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1.
Chin Med J (Engl) ; 2022 Aug 08.
Artigo em Inglês | MEDLINE | ID: mdl-35943251

RESUMO

ABSTRACT: Preoperative neoadjuvant chemoradiotherapy, combined with total mesorectal excision, has become the standard treatment for advanced localized rectal cancer (RC). However, the biological complexity and heterogeneity of tumors may contribute to cancer recurrence and metastasis in patients with radiotherapy-resistant RC. The identification of factors leading to radioresistance and markers of radiosensitivity is critical to identify responsive patients and improve radiotherapy outcomes. MicroRNAs (miRNAs) are small, endogenous, and noncoding RNAs that affect various cellular and molecular targets. miRNAs have been shown to play important roles in multiple biological processes associated with RC. In this review, we summarized the signaling pathways of miRNAs, including apoptosis, autophagy, the cell cycle, DNA damage repair, proliferation, and metastasis during radiotherapy in patients with RC. Also, we evaluated the potential role of miRNAs as radiotherapeutic biomarkers for RC.

2.
IEEE Trans Image Process ; 31: 5317-5331, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35921349

RESUMO

Adaptive Fourier decomposition (AFD) is a newly developed signal processing tool that can adaptively decompose any single signal using a Szegö kernel dictionary. To process multiple signals, a novel stochastic-AFD (SAFD) theory was recently proposed. The innovation of this study is twofold. First, a SAFD-based general multi-signal sparse representation learning algorithm is designed and implemented for the first time in the literature, which can be used in many signal and image processing areas. Second, a novel SAFD based image compression framework is proposed. The algorithm design and implementation of the SAFD theory and image compression methods are presented in detail. The proposed compression methods are compared with 13 other state-of-the-art compression methods, including JPEG, JPEG2000, BPG, and other popular deep learning-based methods. The experimental results show that our methods achieve the best balanced performance. The proposed methods are based on single image adaptive sparse representation learning, and they require no pre-training. In addition, the decompression quality or compression efficiency can be easily adjusted by a single parameter, that is, the decomposition level. Our method is supported by a solid mathematical foundation, which has the potential to become a new core technology in image compression.

3.
Sci Rep ; 12(1): 13639, 2022 Aug 10.
Artigo em Inglês | MEDLINE | ID: mdl-35948625

RESUMO

Matrix metalloproteinase 1 (MMP1) encodes endopeptidases associated with degradation of multiple components of the extracellular matrix. This function has increasingly been considered to play a major proteolysis role in tumor invasion and metastasis. However, the relationship between MMP1 gene expression, tumor-immune microenvironment and prognosis in hepatocellular carcinoma patients remains mostly unclear. This study focused on a comprehensive analysis of MMP1 in hepatocellular carcinoma, specifically the prognosis and tumor-immune microenvironment. MMP1 expression was analyzed using TCGA database and clinical samples. MMP1 associated mechanisms, pathways, mutations and prognosis in hepatocellular carcinoma were evaluated. We also analyzed the tumor-immune microenvironment and corresponding treatments. Our research demonstrated that MMP1 expression was upregulated in patients with hepatocellular carcinoma and correlated with poor survival. A prognostic model was established and its performance evaluated. We also found and report various correlations between MMP1 and immune-related cells/genes, as well the potential therapeutic agents. These findings indicate that MMP1 can potentially be a promising prognostic biomarker and indicator of the tumor-immune microenvironment status in hepatocellular carcinoma.


Assuntos
Carcinoma Hepatocelular , Neoplasias Hepáticas , Biomarcadores Tumorais/genética , Biomarcadores Tumorais/metabolismo , Carcinoma Hepatocelular/patologia , Biologia Computacional , Regulação Neoplásica da Expressão Gênica , Humanos , Neoplasias Hepáticas/patologia , Metaloproteinase 1 da Matriz/genética , Metaloproteinase 1 da Matriz/metabolismo , Prognóstico , Microambiente Tumoral/genética
4.
Sci Rep ; 12(1): 11944, 2022 Jul 13.
Artigo em Inglês | MEDLINE | ID: mdl-35831362

