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2.
Front Mol Biosci ; 9: 889688, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35517862

RESUMO

Background: Ferroptosis induced by SLC7A11 has an important translational value in the treatment of cancers. However, the mechanism of SLC7A11 in the pathogenesis of colon adenocarcinoma (COAD) is rarely studied in detail. Methods: SLC7A11 expression was explored with The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) databases, and Western blot assay. The correlation of SLC7A11 expression with the abundance of infiltrating immune cells was evaluated via the TIMER database. The relation of SLC7A11 expression with immune cell markers was investigated via Gene Expression Profiling Interactive Analysis (GEPIA). The co-expression genes of SLC7A11 were screened by R packages, and the PPI was constructed via the STRING database. SLC7A11 and co-expressed gene modulators were selected by NetworkAnalyst and DSigDB database. The correlations between SLC7A11 and cancer immune characteristics were analyzed via the TIMER and TISIDB databases. Results: SLC7A11 is overexpressed in most tumors, including COAD. The expression level of SLC7A11 has a significant correlation with the infiltration levels of CD8+ T cells, neutrophils, and dendritic cells in COAD. The infiltrated lymphocyte markers of Th1 cell such as TBX21, IL12RB2, IL27RA, STAT1, and IFN-γ were strongly correlated with SLC7A11 expression. Five hub genes co-expressed with SLC7A11 that induce ferroptosis were identified, and mir-335-5p, RELA, and securinine have regulatory effects on it. SLC7A11 was negatively correlated with the expression of chemokines and chemokine receptors, such as CCL17, CCL19, CCL22, CCL23, CXCL14, CCR10, CX3CR1, and CXCR3, in COAD. Conclusion: SLC7A11 may play a role in induced ferroptosis and regulating tumor immunity, which can be considered as potential therapeutic targets in COAD.

3.
Microbiol Immunol ; 2022 May 07.
Artigo em Inglês | MEDLINE | ID: mdl-35524491

RESUMO

The adverse factors impacting the intestine microbiota of newborns remain to be elucidated. We put forward a hypothesis that hyperoxia combined with rituximab has a synergistic effect to interfere neonatal intestine microbiota. Six C57BL/6J mice, aged 12 w and pregnant 18 d, were purchased. Their pups were breast-fed and raised in 75% oxygen or conventional environment. Low-dosage (20 mg/kg) and high-dosage (40 mg/kg) of rituximab were intraperitoneal injection. Fecal genomic DNA was extracted and sequenced by a 16S rRNA platform. Severe intestine dysbiosis in newborns were observed, mild dysbiosis was caused by hyperoxia alone, confirming the synergistic interference from hyperoxia combined with B-cell deletion to neonatal intestine microbiota. Slight dysbiosis conditions were observed in dams' intestine microbiota, indicating much robust ability while confronting hyperoxia. The abundance of Akkermansia muciniphila was significantly and extensively altered in pups and dams after being impacted by hyperoxia and/or rituximab. In conclusion, this work demonstrated the synergistic effect of hyperoxia with rituximab led to severe intestine dysbiosis in newborns. More attention will recommend to the exploration of the precise regulatory mode between hyperoxia and rituximab in intestine microbiota. This article is protected by copyright. All rights reserved.

4.
Phytochem Anal ; 2022 May 11.
Artigo em Inglês | MEDLINE | ID: mdl-35546427

RESUMO

OBJECTIVE: In the present study, the chemical components of Qinghao Biejia decoction (QBD) were qualitatively and quantitatively analyzed using UPLC-Orbitrap Fusion-MS/MS and UPLC-QQQ-MS/MS techniques, followed by identification of each component's origin and evaluation of the antibacterial activity of QBD and its components. METHODS: High-resolution mass spectrometry was used to obtain information on the precise molecular weight, retention time, and fragmentation ion peaks of the compounds used to identify the components of QBD and establish a method for their quantification. In vitro assays including determination of the minimal inhibitory concentration and growth curves were used to assess the antibacterial activity of QBD and its components. RESULTS: A total of 39 components, including fatty acids, phenolic acids, amino acids, flavonoids, coumarins, terpenoids, and alkaloids, were identified by UPLC-Orbitrap Fusion-MS/MS. A high-performance analytical method was also established to quantify 12 components of QBD. The content of mangiferin was relatively high (estimated to be 814 µg/g). The results of the antibacterial assays indicated that mangiferin exhibits antibacterial effects against two strains causing respiratory tract infections. CONCLUSIONS: The present study suggests that mangiferin may serve as a natural compound which shows high antibacterial activity. The results can aid the discovery and analysis of the active antimicrobial components present in QBD and further provide a reference for quality assessment of multi-component herbal prescriptions.

