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1.
Molecules ; 26(4)2021 Feb 18.
Artigo em Inglês | MEDLINE | ID: mdl-33670795

RESUMO

Adenia viridiflora Craib. is an indigenous edible plant that became an endangered species due to limited consumption of the local population with unknown reproduction and growth conditions. The plant is used as a traditional herb; however, its health applications lack scientific-based evidence. A. viridiflora Craib. plant parts (old leaves and young shoots) from four areas as Kamphaeng Phet (KP), Muang Nakhon Ratchasima (MN), Pakchong Nakhon Ratchasima (PN), and Uthai Thani (UT) origins were investigated for phenolic compositions and in vitro health properties through the inhibition of key enzymes relevant to obesity (lipase), diabetes (α-glucosidase and dipeptidyl peptidase-IV), Alzheimer's disease (cholinesterases and ß-secretase), and hypertension (angiotensin-converting enzyme). Phenolics including p-coumaric acid, sinapic acid, naringenin, and apigenin were detected in old leaves and young shoots in all plant origins. Old leaves exhibited higher total phenolic contents (TPCs) and total flavonoid contents (TFCs), leading to higher enzyme inhibitory activities than young shoots. Besides, PN and MN with higher TPCs and TFCs tended to exhibit greater enzyme inhibitory activities than others. These results will be useful to promote this plant as a healthy food with valuable medicinal capacities to support its consumption and agricultural stimulation, leading to sustainable conservation of this endangered species.


Assuntos
Doença , Passifloraceae/química , Fitoterapia , Extratos Vegetais/química , Água/química , Animais , Antioxidantes/análise , Candida/enzimologia , Cromatografia Líquida de Alta Pressão , Inibidores Enzimáticos/farmacologia , Inibidores Enzimáticos/uso terapêutico , Flavonoides/análise , Cavalos , Humanos , Hipertensão/tratamento farmacológico , Fenóis/análise , Folhas de Planta/química , Brotos de Planta/química , Coelhos , Saccharomyces cerevisiae/enzimologia , Solventes
2.
Foods ; 10(1)2021 Jan 08.
Artigo em Inglês | MEDLINE | ID: mdl-33429899

RESUMO

Fermented tea (Cha-miang in Thai) is a local product made by traditional food preservation processes in Northern Thailand that involve steaming fresh tea leaves followed by fermenting in the dark. Information on changes in nutritive values, bioactive compounds, antioxidant activities, and health properties that occur during the steaming and fermenting processes of tea leaves is, however, limited. Changes in nutritive values, phenolics, antioxidant activities, and in vitro health properties through inhibition of key enzymes that control obesity (lipase), diabetes (α-amylase and α-glucosidase), hypertension (angiotensin-converting enzyme (ACE)), and Alzheimer's disease (cholinesterases (ChEs) and ß-secretase (BACE-1)) of fermented tea were compared to the corresponding fresh and steamed tea leaves. Results showed that energy, carbohydrate, and vitamin B1 increased after steaming, while most nutrients including protein, dietary fiber, vitamins (B2, B3, and C), and minerals (Na, K, Ca, Mg, Fe, and Zn) decreased after the steaming process. After fermentation, energy, fat, sodium, potassium, and iron contents increased, while calcium and vitamins (B1, B2, B3, and C) decreased compared to steamed tea leaves. However, the contents of vitamin B1 and iron were insignificantly different between fresh and fermented tea leaves. Five flavonoids (quercetin, kaempferol, cyanidin, myricetin, and apigenin) and three phenolic acids (gallic acid, caffeic acid, and p-coumaric acid) were identified in the tea samples. Total phenolic content (TPC) and antioxidant activities increased significantly after steaming and fermentation, suggesting structural changes in bioactive compounds during these processes. Steamed tea exhibited high inhibition against lipase, α-amylase, and α-glucosidase, while fermented tea possessed high anti-ChE and anti-ACE activities. Fresh tea exhibited high BACE-1 inhibitory activity. Results suggest that tea preparations (steaming and fermentation) play a significant role in the amounts of nutrients and bioactive compounds, which, in turn, affect the in vitro health properties. Knowledge gained from this research will support future investigations on in vivo health properties of fermented tea, as well as promote future food development of fermented tea as a healthy food.