RESUMO

Pancreatic adenocarcinoma (PAAD) has high mortality and a very poor prognosis. Both surgery and chemotherapy have a suboptimal therapeutic effect, and this caused a need to find new approaches such as immunotherapy. Therefore, it is essential to develop a new model to predict patient prognosis and facilitate early intervention. Our study screened out and validated the target molecules based on the TCGA-PAAD dataset. We established the risk signature using univariate and multivariate Cox regression analysis and used GSE62452 and GSE28735 to verify the accuracy and reliability of the model. Expanded application of PAAD-immune-related genes signature (-IRGS) on other datasets was conducted, and the corresponding nomograms were constructed. We also analyzed the correlation between immune-related cells/genes and potential treatments. Our research demonstrated that a high riskscore of PAAD-IRGS in patients with PAAD was correlated with poor overall survival, disease-specific survival and progression free interval. The same results were observed in patients with LIHC. The models constructed were confirmed to be accurate and reliable. We found various correlations between PAAD-IRGS and immune-related cells/genes, and the potential therapeutic agents. These findings indicate that PAAD-IRGS may be a promising indicator for prognosis and of the tumor-immune microenvironment status in PAAD.


Assuntos
Adenocarcinoma , Carcinoma Hepatocelular , Neoplasias Hepáticas , Neoplasias Pancreáticas , Adenocarcinoma/patologia , Biomarcadores Tumorais/genética , Carcinoma Hepatocelular/genética , Regulação Neoplásica da Expressão Gênica , Humanos , Neoplasias Hepáticas/genética , Neoplasias Pancreáticas/patologia , Prognóstico , Reprodutibilidade dos Testes , Fatores de Risco , Microambiente Tumoral/genética
5.
Cancers (Basel) ; 14(14)2022 Jul 08.
Artigo em Inglês | MEDLINE | ID: mdl-35884393

RESUMO

Recently, endoplasmic reticulum (ER) stress has been shown to influence tumor progression and immune cell function in the tumor microenvironment (TME). However, the underlying role of ER stress-related gene patterns in colorectal cancer (CRC) development remains unclear. We analyzed the ER stress-related gene patterns in 884 patients with CRC from the Gene Expression Omnibus database and evaluated the cell-infiltrating patterns in the TME. Two ER stress-related patterns were identified in patients with CRC that had distinct cell-infiltrating patterns in the TME and clinical characteristics. A risk score and nomogram based on 14 screened prognosis-correlated genes was built and validated to predict patient survival. Patients with a higher risk score were shown to have an unfavorable prognosis, and the risk score was associated with cell infiltration and drug sensitivity. Furthermore, spatial transcriptomics data were utilized to explore ER stress-related gene patterns in CRC tissues, and it was shown that ER stress phenotype involves in the formation of the immunosuppressive TME. This study demonstrated that ER stress-related gene patterns play a role in influencing the TME and predicting prognosis. These analyses of ER stress in the TME of CRC might deepen our understanding of CRC progression and immune escape and provide novel insights into therapeutic strategies.

6.
Clin Epigenetics ; 14(1): 92, 2022 07 20.
Artigo em Inglês | MEDLINE | ID: mdl-35858918

RESUMO

BACKGROUND: SLC5A7 (solute carrier family 5 member 7), also known as choline transporter 1 (CHT1), is downregulated in colorectal cancer (CRC) and functions as a tumor suppressor. However, the mechanisms underlying the inactivation of SLC5A7 in CRC remain to be elucidated. RESULTS: In the present study, two broad-spectrum demethylation agents (azacitidine and decitabine) employed to treat CRC cells significantly upregulated SLC5A7 expression. Further results based on the CRC cohort and TCGA database indicated that SLC5A7 promoter methylation inversely correlated with SLC5A7 expression, and the status of SLC5A7 promotor methylation showed a promising prognostic value for patients with CRC. Next, the dCas9-multiGCN4/scFv-TET1CD-based precision demethylation system was constructed, which could significantly and specifically promote SLC5A7 expression in CRC cells through sgRNA targeting the SLC5A7 promoter. Both in vitro and in vivo experiments demonstrated that targeted demethylation of SLC5A7 by dCas9-multiGCN4/scFv-TET1CD-sgSLC5A7 inhibited tumor growth by stabilizing p53 and regulating downstream targets. CONCLUSIONS: Collectively, DNA promoter methylation caused inactivation of SLC5A7 in CRC, and targeted demethylation of SLC5A7 might be a therapeutic target for CRC and other cancers.


Assuntos
Neoplasias Colorretais , Simportadores , Azacitidina/farmacologia , Linhagem Celular Tumoral , Neoplasias Colorretais/tratamento farmacológico , Neoplasias Colorretais/genética , Neoplasias Colorretais/patologia , Metilação de DNA , Desmetilação , Regulação Neoplásica da Expressão Gênica , Humanos , Regiões Promotoras Genéticas , Simportadores/genética , Simportadores/metabolismo , Simportadores/uso terapêutico
7.
Small Methods ; : e2200597, 2022 Jul 19.
Artigo em Inglês | MEDLINE | ID: mdl-35853247

RESUMO

Zinc ion batteries (ZIBs) have been gradually developed in recent years due to their abundant resources, low cost, and environmental friendliness. Therefore, ZIBs have received a great deal of attention from researchers, which are considered as the next generation of portable energy storage systems. However, poor overall performance of ZIBs restricts their development, which is attributed to zinc dendrites and a series of side reactions. Constructing 3D zinc anodes has proven to be an effective way to significantly improve their electrochemical performance. In this review, the challenges of zinc anodes in ZIBs, including zinc dendrites, hydrogen evolution and corrosion, as well as passivation, are comprehensively summarized and the energy storage mechanisms of the zinc anodes and 3D zinc anodes are discussed. 3D zinc anodes with different structures including fiberous, porous, ridge-like structures, plated zinc anodes on different substrates and other 3D zinc anodes, are subsequently discussed in detail. Finally, emerging opportunities and perspectives on the material design of 3D zinc anodes are highlighted and challenges that need to be solved in future practical applications are discussed, hopefully illuminating the way forward for the development of ZIBs.

8.
Artigo em Inglês | MEDLINE | ID: mdl-35870006

RESUMO

PURPOSE: Noninvasive detection of high-risk plaques is still challenging. In this study, we aimed to noninvasively assess αvß3-integrin expression using a customed photoacoustic (PA) computed tomography (PACT)/ultrasound (US) system in atherosclerotic lesions of varying degrees of severity and to explore its potential value for detecting high-risk plaques. METHODS: We constructed αvß3-integrin-targeted ultrasmall gold nanorods (AuNRs) with cyclo Arg-Gly-Asp (cRGD) and tested their properties. Employing C57BL/6 J (wild-type, WT) mice and apolipoprotein E gene knockout (ApoE-/-) mice fed either a chow diet or a high-fat/high-cholesterol diet (HFHCD), we established varying degrees of lesion severity. In vivo PACT/US imaging was performed to assess αvß3-integrin expression in the 4 groups by cRGD-AuNRs. Further histopathologic examination was conducted to evaluate the plaque vulnerability indicators. RESULTS: The data showed that cRGD-AuNRs exhibited excellent photothermal conversion capacity, stability, targeting ability, and biocompatibility. The immunohistochemical results indicated that αvß3-integrin was upregulated with increasing aggravation of the lesions. In vivo PACT/US imaging showed good consistency with αvß3-integrin expression. Notably, ApoE-/- mice fed a HFHCD showed an abrupt PA intensity increase compared with the other groups. The histopathologic examination verified that the atherosclerotic plaques of ApoE-/- mice fed the HFHCD developed unstable phenotypes. Correlation analysis showed that PA intensity was mainly related to inflammation and angiogenesis among all of the indicators. CONCLUSION: Our data indicated that αvß3-integrin is an effective indicator of plaque instability, and noninvasive PACT/US molecular imaging assessment of αvß3-integrin holds promise in detecting high-risk plaques.

9.
Bioengineered ; 13(6): 14667-14680, 2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-35880647

RESUMO

Pulmonary arterial hypertension (PAH) is a group of devastating and progressive disorders, resulting in relentless increases in pulmonary vascular resistance. The number of studies related to PAH has been increasing in recent years. Our study aims to illustrate trends in PAH research over the past decade using bibliometric analysis. Science Citation Index-Expanded was adopted to search studies concerning PAH between 2011 and 2020. The bibliographic information was converted and analyzed automatically using a bibliometric package in R software and citespace. The annual quantity of publications on PAH showed an overall increase last decade. The United States was the most prolific country with 2,479 publications, and it was also the country that cooperated most with other countries. Hôpital Bicêtre made important research achievements on PAH and was a leader in study cooperation. Marc Humbert led the PAH field by publishing 150 articles in the past decade. During the past decade, there was a close transnational relation among countries or regions, institutions and authors. Further, Circulation was the most cited journal, followed by the Journal of the American College of Cardiology and the American Journal of Respiratory and Critical Care Medicine, with 3,895, 3,406, and 3,170 citations, respectively. The global research status and trend of PAH are deeply understood for the first time using bibliometric and visual methods, and the results of our study bring us a valuable reference for clinical researchers.