5.
Indian J Microbiol ; 62(2): 225-233, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35462718

RESUMO

Bacteria play an important role in the biodegradation of feather waste. The exploration of the related microbial community structure and diversity is essential to improve the performance of feather waste treatment processes. In the present work, an in-situ soil sampled from a poultry farm was directly used to simulate and accelerate the natural degradation processes of feather waste under laboratory conditions, in which the dynamics of the microbial communities was further analyzed by Illumina HiSeq high-throughput 16S rRNA gene sequencing. Biochemical factors, including pH, feather degradation rate and soluble protein content were also determined in this study. The biochemical results showed that the in-situ soil exhibited an effective degradability on chicken feathers, and the degradation rate of feathers reached 57.95 ± 3.09% at 120 h of cultivation. Meanwhile, soluble protein content and pH reached 33.62 ± 1.45 mg/mL 8.99 ± 0.08, respectively. The results of bacterial diversity analysis showed that bacterial community structure and composition significantly varied in each phase of degradation. Additionally, the bacteria system with feather degradability might consist of Bacillus, Chryseobacterium, Lysobacter, Brevibacillus, and Stenotrophomonas genera. This system may include the following key pathways: carbohydrate metabolism, amino acid metabolism, nucleotide metabolism, membrane transport, replication and repair, translation, signal transduction and energy metabolism. Moreover, the bacterial communities may occur community succession during the degradation processes of chicken feathers. In summary, the present work provided valuable insights into the understanding of microbial community and metabolic functions for feather degradation, although the in-situ biodegradation process was conducted under laboratory conditions. Supplementary Information: The online version contains supplementary material available at 10.1007/s12088-021-00996-6.

6.
Oxid Med Cell Longev ; 2022: 7906091, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35419169

RESUMO

Oxidative stress (OS) refers to the enhancement of oxidation and the decreased of related antioxidant enzymes activity under pathological conditions, resulting in relatively excess reactive oxygen species (ROS), causing cytotoxicity, which leads to tissue damage and is linked to neurodegenerative diseases, cardiovascular diseases, diabetes, cancers, and many other pathologies. As an important intracellular signaling molecule, ROS can regulate numerous physiological actions, such as vascular reactivity and neuronal function. According to several studies, the uncontrolled production of ROS is related to vascular injury. The growing evidence revealing how traditional risk factors translate into ROS and lead to vasculitis and other vascular diseases. In this review, we sought to mainly discuss the role of ROS and antioxidant mechanisms in vascular-related diseases, especially cardiovascular and common macrovascular diseases.


Assuntos
Antioxidantes , Doenças Vasculares , Antioxidantes/metabolismo , Humanos , Oxirredução , Estresse Oxidativo/fisiologia , Espécies Reativas de Oxigênio
7.
Sensors (Basel) ; 22(8)2022 Apr 14.
Artigo em Inglês | MEDLINE | ID: mdl-35458996

RESUMO

At present, magnetic bearings are a better energy-saving choice than mechanical bearings in industrial applications. However, there are strongly coupled characteristics in magnetic bearing-rotor systems with redundant structures, and uncertain disturbances in the electrical system as well as external disturbances, and these unfavorable factors degrade the performance of the system. To improve the anti-interference performance of magnetic bearing systems, this paper proposes the inverse of the current distribution matrix W-1 meaning that the active disturbance rejection control simulation model can be carried out without neglecting the current of each coil. Firstly, based on the working mechanism of magnetic bearings with redundant structures and the nonlinear electromagnetic force model, the current and displacement stiffness models of magnetic bearings are established, and a dynamic model of the rotor is constructed. Then, according to the dynamic model of the rotor and the mapping relationship between the current of each coil and the electromagnetic force of the magnetic bearing, we established the equivalent control loop of the magnetic bearing-rotor system with redundant structures. Finally, on the basis of the active disturbance rejection control (ADRC) strategy, we designed a linear active disturbance rejection controller (LADRC) for magnetic bearings with redundant structures under the condition of no coil failure, and a corresponding simulation was carried out. The results demonstrate that compared to PID+current distribution control strategy, the LADRC+current distribution control strategy proposed in this paper is able to effectively improve the anti-interference performance of the rotors supported by magnetic bearings with redundant structures.

