Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 24
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Sensors (Basel) ; 21(17)2021 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-34502731

RESUMO

As a sub-direction of image retrieval, person re-identification (Re-ID) is usually used to solve the security problem of cross camera tracking and monitoring. A growing number of shopping centers have recently attempted to apply Re-ID technology. One of the development trends of related algorithms is using an attention mechanism to capture global and local features. We notice that these algorithms have apparent limitations. They only focus on the most salient features without considering certain detailed features. People's clothes, bags and even shoes are of great help to distinguish pedestrians. We notice that global features usually cover these important local features. Therefore, we propose a dual branch network based on a multi-scale attention mechanism. This network can capture apparent global features and inconspicuous local features of pedestrian images. Specifically, we design a dual branch attention network (DBA-Net) for better performance. These two branches can optimize the extracted features of different depths at the same time. We also design an effective block (called channel, position and spatial-wise attention (CPSA)), which can capture key fine-grained information, such as bags and shoes. Furthermore, based on ID loss, we use complementary triplet loss and adaptive weighted rank list loss (WRLL) on each branch during the training process. DBA-Net can not only learn semantic context information of the channel, position, and spatial dimensions but can integrate detailed semantic information by learning the dependency relationships between features. Extensive experiments on three widely used open-source datasets proved that DBA-Net clearly yielded overall state-of-the-art performance. Particularly on the CUHK03 dataset, the mean average precision (mAP) of DBA-Net achieved 83.2%.


Assuntos
Processamento de Imagem Assistida por Computador , Pedestres , Algoritmos , Humanos , Pesquisa , Semântica
2.
PLoS One ; 16(9): e0257013, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34492064

RESUMO

The cardinal symptoms of some ophthalmic diseases observed through exceptional retinal blood vessels, such as retinal vein occlusion, diabetic retinopathy, etc. The advanced deep learning models used to obtain morphological and structural information of blood vessels automatically are conducive to the early treatment and initiative prevention of ophthalmic diseases. In our work, we propose a hierarchical dilation convolutional network (HDC-Net) to extract retinal vessels in a pixel-to-pixel manner. It utilizes the hierarchical dilation convolution (HDC) module to capture the fragile retinal blood vessels usually neglected by other methods. An improved residual dual efficient channel attention (RDECA) module can infer more delicate channel information to reinforce the discriminative capability of the model. The structured Dropblock can help our HDC-Net model to solve the network overfitting effectively. From a holistic perspective, the segmentation results obtained by HDC-Net are superior to other deep learning methods on three acknowledged datasets (DRIVE, CHASE-DB1, STARE), the sensitivity, specificity, accuracy, f1-score and AUC score are {0.8252, 0.9829, 0.9692, 0.8239, 0.9871}, {0.8227, 0.9853, 0.9745, 0.8113, 0.9884}, and {0.8369, 0.9866, 0.9751, 0.8385, 0.9913}, respectively. It surpasses most other advanced retinal vessel segmentation models. Qualitative and quantitative analysis demonstrates that HDC-Net can fulfill the task of retinal vessel segmentation efficiently and accurately.

3.
Sci Rep ; 11(1): 17408, 2021 Aug 31.
Artigo em Inglês | MEDLINE | ID: mdl-34465852

RESUMO

In recent years, the hyperspectral classification algorithm based on deep learning has received widespread attention, but the existing network models have higher model complexity and require more time consumption. In order to further improve the accuracy of hyperspectral image classification and reduce model complexity, this paper proposes an asymmetric coordinate attention spectral-spatial feature fusion network (ACAS2F2N) to capture distinguishing hyperspectral features. Specifically, adaptive asymmetric iterative attention was proposed to obtain the discriminative spectral-spatial features. Different from the common feature fusion method, this feature fusion method can adapt to most skip connection tasks. In addition, there is no manual parameter setting. Coordinate attention is used to obtain accurate coordinate information and channel relationship. The strip pooling module was introduced to increase the network's receptive field and avoid irrelevant information brought by conventional convolution kernels. The proposed algorithm is tested on the mainstream hyperspectral datasets (IP, KSC, and Botswana), experimental results show that the proposed ACAS2F2N can achieve state-of-the-art performance with lower time complexity.