This is the first study to illustrate trends in pulmonary arterial hypertension research using bibliometric analysis.Our study provides extensive and in-depth directions for researchers.Our study may benefit further researches on the etiology, diagnosis, and treatment of pulmonary arterial hypertension.


Assuntos
Hipertensão Arterial Pulmonar , Bibliometria , Humanos , Estados Unidos
10.
Front Pharmacol ; 13: 850967, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35860030

RESUMO

Background: Psoriasis is characterized by keratinocyte proliferation and massive inflammatory leukocytes infiltration, affecting 0.14%-1.99% of the world's population. Our aim was to identify novel potential therapeutic strategies for psoriasis. Methods: Weighted gene co-expression network analysis (WGCNA) was performed to identify gene modules that were closely related to psoriasis based on the GSE30999 dataset, which contained expression data from 85 patients with moderate-to-severe psoriasis. Then, angiopoietin-like 4 (ANGPTL4), one of the most related hub genes, was selected for in vitro and in vivo functional assays. In our experiments, imiquimod (IMQ)-induced psoriasiform dermatitis in mice and human keratinocytes (HaCaT) cells were used to study the potential roles and mechanisms of ANGPTL4 in psoriasis. Results: WGCNA analysis revealed the turquoise module was most correlated with psoriasis, and ANGPTL4 is one of the most related hub genes that significantly upregulated in psoriasis lesions compared with non-lesional skin. Consistent with the bioinformatic analysis, the expression of ANGPTL4 was significantly upregulated in IMQ-induced psoriasiform skin of mice. Exogenous recombinant ANGPLT4 protein treatment could promote the proliferation and induce the expression of inflammatory cytokines in HaCaTs, whereas silencing of ANGPTL4 effectively inhibited these effects. Then we demonstrated that recombinant ANGPTL4 protein exacerbated psoriasiform inflammation and epidermal hyperproliferation in vivo. Mechanismly, extracellular signal-regulated kinase 1/2 (ERK1/2) and signal transducer and activator of transcription 3 (STAT3) pathways were involved in ANGPTL4-mediated regulation of proliferation and inflammation. Conclusion: We found ANGPTL4 was significantly increased in IMQ-induced psoriasiform skin of mice. ANGPTL4 could promote keratinocyte proliferation and inflammatory response via ERK1/2 and STAT3 dependent signaling pathways in psoriasis.

11.
Carbohydr Polym ; 294: 119809, 2022 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-35868769

RESUMO

Moisture-trigged electricity generator (MEG) that can convert ubiquitous moisture into electricity are highly desirable for developing renewable energy supply and ameliorating the crisis in energy. Constructing an asymmetric ordered, namely gradient ordered porous membrane has great potential in MEG. Herein, a series of cellulose acetate (CA)-based membranes with ordered asymmetric honeycomb membranes were fabricated by Breath Figure method, along with silver nanowires (AgNWs) coating. The asymmetric gradient honeycomb pores were achieved by graft modification of lauroyl chloride and adjustment of relative humidity, which not only endowed the MEG with sensitive sensing signals transport under tension and humidity fluctuations but also enhanced voltages generation speed under flowing moisture. The current study provides a facile and scalable strategy for constructing asymmetric gradient ordered porous materials and creates more possibilities for MEG self-powered flexible wearable electronic devices.


