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1.
Arch Bronconeumol ; 55(11): 573-580, 2019 Nov.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-31257011

RESUMO

OBJECTIVES: Some pro-inflammatory lipids derived from 1 lipooxygenase enzyme are potent neutrophil chemoattractant, a cell centrally involved in acute respiratory distress syndrome (ARDS); a syndrome lacking effective treatment. Considering the beneficial effects of the leukotriene receptor inhibitor, montelukast, on other lung diseases, whether montelukast attenuates inflammation in a mouse model of ARDS, and whether it reduces LPS stimulated activation of human neutrophils was investigated. METHODS: Thirty-five C57Bl/6 mice were distributed into control (PBS)+24h, LPS+24h (10µg/mouse), control+48h, LPS+48h, and LPS 48h+Montelukast (10mg/kg). In addition, human neutrophils were incubated with LPS (1µg/mL) and treated with montelukast (10µM). RESULTS: Oral-tracheal administration of montelukast significantly attenuated total cells (P<.05), macrophages (P<.05), neutrophils (P<.01), lymphocytes (P<.001) and total protein levels in BAL (P<.05), as well as IL-6 (P<.05), CXCL1/KC (P<.05), IL-17 (P<.05) and TNF-α (P<.05). Furthermore, montelukast reduced neutrophils (P<.001), lymphocytes (P<.01) and macrophages (P<.01) in the lung parenchyma. In addition, montelukast restored BAL VEGF levels (P<.05). LTB4 receptor expression (P<.001) as well as NF-κB (P<.001), a downstream target of LPS, were also reduced in lung parenchymal leukocytes. Furthermore, montelukast reduced IL-8 (P<.001) production by LPS-treated human neutrophils. CONCLUSION: In conclusion, montelukast efficiently attenuated both LPS-induced lung inflammation in a mouse model of ARDS and in LPS challenged human neutrophils.

2.
In. Consolim-Colombo, Fernanda M; Saraiva, José Francisco Kerr; Izar, Maria Cristina de Oliveira. Tratado de Cardiologia: SOCESP / Cardiology Treaty: SOCESP. São Paulo, Manole, 4ª; 2019. p.488-495.
Monografia em Português | LILACS | ID: biblio-1009422
3.
J Int Med Res ; 46(10): 4214-4225, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30130981

RESUMO

Objective Heart failure (HF) is associated with intermittent hypoxia, and the effects of this hypoxia on the cardiovascular system are not well understood. This study was performed to compare the effects of acute hypoxia (10% oxygen) between patients with and without HF. Methods Fourteen patients with chronic HF and 17 matched control subjects were enrolled. Carotid artery changes were examined during the first period of hypoxia, and brachial artery changes were examined during the second period of hypoxia. Data were collected at baseline and after 2 and 4 minutes of hypoxia. Norepinephrine, epinephrine, dopamine, and renin were measured at baseline and after 4 minutes hypoxia. Results The carotid blood flow, carotid systolic diameter, and carotid diastolic diameter increased and the carotid resistance decreased in patients with HF. Hypoxia did not change the carotid compliance, distensibility, brachial artery blood flow and diameter, or concentrations of sympathomimetic amines in patients with HF, but hypoxia increased the norepinephrine level in the control group. Hypoxia increased minute ventilation and decreased the oxygen saturation and end-tidal carbon dioxide concentration in both groups. Conclusion Hypoxia-induced changes in the carotid artery suggest an intensification of compensatory mechanisms for preservation of cerebral blood flow in patients with HF.


Assuntos
Artérias Carótidas/fisiopatologia , Circulação Cerebrovascular/fisiologia , Cérebro/irrigação sanguínea , Insuficiência Cardíaca/fisiopatologia , Hipóxia/fisiopatologia , Adulto , Idoso , Artéria Braquial/fisiopatologia , Cérebro/fisiopatologia , Feminino , Insuficiência Cardíaca/sangue , Insuficiência Cardíaca/complicações , Hemodinâmica , Humanos , Hipóxia/sangue , Hipóxia/etiologia , Masculino , Pessoa de Meia-Idade , Oxigênio/sangue
5.
Am Heart J ; 176: 10-6, 2016 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-27264215