8.
ACS Appl Mater Interfaces ; 14(18): 20762-20777, 2022 May 11.
Artigo em Inglês | MEDLINE | ID: mdl-35476413

RESUMO

The tumor immunosuppressive microenvironment (TIM) greatly hindered the efficacy of cancer immunotherapy. Overexpressed indoleamine 2,3-dioxygenase-1 (IDO1) in tumor tissues plays a vital role in TIM generation, and downregulation of IDO1 expression may reverse TIM. Inspired by the Watson-Crick base-pairing rule, a versatile noncationic miRNA vector (miDAC@PDA) is developed for cancer immunotherapy. Doxorubicin (DOX), adenosine triphosphate (ATP), and copper ions (Cu2+) are coassembled into coordination polymer nanoparticles (DAC) and bind miRNA via the hydrogen bond interaction (miDAC) between adenine residues (ATP) and uracil residues (miRNA). Polydopamine (PDA) is deposited onto the surface of miDAC for photothermal therapy. miDAC@PDA can efficiently accumulate into tumor tissues for cellular uptake. Under laser irradiation and high intracellular GSH levels, the PDA shell of miDAC@PDA can dissociate from miDAC for miRNA release due to local hyperthermia. Cu2+-mediated GSH consumption and intracellular ATP release can amplify the DOX-based immunogenic cell death (ICD) cascade, together with miR-448-mediated IDO1 inhibition, and these versatile nanoplexes will not only restrain primary tumor growth but also display a remarkable abscopal effect on distant tumors. Collectively, our study provides a unique strategy for intracellular gene delivery and an inspirational approach for multimechanism cancer management.

9.
Circ Res ; 130(9): 1321-1341, 2022 Apr 29.
Artigo em Inglês | MEDLINE | ID: mdl-35382554

RESUMO

BACKGROUND: Cerebral small vessel injury, including loss of endothelial tight junctions, endothelial dysfunction, and blood-brain barrier breakdown, is an early and typical pathology for Alzheimer's disease, cerebral amyloid angiopathy, and hypertension-related cerebral small vessel disease. Whether there is a common mechanism contributing to these cerebrovascular alterations remains unclear. Studies have shown an elevation of BACE1 (ß-site amyloid precursor protein cleaving enzyme 1) in cerebral vessels from cerebral amyloid angiopathy or Alzheimer's disease patients, suggesting that vascular BACE1 may involve in cerebral small vessel injury. METHODS: To understand the contribution of vascular BACE1 to cerebrovascular impairments, we combined cellular and molecular techniques, mass spectrometry, immunostaining approaches, and functional testing to elucidate the potential pathological mechanisms. RESULTS: We observe a 3.71-fold increase in BACE1 expression in the cerebral microvessels from patients with hypertension. Importantly, we discover that an endothelial tight junction protein, occludin, is a completely new substrate for endothelial BACE1. BACE1 cleaves occludin with full-length occludin reductions and occludin fragment productions. An excessive cleavage by elevated BACE1 induces membranal accumulation of caveolin-1 and subsequent caveolin-1-mediated endocytosis, resulting in lysosomal degradation of other tight junction proteins. Meanwhile, membranal caveolin-1 increases the binding to eNOS (endothelial nitric oxide synthase), together with raised circulating Aß (ß-amyloid peptides) produced by elevated BACE1, leading to an attenuation of eNOS activity and resultant endothelial dysfunction. Furthermore, the initial endothelial damage provokes chronic reduction of cerebral blood flow, blood-brain barrier leakage, microbleeds, tau hyperphosphorylation, synaptic loss, and cognitive impairment in endothelial-specific BACE1 transgenic mice. Conversely, inhibition of aberrant BACE1 activity ameliorates tight junction loss, endothelial dysfunction, and memory deficits. CONCLUSIONS: Our findings establish a novel and direct relationship between endothelial BACE1 and cerebral small vessel damage, indicating that abnormal elevation of endothelial BACE1 is a new mechanism for cerebral small vessel disease pathogenesis.