4.
Sensors (Basel) ; 21(15)2021 Jul 30.
Artigo em Inglês | MEDLINE | ID: mdl-34372409

RESUMO

Considerable research and surveys indicate that skin lesions are an early symptom of skin cancer. Segmentation of skin lesions is still a hot research topic. Dermatological datasets in skin lesion segmentation tasks generated a large number of parameters when data augmented, limiting the application of smart assisted medicine in real life. Hence, this paper proposes an effective feedback attention network (FAC-Net). The network is equipped with the feedback fusion block (FFB) and the attention mechanism block (AMB), through the combination of these two modules, we can obtain richer and more specific feature mapping without data enhancement. Numerous experimental tests were given by us on public datasets (ISIC2018, ISBI2017, ISBI2016), and a good deal of metrics like the Jaccard index (JA) and Dice coefficient (DC) were used to evaluate the results of segmentation. On the ISIC2018 dataset, we obtained results for DC equal to 91.19% and JA equal to 83.99%, compared with the based network. The results of these two main metrics were improved by more than 1%. In addition, the metrics were also improved in the other two datasets. It can be demonstrated through experiments that without any enhancements of the datasets, our lightweight model can achieve better segmentation performance than most deep learning architectures.


Assuntos
Dermatopatias , Neoplasias Cutâneas , Retroalimentação , Humanos , Processamento de Imagem Assistida por Computador , Redes Neurais de Computação , Manejo de Espécimes
5.
Psychiatry Investig ; 2020 Dec 11.
Artigo em Inglês | MEDLINE | ID: mdl-33301667

RESUMO

OBJECTIVE: Schizophrenia has been associated with dysfunction of the hypothalamic-pituitary-adrenal axis. Furthermore, alterations in neurotrophic factors might contribute to the pathogenesis of schizophrenia. We aimed to evaluate the effects of a simulated laughter intervention on the levels of cortisol and BDNF and to determine whether the effects associated with simulated laughter could be sustained after discontinuation of the intervention. METHODS: In this randomized controlled study, patients with schizophrenia according to DSM-IV clinical criteria were randomly assigned to receive either 8-week-long simulated laughter intervention (n=32) or treatment-as-usual group (control group, n=27). The serum levels of BDNF and cortisol were measured at baseline, week 8, and four weeks after discontinuation (week 12) of the intervention program. RESULTS: After an 8-week simulated laughter intervention, the laughter group had significantly higher levels of BDNF; however, four weeks after discontinuation of the intervention, the levels of BDNF significantly dropped. Interestingly, the levels of cortisol did not change significantly at week 8, but they were significantly elevated at week 12. The levels of BDNF and cortisol in the control group did not change significantly between week 0 and week 8. CONCLUSION: These findings suggest that the simulated laughter intervention has an early effect on neurogenesis with a significant delayed effect on stress regulation in subjects with schizophrenia.

6.
Entropy (Basel) ; 22(11)2020 Nov 07.
Artigo em Inglês | MEDLINE | ID: mdl-33287034

RESUMO

Deep hashing is the mainstream algorithm for large-scale cross-modal retrieval due to its high retrieval speed and low storage capacity, but the problem of reconstruction of modal semantic information is still very challenging. In order to further solve the problem of unsupervised cross-modal retrieval semantic reconstruction, we propose a novel deep semantic-preserving reconstruction hashing (DSPRH). The algorithm combines spatial and channel semantic information, and mines modal semantic information based on adaptive self-encoding and joint semantic reconstruction loss. The main contributions are as follows: (1) We introduce a new spatial pooling network module based on tensor regular-polymorphic decomposition theory to generate rank-1 tensor to capture high-order context semantics, which can assist the backbone network to capture important contextual modal semantic information. (2) Based on optimization perspective, we use global covariance pooling to capture channel semantic information and accelerate network convergence. In feature reconstruction layer, we use two bottlenecks auto-encoding to achieve visual-text modal interaction. (3) In metric learning, we design a new loss function to optimize model parameters, which can preserve the correlation between image modalities and text modalities. The DSPRH algorithm is tested on MIRFlickr-25K and NUS-WIDE. The experimental results show that DSPRH has achieved better performance on retrieval tasks.

