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Oral Dis ; 9(1): 1-6, 2003 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-12617250


Neoplasms and tumours related to the odontogenic apparatus may be composed only of epithelial tissue or epithelial tissue associated with odontogenic ectomesenchyme. The immunohistochemical detection of different cytokeratins (CKs) polypeptides and vimentin has made it easier to explain the histogenesis of many epithelial diseases. The present study aimed to describe the immunohistochemical expression of cytokeratins 7, 8, 10, 13, 14, 18, 19 and vimentin in the epithelial components of the dental germ and of five types of odontogenic tumours. The results were compared and histogenesis discussed. All cells of the dental germ were positive for CK14, except for the preameloblasts and secreting ameloblasts, in which CK14 was gradually replaced by CK19. CK7 was especially expressed in the cells of the Hertwig root sheath and the stellate reticulum. The dental lamina was the only structure to express CK13. The reduced epithelium of the enamel organ contained CK14 and occasionally CK13. Cells similar to the stellate reticulum, present in the ameloblastoma and in the ameloblastic fibroma, were positive for CK13, which indicates a nature other than that of the stellate reticulum of the normal dental germ. The expression of CK14 and the ultrastructural aspects of the adenomatoid odontogenic tumour probably indicated its origin in the reduced dental epithelium. Calcifying odontogenic epithelial tumour is thought to be composed of primordial cells due to the expression of vimentin. Odontomas exhibited an immunohistochemical profile similar to that of the dental germ. In conclusion, the typical IF of odontogenic epithelium was CK14, while CK8, 10 and 18 were absent. Cytokeratins 13 and 19 labelled squamous differentiation or epithelial cells near the surface epithelium, and CK7 had variable expression.

Queratinas/análise , Tumores Odontogênicos/química , Ameloblastoma/química , Tecido Conjuntivo/química , Órgão do Esmalte/química , Células Epiteliais/química , Humanos , Imuno-Histoquímica , Filamentos Intermediários/química , Queratina-10 , Queratina-14 , Queratina-7 , Queratina-8 , Odontoma/química , Germe de Dente/química , Vimentina/análise
Artigo em Inglês | MEDLINE | ID: mdl-11402283


We report a rare heterotopic gastrointestinal cyst located in the right submandibular/submental area with histopathologic features that included portions resembling a dermoid cyst. Some theories of pathogenesis are discussed, and an origin of this lesion in entrapped undifferentiated endodermal cells is suggested.

Coristoma/patologia , Cisto Dermoide/patologia , Mucosa Gástrica/patologia , Mucosa Intestinal/patologia , Doenças da Boca/patologia , Soalho Bucal/patologia , Neoplasias Bucais/patologia , Adolescente , Endoderma/patologia , Epitélio/patologia , Células Caliciformes/patologia , Folículo Piloso/patologia , Humanos , Masculino , Glândulas Sebáceas/patologia
ASDC J Dent Child ; 68(5-6): 344-6, 300, 2001.
Artigo em Inglês | MEDLINE | ID: mdl-11985196


Lymphangioma is a rare, congenital benign tumor involving vascular malformation, with a great potential for recurrence. It appears during the early years of life and therefore is highly common among children. We report here a five-year-old patient with a simple lymphngioma. The mother of the child reported she had noted the lesion in the palate after an injury in the area with a pen. The recommended treatment was surgical excision since this was a small and well-delimited lesion. Periodic clinical controls for 18 months showed that mucosa presented normal characteristics, with no signs of recurrence.

Linfangioma/patologia , Neoplasias Palatinas/patologia , Criança , Humanos , Linfangioma/cirurgia , Masculino , Neoplasias Palatinas/cirurgia , Palato Duro/patologia , Palato Mole/patologia
Oral Oncol ; 33(3): 204-8, 1997 May.
Artigo em Inglês | MEDLINE | ID: mdl-9307730


Acinic cell carcinoma (ACC) is a rare salivary gland tumour, making up 4% of all minor salivary gland tumors. Typically, it is composed of acinic cells although transitional and duct-like cells are also identified. In the present study, a panel of antibodies was applied to eight minor salivary gland ACCs. Antibodies tested were: cytokeratins 7, 8, 13, 14, 18, 19, vimentin and actin (HHF35). Immunohistochemical staining revealed that cytokeratin 8, among the tested antibodies, was the more specific to neoplastic cells with a pattern of distribution quite variable and peculiar. This staining may be useful in the recognition of neoplastic acinic cells.

Biomarcadores Tumorais/análise , Carcinoma de Células Acinares/química , Queratinas/análise , Neoplasias das Glândulas Salivares/química , Glândulas Salivares Menores , Adulto , Feminino , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade