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1.
Pharmacol Biochem Behav ; 191: 172878, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32112786

RESUMO

Olanzapine has been used for the treatment of schizophrenia and other mental disorders. However, it is associated with serious weight gain and other metabolic side-effects. The antagonistic affinity of olanzapine to muscarinic M3 receptors has been evidenced as one of the main contributors for its weight gain and other metabolic side-effects. Therefore, this study investigated whether the co-treatment of cevimeline (a M3 receptor agonist) could prevent the metabolic side-effects associated with olanzapine medication. Female Sprague Dawley rats were treated orally with olanzapine (2 mg/kg, t.i.d.) and/or cevimeline at 3 dosages (3, 6, 9 mg/kg, t.i.d.), or vehicle for two weeks. Weight gain and food/water intake were measured throughout the drug treatment period. Intraperitoneal glucose tolerance tests and open field tests were conducted. Olanzapine-treated rats demonstrated significantly elevated body weight gain, food intake, feeding efficiency, total white fat mass, liver mass, and plasma triglyceride levels, which could be partly reversed by the co-treatment with cevimeline in a dosage-dependent manner. In general, the body weight gain can only be reversed by the co-treatment of 9 mg/kg cevimeline. The cevimeline co-treatment decreased plasma triglyceride and glucose levels compared with olanzapine only treatment. The results suggested a dosage-dependent effect of cevimeline in ameliorating olanzapine-induced weight gain and metabolic side-effects, which supports further clinical trials using cevimeline to control weight gain and metabolic side-effects caused by antipsychotic medications.

2.
J Colloid Interface Sci ; 570: 223-231, 2020 Feb 27.
Artigo em Inglês | MEDLINE | ID: mdl-32155500

RESUMO

We report a facile and versatile method to homogeneously deposit monolith membrane with uniform, high density of metallic nanoparticles via a "ship-in-a-bottle" strategy. Polyamidoamine (PAMAM) dendrimer, an excellent matrix for complexing with metal ions, is pre-infiltrated and applied as the directing agent for in-situ confined-formation of palladium nanoparticles (PdNPs) inside the mesopores. Efficiency of this method is demonstrated to prepare homogeneous PdNPs-deposited hierarchically porous graphitic carbon (HPGC) membrane with uniform metallic particle size (2.0-2.5 nm) and high palladium loading (~34.4 wt%). Taking advantages of fast molecule diffusion rate in hierarchically porous structure and high conductivity of graphitic carbon substance, the PdNPs-dispersed HPGC membranes are applied as monolith electrodes for electrochemical applications. The PdNPs-deposited HPGC membrane electrode exhibits excellent electrocatalytic activity toward the catalytic oxidation of dopamine, uric acid and ascorbic acid, as well as high sensitivity and selectivity in simultaneous determination of these compounds in real serum samples. The limit of detections for dopamine, uric acid and ascorbic acid are 1.3 × 10-8, 2.6 × 10-8 and 3.7 × 10-8 M, respectively, at least one order lower than that achieved on electrochemical sensors reported previously. This work provides a versatile method for efficient preparation and stabilization of monodisperse metallic NPs in diverse porous materials, leading to possible applications in devices, catalysis, and electrochemical sensing.

3.
J Appl Toxicol ; 2020 Mar 13.
Artigo em Inglês | MEDLINE | ID: mdl-32170788

RESUMO

ET-26 hydrochloride (ET-26HCl), a novel analog of etomidate, induces as effective sedation, with good cardiac and respiratory stability, as etomidate but with mild adrenocortical suppression. The objective of this study was to evaluate the potential adverse effects of ET-26HCl in rats. In a single-dose toxicity study, abnormal urine color (red) was observed in all groups: control (100%), 8 mg/kg (10%), 16 mg/kg (50%), and 20 mg/kg (70%) ET-26HCl, which returned to normal on the day of dosing. There were no mortalities or serious toxicological signs; the maximum tolerable dose of ET-26HCl was 20 mg/kg. In the repeated-dose toxicity study, deaths occurred in the 12- (13.33% of males) and 16-mg/kg/day (20% of males and 3.33% of females) groups. Abnormal urine color (red or brown) was detected in the control group (10%) and all treatment groups (30%, 46.67%, and 40% at 8, 12 and 16 mg/kg/day, respectively), at a frequency of 1.43% in the control group, 4.76% in 8 mg/kg/day, 7.62% in 12 mg/kg/day, and 4.29% in 16 mg/kg/day. Increases in neutrophils and plasma fibrinogen were temporary and recoverable effects. Macroscopic and histopathologic changes were found only at the injection sites: abnormal skin color, scabbing, thrombus, ulceration, and inflammation. During the recovery period, there was evidence of reversibility, including fibroblast proliferation and vessel recanalization. The no-observed-adverse-effect level of ET-26HCl was 8 mg/kg/day. Toxicokinetic variables of ET-26HCl, except the calculated initial concentration in females on Day 1, showed a dose-dependent increase to exposure, with no gender difference and no evidence of accumulation.