7.
Arch Psychiatr Nurs ; 34(5): 384-390, 2020 10.
Artigo em Inglês | MEDLINE | ID: mdl-33032762

RESUMO

This study analyzes the association between social support and depression symptoms of inpatients with major depressive disorder. A total of 160 inpatients were recruited from the acute psychiatric ward of a medical center in northern Taiwan between July 1, 2015, and December 31, 2016. Data were analyzed using descriptive statistics, simple linear regression and multiple linear regression. Our results reveal that patient depression level is significantly associated with gender, age, marital status, education, occupation and number of admissions due to depression. Social support is significantly associated with marital status and number of admissions due to depression. The depression symptoms of the patients were significantly and negatively associated with overall perceived social support and perceived social support from family, friends and a significant other. These results could serve as a reference for the clinical practice of clinical specialists and argue for the inclusion of social support as an intervention for patients with depression.


Assuntos
Depressão/psicologia , Transtorno Depressivo Maior/epidemiologia , Apoio Social , Centros Médicos Acadêmicos , Adulto , Estudos Transversais , Feminino , Humanos , Masculino , Taiwan/epidemiologia
8.
Headache ; 60(10): 2555-2562, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32990364

RESUMO

OBJECTIVE: To determine the effectiveness and safety of erenumab in patients with chronic migraine in the real-world setting of 3 headache centers in Australia. METHODS: Patients with migraine were prescribed erenumab (70 or 140 mg) in the setting of either a product familiarization program or paid access to the medication in 3 headache centers in Australia. We obtained baseline and monthly prospective data on monthly headache days, monthly migraine days, monthly triptan use days, monthly codeine use days, Headache Impact Test-6 scores, and adverse reactions. In this paper, we present our data at 3 and 6 months in our subgroup of patients with chronic migraine with and without medication overuse. RESULTS: A total of 170 patients with chronic migraine were prescribed erenumab in the 3 headache centers. At 3 months, 100/170 (58.8%) had 50% or greater reduction in monthly migraine days. At 6 months, 79/170 (46.5%) had 50% or greater reduction in monthly migraine days. At 6 months, there was a mean reduction in monthly headache days of 9.2 days, a mean reduction in monthly migraine days of 10.2 days. There were few adverse events reported. CONCLUSION: This is the first report from 3 Australian headache centers about erenumab in the real world. Our analysis has supported erenumab as an effective and well-tolerated migraine preventative therapy for patients with chronic migraine who have failed many preventative therapies.

9.
Hum Psychopharmacol ; 35(3): e2729, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-32182388

RESUMO

OBJECTIVE: To compare the psychiatric service utilization between patients who only received long-acting injectable antipsychotics (LAIAs) and those who only received oral antipsychotics (OAPs) in the maintenance treatment of chronic schizophrenia. METHODS: We constructed a cohort of chronic schizophrenia patients who underwent maintenance treatment from the Taiwan National Health Insurance Research Database in 2011 and followed these patients for 12 months. We included patients who had been diagnosed with schizophrenia for at least 3 years, were not hospitalized in 2011, and had received 1 year of maintenance treatment. Inverse probability of treatment weighting logistic, linear, and negative binomial regression models were used to estimate associated psychiatric services utilization and adjust for covariate imbalances between the LAIAs and OAPs groups. RESULTS: Among 40,194 patients, 948 (2.36%) received only LAIAs and 39,246 (97.64%) received only OAPs. Compared with those who received only OAPs, the sole LAIAs users were associated with a lower percentage of psychiatric hospitalization (8.4% and 5.8%, respectively; odds ratio: 0.63, p < .01), shorter lengths of hospitalization days (82.8 and 65.9, respectively; coefficient [b]: -16.87, p = .03), and fewer emergency room visits (2.3 and 1.8, respectively; b: -0.24, p < .01) per patient. CONCLUSIONS: Chronic schizophrenia patients who received only LAIs had a lower risk of disease relapse and a reduction in psychiatric service utilization than those receiving only OAPs.