Assuntos
Doença de Alzheimer , Angiopatia Amiloide Cerebral , Doenças de Pequenos Vasos Cerebrais , Hipertensão , Doença de Alzheimer/metabolismo , Secretases da Proteína Precursora do Amiloide/metabolismo , Peptídeos beta-Amiloides/metabolismo , Precursor de Proteína beta-Amiloide , Animais , Ácido Aspártico Endopeptidases/genética , Ácido Aspártico Endopeptidases/metabolismo , Caveolina 1/genética , Caveolina 1/metabolismo , Angiopatia Amiloide Cerebral/complicações , Angiopatia Amiloide Cerebral/metabolismo , Humanos , Hipertensão/complicações , Camundongos , Camundongos Transgênicos , Óxido Nítrico Sintase Tipo III/metabolismo , Ocludina/metabolismo , Proteínas de Junções Íntimas , Junções Íntimas/metabolismo
11.
Mol Biol Rep ; 2022 Mar 02.
Artigo em Inglês | MEDLINE | ID: mdl-35235160

RESUMO

PURPOSE: Cellular responses following cerebral ischemia/reperfusion injury are critical to recovery and survival after ischemic stroke. Understanding of these cellular responses can help the design of therapies to protect brain tissue and promote recovery after stroke. One of these cellular responses may be mediated by the AKT (protein kinase B) signal transduction pathway. This study was aimed to investigate the cerebral ischemia-induced alterations of AKT signaling and the upstream molecular pathways. METHODS: We modeled cerebral ischemia by middle cerebral artery occlusion in 2-3-month-old male C57BL/6J mice and then analyze the brain samples by using quantitative Western blots and phosphorylation/activation-dependent kinase antibodies. Cerebral ischemia was confirmed by staining of brain slices with 1% 2,3,5-triphenyltetrazolium chloride (TTC) and Nissl, as well as neurological assessments of the mice 24 h after ischemia-reperfusion surgery. RESULTS: We found marked downregulation of AKT within 12 h of cerebral ischemia/reperfusion, which leads to overactivation of glycogen synthase kinase-3ß (GSK-3ß). Furthermore, we found that the downregulation of AKT was mediated by downregulation of mTORC2 (the complex 2 of the mechanistic target of rapamycin) instead of its common upstream kinases, phosphatidylinositol 3-kinase and phosphoinositide-dependent kinase-1. CONCLUSION: Our findings provide new insight into the cellular responses to ischemia/reperfusion brain injury and will help develop new treatments targeting the AKT signaling pathway for the treatment of ischemic stroke.

12.
Nat Prod Res ; : 1-8, 2022 Mar 04.
Artigo em Inglês | MEDLINE | ID: mdl-35245427

RESUMO

Two previously undescribed dihydrophenanthrene derivatives (1 and 2) were isolated along with twelve known analogues from the whole plant of Dendrobium terminale. The structures of the new compounds were elucidated on the basis of detailed spectroscopic analysis. The NMR data of known phenanthrene derivatives (7 and 9) were revised by 2D NMR. The isolated compounds were evaluated for cytotoxicity against three kinds of tumor cell lines (sw1990, HCT-116, and HepG2). Especially compounds 11 and 14 showed stronger antitumor effects, and the structure-activity relationship of these compounds was discussed.