RESUMO

BACKGROUND: Atrial fibrillation (AF) is an important and growing public health problem worldwide, but data about its actual prevalence, therapeutic management, and clinical outcomes in middle- to low-income countries are scarce. DESIGN: The First Brazilian Cardiovascular Registry of Atrial Fibrillation (the RECALL study) will assess demographic characteristics and evidence-based practice of a representative sample of patients with AF in Brazil. The prospective, multicenter registry has a planned sample size of around 5,000 patients at approximately 80 sites. Eligibility criteria include age >18 years and permanent, paroxysmal, or persistent AF documented by electrocardiogram, 24-hour Holter monitoring, or device interrogation. Patients will be followed up through 1 year after enrollment. Information on laboratory tests, echocardiographic data, medication use, and clinical outcomes will be obtained. Various aspects of the population will be described, including demographic characteristics; antithrombotic therapies; antiarrhythmic agents; level of control of international normalized ratio (by average time within the therapeutic range) among patients using vitamin K antagonists; rates of warfarin discontinuation; outcomes such as death, stroke, systemic embolism, and major bleeding within 1 year after enrollment in the study; and rates of electrical cardioversion, percutaneous ablation of AF, ablation of the atrioventricular junction, and pacemaker/cardioverter-defibrillator implantation. SUMMARY: RECALL is the first prospective, multicenter registry of AF in Brazil. This study will provide important information about demographics, practice patterns, treatments, and associated outcomes in patients with AF. The results of this registry will also allow Brazilian data to be put in perspective with other AF registries across the world and provide opportunities to improve care of patients with AF in Brazil.


Assuntos
Antiarrítmicos/uso terapêutico , Anticoagulantes , Fibrilação Atrial , Cardioversão Elétrica , Administração dos Cuidados ao Paciente , Adulto , Anticoagulantes/administração & dosagem , Anticoagulantes/efeitos adversos , Fibrilação Atrial/diagnóstico , Fibrilação Atrial/epidemiologia , Fibrilação Atrial/terapia , Brasil/epidemiologia , Cardioversão Elétrica/métodos , Cardioversão Elétrica/estatística & dados numéricos , Eletrocardiografia/métodos , Feminino , Hemorragia/induzido quimicamente , Hemorragia/prevenção & controle , Humanos , Coeficiente Internacional Normatizado , Masculino , Administração dos Cuidados ao Paciente/métodos , Administração dos Cuidados ao Paciente/organização & administração , Estudos Prospectivos , Sistema de Registros , Projetos de Pesquisa
6.
Curr Hypertens Rep ; 18(4): 31, 2016 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-27002717

RESUMO

Hypertensive patients have a higher risk of developing health complications, particularly cardiovascular (CV) events, than individuals with normal blood pressure (BP). Severity of complications depends on the magnitude of BP elevation and other CV risk factors associated with the target organ damage. Therefore, BP control and management of organ damage may contribute to reduce this risk. BP variability (BPV) has been considered a physiological marker of autonomic nervous system control and may be implicated in increased CV risk in hypertension. This review will present some evidence relating BPV and target organ damage in hypertension in clinical and experimental settings.


Assuntos
Pressão Sanguínea , Hipertensão/fisiopatologia , Animais , Anti-Hipertensivos/uso terapêutico , Sistema Nervoso Autônomo/fisiopatologia , Determinação da Pressão Arterial , Humanos , Hipertensão/tratamento farmacológico , Fatores de Risco
7.
Gynecol Endocrinol ; 31(11): 912-5, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26172927

RESUMO

Combined oral contraceptives (COCs) may increase the risk for cardiovascular disease depending on the ethynyl estradiol (EE) dose and the androgenicity of the progestogens. Our objective was to evaluate the impact of a COC containing 20 mcg EE + 3 mg drospirenone on blood pressure (BP), renin-angiotensin-aldosterone system, insulin resistance, and androgenic profile of healthy young women. Eighty-one healthy young women aged 30 ± 1 years (case group, n = 49, received COC; control group, n = 32, used no COC) were assessed twice, before and after the 6-month study. Statistical analysis employed the paired t-tests and expressed the data in mean and standard deviation. Results were as follows: no changes in BP or in BMI; a significant increase in aldosterone, plasma renin activity, triglycerides, and total cholesterol levels, but a non-significant increase in HDL and no significant changes in LDL levels (these parameters remained within normal ranges); a significant increase in the HOMA-IR index and a significant decrease in dehydroepiandrosterone sulfate (SDHEA), androstenedione, total testosterone, and free testosterone levels; no significant variations in the control group parameters. An oral contraceptive combination of a low EE dose and an anti-androgenic progestogen does not negatively influence the risk factors for a cardiovascular disease.


