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1.
Materials (Basel) ; 14(11)2021 May 27.
Artigo em Inglês | MEDLINE | ID: mdl-34071833

RESUMO

This study investigated the effects of the packing density and particle size distribution of TiO2 nanoparticles on the mechanical properties of TiO2-epoxy nanocomposites (NCs). The uniform dispersion and good interfacial bonding of TiO2 in the epoxy resin resulted in improved mechanical properties with the addition of nanoparticles. Reinforcement nano-TiO2 particles dispersed in deionized water produced by three different ultrasonic dispersion methods were used; the ultrasonication effects were then compared. The nano-TiO2 suspension was added at 0.5-5.0 wt.%, and the mechanical and thermal properties of TiO2-epoxy NCs were compared using a universal testing machine, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), and differential scanning calorimetry (DSC). The tensile strength of the NCs was improved by the dispersion strengthening effect of the TiO2 nanoparticles, and focused sonication improved the tensile strength the most when nano-TiO2 suspensions with a particle size of 100 nm or smaller were used. Thus, the reinforcing effect of TiO2 nanoparticles on the epoxy resin was observed, and the nano-TiO2 suspension produced by focused sonication showed a more distinct reinforcing effect.

2.
Cancers (Basel) ; 13(11)2021 May 31.
Artigo em Inglês | MEDLINE | ID: mdl-34073100

RESUMO

PURPOSE: This nationwide multi-institutional study analyzed the patterns of care and outcomes of external beam radiotherapy (EBRT) in localized prostate cancer patients. We compared various risk classification tools and assessed the need for refinements in current radiotherapy (RT) schemes. METHODS AND MATERIALS: We included non-metastatic prostate cancer patients treated with primary EBRT from 2001 to 2015 in this study. Data of 1573 patients from 17 institutions were analyzed and re-grouped using a risk stratification tool with the highest predictive power for biochemical failure-free survival (BCFFS). We evaluated BCFFS, overall survival (OS), and toxicity rates. RESULTS: With a median follow-up of 75 months, 5- and 10-year BCFFS rates were 82% and 60%, and 5- and 10-year OS rates were 95% and 83%, respectively. NCCN risk classification revealed the highest predictive power (AUC = 0.556, 95% CI 0.524-0.588; p < 0.001). Gleason score, iPSA < 12 ng/mL, intensity-modulated RT (IMRT), and ≥179 Gy1.5 (EQD2, 77 Gy) were independently significant for BCFFS (all p < 0.05). IMRT and ≥179 Gy1.5 were significant factors in the high-risk group, whereas ≥170 Gy1.5 (EQD2, 72 Gy) was significant in the intermediate-risk group and no significant impact of dose was observed in the low-risk group. Both BCFFS and OS improved significantly when ≥179 Gy1.5 was delivered using IMRT and hypofractionation in the high-risk group without increasing toxicities. CONCLUSIONS: With NCCN risk classification, dose escalation with modern high-precision techniques might increase survivals in the high-risk group, but not in the low-risk group, although mature results of prospective studies are awaited.

3.
Nature ; 593(7857): 74-82, 2021 05.
Artigo em Inglês | MEDLINE | ID: mdl-33953415

RESUMO

The land ice contribution to global mean sea level rise has not yet been predicted1 using ice sheet and glacier models for the latest set of socio-economic scenarios, nor using coordinated exploration of uncertainties arising from the various computer models involved. Two recent international projects generated a large suite of projections using multiple models2-8, but primarily used previous-generation scenarios9 and climate models10, and could not fully explore known uncertainties. Here we estimate probability distributions for these projections under the new scenarios11,12 using statistical emulation of the ice sheet and glacier models. We find that limiting global warming to 1.5 degrees Celsius would halve the land ice contribution to twenty-first-century sea level rise, relative to current emissions pledges. The median decreases from 25 to 13 centimetres sea level equivalent (SLE) by 2100, with glaciers responsible for half the sea level contribution. The projected Antarctic contribution does not show a clear response to the emissions scenario, owing to uncertainties in the competing processes of increasing ice loss and snowfall accumulation in a warming climate. However, under risk-averse (pessimistic) assumptions, Antarctic ice loss could be five times higher, increasing the median land ice contribution to 42 centimetres SLE under current policies and pledges, with the 95th percentile projection exceeding half a metre even under 1.5 degrees Celsius warming. This would severely limit the possibility of mitigating future coastal flooding. Given this large range (between 13 centimetres SLE using the main projections under 1.5 degrees Celsius warming and 42 centimetres SLE using risk-averse projections under current pledges), adaptation planning for twenty-first-century sea level rise must account for a factor-of-three uncertainty in the land ice contribution until climate policies and the Antarctic response are further constrained.