Assuntos
Antipsicóticos/uso terapêutico , Utilização de Instalações e Serviços/estatística & dados numéricos , Serviços de Saúde Mental/estatística & dados numéricos , Esquizofrenia/tratamento farmacológico , Administração Oral , Adolescente , Adulto , Idoso , Antipsicóticos/administração & dosagem , Doença Crônica/tratamento farmacológico , Preparações de Ação Retardada/uso terapêutico , Serviços Médicos de Emergência/estatística & dados numéricos , Feminino , Hospitalização/estatística & dados numéricos , Humanos , Injeções Intramusculares , Tempo de Internação/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Pacientes Ambulatoriais , Adulto Jovem
10.
Sensors (Basel) ; 20(6)2020 Mar 11.
Artigo em Inglês | MEDLINE | ID: mdl-32168732

RESUMO

The secure transmission of data within a network has received great attention. As the core of the security management mechanism, the key management scheme design needs further research. In view of the safety and energy consumption problems in recent papers, we propose a key management scheme based on the pairing-free identity based digital signature (PF-IBS) algorithm for heterogeneous wireless sensor networks (HWSNs). Our scheme uses the PF-IBS algorithm to complete message authentication, which is safer and more energy efficient than some recent schemes. Moreover, we use the base station (BS) as the processing center for the huge data in the network, thereby saving network energy consumption and improving the network life cycle. Finally, we indirectly prevent the attacker from capturing relay nodes that upload data between clusters in the network (some cluster head nodes cannot communicate directly). Through performance evaluation, the scheme we proposed reasonably sacrifices part of the storage space in exchange for entire network security while saving energy consumption.

11.
Clin Psychopharmacol Neurosci ; 18(1): 145-152, 2020 Feb 29.
Artigo em Inglês | MEDLINE | ID: mdl-31958915

RESUMO

Objective: Valproic acid (VPA) is an anticonvulsant and commonly long term used as a mood stabilizer for patients with mood disorders. However its chronic effects on the hematological changes were noticed and need to be further evaluated. In this study, we evaluated, in Taiwanese Han Chinese patients with bipolar disorders (BD), the chronic effects of VPA or VPA plus dextromethorphan (DM) on the hematological molecules (white blood cell [WBCs], red blood cells [RBCs], hemoglobin, hematocrit, and platelets). Methods: In a 12-week, randomized, double-blind study, we randomly assigned BD patients to one of three groups: VPA plus either placebo (VPA+P, n = 57) or DM (30 mg/day, VPA+DM30, n = 56) or 60 mg/day (VPA+DM60, n = 53). The Young Mania Rating Scale and Hamilton Depression Rating Scale were used to evaluate symptom severity, and the hematological molecules were checked. Results: Paired t test showed that the WBC, neutrophils, platelets and RBCs were significantly lowered after 12 weeks of VPA+P or VPA+DM30 treatment. VPA+DM60 represented the protective effects in the WBCs, neutrophils, and RBCs but not in the platelets. We further calculated the changes of each hematological molecules after 12 weeks treatment. We found that combination use of DM60 significantly improved the decline in neutrophils induced by the long-term VPA treatment. Conclusion: Hematological molecule levels were lower after long-term treatment with VPA. VPA+DM60, which yielded the protective effect in hematological change, especially in the neutrophil counts. Thus, DM might be adjunct therapy for maintaining hematological molecules in VPA treatment.