3.
BMC Complement Altern Med ; 19(1): 294, 2019 Nov 04.
Artigo em Inglês | MEDLINE | ID: mdl-31684925

RESUMO

BACKGOUND: Obesity and dyslipidemia are major risk factors associated with non-alcoholic fatty liver disease (NAFLD). NAFLD refers to the accumulation of fat in more than 5% of the liver without alcohol consumption. NAFLD is the most common liver disease and is rapidly becoming a global public health problem. Maoberry (Antidesma bunius) is a fruit rich in antioxidants, especially phenolic compounds, which are reported to have benefits for patients with NAFLD. METHODS: We evaluated the effect of Maoberry extract on fat metabolism in liver tissues of high fat diet-induced rats. Five (5) groups (n = 12) of male Sprague-Dawley (SD) rats were divided into those given a high fat diet with no treatment (HF), different dosages of Maoberry extracts (0.38 [ML], 0.76 [MM) and 1.52 [MH] g/kg body weight) and 10 mg/kg statin (STAT). The rats were fed a high fat diet for 4 weeks to induce obesity and subsequently continued more for 12 weeks with treatments of Maoberry extracts or STAT. The levels of triglyceride, liver enzymes, oxidative stress and inflammation markers, triglyceride synthesis regulators, and pathology of the liver in high fat diet-induced rats were investigated. RESULTS: Feeding Maoberry extract in MH groups resulted in decreasing levels of serum alanine aminotransferase (ALT), liver triglyceride, liver thiobarbituric acid reactive substances (TBARS) and mRNA expression of tumour necrosis factor (TNF)-α, interleukin (IL)-6, glycerol-3-phosphate acyltransferase (GPAT)-1 and acetyl-coenzyme A carboxylase (ACC) compared with the HF group (P < 0.05). Moreover, histopathological study of the liver showed reduced fat droplets in the Maoberry extract treatment groups, especially in MH groups and STAT treatment groups. CONCLUSIONS: The improvements of fat metabolism in liver tissues of rats fed a high-fat diet were observed in Maoberry extracts treatment groups. The underline mechanism that link to fat metabolism might be through the process accompanied with down-regulated the gene expression of key enzymes of lipid production, antioxidant activity, and anti-inflammation properties of Maoberry extracts which contains high levels of phenolic and flavonoid compounds.


Assuntos
Antioxidantes/administração & dosagem , Gorduras/metabolismo , Fígado/efeitos dos fármacos , Malpighiales/química , Hepatopatia Gordurosa não Alcoólica/tratamento farmacológico , Extratos Vegetais/administração & dosagem , Acetil-CoA C-Acetiltransferase/genética , Acetil-CoA C-Acetiltransferase/metabolismo , Animais , Antioxidantes/química , Dieta Hiperlipídica/efeitos adversos , Frutas/química , Humanos , Interleucina-6/genética , Interleucina-6/metabolismo , Fígado/metabolismo , Masculino , Hepatopatia Gordurosa não Alcoólica/etiologia , Hepatopatia Gordurosa não Alcoólica/metabolismo , Estresse Oxidativo/efeitos dos fármacos , Extratos Vegetais/química , Ratos , Ratos Sprague-Dawley , Triglicerídeos/metabolismo , Fator de Necrose Tumoral alfa/genética , Fator de Necrose Tumoral alfa/metabolismo
4.
Int J Vitam Nutr Res ; 89(5-6): 246-254, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30982444

RESUMO

A lower serum folate level is common in older populations and is associated with increased serum homocysteine concentration. In turn, an elevated homocysteine level is associated with increased risk of cardiovascular disease and age-related diseases. Contemporary studies of folate and dietary risk factors for cardiovascular disease among the elderly population in Thailand are lacking. This cross-sectional study aimed to investigate the relationships among serum folate, homocysteine level, and nutritional status in the elderly Thai. Three hundred individuals, aged 60 years and over, underwent anthropometric and physiological measurements, and biochemical parameters, and eating habits were also determined. Folate insufficiency was found in approximately 35% of subjects. Folate and homocysteine showed a significant inverse correlation. Serum homocysteine levels rose with increasing age. Folate deficiency and high waist-to-hip ratio were associated with 7-fold and 2.5-fold increased risk for hyperhomocysteinemia, respectively. There were positive correlations between homocysteine and waist-to-hip ratio and systolic blood pressure, but a negative correlation between homocysteine and high-density lipoprotein (r = -0.239, p < 0.01), which are markers for cardiovascular disease risk. Folate negatively correlated with body mass index, waist-to-hip ratio, and diastolic blood pressure, but positively with high-density lipoprotein (r = 0.162, p < 0.01). Investigation of eating habits showed that low consumption of green leafy vegetables and high consumption of sugary foods were associated with high homocysteine levels. Given associations between nutritional status and cardiovascular disease confirmed in this study, nutrition education, holistic health promotion, and appropriate behavioral modification of eating habits represent important measures for preventing premature cardiovascular disease in the elderly Thai population.