5.
J Nanosci Nanotechnol ; 20(11): 7114-7118, 2020 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-32604567

RESUMO

A hexaaluminate support was prepared by a co-precipitation method, and a metal (Cu, Pt, or Ir) was impregnated on the support to prepare a powdered catalyst. After that, organic and inorganic binders were added to the powdery catalyst and then pellets were formed. The so-formed catalysts were heat-treated at 1200°C, and their physicochemical properties were analyzed by N2-adsorption, X-ray diffraction (XRD), X-ray fluorenscence (XRF), and scanning electron microscopy (SEM). The decomposition activity of the catalysts on an ammonium dinitramide (ADN)-based liquid propellant was evaluated repeatedly, and the effects of catalyst composition and morphology on low temperature decomposition activity and durability were investigated. It was confirmed that the Cu-hexa-pellet, Pt-hexa-pellet, and Ir-hexa-pellet catalysts could be recovered and reused as a catalyst for decomposition of an ADN-based liquid monopropellant. The initial activity and the thermal stability of the Cu-hexa-pellet catalyst for the decomposition of ADN-based liquid monopropellants were better than for the other catalysts. The better activity of the Cu-hexa-pellet catalyst seems to be because the dispersion of the copper was higher than the metal dispersion in the other two catalysts.

6.
J Korean Med Sci ; 35(27): e200, 2020 Jul 13.
Artigo em Inglês | MEDLINE | ID: mdl-32657082

RESUMO

Stereotactic cardiac radiation for ablation (radioablation) of life-threatening ventricular arrhythmia was recently introduced into clinical practice. A 76-year-old male patient with apical hypertrophic cardiomyopathy at burnout stage, who received defibrillator implantation for the secondary prevention of sudden arrhythmic death, was admitted for repeated defibrillator therapy. Radiofrequency catheter ablation was unsuccessful due to the induction of ventricular fibrillation (VF) and hemodynamically unstable sustained monomorphic ventricular tachycardia (VT). However, intracardiac activation mapping for the induced VT revealed the earliest ventricular activation at the apical aneurysm. Radioablation was performed to control VT and VF storm refractory to antiarrhythmic drug therapy. A total of 24 Gray was radiated, divided into three fractions around the apical aneurysm. The onset of electrical modulation was instantaneous and the antiarrhythmic effect was maintained for at least 6 months without significant radiation toxicities. This case suggests that radioablation may be considered as a rescue therapy for VT and VF storm refractory to other treatment modalities.


Assuntos
Cardiomiopatia Hipertrófica/patologia , Taquicardia Ventricular/cirurgia , Fibrilação Ventricular/cirurgia , Idoso , Antiarrítmicos/uso terapêutico , Cardiomiopatia Hipertrófica/complicações , Ablação por Cateter , Desfibriladores Implantáveis , Eletrocardiografia , Humanos , Masculino , Radiocirurgia , Recidiva , Taquicardia Ventricular/complicações , Taquicardia Ventricular/diagnóstico , Taquicardia Ventricular/tratamento farmacológico , Tomografia Computadorizada por Raios X , Fibrilação Ventricular/complicações , Fibrilação Ventricular/diagnóstico , Fibrilação Ventricular/tratamento farmacológico
7.
Micromachines (Basel) ; 11(6)2020 Jun 25.
Artigo em Inglês | MEDLINE | ID: mdl-32630533

RESUMO

A stretchable printed circuit board (PCB), which is an essential component of next-generation electronic devices, should be highly stretchable even at high levels of integration, as well as durable under repetitive stretching and patternable. Herein, an island-structured stretchable PCB composed of materials with controlled Young's modulus and viscosity by adding a reinforcing agent or controlling the degree of crosslinking is reported. Each material was fabricated with the most effective structures through a 3D printer. The PCB was able to stretch 71.3% even when highly integrated and was patterned so that various components could be mounted. When fully integrated, the stress applied to the mounted components was reduced by 99.9% even when stretched by over 70%. Consequently, a 4 × 4 array of capacitance sensors in a stretchable keypad demonstration using our PCB was shown to work, even at 50% stretching of the PCB.