Assuntos
Androstenos/farmacologia , Pressão Sanguínea/efeitos dos fármacos , Anticoncepcionais Orais Combinados/farmacologia , Estrogênios/farmacologia , Etinilestradiol/farmacologia , Resistência à Insulina , Antagonistas de Receptores de Mineralocorticoides/farmacologia , Sistema Renina-Angiotensina/efeitos dos fármacos , Adulto , Aldosterona/sangue , Androstenodiona/sangue , Índice de Massa Corporal , Estudos de Casos e Controles , Colesterol/sangue , HDL-Colesterol/sangue , HDL-Colesterol/efeitos dos fármacos , LDL-Colesterol/sangue , LDL-Colesterol/efeitos dos fármacos , Sulfato de Desidroepiandrosterona/sangue , Combinação de Medicamentos , Feminino , Voluntários Saudáveis , Humanos , Renina/sangue , Renina/efeitos dos fármacos , Testosterona/sangue , Triglicerídeos/sangue
8.
J Vasc Nurs ; 33(1): 21-5, 2015 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25700734

RESUMO

The purpose of this study was to examine the association between cardiovascular risk estimated by the Framingham Risk Score and functional capacity in patients with peripheral artery disease using a 6-minute walk test. Fifty-six participants with intermittent claudication were recruited. The Framingham Risk Score was calculated and used to split the participants into two groups: Group A (mild and moderate risk) and group B (severe risk). The ankle-brachial index (ABI) was calculated for each leg using a handheld Doppler probe. Walking ability was verified by a 6-minute walk test. Descriptive statistics were used to describe the sample's demographic and clinical characteristics. To compare clinical data between the two groups, a t test or Mann-Whitney test was used as appropriate according to the type of variable being analyzed. The Pearson coefficient was used to verify the association between cardiovascular risk and functional capacity. Group A had 19 participants (60.5 ± 6.3 years; 36.8% male) and group B had 37 participants (63.4 ± 8.7 years; 73% male). No differences were observed when comparing the ABI between both groups. The total distances covered by the men in group A were shorter compared with those of group B (331.4 + 51.5 vs 257.9 + 84.0; P = .02). The cardiovascular risk score was negative and was significantly correlated with total distances for men (r = -0.53; P = .001) and with pain-free distances for women (r = -0.46; P = .03). Functional capacity, evaluated through a 6-minute walk test, seems to be associated with 10-year total mortality risk.


Assuntos
Claudicação Intermitente/etiologia , Claudicação Intermitente/fisiopatologia , Perna (Membro)/irrigação sanguínea , Doença Arterial Periférica/complicações , Doença Arterial Periférica/fisiopatologia , Caminhada/fisiologia , Idoso , Índice Tornozelo-Braço , Brasil , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Risco
9.
Angiology ; 66(7): 680-6, 2015 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-25100750

RESUMO

We verified whether vascular reactivity is impaired and whether there is any association between vascular reactivity, walking ability, and peripheral artery disease (PAD) severity in patients with intermittent claudication (IC). We studied 63 patients and 17 age- and sex-matched volunteers without PAD. Vascular reactivity was evaluated in the brachial artery during reactive hyperemia (flow-mediated dilation [FMD]) and after a sublingual single dose of nitroglycerin (nitroglycerin-induced vasodilation [NID]). Walking ability was verified by a 6-minute walk test. Vascular reactivity and walking ability were significantly worse in patients with IC compared with control participants. The ankle-brachial index correlated with FMD, NID, as well as total and pain-free distances. The NID and walking ability progressively decreased as PAD severity increased. Walking ability correlated with NID but not with FMD. In patients with IC, vascular reactivity is impaired and is related to the severity of PAD and to walking ability.