12.
Psychiatry Investig ; 15(9): 900-906, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30235918

RESUMO

OBJECTIVE: Cellular, animal, and human epidemiological studies suggested that benzodiazepines increase the risk of cancer and cancer mortality. Obesity is also clearly linked to carcinogenesis. However, no human studies have examined benzodiazepine-associated carcinogenesis as assessed by changes in cancer biomarkers. METHODS: A total of 19 patients were recruited, and received a 6-week treatment of 0.5 mg lorazepam. The measured cancer biomarkers were angiopoietin-2 (ANG-2), soluble CD40 ligand, epidermal growth factor, endoglin, soluble Fas ligand (sFASL), heparin-binding EGF-like growth factor (HB-EGF), insulin-like growth factor binding protein, interleukin (IL)-6, IL-8, IL-18, plasminogen activator inhibitor (PLGF), placental growth factor, transforming growth factor (TGF)-α, tumor necrosis factor (TNF)-α, urokinase-type plasminogen (uPA), vascular endothelial growth factor (VEGF)-A, VEGF-C, and VEGF-D. RESULTS: Six cancer biomarkers were significantly increased in all patients as a whole. The subgroup analysis revealed a distinct pattern of change. Overweight patients showed a significant increase in 11 cancer biomarkers, including ANG-2, sFASL, HB-EGF, IL-8, PLGF, TGF-α, TNF-α, uPA, VEGF-A, VEGF-C, and VEGF-D. However, normal-weight patients did not show any changes in cancer biomarkers. CONCLUSION: Adiposity may have primed the carcinogenic potential, leading to lorazepam-associated carcinogenesis in overweight patients. Epidemiological studies addressing this issue should consider the potential modulator contributing to benzodiazepine-associated carcinogenesis.

14.
J Nurs Res ; 25(6): 429-435, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-28187054

RESUMO

BACKGROUND: Both psychiatric symptoms and the side effects of medication significantly affect patients with schizophrenia. These effects frequently result in a sedentary lifestyle and weight gain, which increase the risk of cardiovascular disease and premature death. PURPOSE: This study developed an aerobic dance program for patients with schizophrenia and then evaluated the effect of this program on health-related fitness outcomes. METHODS: An experimental research design was used. Sixty patients with schizophrenia were recruited from a daycare ward and rehabilitation center at a psychiatric hospital in Taiwan. Paticipants were assigned randomly into an experimental group, which received the 8-week aerobic dance program intervention, and a control group, which received no intervention. All of the participants were assessed in terms of the outcome variables, which included bodyweight, body mass index, muscular endurance, flexibility, and cardiorespiratory endurance. These variables were measured before the intervention (pretest) as well as at 8 weeks (posttest) and 12 weeks (follow-up) after the intervention. This study used a generalized linear model with a generalized estimating equation method to account for the dependence of repeated measurements and to explore the effects of the intervention on health-related fitness outcomes. RESULTS: Twenty-six participants were in the experimental group, and 28 were in the control group. Significant between-group differences were observed at posttest and in the follow-up for all of the health-related fitness outcomes with the exception of muscular endurance. CONCLUSIONS/IMPLICATIONS FOR PRACTICE: This study suggests that an 8-week aerobic dance program may be an effective intervention in patients with schizophrenia in terms of improving bodyweight, body mass index, flexibility, and cardiorespiratory endurance for a period of at least 4 months. Furthermore, although muscular endurance was postively affected during the short-term period, the benefits did not extend into the follow-up examination. On the basis of these findings, aerobic dance is recommended as a nonpharmacological intervention for patients with schizophrenia who are in daycare or rehabilitation settings.


Assuntos
Aptidão Cardiorrespiratória , Dança , Exercício Físico , Esquizofrenia/fisiopatologia , Adulto , Índice de Massa Corporal , Peso Corporal , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Taiwan
15.
Pract Neurol ; 17(1): 21-27, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-27974377

RESUMO

There is increasing awareness and interest in the complex and extensive inter-relationships between sleep disorders and neurological disorders. This review focuses on the clinical interactions between obstructive sleep apnoea and stroke, headaches, epilepsy, cognition and idiopathic Parkinson's disease. We highlight to the neurologist the importance of taking a sleep history and considering the diagnosis and treatment of obstructive sleep apnoea.