13.
J Dent Educ ; 2022 Mar 20.
Artigo em Inglês | MEDLINE | ID: mdl-35307835

RESUMO

OBJECTIVES: The development of virtual reality (VR) has exerted an enormous impact on higher education. However, the VR application in dental education is still at an early stage in China. This study explored the usability of a VR application in training the practical skills of dental students. METHODS: We first utilized the "system usability scale" (SUS) to verify the validity of the VR application in this study. Next, the VR training on orthodontic bracket bonding was experienced by the participants. The subsequent survey was delivered to collect the participants' perception and evaluation of the VR system application in training the practical skills of prospective dentists. RESULTS: The SUS score was 76.17 ± 9.89, suggesting an above-average evaluation of the system's usability and maturity. The response from the questionnaire supplied relatively positive responses to the VR system application on "user experiences," "perceived usefulness of VR application on orthodontics," and "perceived ease of manipulation." The male students exhibited strong interest in manipulating the VR system and were more capable of manipulating the VR system than the female students. VR experience did not affect the participants' responses to the questions. CONCLUSIONS: Overall, the use of VR in dental education achieved the expected outcomes. Most students identified the VR training as an enjoyable learning process, and it could be repetitively experienced without further costs, which might have potential positive effects on long-term learning outcomes, although there is room to further improve the effectiveness evaluation of VR.

14.
Sci Total Environ ; 828: 154458, 2022 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-35278547

RESUMO

Yellow and dark mealworms (Tenebrio molitor and Tenebrio obscurus) biodegrade commercial polyethylene (PE) materials at a high rate. We examined the impact of physical and chemical properties on biodegradation using high purity microplastics (MPs). These included high-density polyethylene (HDPE), low-density polyethylene (LDPE), and linear low-density polyethylene (LLDPE), all with different weight average molecular weights (Mw) and different crystallinity degrees in T. molitor and T. obscurus larvae. The biodegradation extent in the two mealworms was similar but strongly depended on the polymer type in sequence, since LDPE > LLDPE> HDPE (with respective Mw of 222.5, 110.5 and 182 kDa). When LDPE MPs with Mw of 0.84, 6.4 and 106.8 kDa and HDPE with Mw of 52, 105 and 132.7 kDa were tested, the PE MPs with lower Mw showed a greater extent of depolymerization. The results of dominance analysis indicated that less branching structure and higher crystallinity degree negatively impacted depolymerization and biodegradation. Py-GC/MS analysis confirmed the breaking of the macromolecule backbone as well as the formation of oxidized functional groups after all the tested PE materials passed through the mealworm intestine. The results demonstrated that molecular weight, PE type, branching, and crystallinity degree significantly affect the biodegradation capability of PE by the mealworms, and possibly by other biological systems as well.


Assuntos
Tenebrio , Animais , Biodegradação Ambiental , Larva/metabolismo , Microplásticos , Plásticos/metabolismo , Polietileno/metabolismo , Poliestirenos/metabolismo , Tenebrio/metabolismo
15.
Environ Technol ; : 1-14, 2022 Mar 31.
Artigo em Inglês | MEDLINE | ID: mdl-35316154

RESUMO

Conventional bioretention filters lack satisfactory performance in nitrogen removal. In this study, we used a mixture of cultivated soil and river sand as the bioretention filter to remove nitrogen pollutants from simulated rainwater runoff. To improve its permeability and nitrogen removal performance, both activated carbon and ceramsite were used as additives. The nitrogen removal processes and its mass accumulation in the modified bioretention filters were studied. The contribution of adsorption and biotransformation processes, together with the effects of percolate rate on nitrogen removal performance was explored. The results showed that an activated carbon layer in the bioretention filters could obviously improve nitrogen removal efficiencies, but its location made no significant difference in nitrogen removal performance. Bioretention filters modified with 20% of ceramsite could achieve the optimal percolate rate and nitrogen removal efficiencies. At given conditions, the average removal efficiencies of ammonium nitrogen (NH3-N), nitrate-nitrogen (NO3-N), and total nitrogen (TN) by the modified bioretention filter reached 80.27%, 41.48%, and 59.45%, respectively. During the leaching processes, organic nitrogen originated in the filter materials can be mineralised into NH3-N, then be denitrified and completely removed in the anaerobic environment under flooding conditions. Biotransformation in the modified bioretention filters caused a reduction of NH3-N removal efficiency by 15.41% and an increase of NO3-N removal efficiency by 31.03%. The modified bioretention filter can withstand a long-term operation. Compared with NO3-N and TN, the pollutant of NH3-N in rainwater runoff is not easy to form a mass accumulation in the modified bioretention filter.