Assuntos
Nanofios , Dispositivos Eletrônicos Vestíveis , Celulose , Eletricidade , Umidade
12.
FASEB J ; 36(8): e22446, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-35816159

RESUMO

d-alanine (d-Ala) and several other d-amino acids (d-AAs) act as hormones and neuromodulators in nervous and endocrine systems. Unlike the endogenously synthesized d-serine in animals, d-Ala may be from exogenous sources, e.g., diet and intestinal microorganisms. However, it is unclear if the capability to produce d-Ala and other d-AAs varies among different microbial strains in the gut. We isolated individual microorganisms of rat gut microbiota and profiled their d-AA production in vitro, focusing on d-Ala. Serial dilutions of intestinal contents from adult male rats were plated on agar to obtain clonal cultures. Using MALDI-TOF MS for rapid strain typing, we identified 38 unique isolates, grouped into 11 species based on 16S rRNA gene sequences. We then used two-tier screening to profile bacterial d-AA production, combining a d-amino acid oxidase-based enzymatic assay for rapid assessment of non-acidic d-AA amount and chiral LC-MS/MS to quantify individual d-AAs, revealing 19 out of the 38 isolated strains as d-AA producers. LC-MS/MS analysis of the eight top d-AA producers showed high levels of d-Ala in all strains tested, with substantial inter- and intra-species variations. Though results from the enzymatic assay and LC-MS/MS analysis aligned well, LC-MS/MS further revealed the existence of d-glutamate and d-aspartate, which are poor substrates for this enzymatic assay. We observed large inter- and intra-species variation of d-AA production profiles from rat gut microbiome species, demonstrating the importance of chemical profiling of gut microbiota in addition to sequencing, furthering the idea that microbial metabolites modulate host physiology.


Assuntos
Microbioma Gastrointestinal , Alanina , Aminoácidos/metabolismo , Animais , Cromatografia Líquida , Microbioma Gastrointestinal/fisiologia , Masculino , RNA Ribossômico 16S/genética , Ratos , Espectrometria de Massas em Tandem
13.
Oncol Lett ; 24(2): 248, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-35761942

RESUMO

The lymph node status is one of the most critical prognostic factors used in determining adjuvant treatment in endometrial cancer (EC). Lymphadenectomy is associated significant surgical and postoperative risks. The use of sentinel lymph node mapping (SLNM) has emerged as an alternative method to complete lymphadenectomy in EC. However, there remains controversy surrounding the use of SLNM in high-risk disease and its false-negative rate (3%). The authors previously identified miR-204-5p as a tumor-suppressor miRNA associated with lymph node metastasis in EC tissues. The present study demonstrated that serum miR-204-5p in patients with EC has the potential for use as an early diagnostic biomarker combined with SLNM to assess the lymph node status prior to surgery. The present study also aimed to identify the optimal cut-off value of serum miR-204-5p. The relative expression levels of miR-204-5p were detected using reverse transcription-quantitative PCR in the serum of 52 patients with EC (total SLNM). A total of 20 patients diagnosed with ovarian cysts, 20 patients diagnosed with myoma, and 20 participants diagnosed with endometrial polyps or endometrial hyperplasia were included as the control group. miR-204-5p expression was also detected in lymph node tissues using in situ hybridization. The results revealed that serum miR-204-5p expression was downregulated in patients with EC compared with its expression in patients with benign ovarian cysts, myoma and endometrial hyperplasia/polyps (P<0.01). In accordance with the final pathological evaluation, patients with EC with a positive SLN status had a significantly lower level of miR-204-5p compared with those with a negative SLN status (P<0.01). The area under the ROC curve of miR-204-5p was 0.923, 95% CI (0.847-1.000), and the diagnostic value had a sensitivity of 87.2% and specificity of 80.0%, with an optimal cut-off value of 0.253. On the whole, it was demonstrated that a lower miR-204-5p expression is associated with lymph node metastasis in these SLN(+) EC tissues, indicating that the downregulation of serum miR-204-5p in patients with EC has potential for use as an early diagnostic biomarker combined with SLNM. In addition, with a cut-off value of 0.253, it appeared optimal for the prediction of lymph node metastasis in EC.