Assuntos
Comportamento Alimentar , Idoso , Estudos Transversais , Ácido Fólico , Homocisteína , Humanos , Hiper-Homocisteinemia , Lipídeos , Pessoa de Meia-Idade , Tailândia , Vitamina B 12 , Relação Cintura-Quadril
5.
Per Med ; 15(5): 371-379, 2018 09.
Artigo em Inglês | MEDLINE | ID: mdl-30259785

RESUMO

AIM: The risk of vitamin D binding protein (DBP) variations in chronic obstructive pulmonary disease (COPD) compared with non-COPD Thai males were investigated. MATERIALS & METHODS: The rs7041 and rs4588 polymorphisms of the DBP gene and protein level were measured in 136 COPD and 68 non-COPD Thai males. RESULTS: In the COPD group, GC1-1 gave increased forced expiratory volume at 1 s % predicted compared with GC1-2 but with no significant difference. Significantly lower average DBP serum levels were observed in COPD than non-COPD subjects. Positive correlation between serum DBP and forced expiratory volume at 1 s % predicted was observed in non-COPD subjects. DISCUSSION & CONCLUSION: DBP variations might be associated with risk factors in COPD caused by both inflammatory and vitamin D circulation processes.


Assuntos
Doença Pulmonar Obstrutiva Crônica/genética , Proteína de Ligação a Vitamina D/genética , Idoso , Idoso de 80 Anos ou mais , Estudos de Casos e Controles , Volume Expiratório Forçado/genética , Volume Expiratório Forçado/fisiologia , Predisposição Genética para Doença/genética , Humanos , Masculino , Pessoa de Meia-Idade , Polimorfismo de Nucleotídeo Único/genética , Doença Pulmonar Obstrutiva Crônica/metabolismo , Testes de Função Respiratória , Fatores de Risco , Índice de Gravidade de Doença , Tailândia , Transcriptoma/genética , Vitamina D/metabolismo , Proteína de Ligação a Vitamina D/sangue , Proteína de Ligação a Vitamina D/metabolismo
6.
Recent Pat Food Nutr Agric ; 9(2): 127-133, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30019656

RESUMO

BACKGROUND: Coconut jelly is a popular dessert among Asian people. However, it contains high levels of sugar. The recent patents on steviol glycoside (WO2015014969A1), steviol glycoside compositions for oral ingestion or use (WO2017095932A1) and sweetener composition for preventing and improving obesity, containing glycolysis inhibitor ingredient (EP2756764B1) help to select the sweetener for development of coconut jelly. OBJECTIVE: Therefore, the purposes of this study were to develop a healthier coconut jelly formula by using stevia as a natural sweetener as well as to investigate the short-term effects of Modified Coconut Jelly (MCJ) compared to Control Formula (CCJ) consumption on glycemic and insulin responses in twelve healthy participants. METHODS: The sensory evaluation found that MCJ with 50% sugar replacement using stevia obtained the highest acceptability score compared to other formulas. In a cross-over design, participants were required to consume MCJ and CCJ containing 50 g of available carbohydrates. Blood samples were collected at 0 (baseline), 30, 60, 90 and 120 minutes for postprandial blood glucose, insulin, and C-peptide. RESULTS: The incremental Areas Under the Curve (iAUC) of blood glucose and insulin of MCJ had a lower trend than CCJ by 15.7 and 5.4 percent, respectively. MCJ consumption had blood glucose slowly decline after 60 to 120 minute. MCJ tended to decrease in postprandial blood glucose level without inducing insulin secretion. CONCLUSION: This might be an effect of stevia. Nutrient composition is lower in total sugar and higher in fiber, which has been reported as antihyperglycemia in humans. Therefore, MCJ might be an optional food product for healthy people or patients with Non-Communicable Diseases (NCDs) such as diabetes mellitus.