8.
Materials (Basel) ; 13(11)2020 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-32492919

RESUMO

The pH-responsive polymers, such as polyacrylamide (PAM), show distinct conformational states according to the pH of their environmental groundwater. Therefore, the interactions between clay-polymer and polymer-water molecules, which determine the yield stress of bentonite-polymer composites, can be affected by the pH of groundwater. This study aims to evaluate the effect of pH variation on the yield stress of calcium bentonite treated with PAM. The yield stresses (τy) of untreated and PAM treated clays were measured with varying volume fractions of solid (VF = 10-23%) and under varying pH conditions (pH = 7.6-9.6). In addition, the zeta potential was measured for both untreated and treated clays to figure out the change in the surface charge of the mineral surface due to PAM treatment. The results of this study demonstrate that τy for treated clay is higher than that for untreated clay at a given VF, because van der Walls attraction dominates electrostatic repulsion in the case of treated clay. Due to the change in conformational states of PAM and the consequent change in surface charge that comes with varying pH, the pH-dependent change in τy of treated clay is significantly different from that of untreated clay.

9.
ACS Omega ; 5(4): 1956-1965, 2020 Feb 04.
Artigo em Inglês | MEDLINE | ID: mdl-32039332

RESUMO

Recently, the development of pressure sensor devices composed of mechanically flexible materials has gained a tremendous attention for emerging wearable electronics applications. Compared with various sensing materials, piezoelectric composite materials provide a characteristic advantage of enabling energy unit-free integration of sensor compartments. In this study, we develop a new chemical method of synthesizing highly functioning piezoelectric composite materials with electrostatically reinforced heterogeneous interfaces to improve the voltage output signal in all-printed sensor arrays. The surfaces of piezoelectric oxide nanoparticles are decorated subsequently with a cationic polyelectrolyte, polyethyleneimine, and a tri-block copolymer, styrene-ethylene/butylene-styrene grafted with maleic anhydride. To elucidate the factors determining the performance of pressure sensor devices, both the electrical properties and piezoelectric characteristics are investigated comprehensively for various compositional composite materials prepared from chemical and physical rubbers. The resulting device exhibits a sensitivity of 0.28 V·kPa-1 with a linear increment of output voltage in a pressure range up to 30 kPa. It is also demonstrated that the all-printed sensor array is fabricated successfully by a multistack-printing process of conductive, insulating, and piezoelectric composite materials in an additive manufacturing fashion.

10.
Small ; 16(5): e1905875, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31943743

RESUMO

The anionic redox chemistries of layered cathode materials have been in focus recently due to an intriguing phenomenon that cannot be described by the number of electrons of transition metal ions. However, even though several studies have investigated the anionic redox chemistry of layered materials in terms of the charge compensation, the relationship between the origin of the structural behavior and anionic redox chemistry in layered materials remains poorly understood. In addition, a simultaneous redox process of transition metal ions could occur through the d bands interaction. Here, it is demonstrated that the anionic redox chemistry is associated with the anisotropic structural behavior of the layered cathode materials albeit without providing additional capacities exceeding the theoretical values. These findings will provide a foundation of a new chapter in the understanding of the properties of materials.

11.
Cancer Res Treat ; 52(1): 167-180, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31291715

RESUMO

PURPOSE: The purpose of this study was to investigate the clinical outcomes of postoperative radiotherapy (PORT) patients who underwent radical prostatectomy for localized prostate cancer. Materials and Methods: Localized prostate cancer patients who received PORT after radical prostatectomy between 2001 and 2012 were identified retrospectively in a multi-institutional database. In total, 1,117 patients in 19 institutions were included. Biochemical failure after PORT was defined as prostate-specific antigen (PSA) ≥ nadir+2 after PORT or initiation of androgen deprivation therapy (ADT) for increasing PSA regardless of its value. RESULTS: Ten-year biochemical failure-free survival, clinical failure-free survival, distant metastasisfree survival, overall survival (OS), and cause-specific survival were 60.5%, 76.2%, 84.4%, 91.1%, and 96.6%, respectively, at a median of 84 months after PORT. Pre-PORT PSA ≤ 0.5 ng/ml and Gleason's score ≤ 7 predicted favorable clinical outcomes, with 10-year OS rates of 92.5% and 94.1%, respectively. The 10-year OS rate was 82.7% for patients with a PSA > 1.0 ng/mL and 86.0% for patients with a Gleason score of 8-10. The addition of longterm ADT (≥ 12 months) to PORT improved OS, particularly in those with a Gleason score of 8-10 or ≥ T3b. CONCLUSION: Clinical outcomes of PORT in a Korean prostate cancer population were very similar to those in Western countries. Lower Gleason score and serum PSA level at the time of PORT were significantly associated with favorable outcomes. Addition of long-term ADT (≥ 12 months) to PORT should be considered, particularly in unfavorable risk patients with Gleason scores of 8-10 or ≥ T3b.


