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1.
Vestn Khir Im I I Grek ; 165(2): 11-4, 2006.
Artigo em Russo | MEDLINE | ID: mdl-16752631

RESUMO

The authors have analyzed results of operative treatment of 128 patients with terminal chronic renal failure (59) and cardiac pathology (69) associated with general surgical diseases (cholelithiasis, abdominal hernias, ulcer disease, malignant tumors etc). The authors recommend the indications, terms and character of operative measures be defined individually.


Assuntos
Procedimentos Cirúrgicos Cardíacos/tendências , Cardiopatias/cirurgia , Falência Renal Crônica/cirurgia , Transplante de Rim/tendências , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do Tratamento
2.
Acta Crystallogr A ; 59(Pt 6): 551-9, 2003 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-14581754

RESUMO

Triple-axis X-ray diffractometry was used to study diffuse scattering from an AlAs/GaAs superlattice grown on an [001]-oriented GaAs substrate by molecular beam epitaxy. Reciprocal-space maps were obtained around the 002 reflection from the superlattice and its low-angle first-order satellite. The data obtained reveal quasi-Bragg diffuse-scattering sheets caused by conformal behavior of interfacial roughness as well as amplification of diffuse scattering when the incoming or outgoing angle is nearly equal to the Bragg angle of the superlattice or substrate. The observed features of diffuse-scattering fine structure are explained within the framework of the distorted-wave Born approximation. Nevertheless, this approximation is shown to be incorrect for quantitative analysis of diffuse scattering. In particular, the observed domination in intensity of the incoming Bragg features over the outgoing ones is shown to reflect the decay rate of the coherent X-ray field through the diffuse-scattering channel, which is not negligible relative to the coherent diffraction.

3.
Anesteziol Reanimatol ; (5): 30-3, 2002.
Artigo em Russo | MEDLINE | ID: mdl-12611297

RESUMO

The study was undertaken to examine the myoplegic, hemodynamic, and histamine-releasing effects of the new aminosteroidal myorelaxant Rocuronium (esmerone, Organon firm) used to maintain anesthesia in cardiac surgical patients by orienting to early tracheal extubation. Twenty two patients aged 50 +/- 3 years operated on under extracorporeal circulation were examined. At the initial stage of maintenance, the agent in a dose of 0.6 mg/kg failed to affect cardiac pump function and to elevate plasma histamine levels. A moderate vagolytic effect was shown in 45% of cases. The incidence of myoplegia reduced in patients with significant circulatory insufficiency. In the preperfusion period, Rocuronium in a dose of 10.2 +/- 0.9 micrograms/kg/min blocked neuromuscular conduction (NMC) at a level of 5.1 +/- 1.8 to 19.2 +/- 3.5%. During hypothermic extracorporeal circulation and postperfusion period, the dosage of the myorelaxant substantially decreased. After termination of Rocuronium infusion, the time of up to 95%-recovery of NMC was 63 +/- 6 min. Early tracheal extubation was conducted in 68% of the patients 69 +/- 7.6 min after the end of the operation. Residual myoplegia was absent. The predictable recovery of NMC following the use of Rocuronium creates conditions for early activation of patients operated on under extracorporeal circulation.


Assuntos
Androstanóis/administração & dosagem , Anestesia Geral/métodos , Procedimentos Cirúrgicos Cardíacos/métodos , Circulação Extracorpórea , Intubação Intratraqueal , Fármacos Neuromusculares não Despolarizantes/administração & dosagem , Androstanóis/farmacologia , Período de Recuperação da Anestesia , Anestesia Intravenosa/métodos , Anestésicos Intravenosos , Feminino , Hemodinâmica/efeitos dos fármacos , Histamina/sangue , Humanos , Masculino , Pessoa de Meia-Idade , Monitorização Intraoperatória , Relaxamento Muscular/efeitos dos fármacos , Fármacos Neuromusculares não Despolarizantes/farmacologia , Rocurônio
5.
J Xray Sci Technol ; 5(1): 65-72, 1995 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-21307478

RESUMO

In the present work we have used the EXAFS and SAXS methods to study the inner structure of "classical" Co/C and Ni/C multilayers. This enabled us to study in detail the structure of a multilayer as a function of the thickness of a metal layer within the multilayer. On the basis of these data a model for multilayer growth produced with pulsed laser evaporation technology is proposed.