Assuntos
Glicemia , Cocos/química , Carboidratos da Dieta/farmacologia , Período Pós-Prandial , Stevia , Adulto , Peptídeo C , Feminino , Voluntários Saudáveis , Humanos , Insulina , Masculino , Pessoa de Meia-Idade , Patentes como Assunto , Edulcorantes , Fatores de Tempo , Adulto Jovem
7.
Contemp Oncol (Pozn) ; 20(3): 225-8, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27647987

RESUMO

Matrix metalloproteinase-13 (MMP-13) has a potential role in tumour invasion and metastasis. However, its relevance to the prognosis of human breast cancer is poorly understood. The aim of this study is to investigate the expression patterns of MMP-13 protein and to determine its prognostic value in breast cancer, and to define its relation to the clinicopathological features. Immunohistochemistry analysis of MMP-13 was performed on formalin-fixed, paraffin-embedded sections of cancerous breast tissue (n = 76) and normal breast tissue (n = 20), all of which had clinicopathological information available. Based on the principle of immunoreactivity, the detection of MMP-13 on breast tissue was conducted using monoclonal antibodies against MMP-13. A semi-quantitative scoring system was used to assess the presence of, as well as the cellular localisation of MMP-13. MMP-13 expression was significantly greater in the cancerous breast tissues in comparison to those of normal breast tissues. In addition, high levels of MMP-13 expression were also found to be related to the positive detection of breast cancer cells in lymph nodes-amongst breast cancer patients. The results of this study showed that MMP-13 was frequently present in breast tumours, especially when tumours were accompanied by positive breast cancer cell detection in lymph nodes. This suggests that MMP-13 plays a potentially significant role in breast cancer invasion and metastasis.

8.
J Med Assoc Thai ; 99(6): 723-31, 2016 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29901322

RESUMO

Background: The high blood cholesterol level could be prevented by plant stanol ester (Staest) consumption. In addition, the genetic polymorphism of cholesterol transporters might be related with lipid profile and subsequently response to Staest intake. Objective: To investigate the effect of single nucleotide polymorphism in ATP-binding cassette hetero-dimeric G5/G8 (ABCG5/G8) and Niemann-Pick C1 Like1 protein (NPC1L1) gene on LDL-C response subsequent to plant Staest intake in Thai Subjects. Material and Method: The blood samples were collected from 113 subjects for genotyping. The single nucleotide polymorphisms (SNPs) of ABCG5/G8 positions; rs6720173 (Q604E), rs4148211 (C54Y), rs4148217 (T400K), rs3806471 (5'UTR-145), and NPC1L1; positon; rs2072183 (L272L) were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: After Staest intake, the subjects with QE genotype (Q604E of ABCG5) showed a 4-fold significant decrease in LDL-C level (14.17±10.67%) compared to subjects with QQ genotype (3.50±10.65%) (p = 0.003). Moreover, the pronounced effect of Q604E polymorphism was observed in subjects after intake of Staest with meal. However, no significant difference in these markers was observed in subjects carrying other mutations. Conclusion: Thus, it could be suggested that non-synonymous gene polymorphism resulted substitution of uncharged glutamine (Q) with negatively charged glutamic acid (E) at position 604, thereby possibly alter the function of transporter proteins. Besides, the genetic variation in these genes might be related with serum lipid profiles. Moreover, Q604E mutation of ABCG5 in each individual with meal effect could lead to particular response towards LDL-C level after Staest intervention.


Assuntos
LDL-Colesterol , Polimorfismo de Nucleotídeo Único/genética , Sitosteroides , Membro 5 da Subfamília G de Transportadores de Cassetes de Ligação de ATP/genética , LDL-Colesterol/sangue , LDL-Colesterol/efeitos dos fármacos , LDL-Colesterol/genética , Genótipo , Humanos , Hipercolesterolemia , Lipoproteínas/genética , Proteínas de Membrana/genética , Proteínas de Membrana Transportadoras , Sitosteroides/administração & dosagem , Sitosteroides/farmacologia , Tailândia
9.
PLoS One ; 10(3): e0121057, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25807235