Assuntos
Cuidados Pós-Operatórios , Neoplasias da Próstata/diagnóstico , Neoplasias da Próstata/terapia , Biomarcadores Tumorais , Terapia Combinada , Humanos , Estimativa de Kaplan-Meier , Masculino , Gradação de Tumores , Estadiamento de Neoplasias , Prognóstico , Prostatectomia/efeitos adversos , Prostatectomia/métodos , Neoplasias da Próstata/mortalidade , Radioterapia Adjuvante , República da Coreia , Estudos Retrospectivos , Resultado do Tratamento
12.
ACS Appl Mater Interfaces ; 11(51): 48459-48465, 2019 Dec 26.
Artigo em Inglês | MEDLINE | ID: mdl-31818098

RESUMO

Stretchable electrodes, which are essential components of next-generation electronic devices, should be highly conductive under multiaxial tensile strain, durable under repetitive stretching, and patternable for integrating stretchable devices. Herein, a lubricant-added stretchable conductive composite of a polydimethylsiloxane-based elastomer containing silver flakes is reported. The added lubricant minimizes changes in conductivity during stretching and maximizes elastic durability by reducing friction. The conductivity varies from 1933.3 S·cm-1 at 0% strain to 307.5 S·cm-1 at 300% uniaxial stretching and 1264.1 S·cm-1 at 50% biaxial stretching. Furthermore, the composite exhibits high durability, even after 1000 cycles of stretching at 200%, and the conductive composite paste can be applied to fine-linewidth direct writing.

13.
Radiat Oncol J ; 37(3): 207-214, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31591869

RESUMO

PURPOSE: To identify the prognostic factors that could influence survival and to compare prognoses of the patients with the number of the risk factors that might assist in the adequate management of hepatocellular carcinoma (HCC) patients with bone metastases that showed a heterogeneous range of survival. MATERIALS AND METHODS: A total of 41 patients, treated with radiotherapy (RT) for bone metastases from HCC from 2014 to 2017, were enrolled retrospectively. Survival was determined by the Kaplan-Meier method from the start of the RT for metastatic bone lesions. Pre-RT clinical features were evaluated and their influences on survival were analyzed. The significant factors were considered to compare survivals according to the number of prognostic factors. RESULTS: Median follow-up was 6.0 months (range, 0.5 to 47.0 months). The median overall survival was 6.5 months, and the 1-year and 2-year survival rates were 35.5% and 13.5%, respectively. Multivariate analysis revealed that the Child-Pugh class A group, alpha-fetoprotein increased more than 30 ng/mL, and HCC size of more than 5 cm were associated with worse overall survival. The median survivals in HCC with none, 1, 2, and 3 of the aforementioned risk factors were 19.5, 9.0, 2.5, and 1.0 months, respectively (p < 0.05). CONCLUSION: Our results show that the overall survivals were significantly different according to the number of the risk factors among HCC patients with bone metastases who showed various lengths of survival.

14.
ACS Appl Mater Interfaces ; 11(22): 20134-20142, 2019 Jun 05.
Artigo em Inglês | MEDLINE | ID: mdl-31056900

RESUMO

Printing techniques that enable the formation of arbitrarily designed architectures have been implemented in various research fields owing to their characteristic advantages in processing over other techniques. In particular, low-cost, printable conductors are of paramount importance in the production of highly functioning printed electronics. Among various candidates, copper (Cu) particle-based printable fluid has been regarded as the most promising constituent material in conjunction with the use of the flash-light-sintering (FLS) process in air. In this study, we synthesized surface-oxidation-suppressed Cu nanoparticles, sub-micronparticles, and flakes to regulate the optical absorption characteristics in FLS-processed, Cu-based printed conductors. Our results revealed clearly that the critical issues in FLS-processed conductors, namely, undesirable crack formation and a limitation of thickness, are resolved by adjusting the optical behaviors of particulate layers by variation of the composition of multidimensional mixture particles. It is suggested that crack-free, 13.2 µm thick printed Cu conductors can be generated with a resistivity of 11.4 µΩ cm by printing and FLS processes in air. The proposed alternative approach is demonstrated with electrical circuits comprising electrodes and interconnections.

