomerase activity. Notably, there were obvious discrepancies in immune activity and immune cell infiltration level between patients with "10 loss → 13q/16q loss" and "10 loss → 19 gain", highlighting the bifurcated paths' effect on tumor immune microenvironment. In summary, our study identifies four key bifurcated paths in GBM for the first time, suggesting the feasibility of patient stratification and prognosis prediction based on key bifurcated paths.

13.
Microb Pathog ; 149: 104514, 2020 Sep 22.
Artigo em Inglês | MEDLINE | ID: mdl-32976967

RESUMO

The antibiotic resistance of Pseudomonas aeruginosa (P. aeruginosa) is correlated with the formation of biofilms. Several studies have focused on biofilms and the treatment of biofilm infection by antimicrobial peptides (AMPs). The present study analyzed the feasibility of cCATH-2 (a chicken-derived antimicrobial peptide) as a new strategy for anti-biofilm activities. Biofilm biomass (crystal violet staining) and viability of biofilm bacteria (colony counting) were measured in P. aeruginosa PAO1 biofilm at the stage of attachment (4 h), formation (14 h), and maturation (24 h). cCATH-2 (1/2MIC) had the ability to reduce the initial attachment of viable bacteria due to decreasing planktonic bacteria. All tested concentrations of cCATH-2 (1/32-1/2MIC) significantly reduced the biomass at the biofilm formation stage. In addition, cCATH-2 (2MIC) had significant effects on the biomass and viability of bacteria of pre-biofilms, which caused significant killing (>90%) of the bacteria in the biofilm. Thus, it was confirmed that cCATH-2 could infiltrate into pre-biofilm to kill the biofilm cells, as assessed by confocal laser scanning microscopy (CLSM). Furthermore, cCATH-2 had an obvious effect on the production of the majority of the virulence factors of PAO1 biofilms, and the effect was better than that of ciprofloxacin, especially on alginate (the structural component of biofilms). These findings suggested that cCATH-2 is a putative candidate for the development of anti-biofilm and anti-infective drugs.

15.
Theranostics ; 10(23): 10665-10679, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32929373

RESUMO

Background: Gut microbiota, which plays a crucial role in inflammatory bowel diseases (IBD), might have therapeutic benefits for ulcerative colitis or Crohn's disease. Targeting gut microbiota represents a new treatment strategy for IBD patients. Rhein is one of the main components of rhubarb and exhibits poor oral bioavailability but still exerts anti-inflammatory effects in some diseases. Therefore, we investigated the effect of rhein on colitis and studied its possible mechanisms. Methods: The chronic mouse colitis model was induced by four rounds of 2% dextran sulfate sodium (DSS) treatment. The mice were treated with 50 mg/kg and 100 mg/kg rhein daily, body weight, colon length, histological score, inflammatory cytokines in serum or intestine, and fecal lipocalin 2 concentration were determined. Th17 cell, Th1 cell and Th2 cell infiltration in the mesenteric lymph node were analyzed by flow cytometry. Metabolic profiles were collected by non-targeted metabolomics and key metabolic pathways were identified using MetaboAnalyst 4.0. We also assessed intestinal barrier permeability and performed 16s rDNA sequencing. Lactobacillus sp. was cultured, and fecal microbiota transplantation (FMT) was employed to evaluate the contribution of gut microbiota. Results: Rhein could significantly alleviate DSS-induced chronic colitis. Uric acid was identified as a crucial modulator of colitis and rhein treatment led to decreased uric acid levels. We determined that rhein changed purine metabolism indirectly, while the probiotic Lactobacillus was involved in the regulation of host metabolism. Uric acid resulted in a worsened intestinal barrier, which could be rescued by rhein. We further confirmed that rhein-treated gut microbiota was sufficient to relieve DSS-induced colitis by FMT. Conclusion: We showed that rhein could modulate gut microbiota, which indirectly changed purine metabolism in the intestine and subsequently alleviated colitis. Our study has identified a new approach to the clinical treatment of colitis.

16.
J Mol Neurosci ; 2020 Sep 21.
Artigo em Inglês | MEDLINE | ID: mdl-32959225

RESUMO

Exosomes are cell-derived membrane vesicles with cargo that can be transported into receiver cells to exert their biological roles. Exosomal RNA signature profiles and exosome-derived proteomics are often used to explore the molecular regulation of diseases, and can mirror the conditional state of their tissue of origin, thus serving as biomarkers. The onset of meningeal carcinomatosis (MC) is concealed, and early diagnosis is difficult. To enable early diagnosis of MC, it is essential to identify new biomarkers. Few studies have investigated the function of exosomes in MC. In this study, high-throughput sequencing was used to examine the mRNA profiles of exosomes in the cerebrospinal fluid (CSF) of patients with MC. We further analyzed the functions and signaling pathways associated with the differentially expressed genes in exosomes to reveal the putative mechanisms by which the exosomal mRNAs function in MC. In summary, this study identified biomarker candidates for MC, and provided new insights into the significant role of exosomal mRNA regulation in MC.