RESUMO

Changes in blood cell parameters are already a well-known feature of malarial infections. To add to this information, the objective of this study was to investigate the varying effects that different levels of parasite density have on blood cell parameters. Patients diagnosed with malaria at Phobphra Hospital, Tak Province, Thailand between January 1st 2009 and January 1st 2012 were recruited as subjects for data collection. Blood cell parameters of 2,024 malaria-infected patients were evaluated and statistically analyzed. Neutrophil and platelet counts were significantly higher, however, RBC count was significantly lower in patients with P. falciparum infection compared to those with P. vivax infection (p<0.0001). Leukocyte counts were also significantly higher in patients with high parasitemia compared to those with low and moderate parasitemia. In terms of differential leukocyte count, neutrophil count was significantly higher in patients with high parasitemia compared to those with low and moderate parasitemia (p<0.0001). On the other hand, both lymphocyte and monocyte counts were significantly lower in patients with high parasitemia (p<0.0001). RBC count and Hb concentration, as well as platelet count were also significantly reduced (p<0.05) and (p<0.0001), respectively. To summarize, patients infected with different malaria parasites exhibited important distinctive hematological parameters, with neutrophil and eosinophil counts being the two hematological parameters most affected. In addition, patients infected with different malarial densities also exhibited important changes in leukocyte count, platelet count and hemoglobin concentration during the infection. These findings offer the opportunity to recognize and diagnose malaria related anemia, help support the treatment thereof, as well as relieve symptoms of severe malaria in endemic regions.


Assuntos
Células Sanguíneas/parasitologia , Malária Falciparum/sangue , Malária Falciparum/parasitologia , Malária Vivax/sangue , Malária Vivax/parasitologia , Parasitemia/sangue , Parasitemia/parasitologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Eosinófilos/parasitologia , Feminino , Humanos , Lactente , Contagem de Leucócitos/métodos , Masculino , Pessoa de Meia-Idade , Neutrófilos/parasitologia , Plasmodium falciparum/fisiologia , Plasmodium vivax/fisiologia , Contagem de Plaquetas/métodos , Tailândia , Adulto Jovem
10.
Health Expect ; 18(6): 3069-78, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25327582

RESUMO

BACKGROUND: Breast cancer is the most common cancer among women worldwide. METHODS: This study aimed to assess the knowledge, awareness and practice of breast cancer screening for early detection of breast cancer among female personnel at a university. A cross-sectional descriptive study was administered to female personnel of Walailak University in Nakhon Si Thammarat, Thailand. Data were analysed by SPSS version 16. RESULTS: Among total of 217 female personnel, the lecturers and laboratory scientists and general officers had a significantly higher mean knowledge score about the practice of breast cancer screening than temporary employees (P < 0.0001). The level of education and income of respondents may be involved with this difference in knowledge (P < 0.05). CONCLUSION: This study concludes that knowledge about the practice of breast cancer screening could be attributed to different career groups, level of education and income of respondents. There is a very urgent need for regular learning courses for personnel concerning knowledge about the practice of breast cancer screening especially for those personnel with less formal education and low income.


Assuntos
Neoplasias da Mama/diagnóstico , Detecção Precoce de Câncer , Conhecimentos, Atitudes e Prática em Saúde , Universidades , Adulto , Estudos Transversais , Feminino , Humanos , Pessoa de Meia-Idade , Fatores de Risco , Classe Social , Tailândia
11.
Asian Pac J Cancer Prev ; 15(18): 7625-8, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25292038

RESUMO

Breast cancer is the most common cancer among women worldwide. The primary aim of this work was to provide an in-depth evaluation of research publications in the field of diets and breast cancer. The impact of economic outcome on national academic productivity was also investigated. Data were retrieved using Pubmed for English-language publications. The search included all research for which articles included words relating to "diets and breast cancer". Population and national income data were obtained from publicly available databases. Impact factors for journals were obtained from Journal Citation Reports® (Thomson Scientific). There were 2,396 publications from 60 countries in 384 journals with an impact factor. Among them, 1,652 (68.94%) publications were Original articles. The United States had the highest quantity (51% of total) and highest of mean impact factor (8.852) for publication. Sweden had the highest productivity of publication when adjusted for number of population (6 publications per million population). Publications from the Asian nation increased from 5.3% in 2006 to 14.6% in 2012. The Original article type was also associated with geography (p<0.001; OR=2.183; 95%CI=1.526-3.123), Asian countries produced more proportion of Original articles (82%) than those of rest of the world (67.6%). Diets and breast cancer-associated research output continues to increase annually worldwide including publications from Asian countries. Although the United States produced the most publications, European nations per capita were higher in publication output.