6.
J Xray Sci Technol ; 5(4): 389-95, 1995 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-21307508

RESUMO

A detailed study of structural changes occurring in films and on boundaries in multilayers upon annealing with EXAFS, WAXS, and SAXS methods was performed. The optimum temperature of annealing for the Ni/C and Co/C multilayers obtained by the pulsed laser evaporation method was found.

8.
Farmakol Toksikol ; 53(2): 58-60, 1990.
Artigo em Russo | MEDLINE | ID: mdl-2369958

RESUMO

The effects of new antitumor drugs spirobromin and prospidin on acute (carraghenin-induced rat paw edema) and chronic ("pellet granuloma") inflammation in rats were studied. The drugs were found to exert the anti-inflammatory effect on the model of chronic proliferative inflammation but to produce no significant changes in the degree of the acute inflammatory reaction. Spirobromin is superior to prospidin by the power of the anti-inflammatory effect. The electron microscopic studies showed that spirobromin and prospidin decrease the activity of fibroblasts in the focus of chronic inflammation.


Assuntos
Anti-Inflamatórios não Esteroides/uso terapêutico , Inflamação/tratamento farmacológico , Piperazinas/uso terapêutico , Prospídio/uso terapêutico , Compostos de Espiro/uso terapêutico , Animais , Carragenina , Avaliação Pré-Clínica de Medicamentos , Edema/induzido quimicamente , Edema/tratamento farmacológico , Edema/patologia , Granuloma de Corpo Estranho/tratamento farmacológico , Granuloma de Corpo Estranho/etiologia , Granuloma de Corpo Estranho/patologia , Inflamação/etiologia , Inflamação/patologia , Masculino , Microscopia Eletrônica , Ratos , Fatores de Tempo
9.
Vopr Onkol ; 36(1): 37-40, 1990.
Artigo em Russo | MEDLINE | ID: mdl-2154897

RESUMO

Some 3,3-dimethyltriazenes were shown to be capable of selective antimetastatic activity, i. e. preventing metastatic spreading of experimental tumors without affecting primary tumor or apparent metastases. The mechanism of antimetastatic effect of 3,3-dimethyltriazenes is discussed. The drugs represent a new promising pharmacological class of agents used for postsurgical adjuvant treatment of cancer. The effect of diazo derivatives produced in the course of disintegration of aromatic and heterocyclic 3,3-dimethyltriazenes on the in vitro activity of Ca-ATPase of the sarcoplasmic reticulum should be evaluated as a test-system for selecting new antimetastatic agents with cryptodiazonic properties.


Assuntos
Carcinoma de Células Escamosas/tratamento farmacológico , Neoplasias Pulmonares/tratamento farmacológico , Metástase Neoplásica/prevenção & controle , Triazenos/uso terapêutico , Animais , Canais de Cálcio/efeitos dos fármacos , ATPases Transportadoras de Cálcio/análise , Carcinoma de Células Escamosas/cirurgia , Neoplasias Pulmonares/cirurgia , Masculino , Camundongos , Cuidados Pós-Operatórios , Retículo Sarcoplasmático/efeitos dos fármacos , Retículo Sarcoplasmático/enzimologia , Triazenos/farmacologia
10.
Izv Akad Nauk SSSR Biol ; (5): 660-5, 1989.
Artigo em Russo | MEDLINE | ID: mdl-2584530

RESUMO

The influence of new antitumor drug, spirobromine, a derivative of dispirotripiperazine, on DNA synthesis in tumor cells and organs at different times after its injection into mice with P388 leukemia has been studied. The duration of DNA synthesis inhibition in tumor cells was found to correlate with spirobromine antitumor activity. A certain selectivity of action of the studied compound on DNA synthesis in P 388 leukemia cells as compared to the action on DNA synthesis in bone marrow, small intestine, spleen and liver of tumor animals was observed.