16.
World J Microbiol Biotechnol ; 38(4): 67, 2022 Mar 05.
Artigo em Inglês | MEDLINE | ID: mdl-35246726

RESUMO

The control of food-borne pathogens and spoilage organisms in meat and related products is urgently needed. Bacteriocins produced by lactic acid bacteria (LAB) are promising natural food preservatives. In this study, six bacteriocin-producing bacteria were screened from soil and fresh cow dung. Pseudomonas koreensis PS1, a specific spoilage organism from spoiled chilled pork, was used as the indicator bacteria. From the analyses, the strain C010 was selected due to its high yield, broad spectrum, and subculture stability. Through morphological, biochemical, and 16S rDNA gene sequence analysis, this strain was identified as Lactobacillus plantarum. Crude bacteriocin extracted from the cell-free supernatant (CFS) of L. plantarum C010 was stable under high temperature, ultraviolet radiation, and protease attack (pepsin, trypsin, and proteinase K). The kinetics of bacterial growth and bacteriocin production by L. plantarum C010 were analyzed during batch fermentation. Bacteriocin was produced throughout the logarithmic growth phase, and the Leudeking-Piret model characterized the synthesis of bacteriocins. The present study indicates that this novel bacteriocin produced by bacteria is a promising option for reducing spoilage microorganisms and can be widely used as a bio-preservative in meat and other foods.


Assuntos
Bacteriocinas , Lactobacillus plantarum , Bacteriocinas/genética , Fermentação , Cinética , Lactobacillus plantarum/química , Lactobacillus plantarum/genética , Raios Ultravioleta
17.
Artigo em Inglês | MEDLINE | ID: mdl-35257334

RESUMO

Worldwide degradation of the ecological environment could be the cause of poverty. The poverty-stricken areas may face the dilemma of a "vicious circle of poverty." The complex ecological conditions have intertwined with poverty alleviation, which makes the demand for ecological poverty alleviation particularly prominent in these areas. However, the research on the relationship between agro-ecological efficiency and poverty are limited. It is far from clear what is the impact of the agro-ecological efficiency on poverty. To explore the impact of agro-ecological efficiency on poverty reduction, we adopt the panel data model based on cross-correlation and regression coefficient, using the data from 25 counties/districts in the Three Gorges Reservoir Region (TGRR) from 2006 to 2017. The results show that (1) there is significant heterogeneity in agro-ecological efficiency in the TGRR, and the agro-ecological efficiency in the middle area is significantly lower than that of the head and tail areas of the TGRR; (2) the improvement of regional agro-ecological efficiency could accelerate the alleviation of poverty; and (3) the widening of urban-rural income disparity is not conducive to poverty alleviation and eradication. This study would provide basis for further policy recommendations aimed at improving agro-ecological efficiency and alleviating poverty.

18.
Ecotoxicol Environ Saf ; 235: 113400, 2022 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-35325607

RESUMO

In recent years, more and more countries are focusing on the control of mining sites and the surrounding ecological environment, and the new environmental concept of green mines has been proposed. By investigating the ecological background of a mine site, pollution and ecological imbalances in the mine can be predicted, managed or transformed. This study investigated the effects of rare earth elements on plant growth in the Baotou Bayan Obo Rare Earth Mine and evaluated soil contamination and subsequent remediation through the measured plant height. Using linear regression, BP(Back Propagation) neural networks, GA-BP(Genetic Algorithm- Back Propagation) neural networks, ELM(Extreme Learning Machine) and GA-ELM(Genetic Algorithm- Extreme Learning Machine) model prediction instruments, the different rare earth solution concentrations were set as input values and the heights of Artemisia desertorum, which as the model plant, were set as output values in the prediction. The results showed that the linear regression predicted the standard error of single La(III), Ce(III) solution and compound La(III) + Ce(III) solution for Artemisia desertorum growth stress was on the high side, 7.02%- 8.92%; the efficiency range of each group of models under BP neural network, GA-BP neural network and ELM neural network were 1.15%- 2.53%, 0.85%- 1.28%, 1.76%- 3.53%; while the efficiency range under GA-ELM neural network was 0.59%- 0.68%, with average error values and predicted values close to the true values. Among them, the MAPE of GA-ELM neural network are significantly lower than other models, and the error decreases with increasing concentration of the compound solution. So GA-ELM neural network can be used as an efficient, fast and reasonable optimal model for predicting the growth stress of Artemisia desertorum in Bayan Obo mining area. The experimental results can provide a theoretical basis for assessing the risk of soil rare earth contamination in the area, evaluating the expectation of later remediation, and provide a degree of new ideas for the construction of green mines.