4.
IEEE Trans Cybern ; 2020 Mar 03.
Artigo em Inglês | MEDLINE | ID: mdl-32149704

RESUMO

In this article, we investigate the distributed resilient control problem for a class of cyber-physical systems with communication delays under denial-of-service (DoS) attacks. In contrast to the previous DoS attacks results based on multiagent systems (MASs), a new distributed resilient control approach is proposed for more general heterogeneous linear MASs with nonuniform communication delays. Two types of sampled-based observers are, respectively, proposed. Namely, adaptive distributed observers are designed by introducing a buffer mechanism to eliminate the heterogeneous behavior caused by communication delays while adaptive distributed resilient observers are designed by introducing resilient mechanisms to resist the DoS attacks. Furthermore, a time-varying sampling period sequence is provided to prevent the attacker from identifying the sampling period of the system. Based on the developed resilient observers, a controller is developed. It is proved that the considered problem can be solved by the developed method. Finally, a numerical example is given to illustrate the effectiveness of the obtained result.

5.
Pharmacol Res ; 155: 104703, 2020 Feb 14.
Artigo em Inglês | MEDLINE | ID: mdl-32068120

RESUMO

The antipsychotic drug olanzapine is widely used in the treatment of schizophrenia, bipolar and other mental disorders; however, it causes serious metabolic disorders, including dyslipidemia. Our previous studies have identified that olanzapine activated expression of the sterol regulatory element binding transcription factor 1 (SREBP-1) gene, a key transcriptional factor for lipogenesis in the liver and adipocytes. SREBP-1 has been reported to positively regulate the peroxisome proliferator-activated receptor gamma (PPARγ), a master regulator in the process of adipogenesis. This study aimed to investigate epigenetic modulations of the hepatic PPARγ pathway in olanzapine-induced lipid dysfunctions. Olanzapine led to significant increases of body weight gain, white adipose tissue, fasting triglyceride, and fat accumulation in the liver. A significant upregulation of PPARγ was observed in olanzapine-treated rats. ChIP-deep sequencing showed the increase of H3K4me2 binding on the whole gene loci of key regulators of adipogenesis and lipogenesis, the Pparg, Srebp-1, Cebps families (Cebpa, Cebpb and Cebpd), the Signal transducer and activator of transcription 5 families (Stat5a and Stat5b) and Klfs families (Klf9 and Klf15), as well as muscarinic M3 receptor (Chrm3). ChIP-qPCR revealed that H3K9me3 binding on the promoter of Pparg2 was significantly decreased. Consistently, KDM4B, KDM1A and PHF2, the three histone demethylases responsible for site-specific erasure of H3K9me, was increased in olanzapine-treated rats. These results suggested that olanzapine acted as stimuli to trigger the cascade of adipogenesis and lipogenesis through modulating hepatic histone modifications and subsequently upregulating key transcriptional factors. These findings provided new insight into effective strategies for the prevention and treatment of metabolic side-effects induced by antipsychotic medication.