Assuntos
Endotélio Vascular/fisiopatologia , Claudicação Intermitente/fisiopatologia , Caminhada , Índice Tornozelo-Braço , Estudos de Casos e Controles , Estudos Transversais , Progressão da Doença , Eletrocardiografia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Índice de Gravidade de Doença , Gravação em Vídeo
10.
Rev. bras. educ. fís. esp ; 28(4): 553-560, 12/2014. tab
Artigo em Inglês | LILACS | ID: lil-731187

RESUMO

Body composition has fundamental importance in the quality of life and is a powerful predictor of mortality and morbidity in humans. The identification and monitoring of the amount of body fat have been receiving special attention in aspects related to health promotion, not just for its actions in the prevention and in the control of cardiovascular diseases but also for their induction and association with risk factors, especially in the plasmatic lipid levels and arterial pressure. It was investigated the relationship between body mass index (BMI) and body fat percentage (%BF) by bioelectrical impedance analysis (BIA) with the blood pressure levels (systolic and diastolic) and serum lipids (TC, HDL-c, LDL-c, VLDL-c, TG). In a group of fifty seven women (aged 18 to 26 years old ), obesity was detected in 5 and 19 women by BMI (≥ 30 kg/m2) and %BF (≥ 30%), respectively. BMI and % BF were positively correlated with blood pressure (systolic and diastolic), and highly significant in the obese group by %BF. Moreover, BMI and % BF were significantly correlated with all lipids and lipoprotein fractions VLDL-c and triglyceride, respectively. These results suggest that %BF is a good indicator of "occult obesity" in subjects with normal body mass index. The associated use of BMI and % BF to better evaluate obesity may improve the study of blood pressure levels and serum lipid changes that are commonly associated with obesity


Composição corporal tem importância fundamental para a qualidade de vida e é um forte preditor de mortalidade e morbidade nos seres humanos. A identificação e o monitoramento da quantidade de gordura corporal têm recebido atenção especial no que se refere aos aspectos relacionados com a promoção da saúde, não apenas de suas ações na prevenção e no controle das doenças cardiovasculares, mas também pela sua associação com fatores de risco, especialmente em níveis de lipídeos plasmáticos e da pressão arterial. Foi investigado a relação entre o índice de massa corporal (IMC) e percentual de gordura corporal (% GC) pela bioimpedância elétrica (BIA), com os níveis de pressão arterial (sistólica e diastólica) e lipídeos séricos (CT, HDL-c, LDL-c, VLDL-c, TG). Em um grupo de 57 mulheres (com idades entre 18 e 26 anos de idade), a obesidade foi detectada em cinco e 19 mulheres, IMC (≥ 30 kg/m2) e % BF (≥ 30%), respectivamente. IMC e % GC foram positivamente correlacionados com a pressão arterial (sistólica e diastólica), e altamente significativos no grupo dos obesos pelo % GC. Além disso, o IMC e % GC foram significativamente correlacionados com todos os lipídios e frações de lipoproteínas VLDL-C e triglicérides, respectivamente. Estes resultados sugerem que o % GC é um bom indicador de "obesidade oculta" em indivíduos com índice de massa corporal normal. Que o uso associado de IMC e % GC para melhor avaliar a obesidade pode melhorar o estudo dos níveis de pressão arterial e alterações de lipídios que é geralmente associada à obesidade


Assuntos
Humanos , Feminino , Adulto Jovem , Índice de Massa Corporal , Pressão Arterial , Lipídeos , Obesidade
12.
Eur J Obstet Gynecol Reprod Biol ; 175: 62-6, 2014 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-24480113

RESUMO

BACKGROUND: The use of combined oral contraceptives has been associated with an increased risk of adverse cardiovascular events. Whether these drugs alter cardiac autonomic nervous system control is not completely determined. OBJECTIVE: To evaluate the effect of a contraceptive containing 20mcg of ethinyl estradiol and 3mg of drospirenone on the heart rate variability, baroreflex sensitivity and blood pressure of healthy women. STUDY DESIGN: Prospective controlled trial with 69 healthy women allocated in two groups: 36 volunteers under oral combined contraceptive use and 33 volunteers using of non-hormonal contraceptive methods. Subjects were tested before the introduction of the contraceptive method and 6 months after its use. For data acquisition, we used continuous non-invasive beat-to-beat blood pressure curve recordings. Multiple ANOVA was used to determine differences between groups and moments and p< 0.05 was considered statistically significant. RESULTS: At baseline, there were no differences in demographic and autonomic parameters between groups. Comparing cardiac sympatho-vagal modulation, baroreceptor sensitivity and blood pressure measurements between baseline and after 6 months, no significant difference was detected in each group or between groups. CONCLUSION: A contraceptive containing 20mcg of ethinyl estradiol and 3mg of drospirenone causes no significant changes in clinical, hemodynamic and autonomic parameters of normal women.