17.
Sensors (Basel) ; 20(17)2020 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-32872196

RESUMO

In recent years, Generative Adversarial Networks (GANs)-based illumination processing of facial images has made favorable achievements. However, some GANs-based illumination-processing methods only pay attention to the image quality and neglect the recognition accuracy, whereas others only crop partial face area and ignore the challenges to synthesize photographic face, background and hair when the original face image is under extreme illumination (Image under extreme illumination (extreme illumination conditions) means that we cannot see the texture and structure information clearly and most pixel values tend to 0 or 255.). Moreover, the recognition accuracy is low when the faces are under extreme illumination conditions. For these reasons, we present an elaborately designed architecture based on convolutional neural network and GANs for processing the illumination of facial image. We use ResBlock at the down-sampling stage in our encoder and adopt skip connections in our generator. This special design together with our loss can enhance the ability to preserve identity and generate high-quality images. Moreover, we use different convolutional layers of a pre-trained feature network to extract varisized feature maps, and then use these feature maps to compute loss, which is named multi-stage feature maps (MSFM) loss. For the sake of fairly evaluating our method against state-of-the-art models, we use four metrics to estimate the performance of illumination-processing algorithms. A variety of experimental data indicate that our method is superior to the previous models under various illumination challenges in illumination processing. We conduct qualitative and quantitative experiments on two datasets, and the experimental data indicate that our scheme obviously surpasses the state-of-the-art algorithms in image quality and identification accuracy.

18.
J Affect Disord ; 277: 368-374, 2020 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-32861837

RESUMO

BACKGROUND: Previous studies about the reliability and validity of the updated PCL version for the fifth edition of the Diagnostic and Statistical Manual for Mental Disorders (PCL-5) have only been evaluated in certain samples of the population, which lacks in the sample of Healthcare Workers. Our study focused on the factor structure, reliability and validity of the PCL-5 among Chinese Healthcare Workers during the Outbreak of Corona Virus Disease 2019. METHODS: We conducted an online survey of frontline healthcare workers using the PCL-5 for PTSD. Total of 212 frontline healthcare providers were included in this study. RESULTS: The findings showed that PCL-5 is a reliable instrument in our sample. The total and subscale scores showed good internal consistency. The convergent and discriminant validity of the PCL-5 were also well demonstrated. Our result showed a better fit with the seven-factor hybrid model compared with other models and supported that the PCL-5 Chinese version can be used as a reliable screening tool to conduct psychological screening for Chinese healthcare workers. LIMITATION: We could not examine other aspects of reliability and validity like test-retest reliability or criterion validity. We didn't use the gold-standard structured interview for PTSD in our study. Besides, most of our samples were young people who had access to the internet. Not all professional levels and seniorities were presented because our sample had a lower mean income and educational level. CONCLUSION: Our study shows that the Chinese PCL-5 has good validity and reliability in frontline healthcare workers during the outbreak.

19.
Sci Total Environ ; 748: 141359, 2020 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-32798869

RESUMO

The marine bivalve, Tridacna spp. is an iconic invertebrate of the Indo-Pacific coral reef communities from Eocene to present. However, field observations found that the population of Tridacna spp. has declined in recent decades and some species are now endangered in the northern South China Sea (SCS) of western Pacific, which are speculated to be connected with the human overfishing and/or climate changes. Thus distinguishing the impacts of human activities and climate changes on Tridacna spp. populations is essential for understanding the dynamic of Tridacna spp. population variability. Such effort will be important in launching conservation policies and restoring population. Here, extensive sampling was applied on sub-fossil Tridacna spp. shells at the North Reef of the northern SCS, and the long-lived (with a lifespan more than 30 years) Tridacna spp. population index (LTPI) over the past 4500 years was obtained based on the AMS14C dating method. The results show that LTPI has experienced several short-term collapses (shorter than 200 years) over the past 4500 years, which may be associated with excessive cold winter temperatures. Remarkably, LTPI usually recovered rapidly after the rewarming of temperatures, indicating a robust self-recruitment mechanisms in response to natural climate changes. However, the last catastrophic collapse of LTPI that occurred at around ~1820 CE - ~1900 CE didn't rebound despite the significant rise in temperature over the recent 100 years. The decoupling between LTPI and climate changes in recent hundred years was probably induced by the increased commercial fishing in the SCS, which has overwhelmed and exacerbated the self-recruitment mechanisms between Tridacna spp. population and climate changes.

20.
BMC Musculoskelet Disord ; 21(1): 510, 2020 Jul 31.
Artigo em Inglês | MEDLINE | ID: mdl-32736621

RESUMO

BACKGROUND: Increased physical activity level is related to lower risk of depressive symptoms, and there is an inverse association between muscle strength and risk of depressive symptoms among the elderly. Although there is evidence of an inverse association between muscle strength and depressive symptoms, the relationship between these variables in a younger population is still unknown. This study aimed to examine the association between handgrip strength, a representative indicator of skeletal muscle strength, and the risk of depressive symptoms among Chinese female college freshmen. METHODS: A cross-sectional study was conducted among 867 participants aged between 16 and 23 years. Handgrip strength was measured with a handheld digital Smedley dynamometer, and handgrip strength relative to body weight (kg/kg) was calculated and was classified into tertiles as follows: low (0.32-0.50), medium (0.51-0.58), and high (0.59-0.94). Depressive symptoms were evaluated using the 20-item Zung self-rating depression scale (SDS), and three cutoff points were used to indicate different depression levels. RESULTS: We found that 10.7% of participants were classified as having severe depressive symptoms using an SDS score of 50 as the cutoff point. After adjusting for potential confounders, the adjusted odds ratios and 95% confidence intervals (CIs) for moderate-to-severe depressive symptoms across tertiles of the relative handgrip strength were 1.00 (reference) for tertile 1, 0.614 (0.353, 1.069) for tertile 2, and 0.537 (0.292, 0.988) for tertile 3 (P for trend = 0.041). The significant associations remained when other cutoff points (SDS scores: 48 or 45) were used. Interactions between handgrip strength and potential confounders for depressive symptoms in the final models were not significant. CONCLUSIONS: Our findings indicate that handgrip strength is inversely and independently related to the risk of depressive symptoms among Chinese female college freshmen. The present findings can help develop an effective intervention strategy against depression. Further intervention studies are needed to explore the mechanisms underlying the effects of handgrip strength on depressive symptoms.

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