6.
Appetite ; 148: 104586, 2020 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-31926176

RESUMO

The concept of food addiction refers to addiction-like behaviours that develop in association with the intake of highly palatable foods. Previous research indicates that a high proportion of individuals with Major Depressive Disorder (MDD) meet the criteria for food addiction, and are also at an increased risk of weight gain and chronic disease. In the central nervous system, dopamine is a neurotransmitter associated with reward salience and food intake, whereas peripheral dopamine is involved in sympathetic stress regulation, digestion and gastrointestinal motility. However, little research has examined relationships between peripheral dopamine, depressive symptoms and problematic eating behaviours in MDD. Biometrics, psychopathology and plasma dopamine levels were compared between participants with MDD (n = 80) and controls (n = 60). Participants were sub-categorised into those meeting or not meeting Yale Food Addiction Scale (YFAS) criteria. Psychometric measures of mood and appetite were used to assess MDD symptoms, problematic eating behaviours and food-addiction related symptoms. Twenty-three (23; 29%) MDD participants met the Yale criteria for food addiction. Depressed individuals meeting YFAS criteria had significantly greater psychopathology scores for both mood and eating compared to depressed individuals not meeting YFAS criteria and controls. A significant interaction between food addiction status and sex was also observed for plasma dopamine levels. Plasma dopamine levels correlated positively with disordered eating behaviours in females, and negatively in males. The results provide evidence that depressogenic excess eating and weight gain are associated with peripheral dopamine levels. Longitudinal research is warranted investigating endocrine dysregulation and excess eating in MDD, which may inform interventions and reduce chronic disease risk in affected individuals.

7.
Mol Plant Pathol ; 21(3): 388-400, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31916392

RESUMO

Gamma-proteobacteria Xanthomonas spp. cause at least 350 different plant diseases among important agricultural crops, which result in serious yield losses. Xanthomonas spp. rely mainly on the type III secretion system (T3SS) to infect their hosts and induce a hypersensitive response in nonhosts. HrpG, the master regulator of the T3SS, plays the dominant role in bacterial virulence. In this study, we used chromatin immunoprecipitation followed by sequencing (ChIP-seq) and tandem affinity purification (TAP) to systematically characterize the HrpG regulon and HrpG interacting proteins in vivo. We obtained 186 candidate HrpG downstream genes from the ChIP-seq analysis, which represented the genomic-wide regulon spectrum. A consensus HrpG-binding motif was obtained and three T3SS genes, hpa2, hrcU, and hrpE, were confirmed to be directly transcriptionally activated by HrpG in the inducing medium. A total of 273 putative HrpG interacting proteins were identified from the TAP data and the DNA-binding histone-like HU protein of Xanthomonas campestris pv. campestris (HUxcc ) was proved to be involved in bacterial virulence by increasing the complexity and intelligence of the bacterial signalling pathways in the T3SS.

8.
Medicine (Baltimore) ; 99(4): e18849, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31977883

RESUMO

BACKGROUND: Molecular targeted anticancer drugs such as multikinase inhibitors have shown obvious therapeutic advantages in a variety of tumors. The occurrence of hand-foot skin reaction (HFSR) is positively correlated with therapeutic effect, but it is also the most common cause of dose limiting toxicity for this treatment. This can lead to interruption or decrement of the treatment, a reduction in quality of life for patients, as well as potentially leading to secondary infections. As a result, the curative effect of targeted anticancer drugs will be negatively impacted. Currently, there is no certain and effective therapy. External use of Chinese herb medicine LC09 in the early treatment of HFSR has shown positive outcomes, but it is necessary to carry out further clinical research to confirm. OBJECTIVES: The purpose of this study was to investigate the efficacy and safety of topical soaks of Chinese herbal medicine LC09 for HFSR induced by molecular targeted anticancer drugs. METHODS: The trial is a prospective, randomized, controlled, double-blind, monocentric, and interventional study. A total of 66 patients with HFSR will be recruited and randomly assigned to receive either LC09 Granules or placebo. The primary outcomes are the assessment of HFSR grade and pain score. The secondary outcomes are the evaluation of the quality of life, incidence of targeted drug dosage reduction, and incidence of targeted drug withdrawal. DISCUSSION: This prospective, randomized clinical trial will provide valuable data regarding the efficacy and safety of topical soak treatments with LC09 granules for HFSR. Positive results would provide evidence-based complementary therapeutic approach future treatments of HFSR. TRIAL REGISTRATION: Chinese Clinical Trial Registry, http://www.chictr.org.cn, ChiCTR1900023679. Registered on 7 June 2019.