Assuntos
Neurologistas , Papel do Médico , Síndromes da Apneia do Sono/diagnóstico , Síndromes da Apneia do Sono/terapia , Epilepsia/diagnóstico , Epilepsia/epidemiologia , Epilepsia/terapia , Cefaleia/diagnóstico , Cefaleia/epidemiologia , Cefaleia/terapia , Humanos , Neurologistas/normas , Doença de Parkinson/diagnóstico , Doença de Parkinson/epidemiologia , Doença de Parkinson/terapia , Síndromes da Apneia do Sono/epidemiologia
16.
Int J Psychophysiol ; 109: 132-137, 2016 11.
Artigo em Inglês | MEDLINE | ID: mdl-27577961

RESUMO

A bidirectional connection exists between obesity and altered heart rate variability (HRV). Schizophrenia has been associated with a high risk of obesity and decreased vagal modulation. Few studies have examined the link between obesity and HRV in patients with schizophrenia. The aim of this study was to investigate the effects of aerobic exercise on body weight and HRV, and if so, whether these effects could be sustained after discontinuation of exercise training. A total of 18 overweight patients with schizophrenia completed an 8-week moderate-intensity aerobic exercise program conducted twice weekly for 50min. Body weight and heart rate variability were measured at baseline, week 8, and 4weeks after discontinuation of exercise training. Compared with the control group (15 overweight patients with schizophrenia without exercise training), the exercise group had reduced 2.3kg at week 8. Furthermore, the exercise program increased the low frequency, high frequency, and low frequency plus high frequency of HRV. However, after discontinuation of the exercise program for 4weeks, the changes in body weight and the HRV parameters diverged. All of the HRV parameters returned to their baseline values, but no change was seen in the reduced body weight. This suggests that HRV analysis is a more sensitive tool to detect health conditions in patients with schizophrenia. Although exercise is an easy and effective way to prevent and improve health problems, mental health providers might have underestimated the benefits of exercise in daily clinical practice. A regular exercise program should be considered as an essential part of treatment strategies for patients with schizophrenia.


Assuntos
Peso Corporal/fisiologia , Exercício Físico/fisiologia , Frequência Cardíaca/fisiologia , Esquizofrenia/fisiopatologia , Adulto , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade
17.
Exp Ther Med ; 12(6): 3873-3876, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-28105119

RESUMO

The clinical efficacy and safety of different combinations of non-bio artificial liver in the treatment of acute liver failure was examined. A total of 61 cases were selected under blood purification treatment from the patients with severe acute liver failure admitted to the severe disease department of the hospital from December, 2010 to December, 2015. Three types of artificial liver combinations were observed, i.e., plasma exchange plus hemoperfusion plus continuous venovenous hemodiafiltration (PE+HP+CVVHDF), PE+CVVHDF and HP+CVVHDF. The heart rate (HR), mean arterial pressure (MAP), respiratory index (PaO2/FiO2), liver and kidney function indicator, as well as platelet and coagulation function were compared. A comparison before and after the treatment using the three methods, showed improvement in the HRs, MAPs, PaO2/FiO2, total bilirubins (TBIL) and alanine aminotransferases (ALT) (P<0.05), of which TBIL and ALT were decreased more significantly (P<0.01) in the PE+CVVHDF and PE+HP+CVVHDF groups. Only changes in the PE+HP+CVVHDF and PE+CVVHDF groups were statistically significant after prothrombin time and albumin treatment (P<0.05). The difference between the decrease in TBIL in the PE+HP+CVVHDF group and that in the HP+CVVHDF group was statistically significant (P<0.05). Treatment of the 61 patients using the artificial liver support system yielded a survival rate of 62.3% (38/61), and a viral survival rate of 35.0% (7/20); with the non-viral survival rate being 75.6% (31/41). In conclusion, following the treatment of three types of artificial livers, the function was improved to varying degrees, with the PE+HP+CVVHDF and the PE+CVVHDF method being better. By contrast, after the treatment of non-viral liver failure, the survival rate was significantly higher than the patients with viral liver failure.