14.
Comput Intell Neurosci ; 2022: 5768291, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35694593

RESUMO

In today's society, with the gradual improve5ment of material living standards, people are also more in pursuit of their own spiritual enjoyment. The study of piano has gradually become a way for people to enrich their spiritual life, and more and more people attach importance to it. In the field of piano teaching, the two-piano method is a unique form of playing the piano. In order to solve the problem that the recognition accuracy of the sequence of two pianos is seriously reduced in the environment of noise and reverberation, this paper proposes an auxiliary training analysis system based on the neural network model. Firstly, in order to learn the nonlinear relationship between the sound order and the target task label from the massive data, a multitask preprocessing method combining speech enhancement and detection is used to supervise the deep neural network training. Then, convolutional neural network is used to construct the end-to-end recognition system, and the initial recognition results are checked and corrected by the phonological sequence model. Finally, the sequence recognition is carried out under the condition of noise, and the articulation is improved by speech enhancement front-end module, and then the sequence recognition model is used for recognition. Compared with traditional training methods, it is proved that our method is effective in improving the training efficiency and performance quality of players. At the same time, this method breaks through the limitation of traditional training method of double piano, creates a more scientific training means, and realizes the practice and application of artificial intelligence technology in the teaching of double piano.


Assuntos
Inteligência Artificial , Redes Neurais de Computação , Emoções , Humanos , Reconhecimento Psicológico
15.
Int J Biol Macromol ; 213: 226-233, 2022 Jul 31.
Artigo em Inglês | MEDLINE | ID: mdl-35654216

RESUMO

The fabrication of hydrogel for sensing purposes remains to be a challenge since the hydrogel needs to have both good mechanical strength and adhesiveness. This work reports a robust and adhesive hydrogel mainly constructed with AgNPs@lignin, polyacrylamide (PAM) and sodium alginate (SA). The silver nanoparticles (AgNPs) were in-situ generated via the reaction between lignin and silver ammonia ([Ag(NH3)2]+). The resultant lignin hybrid hydrogel exhibited a stress, strain and tearing energy up to 0.055 MPa, 1000% and 250 J·m-2, respectively. Furthermore, the hydrogel adhered to different materials with an adhesion energy of higher than 230 J·m-2. This hydrogel was demonstrated to be an ideal sensing material since it could detect both large-scale motions and tiny physiological signals including breathing and pulse. The hydrogel also exhibited good antibacterial performance and biocompatibility. This work provides a good example to design a lignin-based high-performance hydrogel material for sensing purposes.


Assuntos
Hidrogéis , Nanopartículas Metálicas , Adesivos , Antibacterianos , Lignina , Prata
16.
Front Pharmacol ; 13: 896523, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35754467

RESUMO

Obesity-related acute pancreatitis (AP) is characterized by increasing prevalence worldwide and worse clinical outcomes compared to AP of other etiologies. Chaiqin chengqi decoction (CQCQD), a Chinese herbal formula, has long been used for the clinical management of AP but its therapeutic actions and the underlying mechanisms have not been fully elucidated. This study has investigated the pharmacological mechanisms of CQCQD in a novel mouse model of obesity-related alcohol-induced AP (OA-AP). The mouse OA-AP model was induced by a high-fat diet for 12 weeks and subsequently two intraperitoneal injections of ethanol, CQCQD was administered 2 h after the first injection of ethanol. The severity of OA-AP was assessed and correlated with changes in transcriptomic profiles and network pharmacology in the pancreatic and adipose tissues, and further docking analysis modeled the interactions between compounds of CQCQD and their key targets. The results showed that CQCQD significantly reduced pancreatic necrosis, alleviated systemic inflammation, and decreased the parameters associated with multi-organ dysfunction. Transcriptomics and network pharmacology analysis, as well as further experimental validation, have shown that CQCQD induced Nrf2/HO-1 antioxidant protein response and decreased Akt phosphorylation in the pancreatic and adipose tissues. In vitro, CQCQD protected freshly isolated pancreatic acinar cells from H2O2-elicited oxidative stress and necrotic cell death. The docking results of AKT1 and the active compounds related to AKT1 in CQCQD showed high binding affinity. In conclusion, CQCQD ameliorates the severity of OA-AP by activating of the antioxidant protein response and down-regulating of the PI3K/Akt signaling pathway in the pancreas and visceral adipose tissue.