Assuntos
Antineoplásicos/efeitos adversos , Medicamentos de Ervas Chinesas/administração & dosagem , Dermatopatias/induzido quimicamente , Dermatopatias/tratamento farmacológico , Banhos , Método Duplo-Cego , , Mãos , Humanos , Estudos Prospectivos , Ensaios Clínicos Controlados Aleatórios como Assunto , Resultado do Tratamento
9.
Small ; 16(7): e1906475, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31994360

RESUMO

Organic luminogens constitute promising prototypes for various optoelectronic applications. Since gaining distinct color emissions normally requires the alternation of the conjugated backbone, big issues remain in material synthetic cost and skeleton compatibility while pursuing full-color luminescence. Upon a facile one-step coupling, three simple but smart perchalcogenated (O, S, and Se) arenes are synthesized. They exhibit strong luminescent tricolor primaries (i.e., blue, green, and red, respectively) in the solid state with a superior quantum yield up to >40% (5-10 times higher than that in corresponding solutions). The properties originate from a fluorescence-phosphorescence-phosphorescence triple-channel emission effect, which is regulated by S and Se heavy atoms-dependent intersystem crossing upon molecular packing, as well as Se-Se atom interaction-caused energy splittings. Consequently, full-color luminescence, including a typical white-light luminescence with a Commission Internationale de I'Eclairage coordinate of (0.30, 0.35), is realized by complementarily incorporating these tricolor luminescent materials in the film. Moreover, mechanochromic luminescent color conversions are also observed to achieve the fine-tuning of the luminescent tints. This strategy can be smart to address full-color luminescence on the same molecular skeleton, showing better material compatibility as an alternative to the traditional multiple-luminophore engineering.

10.
Artigo em Inglês | MEDLINE | ID: mdl-31898645

RESUMO

Background/Aim: Irritable Bowel Syndrome (IBS) is a common chronic functional bowel disorder and the evidence shows most drug therapies in the treatment of IBS are weak. Recently, some studies showed probiotics may have a positive effect in IBS and they are widely used to improve the symptom of IBS, which indicate probiotics may play an important role in the treatment of IBS. However, the exact effectiveness and safety of probiotics are largely unknown. This systematic review focuses on identifying the efficacy and safety of probiotics in the treatment of IBS. Materials and Methods: Data sources were searched up to February 2019. Databases included MEDLINE, CENTRAL, CINAHL, and Embase. Randomized controlled trials (RCTs) comparing probiotics including complex or individual probiotics with placebo or no therapy were screened, extracted, and appraised by two independent reviewers. The data were pooled using a random-effects model. The methodological quality of all RCTs was assessed using the Cochrane risk of bias and Jadad scale. Outcomes included symptom-relevant and patient-relevant characteristics, such as symptom relief, abdominal pain, bloating, flatulence, quality of life, and adverse event. Results: This review includes 28 studies with a total of 3606 participants. Particular combinations of probiotics, or specific species and strains, showed probiotics have beneficial effect on overall IBS symptoms (22 studies, n = 3144, RR of improvement in overall IBS symptoms = 1.5, CI 1.23 to 1.83) or overall IBS symptom and abdominal pain scores (18 studies, n = 2766, SMD = -0.31, CI -0.45 to -0.17). In addition, adverse events were not significantly higher with probiotics (8 studies, n = 923, RR = 1.05; 95% CI 0.85-1.31). However, there was no significant benefit on individual IBS symptom scores and quality of life. Conclusion: Current evidence shows particular combinations, species or strains of probiotics are effective for overall IBS symptoms. However, it is hard to derive a definite conclusion due to high heterogeneity and unclear risk of bias of some trials. Large well-designed and rigorous trials are warranted.

11.
Pathol Res Pract ; 216(2): 152780, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31889586

RESUMO

BACKGROUND: Renal cancer represents about 3 % of all human cancers. Clear cell renal cell carcinoma (ccRCC) is the main type of renal cancer. Methionine sulfoxide reductase B3 (MSRB3) is a protein repair enzyme that specifically catalyzes the reduction of methionine-R-sulfoxide residues and has an antioxidant function. However, MSRB3's role in ccRCC is still obscure. METHODS: Immunohistochemical staining and Real-time PCR were used to compare the expression level of MSRB3 in ccRCC tissues and adjacent tissues. Western blot was used to detect the expression of MSRB3 in cell lines. Chi-square test were applied to evaluate the potential of MSRB3 to function as a cancer biomarker. RNA interference was used to inhibit MSRB3 expression in ccRCC cells, followed by detecting cell proliferation, apoptosis, migration and invasion. The markers of endoplasmic reticulum stress were then detected by western blot. RESULTS: In this study, we validated that MSRB3 was significantly up-regulated in ccRCC samples and cell lines. It was also demonstrated that the up-regulation of MSRB3 was associated with several clinicopathologic features. Knockdown of MSRB3 remarkably arrested the proliferation, migration and invasion, while promoted apoptosis, and induced the changes of markers of endoplasmic reticulum stress. CONCLUSION: In conclusion, we demonstrated that MSRB3 was an oncogene of ccRCC associated with patients' pathological characteristics and modulated endoplasmic reticulum stress of cancer cells.