Assuntos
Androstenos/efeitos adversos , Sistema Nervoso Autônomo/efeitos dos fármacos , Anticoncepcionais Orais Combinados/efeitos adversos , Etinilestradiol/efeitos adversos , Hemodinâmica/efeitos dos fármacos , Adulto , Estrogênios/efeitos adversos , Feminino , Humanos , Antagonistas de Receptores de Mineralocorticoides/efeitos adversos , Estudos Prospectivos
15.
Am J Hypertens ; 26(7): 912-7, 2013 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-23475700

RESUMO

BACKGROUND: The presence of asymptomatic left ventricular diastolic dysfunction (LVDD) in hypertensive patients can be associated with the development of cardiac events. The increase in sympathetic activity may be 1 of the mechanisms that predisposes to this outcome. In this study, we analyzed 2 hypotheses: (i) whether sympathetic activity is higher in the presence of LVDD, independent of blood pressure control and (ii) whether different classes of LVDD have a different effect on sympathetic activity. METHODS: After analyzing left ventricular function using echo Doppler cardiography, 45 hypertensive patients receiving treatment were allocated into 3 groups: normal function (LV-NF, n = 15), impaired relaxation (LV-IR, n = 15), and pseudonormal or restrictive (LV-P/R, n = 15). An age-, sex-, and body mass index-matched control group of normotensive volunteers (N, n = 14) was included. Muscle sympathetic nerve activity (MSNA), heart rate, and systolic blood pressure variabilities and baroreflex sensitivity were evaluated while the patient was in a supine position. RESULTS: Blood pressure and antihypertensive drug use were similar among the hypertensive groups. The LV-IR and LV-P/R groups had similar MSNA (33±1 and 32±1 bursts/min, respectively), which was significantly higher than that of the LV-NF and N groups (26±3 and 15±2 bursts/min, respectively). The LV-IR and LV-P/R groups had significantly higher LF-systolic blood pressure variability and significantly lower baroreflex sensitivity compared with the N group. CONCLUSIONS: The presence of asymptomatic LVDD is associated with increased MSNA, independent of blood pressure control. The sympathetic hyperactivity associated with LVDD is similar in the different patterns of LVDD studied.


Assuntos
Anti-Hipertensivos/uso terapêutico , Pressão Sanguínea/fisiologia , Hipertensão/fisiopatologia , Músculo Esquelético/inervação , Sistema Nervoso Simpático/fisiopatologia , Disfunção Ventricular Esquerda/fisiopatologia , Adulto , Barorreflexo/fisiologia , Diástole , Progressão da Doença , Ecocardiografia Doppler , Feminino , Humanos , Hipertensão/complicações , Hipertensão/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Disfunção Ventricular Esquerda/etiologia
18.
Eur J Heart Fail ; 14(12): 1366-73, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-23099357

RESUMO

AIMS: To evaluate the feasibility, safety, and potential beneficial effects of left cardiac sympathetic denervation (LCSD) in systolic heart failure (HF) patients. METHODS AND RESULTS: In this prospective, randomized pilot study, inclusion criteria were New York Heart Association (NYHA) functional class II or III, left ventricular ejection fraction (LVEF) ≤40%, sinus rhythm, and resting heart rate >65 b.p.m., despite optimal medical therapy (MT). Fifteen patients were randomly assigned either to MT alone or MT plus LCSD. The primary endpoint was safety, measured by mortality in the first month of follow-up and morbidity according to pre-specified criteria. Secondary endpoints were exercise capacity, quality of life, LVEF, muscle sympathetic nerve activity (MSNA), brain natriuretic peptide (BNP) levels and 24 h Holter mean heart rate before and after 6 months. We studied clinical effects in long-term follow-up. Ten patients underwent LCSD. There were no adverse events attributable to surgery. In the LCSD group, LVEF improved from 25 ± 6.6 to 33 ± 5.2 (P = 0.03); 6 min walking distance improved from 167 ± 35 to 198 ± 47 m (P = 0.02). Minnesota Living with Heart Failure Questionnaire (MLWHFQ) score physical dimension changed from 21 ± 5 to 15 ± 7 (P = 0.06). The remaining analysed variables were unchanged. During 848 ± 549 days of follow-up, in the MT group, three patients either died or underwent cardiac transplantation (CT), while in the LCSD group six were alive without CT. CONCLUSIONS: LCSD was feasible and seemed to be safe in systolic HF patients. Its beneficial effects warrant the development of a larger randomized trial. Trail registration: NCT01224899.