Assuntos
Antineoplásicos/uso terapêutico , Leucemia P388/tratamento farmacológico , Compostos de Espiro/uso terapêutico , Animais , DNA de Neoplasias/biossíntese , DNA de Neoplasias/efeitos dos fármacos , Relação Dose-Resposta a Droga , Avaliação Pré-Clínica de Medicamentos , Leucemia P388/metabolismo , Leucemia Experimental , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Endogâmicos DBA , Transplante de Neoplasias , Fatores de Tempo
11.
Mol Biol (Mosk) ; 23(5): 1440-6, 1989.
Artigo em Russo | MEDLINE | ID: mdl-2608045

RESUMO

By the methods of heat denaturation and luminescence the interaction between an antitumor drug prospidine and DNA in aqueous solutions at two ionic strengths (0.1 and 0.001 M NaCl) and at various prospidine concentrations was studied. For the first time it has been demonstrated that the interaction occurs at 0.1 M NaCl and therapeutic prospidine concentrations. In the framework of Frank-Kamenetsky's theory of melting of a polymer with stabilizing ligands the size of the binding site and binding constants (K) with the decrease of ionic strength, the lack of alterations in the DNA UV absorption spectrum on complex formation and the data on the competitive binding of ethydium bromide suggest that at the first stage of the reaction an external complex is formed due to electrostatic interactions between quaternary nitrogen atoms of prospidine and DNA phosphate groups. Incubation of the complex at 37 0 C leads to a decrease of the DNA melting temperature and hyperchromic effect. Presumably this is due to the relatively slow formation of chemical bonds between alkylating groups of prospidine and nucleophilic groups of DNA bases, which results in the destabilization and denaturation of DNA. It is concluded that the interaction between prospidine and DNA must be taken into consideration when studying the molecular mechanism of prospidine antitumour activity.


Assuntos
DNA/metabolismo , Piperazinas/metabolismo , Prospídio/metabolismo , Animais , Galinhas , DNA/efeitos dos fármacos , Eritrócitos/metabolismo , Etídio/metabolismo , Técnicas In Vitro , Desnaturação de Ácido Nucleico , Prospídio/farmacologia , Espectrometria de Fluorescência , Espectrofotometria Ultravioleta , Termodinâmica
12.
Vopr Onkol ; 35(8): 961-7, 1989.
Artigo em Russo | MEDLINE | ID: mdl-2641210

RESUMO

The effect of prospidin on Lewis lung carcinoma spreading under hyper- and hypocalcemia was studied. At early stages, increased extracellular calcium level was associated with inhibition of tumor dissemination to the lungs; however, later, colony growth was stimulated. Extracellular calcium level was shown to modulate the antitumor and antimetastatic effect of prospidin.


Assuntos
Adenocarcinoma/secundário , Cálcio/sangue , Neoplasias Pulmonares/secundário , Piperazinas/farmacologia , Prospídio/farmacologia , Adenocarcinoma/sangue , Animais , Neoplasias Pulmonares/sangue , Camundongos , Camundongos Endogâmicos C57BL
13.
Kardiologiia ; 28(9): 21-7, 1988 Sep.
Artigo em Russo | MEDLINE | ID: mdl-3236639

RESUMO

A follow-up study of 444 patients with artificial heart valves of different makes demonstrated increased wear and thrombogenic properties of the hemispheric MKC-27 prosthesis, used in mitral position, over 5 years of follow-up. High risk of thrombo-embolic complications is related to interrupted anticoagulant treatment. Their rate could be reduced through improving the quality of anticoagulant treatment, i.e. continuous administration of anticoagulants under adequate monitoring.


Assuntos
Doenças das Valvas Cardíacas/cirurgia , Próteses Valvulares Cardíacas/efeitos adversos , Complicações Pós-Operatórias/etiologia , Tromboembolia/etiologia , Anticoagulantes/uso terapêutico , Valva Aórtica/cirurgia , Humanos , Valva Mitral/cirurgia , Cuidados Pós-Operatórios , Complicações Pós-Operatórias/prevenção & controle , Tromboembolia/prevenção & controle , Valva Tricúspide/cirurgia
14.
Eksp Onkol ; 10(5): 52-5, 1988.
Artigo em Russo | MEDLINE | ID: mdl-3061779

RESUMO

The Ames test on indicator bacteria S. typhimurium TA 1950 and TA 100 and the differential spectrophotometry have shown that cytochrome P-450-dependent monooxygenases of mammalian liver participate in the metabolism of antitumour drugs (cyclophosphamide, thiophosphamide) and of nitrosomorpholine (promutagen). Data concerning prospidin indicate that microsomal liver enzymes either induce no metabolic transformations of this preparation or the formed metabolites possess the mutagenic activity similar to that of the parent compound.