12.
Angew Chem Int Ed Engl ; 59(4): 1666-1673, 2020 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-31724314

RESUMO

6π electrocyclization has attracted interest in organic synthesis because of its high stereospecificity and atom economy in the construction of versatile 5-7-membered cycles. However, examples of asymmetric 6π electrocyclization are quite scarce, and have to rely on the use of chiral organocatalysts, and been limited to pentadienyl-anion- and triene-type 6π electrocyclizations. Described herein is a zinc-catalyzed formal [4+3] annulation of isoxazoles with 3-en-1-ynol ethers via 6π electrocyclization, leading to the site-selective synthesis of functionalized 2H-azepines and 4H-azepines in good to excellent yields with broad substrate scope. Moreover, this strategy has also been used to produce chiral 2H-azepines with high enantioselectivities (up to 97:3 e.r.). This protocol not only is the first asymmetric heptatrienyl-cation-type 6π electrocyclization, but also is the first asymmetric reaction of isoxazoles with alkynes and the first asymmetric catalysis based on ynol ethers.

13.
Biomacromolecules ; 21(1): 104-113, 2020 Jan 13.
Artigo em Inglês | MEDLINE | ID: mdl-31532629

RESUMO

Metastasis is responsible for >90% of the deaths of breast cancer patients in the clinic. Here, we report on cross-linked multifunctional hyaluronic acid nanoparticles carrying docetaxel (DTX-CMHN) for enhanced suppression of highly metastatic 4T1 breast tumors in vivo. DTX-CMHN was formed from a single and all-natural hyaluronic acid-g-polytyrosine-lipoic acid conjugate (HA-g-PTyr-LA; HA, 20 kDa; PTyr, 2.2 kDa), and the size of DTX-CMHN increased from 69 to 78 to 96 nm as the increasing degree of substitution (DS) of PTyr increased from 4 to 11 to 15, respectively. Robust encapsulation of DTX was obtained when DS ≥ 11. DTX-CMHN while steady in a nonreducing environment was destabilized under 10 mM glutathione releasing ∼90% of the DTX within 24 h. It is noteworthy that DTX-CMHN exhibited better antitumor, antimigration, and anti-invasion activity in CD44-overexpressed 4T1-Luc breast cancer cells than free DTX. Interestingly, DTX-CMHN displayed a long elimination half-life of 5.75 h, in contrast to half-lives of 2.11 and 0.75 h for its non-cross-linked counterpart (DTX-MHN) and free DTX, respectively. In vivo therapeutic studies showed significantly better inhibition of primary 4T1-Luc tumor growth and lung metastasis and lower toxicity of DTX-CMHN compared with that of free DTX. These multifunctional nanoformulations based on a single and all-natural hyaluronic acid conjugate emerge as a potential nanoplatform for targeted treatment of CD44-positive metastatic tumors.

14.
Neurochem Res ; 45(2): 268-277, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31811458

RESUMO

Pramipexole (PPX) is a common drug for the treatment of Parkinson's disease. However, the mechanism allows PPX in the progression of Parkinson's disease remains largely unknown. This study aimed to investigate the role of PPX in 1-Methyl-4-phenylpyridinium (MPP+)-treated neuroblastoma cells and explore the interaction between PPX and miR-494-3p/brain derived neurotrophic factor (BDNF) axis. SK-N-SH and CHP 212 cells challenged by MPP+ were used as cellular model of Parkinson's disease and incubated with PPX. The expression levels of miR-494-3p and BDNF were measured by quantitative real-time polymerase chain reaction or western blot. Neurotoxicity was investigated by cell apoptosis, inflammatory response and oxidative stress. The target association between miR-494-3p and BDNF was confirmed by luciferase reporter and RNA immunoprecipitation assays. miR-494-3p expression was increased and BDNF level was decreased in MPP+-treated SK-N-SH and CHP 212 cells, which were reversed by introduction of PPX. Pramipexole attenuated cell apoptosis, inflammatory response and oxidative stress in MPP+-treated SK-N-SH and CHP 212 cells. Knockdown of miR-494-3p also suppressed neurotoxicity induced by MPP+ in SK-N-SH and CHP 212 cells. BDNF was validated as a target of miR-494-3p and its silence abated the suppressive effect of miR-494-3p on MPP+-induced neurotoxicity. Moreover, addition of miR-494-3p and silence of BDNF mitigated the effect of PPX on MPP+-induced neurotoxicity. PPX inhibited MPP+-induced neurotoxicity in SK-N-SH and CHP 212 cells by decreasing miR-494-3p and increasing BDNF, indicating the potential therapeutic effect of PPX on Parkinson's disease.