Assuntos
Insuficiência Cardíaca Sistólica/fisiopatologia , Insuficiência Cardíaca Sistólica/cirurgia , Simpatectomia/métodos , Adulto , Idoso , Determinação de Ponto Final , Feminino , Insuficiência Cardíaca Sistólica/mortalidade , Humanos , Masculino , Pessoa de Meia-Idade , Resistência Física/fisiologia , Projetos Piloto , Estudos Prospectivos , Qualidade de Vida , Taxa de Sobrevida , Resultado do Tratamento , Disfunção Ventricular Esquerda/fisiopatologia
19.
Rev Lat Am Enfermagem ; 20(2): 251-8, 2012 Mar-Apr.
Artigo em Inglês, Português, Espanhol | MEDLINE | ID: mdl-22699724

RESUMO

Distances walked in walking tests are important functional markers, although they are not accepted as defining characteristics of Ineffective Peripheral Tissue Perfusion. The aims of this study were to verify the distances participants with and without this nursing diagnosis walked in the six-minute walk test and if these measures may be considered defining characteristics of this phenomenon. Participants with (group A; n=65) and without (group B; n=17) this nursing diagnosis were evaluated regarding physical examination, vascular function and functional capacity. Participants of group A seemed to have worse vascular function and functional capacity compared with those of group B. Pain-free travelled distance was predictive of the nursing diagnosis. These results are important for the refinement of this diagnosis. In conclusion, this study provides evidences that the distances walked in the six-minute walk test may be considered defining characteristics of Ineffective Peripheral Tissue Perfusion.


Assuntos
Teste de Esforço/métodos , Diagnóstico de Enfermagem/métodos , Doenças Vasculares Periféricas/diagnóstico , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Tempo , Caminhada
20.
J Appl Physiol (1985) ; 113(2): 232-6, 2012 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-22539169

RESUMO

Sleep deprivation is common in Western societies and is associated with increased cardiovascular morbidity and mortality in epidemiological studies. However, the effects of partial sleep deprivation on the cardiovascular system are poorly understood. In the present study, we evaluated 13 healthy male volunteers (age: 31 ± 2 yr) monitoring sleep diary and wrist actigraphy during their daily routine for 12 nights. The subjects were randomized and crossover to 5 nights of control sleep (>7 h) or 5 nights of partial sleep deprivation (<5 h), interposed by 2 nights of unrestricted sleep. At the end of control and partial sleep deprivation periods, heart rate variability (HRV), blood pressure variability (BPV), serum norepinephrine, and venous endothelial function (dorsal hand vein technique) were measured at rest in a supine position. The subjects slept 8.0 ± 0.5 and 4.5 ± 0.3 h during control and partial sleep deprivation periods, respectively (P < 0.01). Compared with control, sleep deprivation caused significant increase in sympathetic activity as evidenced by increase in percent low-frequency (50 ± 15 vs. 59 ± 8) and a decrease in percent high-frequency (50 ± 10 vs. 41 ± 8) components of HRV, increase in low-frequency band of BPV, and increase in serum norepinephrine (119 ± 46 vs. 162 ± 58 ng/ml), as well as a reduction in maximum endothelial dependent venodilatation (100 ± 22 vs. 41 ± 20%; P < 0.05 for all comparisons). In conclusion, 5 nights of partial sleep deprivation is sufficient to cause significant increase in sympathetic activity and venous endothelial dysfunction. These results may help to explain the association between short sleep and increased cardiovascular risk in epidemiological studies.


Assuntos
Pressão Sanguínea , Endotélio Vascular/fisiopatologia , Frequência Cardíaca , Atividade Motora , Privação do Sono/fisiopatologia , Sistema Nervoso Simpático/fisiopatologia , Adulto , Humanos , Masculino , Vasodilatação
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