15.
Cancer Res Treat ; 51(4): 1589-1599, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30971065

RESUMO

PURPOSE: There is limited data on radiotherapy (RT) for hepatocellular carcinoma (HCC) in patients with Child-Pugh classification B (CP-B). This study aimed to evaluate the treatment outcomes of fractionated conformal RT in HCC patients with CP-B. Materials and Methods: We retrospectively reviewed the data of HCC patients with CP-B treated with RT between 2009 and 2014 at 13 institutions in Korea. HCC was diagnosed by the Korea guideline of 2009, and modern RT techniques were applied. Fraction size was ≤ 5 Gy and the biologically effective dose (BED) ≥ 40 Gy10 (α/ß = 10 Gy). A total of 184 patients were included in this study. RESULTS: Initial CP score was seven in 62.0% of patients, eight in 31.0%, and nine in 7.0%. Portal vein tumor thrombosis was present in 66.3% of patients. The BED ranged from 40.4 to 89.6 Gy10 (median, 56.0 Gy10). After RT completion, 48.4% of patients underwent additional treatment. The median overall survival (OS) was 9.4 months. The local progression-free survival and OS rates at 1 year were 58.9% and 39.8%, respectively. In the multivariate analysis, non-classic radiation-induced liver disease (RILD) (p < 0.001) and additional treatment (p < 0.001) were the most significant prognostic factors of OS. Among 132 evaluable patients without progressive disease, 19.7% experienced non-classic RILD. Normal liver volume was the most predictive dosimetric parameter of non-classic RILD. CONCLUSION: Fractionated conformal RT showed favorable OS with a moderate risk non-classic RILD. The individual radiotherapy for CP-B could be cautiously applied weighing the survival benefits and the RILD risks.


Assuntos
Carcinoma Hepatocelular/radioterapia , Hepatopatias/complicações , Neoplasias Hepáticas/radioterapia , Radioterapia Conformacional/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Fracionamento da Dose de Radiação , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Radioterapia Conformacional/efeitos adversos , República da Coreia , Estudos Retrospectivos , Resultado do Tratamento
16.
ACS Appl Mater Interfaces ; 11(13): 12622-12631, 2019 Apr 03.
Artigo em Inglês | MEDLINE | ID: mdl-30855933

RESUMO

A stretchable conductor is a critical prerequisite to achieve various forms of stretchable electronics. In particular, directly printable stretchable conductors have gathered considerable attention with recent growing interest in a variety of large-area, deformable electronics. In this study, we have developed a chemical pathway of incorporating a surfactant with a moderate hydrophilic-lipophilic balance in formulating composite pastes for printed stretchable conductors, with a possibility of a vertically stackable, three-dimensional printing process. We demonstrate that the addition of a nonionic surfactant, sorbitane monooleate (commonly called SPAN 80) in Ag flake-based composite pastes, allows a critical reduction in resistance variation under an external strain. The four-layer stacked, surfactant-added composite conductors show a resistance variation of merely 1.6 at a strain of 0.6 and excellent cycling durability over 1000 cycles. The effectiveness of the methods suggested in this study is demonstrated with basic light-emitting diode circuits and the thermal heating characteristics of stretchable conductors.

17.
ACS Nano ; 12(12): 11838-11846, 2018 Dec 26.
Artigo em Inglês | MEDLINE | ID: mdl-30395434

RESUMO

Wireless electronic devices require small, rechargeable batteries that can be rapidly designed and fabricated in customized form factors for shape conformable integration. Here, we demonstrate an integrated design and manufacturing method for aqueous zinc-ion batteries composed of polyaniline (PANI)-coated carbon fiber (PANI/CF) cathodes, laser micromachined zinc (Zn) anodes, and porous separators that are packaged within three-dimensional printed geometries, including rectangular, cylindrical, H-, and ring-shapes. The PANI/CF cathode possesses high surface area and conductivity giving rise to high rate (∼600 C) performance. Due to outstanding stability of Zn-PANI batteries against oxygen and moisture, they exhibit long cycling stability in an aqueous electrolyte solution. As exemplar, we demonstrated rechargeable battery packs with tunable voltage and capacity using stacked electrodes that are integrated with electronic components in customized wearable devices.