15.
ACS Appl Mater Interfaces ; 12(5): 6127-6136, 2020 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-31847516

RESUMO

Triplet excitons can be effectively harvested in organic light-emitting diodes employing thermally activated delayed fluorescence (TADF) molecules as the emitter and host. A design strategy for blue and green emitters with small S1-T1 splitting (ΔEST) is to construct a donor-acceptor (D-A) type molecule with moieties combining a high T1 level with a strong electron-donating/withdrawing character. Here, we report a new kind of TADF emitter with an indolo[2,3-b]indole (IDID) donor. In comparison to other reported indolocarbazole and indoloindole donors, IDID has a higher T1 level, which is comparable to that of the classical donor 9,9-dimethyl-9,10-dihydroacridine (DMAC) for blue TADF emitters. The sky-blue and green TADF emitters based on the IDID donor and a phenyltriazine acceptor exhibit high photoluminescence quantum yields (0.78-0.92) and short TADF lifetimes (1.1-1.7 µs) in doped films. Devices employing these IDID-based emitters offer an external quantum efficiency of 19.2%, which is comparable to that obtained for a device employing an analogous compound with a DMAC donor, while the stability of the former is higher than that of the latter owing to the just-right D-A twisting angles (∼59°) in the IDID-based emitters leading to a balance between ΔEST and the fluorescence rate. The utilization of host materials with a similar polarity to the emitter is found to be an effective strategy to improve device stability.

16.
J Nanosci Nanotechnol ; 20(3): 1907-1916, 2020 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-31492360

RESUMO

In the present study, a novel microbial nanocomposite "Paecilomyces lilacinus-silica nanoparticlescalcium-alginate beads" (P. lilacinus-SN-Cal-Alg) were synthesized and their high efficiency for removing Pb(II) ions was demonstrated in aqueous solution. P. lilacinus-SN-Cal-Alg beads before and after the adsorption of Pb(II) were characterized by FT-IR, SEM-EDS, and XPS analyses. The adsorption capacity of Pb(II) by P. lilacinus-SN-Cal-Alg beads was analyzed in aqueous solution. For comparison, the adsorption capacity of Pb(II) by another type of microbial composites, namely, P. lilacinus-Cal-Alg beads, without addition of silica nanoparticles, was also studied in parallel. Lastly, the equilibrium data in adsorption process were examined by both Langmuir and Freundlich isotherm models to evaluate adsorption mechanism. The results showed that an excellent removal efficiency of Pb(II) in aqueous solution (85.54%) was obtained at initial concentration of 200 mg/L by using the P. lilacinus-SN-Cal-Alg beads. Meanwhile, they exhibited the better adsorption capacity for Pb(II) than P. lilacinus-Cal-Alg beads. The adsorption process by P. lilacinus-SN-Cal-Alg beads was best described by the Langmuir model indicating that monolayer adsorption of Pb(II) ions takes place on the beads surfaces and showed that its maximum adsorption capacity was 282.49 mg/g.

17.
Ann Vasc Surg ; 62: 499.e5-499.e8, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31536792

RESUMO

PURPOSE: This case aimed to explore the clinical, histological, and immunohistochemical features of intravascular fasciitis (IVF) that involve a large blood vessel. CASE REPORT: A 27-year-old man presented with swelling and pain of the left lower limb for 5 days. The report of Doppler ultrasonography confirmed deep venous thrombosis (DVT) in the lower left limb (acute phase). However, laboratory value for the presence of D-dimer was negative. Thus, we performed an ascending venography and identified a mass in the common femoral vein. At operation, an incision of the left common femoral vein was made, and the mass was completely resected. CONCLUSIONS: The situation of IVF that grew in a large vein is extremely rare and can easily be misdiagnosed as DVT. The presence of D-dimer is important for a differential diagnosis. Ascending venography can be applied in making an accurate diagnosis.