18.
PLoS One ; 10(9): e0137842, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26355455

RESUMO

The impact of social influence causes people to adopt the behaviour of others when interacting with other individuals. The effects of social influence can be direct or indirect. Direct social influence is the result of an individual directly influencing the opinion of another, while indirect social influence is a process taking place when an individual's opinion and behaviour is affected by the availability of information about others' actions. Such indirect effect may exhibit a more significant impact in the on-line community because the internet records not only positive but also negative information, for example on-line written text comments. This study focuses on indirect social influence and examines the effect of preceding information on subsequent users' opinions by fitting statistical models to data collected from an on-line bulletin board. Specifically, the different impacts of information on approval and disapproval comments on subsequent opinions were investigated. Although in an anonymous situation where social influence is assumed to be at minimum, our results demonstrate the tendency of on-line users to adopt both positive and negative information to conform to the neighbouring trend when expressing opinions. Moreover, our results suggest unequal effects of the local approval and disapproval comments in affecting the likelihood of expressing opinions. The impact of neighbouring disapproval densities was stronger than that of neighbouring approval densities on inducing subsequent disapproval relative to approval comments. However, our results suggest no effects of global social influence on subsequent opinion expression.


Assuntos
Internet , Comportamento Social , Humanos , Modelos Estatísticos , Taiwan
19.
Oncotarget ; 6(4): 2277-89, 2015 Feb 10.
Artigo em Inglês | MEDLINE | ID: mdl-25537511

RESUMO

Metastasis is the major reason for the death of patients suffering from malignant diseases such as human hepatocellular carcinoma (HCC). Among the complex metastatic process, resistance to anoikis is one of the most important steps. Previous studies demonstrate that microRNA-26a (miR-26a) is an important tumor suppressor that inhibits the proliferation and invasion of HCC cells by targeting multiple oncogenic proteins. However, whether miR-26a can also influence anoikis has not been well established. Here, we discovered that miR-26a promotes anoikis of HCC cells both in vitro and in vivo. With a combinational analysis of bioinformatics and public clinical databases, we predicted that alpha5 integrin (ITGA5), an integrin family member, is a putative target of miR-26a. Furthermore, we provide experimental evidence to confirm that ITGA5 is a bona fide target of miR-26a. Through gain- and loss-of-function studies, we demonstrate that ITGA5 is a functional target of miR-26a-induced anoikis in HCC cells. Collectively, our findings reveal that miR-26a is a novel player during anoikis and a potential therapeutic target for the treatment of metastatic HCC.


Assuntos
Anoikis/genética , Carcinoma Hepatocelular/genética , Integrina alfa5/genética , Neoplasias Hepáticas/genética , MicroRNAs/genética , Animais , Carcinoma Hepatocelular/metabolismo , Carcinoma Hepatocelular/patologia , Linhagem Celular Tumoral , Regulação Neoplásica da Expressão Gênica , Células HEK293 , Células Hep G2 , Humanos , Integrina alfa5/metabolismo , Neoplasias Hepáticas/metabolismo , Neoplasias Hepáticas/patologia , Camundongos Endogâmicos BALB C , Camundongos Nus , Metástase Neoplásica , Proteínas Proto-Oncogênicas c-akt/metabolismo , Interferência de RNA , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Transplante Heterólogo
20.
Epileptic Disord ; 16(4): 385-94, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25497575

RESUMO

Altered mental state is a very common presentation in the elderly admitted to the emergency department. It has been determined that about 16% of patients aged 60 or older with confusion of unknown origin have non-convulsive status epilepticus. The diagnosis of non-convulsive status epilepticus is difficult in the elderly because possible aetiologies of confusion may present with the same clinical picture. Non-convulsive status epilepticus in the elderly carries major morbidity and mortality, attributable primarily to aetiology, and treatment is complex, involving treatment of the aetiology and concomitant medical illnesses, whilst balancing the side effects and drug interactions of antiepileptic drugs.


Assuntos
Envelhecimento , Transtornos da Consciência , Eletroencefalografia , Estado Epiléptico , Idoso , Transtornos da Consciência/diagnóstico , Transtornos da Consciência/etiologia , Transtornos da Consciência/mortalidade , Humanos , Estado Epiléptico/diagnóstico , Estado Epiléptico/etiologia , Estado Epiléptico/mortalidade
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...