17.
Carbohydr Polym ; 291: 119624, 2022 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-35698350

RESUMO

Although synthetic polymer hydrogels have excellent mechanical properties, they are not easily degraded, are toxic, and easily cause environmental pollution. Therefore, starch-based hydrogels have attracted great interest due to their biodegradability, biocompatibility, and non-toxicity. First of all, this review describes in detail the preparation of starch-based hydrogels by physical retrogradation method and chemical crosslinking methods, as well as the intrinsic and extrinsic factors that affect the performance of the hydrogels. Moreover, the commonly used methods to characterize starch-based hydrogels and the properties of responsive (thermo-, pH-, and enzyme-responsive) starch-based hydrogels have also attracted wide attention from researchers. In addition, the applications of starch-based hydrogels in starch noodles, treatment of sewage from the food industry, and food bioactive ingredient carriers are discussed. Furthermore, prospects and future directions of starch-based hydrogels are discussed. We believe that this review provides a valuable reference for the efficient preparation and application of starch-based hydrogels.


Assuntos
Hidrogéis , Amido , Fenômenos Químicos , Hidrogéis/química , Polímeros/química , Amido/química
18.
Nano Lett ; 22(13): 5214-5220, 2022 Jul 13.
Artigo em Inglês | MEDLINE | ID: mdl-35727226

RESUMO

Solid sodium-ion batteries (SSIBs) are considered as one of the promising energy storage systems because of their high safety and high energy density. However, the sodium metal anode presents poor wettability with a solid electrolyte, resulting in high interface impedance and dendrite growth, which severely limits their application in practice. Herein, a novel liquid film (Na-BP) interface is constructed between sodium and solid electrolyte (Na3Hf2Si2PO12) with an excellent kinetic mass transfer ability and good fluidity, which could guarantee a close contact and fast charge transfer at interface. The symmetric cells with the designed interface show a high-rate and long-cycle performance and could cycle stably more than 1000 and 700 h at 0.2 and 0.5 mA cm-2, respectively. The critical current density of the cells can reach 3.6 mA cm-2 at room temperature, which is the highest value in similar works.

19.
Small Methods ; 6(7): e2200345, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35490410

RESUMO

Sodium-air battery has great development potential due to its high energy density and high safety. However, most previous works are based on liquid electrolyte or polymer electrolyte, which will inevitably result in safety hazards such as electrolyte leakage and sodium dendrite growth. Herein, an all-solid-state Na-O2 battery based on a well-designed NASICON-type electrolyte Na3.2 Hf2 Si2.2 P0.8 O11.85 F0.3 , which has high ionic conductivity (2.39 × 10-3 S cm-1 ) and excellent chemical stability, is developed. Collaborating with the reasonable humidity of the atmosphere, the battery shows good cycle stability. This research demonstrates that NASICON-type electrolyte Na3.2 Hf2 Si2.2 P0.8 O11.85 F0.3 has good application potential for all-solid-state Na-O2 batteries and lays a solid foundation on the material preparation and optimization for developing high-energy sodium-air batteries.

20.
ISME J ; 16(8): 2040-2055, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-35597888

RESUMO

Dietary fibers are generally thought to benefit intestinal health. Their impacts on the composition and metabolic function of the gut microbiome, however, vary greatly across individuals. Previous research showed that each individual's response to fibers depends on their baseline gut microbiome, but the ecology driving microbiota remodeling during fiber intake remained unclear. Here, we studied the long-term dynamics of the gut microbiome and short-chain fatty acids (SCFAs) in isogenic mice with distinct microbiota baselines fed with the fermentable fiber inulin and resistant starch compared to the non-fermentable fiber cellulose. We found that inulin produced a generally rapid response followed by gradual stabilization to new equilibria, and those dynamics were baseline-dependent. We parameterized an ecology model from the time-series data, which revealed a group of bacteria whose growth significantly increased in response to inulin and whose baseline abundance and interspecies competition explained the baseline dependence of microbiome density and community composition dynamics. Fecal levels of SCFAs, such as propionate, were associated with the abundance of inulin responders, yet inter-individual variation of gut microbiome impeded the prediction of SCFAs by machine learning models. We showed that our methods and major findings were generalizable to dietary resistant starch. Finally, we analyzed time-series data of synthetic and natural human gut microbiome in response to dietary fiber and validated the inferred interspecies interactions in vitro. This study emphasizes the importance of ecological modeling to understand microbiome responses to dietary changes and the need for personalized interventions.


Assuntos
Microbioma Gastrointestinal , Animais , Fibras na Dieta/metabolismo , Ácidos Graxos Voláteis/metabolismo , Fezes/microbiologia , Humanos , Inulina , Camundongos , Amido Resistente
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