18.
Materials (Basel) ; 12(23)2019 Nov 27.
Artigo em Inglês | MEDLINE | ID: mdl-31783630

RESUMO

Wet-laid hydroentangled nonwovens are widely used for disposable products, but these products generally do not have good dispersibility and can block sewage systems after being discarded into toilets. In this study, both pulp fibers and Danufil fibers are selected as we hypothesize that the high wet strength and striated surface of Danufil fibers would allow us to produce nonwovens with better dispersibility while having enough mechanical properties. The wet strength and dispersibility of nonwovens are systematically studied by investigating the influence of the fiber blend ratio, fiber length, and water jet pressure. The results indicate that the percent dispersion could be as high as 81.3% when the wet strength is higher than 4.8 N, which has been improved greatly comparing the percent dispersion of 67.6% reported before.

19.
Curr Drug Metab ; 20(13): 1073-1081, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31870260

RESUMO

BACKGROUND: ET-26 hydrochloride is a novel intravenous anesthetic, approved for clinical trials, that produces a desirable sedative-hypnotic effect with stable myocardial performance and mild adrenocortical suppression in rats and beagle dogs. The objective of this study was to assess the absorption, distribution, metabolism, and excretion of ET-26 hydrochloride. METHODS: Hepatocytes from human, monkey, dog, rat, and mouse were used to determine the metabolites of ET-26 hydrochloride. Distribution and excretion were assessed in rats and pharmacokinetic studies were performed in beagle dogs. RESULTS: The metabolic pathway and proposed structure of metabolites were fully assessed resulting from the biotransformation reactions of hydrolysis, dehydrogenation, demethylation and glucuronic acid conjugation. The main distribution of the drug was in fat (15067 ± 801 ng/ml) and liver (13647 ± 1126 ng/ml), and the kidney was the primary excretion route (4.47%-11.94%). The Cmax after injection with 1.045 mg/kg, 2.09 mg/kg, and 4.18 mg/kg was 1476.5 ± 138.9 ng/ml, 2846.1 ± 223.3 ng/ml, and 6233.3 ± 238.9 ng/ml, respectively. The t1/2 of the drug was similar across dose groups at 74.8 ± 10.8 min to 81.4 ± 4.2 min. The AUC0-t values were 30208.1 ± 2026.5 min*ng/ml, 62712.8 ± 1808.3 min*ng/ml, and 130465.2 ± 7457.4 min*ng/ml, respectively. CONCLUSION: The metabolic pathway and the proposed structure of metabolites for ET-26 hydrochloride were fully assessed. The majority of distribution for ET-26 hydrochloride occurs in the fat and liver, while the primary route of excretion for ET-26 hydrochloride is through the kidney. In dogs, pharmacokinetic features of ET-26 hydrochloride had a linear relationship with dosage.

20.
J Appl Toxicol ; 2019 Dec 22.
Artigo em Inglês | MEDLINE | ID: mdl-31867768

RESUMO

ET-26 hydrochloride (ET-26HCl) is a novel etomidate analogue, approved for clinical trials, which has an effective sedative-hypnotic effect, a stable myocardial performance, and milder adrenocortical suppression than etomidate in rats and beagle dogs. Additionally, ET-26HCl showed similar hemodynamic stability as etomidate in the rat uncontrolled hemorrhagic shock model. Furthermore, ET-26HCl, in the rat lipopolysaccharide-induced sepsis model, was found to have a higher survival rate, a lower inflammatory reaction, and less organ injury. In the present study, we measured the potential adverse effects of ET-26HCl in beagle dogs in accordance with the Guidance on single- and repeated-dose toxicity published by the China Food and Drug Administration. In toxicity studies, single and repeated (14 days) intravenous doses of up to 16 mg/kg were well tolerated, with only pharmacologically related clinical signs seen in both studies. Thus, the no-observed-adverse-effect level (NOAEL) of ET-26HCl was found at 16 mg/kg/day. Toxicokinetic examination demonstrated that ET-26HCl showed a dose-dependent increase to exposure, no gender difference, and no evidence of accumulation. These results provide useful information for guiding a phase I clinical trial of ET-26HCl in healthy volunteers.

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