Assuntos
Artemisia , Aprendizagem , Modelos Lineares , Redes Neurais de Computação , Desenvolvimento Vegetal
19.
Heart Surg Forum ; 25(1): E056-E064, 2022 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-35238304

RESUMO

BACKGROUND: We aimed to investigate risk factors of early mortality following pericardiectomy. METHODS: This was a retrospective study of patients undergoing pericardiectomy between January 1994 and May 2021 at The People's Hospital of Guangxi Zhuang Autonomous Region, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, and The People's Hospital of Liuzhou City. RESULTS: This study included 826 patients, who were divided into two groups: group with operative deaths (N = 66) and group without operative deaths (N = 760). There were 66 operative deaths (66/826, 8.0%). The causes of operative deaths were multiorgan failure (86/826, 10.4%). Preoperative CVP (P < 0.001), chest drainage (P < 0.001), surgical duration (P < 0.001), fluid balance postoperative day D2 (P < 0.001), and tuberculosis pericarditis (P = 0.001) in group with operative deaths were significantly higher than those in group without operative deaths. Univariate and multivariate analyses showed that factors associated with operative deaths include male (P < 0.001), age (P < 0.001), ICU retention time (P < 0.001), postoperative hospitalization time (P < 0.001), preoperative central venous pressure (P = 0.018), postoperative central venous pressure (P < 0.001), D0 fluid balance (P < 0.001), D2 fluid balance (P < 0.001), postoperative chest drainage (P = 0.029), surgical duration (P = 0.003), serum creatinine baseline (P = 0.002), serum creatinine 24h after surgery (P < 0.001), serum creatinine 48h after surgery (P < 0.001), blood lactate (P < 0.001), and tuberculosis pericarditis (P = 0.033). CONCLUSION: In our study, incomplete pericardial dissection, fluid overload, and tuberculosis pericarditis are associated with operative deaths following pericardiectomy.


Assuntos
Pericardiectomia , Pericardite Constritiva , China/epidemiologia , Humanos , Masculino , Pericardiectomia/efeitos adversos , Pericardite Constritiva/cirurgia , Estudos Retrospectivos , Fatores de Risco
20.
Front Bioeng Biotechnol ; 10: 851668, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35242752

RESUMO

Hydroxymethylfurfural (HMF) derivatives such as 2,5-bis(hydroxymethyl)furan (BHMF) and furandicarboxylic acid (FDCA) are promising alternative of fossil-based diols and dicarboxylic acids for synthesis of polyesters such as polyethylene terephthalate (PET). However, high cost for preparing HMF from biomass discourages the commercialization of HMF-derived polyesters. Since producing furfural (FUR) from five-carbon sugars (e.g., xylose) via dehydration is an inexpensive and commercialized process, we herein reported a method to synthesize BHMF derivatives (5-(ethoxymethyl)furan-2-methanol (EMFM), 2,5-bis(hydroxymethyl)furan monoacetate (BHMFM) and 2,5-bis(hydroxymethyl)furan diacetate (BHMFD) from furfural derivatives, i.e., (2-(ethoxymethyl)furan (EMF) and furfuryl acetate (FA)). To avoid strong acid-induced side reactions (e.g., furan ring opening, condensation and carbonization), two reaction systems, i.e., a low-concentration HCl aqueous solution combined with formaldehyde and anhydrous acetic acid combined with paraformaldehyde, were found to be suitable for such a hydroxymethylation reaction and could lead to decent product yields. In order to improve the carbon utilization, condensed furanic byproducts were further converted into hydrocarbon fuels via a reported two-step hydrodeoxygenation (HDO) process. This study not only validates the possibility of synthesizing functional HMF derivatives (EMFM, BHMFM, and BHMFD) from commercially-available FUR derivatives (EMF and FA), but also provide a new way to transform condensed furanics to value-added hydrocarbon fuels.

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