Assuntos
Bibliometria , Pesquisa Biomédica/tendências , Neoplasias da Mama/dietoterapia , Dieta , Feminino , Humanos , Prognóstico
12.
Malar J ; 13: 218, 2014 Jun 05.
Artigo em Inglês | MEDLINE | ID: mdl-24898891

RESUMO

BACKGROUND: Malaria is a major mosquito-borne public health problem in Thailand with varied haematological consequences. The study sought to elucidate the haematological changes in people who suspected malaria infection and their possible predictive values of malaria infection. METHODS: Haematological parameters of 4,985 patients, including 703 malaria-infected and 4,282 non-malaria infected, who admitted at Phop Phra Hospital, Tak Province, an area of malaria endemic transmission in Thailand during 2009 were evaluated. RESULTS: The following parameters were significantly lower in malaria-infected patients; red blood cells (RBCs) count, haemoglobin (Hb), platelets count, white blood cells (WBCs) count, neutrophil, monocyte, lymphocyte and eosinophil counts, while mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), Mean corpuscular haemoglobin concentration (MCHC), neutrophil-lymphocyte ratio (NLR), and monocyte-lymphocyte ratio (MLR) were higher in comparison to non-malaria infected patients. Patients with platelet counts < 150,000/uL were 31.8 times (odds ratio) more likely to have a malaria infection. Thrombocytopenia was present in 84.9% of malaria-infected patients and was independent of age, gender and nationality (P value < 0.0001). CONCLUSION: Patients infected with malaria exhibited important changes in most of haematological parameters with low platelet, WBCs, and lymphocyte counts being the most important predictors of malaria infection. When used in combination with other clinical and microscopy methods, these parameters could improve malaria diagnosis and treatment.


Assuntos
Biomarcadores/sangue , Malária/diagnóstico , Malária/patologia , Adolescente , Adulto , Feminino , Humanos , Masculino , Mianmar , Tailândia , Adulto Jovem
13.
J Med Assoc Thai ; 97(10): 1004-8, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-25632614

RESUMO

BACKGROUND: The inhibitor of DNA binding 4 (ID4) protein regulates osteogenic and adipogenic cell fate and lack of lD4 gene expression decreased osteoblast differentiation. Variant in the ID4 gene polymorphism has not been reported with osteoporosis. OBJECTIVE: To identify whether ID4 can be a marker gene for osteoporosis in Thai menopausal women. MATERIAL AND METHOD: The 3 'UTR of lD4 (rs3798339) single nucleotide polymorphism was examined bypolymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP), together with lumbar spine bone mineral density (BAMD) in 160 Thai menopausal women. RESULTS: Lumbar spine 3 (L3) had a significantly lower BMD score in women with the TT genotype, compared with the CT+CC genotypes (p = 0.037). This disappeared after the adjustment of various factors. CONCLUSION: The polymorphism at 3'UTR of lD4 gene can alter ID4 mRNA stability, and may be linked to the function of proteins. However, this needs confirmation in larger populations. The present study is useful as an initial investigation into ID4 gene polymorphism in osteoporosis.


Assuntos
Regiões 3' não Traduzidas/genética , Proteínas Inibidoras de Diferenciação/genética , Osteoporose Pós-Menopausa/genética , Polimorfismo Genético , Adulto , Idoso , Grupo com Ancestrais do Continente Asiático , Densidade Óssea/fisiologia , Feminino , Genótipo , Humanos , Vértebras Lombares/fisiologia , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase , Polimorfismo de Fragmento de Restrição , Polimorfismo de Nucleotídeo Único , Tailândia
14.
Asian Pac J Cancer Prev ; 14(6): 3815-7, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23886188

RESUMO

BACKGROUND: Breast cancer is a common cancer worldwide. With the establishment of Thailand's population- based cancer registry and availability of complete data from 2002-2011, it is of interest to investigate the epidemiologic and clinic-pathological profiles of breast cancer based on the population-based registry data. METHODS: The data of all breast cancer patients in the registry for the period of 2002-2011 were included. All medical records of the patients diagnosed from documents of National Cancer Registry of Thailand were retrieved and the following information abstracted: age, clinical characteristics, and histological variables. Thailand census data for the period of 2002-2011 were used to provide the general population's statistics on age, gender, and other related demographic factors. RESULTS: Over the 10 year-period, 7,711 breast cancer cases were included. The disease incidence under age 40 years was relatively low (4.13/105) while the incidence in the age groups 40 and older was very high (39.2/105). The vast majority of breast cancer cases (88.8%) were diagnosed by histology as primary lesions in the breast. The most common of patients with breast cancer (36.4%) had regional lymph node involvement and the most common of histopathology diagnosed in patients (84.2%) was an infiltrating duct carcinoma. CONCLUSIONS: This study showed a high incidence of breast cancer in older subjects, and high rate of breast cancer in Thailand. Future studies should explore clinical and molecular disease patterns.