18.
Food Sci Biotechnol ; 27(2): 333-342, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30263756

RESUMO

This study evaluated the effect of different cooking methods including blanching, boiling, microwaving and steaming on the content of vitamins in vegetables. True retention was estimated using the yield expressed as a ratio of the weight of the cooked sample to the weight of the raw sample. The retention of vitamin C ranged from 0.0 to 91.1% for all cooked samples. Generally, higher retention of vitamin C was observed after microwaving with the lowest retention recorded after boiling. Cooked vegetables were occasionally higher contents of fat-soluble vitamins, including α-tocopherol and ß-carotene, than that of their fresh counterparts, but it depends on the type of vegetables. Microwave cooking caused the greatest loss of vitamin K in crown daisy and mallow; in contrast, it caused the least loss of vitamin K in spinach and chard. Cooking may cause changes to the contents of vitamins, but it depends on vegetables and cooking processes.

19.
Radiat Oncol J ; 36(2): 114-121, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29983031

RESUMO

PURPOSE: To explore the feasibility of maximum diameter as a response assessment method for vestibular schwannomas (VS) after stereotactic radiosurgery or fractionated stereotactic radiotherapy (RT), we analyzed the concordance of RT responses between maximum diameters and volumetric measurements. Materials and. METHODS: Forty-two patients receiving curative stereotactic radiosurgery or fractionated stereotactic RT for VS were analyzed retrospectively. Twelve patients were excluded: 4 did not receive follow-up magnetic resonance imaging (MRI) scans and 8 had initial MRI scans with a slice thickness >3 mm. The maximum diameter, tumor volume (TV), and enhanced tumor volume (ETV) were measured in each MRI study. The percent change after RT was evaluated according to the measurement methods and their concordances were calculated with the Pearson correlation. The response classifications were determined by the assessment modalities, and their agreement was analyzed with Cohen kappa statistics. RESULTS: Median follow-up was 31.0 months (range, 3.5 to 86.5 months), and 90 follow-up MRI studies were analyzed. The percent change of maximum diameter correlated strongly with TV and ETV (r(p) = 0.85, 0.63, p = 0.000, respectively). Concordance of responses between the Response Evaluation Criteria in Solid Tumors (RECIST) using the maximum diameters and either TV or ETV were moderate (kappa = 0.58; 95% confidence interval, 0.32-0.85) or fair (kappa = 0.32; 95% confidence interval, 0.05-0.59), respectively. Conclusions: The percent changes in maximum diameter and the responses in RECIST were significantly concordant with those in the volumetric measurements. Therefore, the maximum diameters can be used for the response evaluation of VS following stereotactic RT.

20.
J Vet Med Sci ; 80(6): 1041-1046, 2018 Jun 29.
Artigo em Inglês | MEDLINE | ID: mdl-29695679

RESUMO

Although several Edwardsiella tarda infections have been reported, its pathogenic role in marine mammals has not been investigated at the genome level. We investigated the genome of E. tarda strain KC-Pc-HB1, isolated from the false killer whale (Pseudorca crassidens) found bycaught in South Korea. The obtained genome was similar to that of human pathogenic E. tarda strains, but distinct from other Edwardsiella species. Although type III and VI secretion systems, which are essential for the virulence of other Edwardsiella species, were absent, several virulence-related genes involved in the pathogenesis of E. tarda were found in the genome. These results provide important insights into the E. tarda infecting marine mammals and give valuable information on potential virulence factors in this pathogen.


Assuntos
Golfinhos/microbiologia , Edwardsiella tarda/isolamento & purificação , Infecções por Enterobacteriaceae/veterinária , Animais , Edwardsiella tarda/genética , Infecções por Enterobacteriaceae/diagnóstico , Infecções por Enterobacteriaceae/microbiologia , Genoma Bacteriano , Humanos , República da Coreia , Virulência
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