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Cutan Ocul Toxicol ; 38(3): 290-293, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31010341


Purpose: Carvone (CVN) is a natural monoterpene found in essential oils of many aromatic plant species. In this study, we investigated the protective effect of CVN against paclitaxel (PTX)-induced retinal and optic nerve cytotoxicity in rats. Methods: Twenty-four male adult Wistar albino rats (250-400 g) were randomized into four equal groups comprising six animals in each. Group 1 (control group) received intraperitoneal (i.p.) saline solution (0.5 mL/200 g) weekly for 4 weeks. Group 2 received i.p. CVN [(S)-(+)- CVN, (5S)-5-Isopropenyl-2-methyl-2-cyclohexen-1-one, C10H14, 25 mg/kg], while Group 3 received i.p. PTX (5 mg/kg) weekly for 4 weeks. Group 4 received i.p. CVN (25 mg/kg) 30 min after i.p. PTX (5 mg/kg) weekly for 4 weeks. At the end of the experimental period, retinal and optic nerve tissues were evaluated histopathologically. Results: All retinal specimens in control and CVN groups were histopathologically normal. In PTX group all eyes (6/6) demonstrated increased retinal vascularity and rosette-like structures in the outer nuclear layer, while in PTX-CVN group all eyes (6/6) demonstrated normal retinal vascularity and absence of rosette-like structures. All optic nerve specimens in control and CVN groups were histopathologically normal. In PTX group all eyes (6/6) demonstrated severe vacuolization and decrease in the number of astrocytes and oligodendrocytes, while 3 eyes (3/6) demonstrated marked single cell necrosis. In PTX-CVN group, 4 eyes (4/6) demonstrated moderate vacuolization while, 2 eyes (2/6) had none. Compared with PTX group, 1 eye (1/6) in PTX-CVN group demonstrated a decrease in numbers of astrocytes and oligodendrocytes while 5 eyes (5/6) were normal. No remarkable single cell necrosis was observed in PTX-CVN group. Conclusions: Our histopathological findings demonstrated the potential protective role of CVN against PTX-induced retinal and optic nerve cytotoxicity. CVN might be a promising molecule in counteracting oxidative stress-based cytotoxicity in the field of retinal and optic nerve disorders.

Antineoplásicos Fitogênicos/efeitos adversos , Monoterpenos Cicloexânicos/uso terapêutico , Nervo Óptico/efeitos dos fármacos , Paclitaxel/efeitos adversos , Substâncias Protetoras/uso terapêutico , Retina/efeitos dos fármacos , Animais , Masculino , Nervo Óptico/patologia , Ratos Wistar , Retina/patologia
Turk Kardiyol Dern Ars ; 37(2): 132-5, 2009 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-19404037


Diaphragmatic paralysis (DP) due to phrenic nerve paralysis is a rare complication after cardiac surgery. A 48-year-old male patient developed respiratory insufficiency, tachypnea, sinus tachycardia, chest pain, pneumonia, and fever immediately after coronary artery bypass grafting. Paradoxical movement of the epigastrium was noted during spontaneous ventilation and the chest X-ray showed elevation of the left hemidiaphragm. The diagnosis of DP was confirmed by ultrasonographic assessment. Antibiotherapy and intermittent positive airway pressure ventilation by a nasal mask resulted in significant improvement in the general condition of the patient. Respiratory problems were observed only on exertion. Spontaneous recovery of DP was considered and the patient was discharged 10 days after surgery with grade 1 dyspnea. However, after six months of follow-up, increased elevation of the left hemidiaphragm was noted on the chest X-ray with worsening respiratory discomfort even at rest. Thoracoscopic diaphragmatic plication was performed. After the operation, dyspnea disappeared, the chest X-ray showed the left hemidiaphragm in its normal position, and there was marked improvement in spirometric values.

Ponte de Artéria Coronária/efeitos adversos , Dispneia/etiologia , Nervo Frênico/fisiopatologia , Complicações Pós-Operatórias/etiologia , Paralisia Respiratória/complicações , Ponte Cardiopulmonar/efeitos adversos , Doença da Artéria Coronariana/cirurgia , Diafragma/cirurgia , Dispneia/terapia , Humanos , Hipotermia Induzida/efeitos adversos , Ventilação com Pressão Positiva Intermitente , Masculino , Pessoa de Meia-Idade , Testes de Função Respiratória , Paralisia Respiratória/diagnóstico , Paralisia Respiratória/etiologia , Paralisia Respiratória/cirurgia