Assuntos
Neoplasias da Mama/epidemiologia , Sistema de Registros/estatística & dados numéricos , Adolescente , Adulto , Distribuição por Idade , Idoso , Neoplasias da Mama/patologia , Criança , Pré-Escolar , Feminino , Seguimentos , Humanos , Incidência , Lactente , Recém-Nascido , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Prognóstico , Tailândia/epidemiologia , Adulto Jovem
15.
Biomark Med ; 6(1): 103-8, 2012 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-22296203

RESUMO

AIMS: To investigate the genetic markers for osteoporosis bone mineral density by the genotyping of rs7041, rs4588 and rs1352845 in the DBP gene with either bone mineral density or serum 25-hydroxycholecalciferol, retinol and α-tocopherol, among 365 postmenopausal Thai women. MATERIALS & METHODS: The DBP genotypes were analyzed by a PCR restriction fragment-length polymorphism method. Serum 25-hydroxycholecalciferol was assessed using a commercial chemiluminescent immunoassay. Serum retinol and α-tocopherol were measured by reverse-phase high-performance liquid chromatography. RESULTS: After adjustment for age >50 years, elder Thai subjects with low BMI (≤25 kg/m(2)) and carrying the rs4588 CC genotype had a higher risk of radial bone mineral density osteoporosis (odds ratio: 6.29; p = 0.048). The rs1352845 genotype also had a statistical association with total hip bone mineral density; however, it disappeared after adjustment for age and BMI. No association was found in fat-soluble vitamins with bone mineral density. CONCLUSION: DBP genotypes may influence the osteoporosis bone mineral density in postmenopausal Thai women.


Assuntos
Densidade Óssea , Gorduras/química , Polimorfismo de Nucleotídeo Único , Pós-Menopausa/genética , Proteína de Ligação a Vitamina D/genética , Vitaminas/sangue , Vitaminas/química , Idoso , Feminino , Marcadores Genéticos/genética , Genótipo , Humanos , Pessoa de Meia-Idade , Osteoporose/sangue , Osteoporose/genética , Osteoporose/fisiopatologia , Pós-Menopausa/sangue , Pós-Menopausa/fisiologia , Solubilidade , Tailândia
16.
Southeast Asian J Trop Med Public Health ; 42(6): 1515-20, 2011 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-22299423

RESUMO

High vitamin A ingestion or high serum retinol have been postulated to increase the risk of fractures and osteoporosis by reduced bone mineral density (BMD). Retinol is carried and transported to the tissues bound to retinol binding protein 4 (RBP4) and transthyretin (TTR). The relationships between retinol, retinol transport protein, retinol binding protein 4 (RBP4) and transthyretin (TTR) and BMD and osteoporosis are unclear. To examine the association between retinol and RBP4 and TTR and osteoporosis, 73 osteoporotic and 71 normal Thai postmenopausal women were studied. RBP4 and retinol levels did not differ between the groups. Serum TTR was significantly higher in control than osteoporotic subjects (89.47 and 144.53 microg/ml, respectively, p = 0.003, Mann-Whitney U test). TTR was positively correlated with BMD at several sites, such as the total radius bone (r = 0.172, p = 0.008, Spearman rank test). Osteoporosis risk was analyzed with binary logistic regression. Lean elderly Thais with lower TTR levels had a higher risk of osteoporosis. RBP4 and retinol levels had no relationship with disease status among Thai post-menopausal women. These results suggest calcium, minerals, vitamins and the retinol transport protein, transthyretin may be involved in the pathogenesis of osteoporosis.


Assuntos
Osteoporose/sangue , Pós-Menopausa , Proteínas Plasmáticas de Ligação ao Retinol/metabolismo , Estudos de Casos e Controles , Cromatografia Líquida de Alta Pressão , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Modelos Logísticos , Pessoa de Meia-Idade , Fatores de Risco , Estatísticas não Paramétricas , Tailândia
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