Assuntos
Antineoplásicos/farmacocinética , Testes de Mutagenicidade , Mutagênicos/farmacocinética , Animais , Antineoplásicos/toxicidade , Biotransformação , Masculino , Microssomos Hepáticos/enzimologia , Microssomos Hepáticos/metabolismo , Mutação , Ratos , Ratos Endogâmicos , Salmonella typhimurium/genética
15.
Eksp Onkol ; 10(4): 11-7, 1988.
Artigo em Russo | MEDLINE | ID: mdl-3053148

RESUMO

Improvement and development of new methods for primary screening of antitumour drugs in vitro are based on the data on the points open to injury in the tumour cell metabolism and on the evidence of the known carcinostatic drug mechanism. Further development of the primary screening methods should proceed, probably, in two main directions. Further improvement of the methods for cloning tumour cells in the semifluid nutrient media is of great interest. On the whole the creation of new test systems is a significant trend of the scientific screening.


Assuntos
Antineoplásicos/uso terapêutico , Ensaios de Seleção de Medicamentos Antitumorais/métodos , Animais , Antineoplásicos/toxicidade , Células Clonais/efeitos dos fármacos , Humanos , Modelos Biológicos , Células Tumorais Cultivadas
16.
Biull Eksp Biol Med ; 104(12): 722-5, 1987 Dec.
Artigo em Russo | MEDLINE | ID: mdl-2961375

RESUMO

Using nucleoprotein celite chromatography, it has been shown that DNA of human cultured fibroblasts was strongly bound to the proteins of the nuclear matrix. N-methyl-N-nitrosourea and prospidin-active antitumor agents with marked mutagenic action--were shown to attenuate the interactions, which appeared to be partially sensitive in cultured fibroblasts from patients with Down's syndrome.


Assuntos
DNA/metabolismo , Mutagênicos , Proteínas Nucleares/metabolismo , Antineoplásicos/farmacologia , Cromatografia , Síndrome de Down/genética , Síndrome de Down/metabolismo , Fibroblastos , Humanos , Técnicas In Vitro , Metilnitrosoureia/farmacologia , Prospídio/farmacologia , Ligação Proteica/efeitos dos fármacos
19.
Genetika ; 22(9): 2265-71, 1986 Sep.
Artigo em Russo | MEDLINE | ID: mdl-3533723

RESUMO

The effect of transplantation of rat tumours Jensen sarcoma, sarcoma 45, sarcoma M-1, as well as of inoculation of rat normal connective tissue on the processes of biotransformation of antitumour preparations cyclophosphane (CP), thiophosphamide, prospidine and of model compound nitrosomorpholine (NM) was studied. The study was accomplished by means of the Ames test with indicator bacterial strain Salmonella typhimurium TA 1950 in relation to the reactions of the 1st and the 2nd phases of xenobiotics metabolism. It was shown that the presence of tumours leads to inhibition of both metabolic activation processes of the promutagens NM and CP and the conjugation reactions of genetically active metabolites of these compounds with reduced glutathione. Genetic danger is supposed to be increased during application of antitumour preparations, the mutagenic activity of which is due to the activity of their metabolites. It is noted that the most essential effect on biotransformation processes of NM and CP was exhibited by sarcoma M-1, the most important changes of the biotransformation processes of promutagens being observed in the initial period of pathologic process, i.e. on the 3rd day after inoculation. Transplantation of the normal connective tissue of rats had no effect on reactions of both the 1st and the 2nd phase of metabolism of the promutagens studied.


Assuntos
Antineoplásicos/toxicidade , Mutagênicos/metabolismo , Sarcoma Experimental/metabolismo , Animais , Antineoplásicos/metabolismo , Biotransformação , Masculino , Microssomos Hepáticos/metabolismo , Testes de Mutagenicidade , Transplante de Neoplasias , Ratos , Salmonella typhimurium/genética
20.
Kardiologiia ; 26(8): 53-7, 1986 Aug.
Artigo em Russo | MEDLINE | ID: mdl-3761849

RESUMO

Ninety-six patients with mitral, aortic and tricuspid valvular prostheses were investigated echocardiographically, with a total of 116 assessments of prosthetic function between 8 days and 20 years after surgery, using one-dimensional, two-dimensional and dopplerographic techniques. Possibilities of prosthetic dysfunction diagnosis by these techniques are discussed.


Assuntos
Ecocardiografia , Próteses Valvulares Cardíacas , Valva Aórtica/fisiopatologia , Bioprótese , Ecocardiografia/métodos , Seguimentos , Humanos , Valva Mitral/fisiopatologia , Falha de Prótese , Valva Tricúspide/fisiopatologia
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