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Int J Med Mushrooms ; 19(11): 1001-1008, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-29345562

RESUMO

Pleurotus citrinopileatus is an edible medicinal mushroom rich in biomolecules and thus has a high potential for use in formulating pharmaceutical and nutraceutical products. To test its effect on body weight and glucose control, we generated diet-induced obese (DIO) C57BL/6J male mice by feeding the mice a high-fat diet (60% fat) for 8 weeks and treating them with an ethanolic P. citrinopileatus extract (PCE) at either 200 or 500 mg/kg body weight for 12 additional weeks. The results showed that PCE significantly inhibited high-fat diet-induced weight gain, fat accumulation, and glucose intolerance in the DIO mice. Moreover, the PCE had a beneficial effect on liver and kidney function. On the basis of these results, we conclude that PCE is effective in the treatment of metabolic syndrome and thus could be a good candidate for use in future pharmaceutical or nutraceutical applications.


Assuntos
Misturas Complexas/administração & dosagem , Misturas Complexas/isolamento & purificação , Síndrome Metabólica/tratamento farmacológico , Pleurotus/química , Tecido Adiposo/patologia , Animais , Peso Corporal , Intolerância à Glucose/prevenção & controle , Camundongos Endogâmicos C57BL , Camundongos Obesos , Obesidade/prevenção & controle , Resultado do Tratamento
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