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1.
Sci Total Environ ; 753: 142041, 2021 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-32906050

RESUMO

Over the last decade, microplastics (MPs, plastic particles <5 mm) as emerging contaminants have received a great deal of international attention, not only because of their continuous accumulation in both marine and terrestrial environment, but also due to their serious threats posed to the environment. Voluminous studies regarding sources, distribution characterization, and fate of MPs in the different environmental compartments (e.g., marine, freshwater, wastewater, and soil) have been reported since 2004, whereas MPs pollution in unique marine ecosystems (e.g., coastal mangrove habitat) receives little scientific attention. Mangrove ecosystem, an important buffer between the land and the sea, has been identified as a potential sink of MPs caused by both marine and land-based activities. Moreover, the source and distribution characteristics of MPs in this ecosystem are significantly different from other coastal habitats, mainly owing to its unique features of high productivity and biomass. With the impetus to provide a more integrated view of MPs pollution in mangrove habitats, a literature review was conducted based on the existing studies related to this topic. This is the first review to present the current state of MPs pollution in mangrove ecosystems, specially including (i) the possible sources of MPs in mangrove areas and their pathways entering into this habitat; (ii) MPs pollution in the different mangrove compartments (including surface seawater, sediments, and biotas); and (iii) factors influencing MPs distribution in mangrove areas. Toward that end, the research gaps are proposed to guide for future research priorities.

2.
J Surg Res ; 260: 350-358, 2020 Dec 28.
Artigo em Inglês | MEDLINE | ID: mdl-33383282

RESUMO

BACKGROUND: Intestinal ischemia/reperfusion (I/R) is a common clinical problem that occurs during various clinical pathological processes. Dexmedetomidine (DEX), a widely used anesthetic adjuvant agent, can induce protection against intestinal I/R in vivo; however, the underlying mechanism is not fully understood. In the present study, we aimed to investigate the protective effects of DEX and examine whether its mechanism was associated with the TLR4/MyD88/NF-κB signaling pathway. METHODS: Sprague-Dawley rats were pretreated with DEX and then subjected to I/R-induced intestinal injury. In vivo, intestinal histopathological examination and scoring were performed, the levels of serum intestinal fatty acid-binding protein (I-FABP), intestinal tumor necrosis factor-α (TNF-α), interleukin-1ß (IL-1ß), and expression levels of TLR4, MyD88, and NF-κB in the intestine were determined. In in vitro experiments, the human colon carcinoma cell line (Caco-2) was incubated with DEX before deprivation/reoxygenation (OGD/R) treatment. The cell viability of Caco-2 cells, the levels of lactate dehydrogenase (LDH), TNF-α, and IL-1ß in the supernatant, as well as protein expression of TLR4, MyD88, and NF-κB in Caco-2 cells, were measured. Statistical analysis was performed using SPSS version 21.0. RESULTS: DEX preconditioning significantly reduced the intestinal pathological Chiu's score, serum I-FABP, intestinal TNF-α, IL-1ß levels, and the protein expression of TLR4, MyD88, and NF-κB in the rats with intestinal I/R injury. Similarly, in vitro, DEX pretreatment protected against OGD/R-induced Caco-2 cell damage and inhibited TLR4/MyD88/NF-κB signaling, as evidenced by increased cell viability, decreased LDH activity, reduced TNF-α and IL-1ß levels, as well as downregulated TLR4, MyD88, and NF-κB protein levels. CONCLUSIONS: Our findings suggested that DEX could reduce intestinal I/R injury in rats and OGD/R damage in Caco-2 cells, and this protection might be attributed to antiinflammatory effects and inhibition of the TLR4/MyD88/NF-κB signaling pathway.

3.
ISA Trans ; 2020 Dec 13.
Artigo em Inglês | MEDLINE | ID: mdl-33334597

RESUMO

With high penetration of renewable energy sources in nested multiple-microgrids, conventional solutions for the integration of load frequency control and economic dispatch may degrade frequency control performance and decrease operational economy. In this paper, a fast frequency recovery-oriented distributed optimal control strategy is proposed to deal with these problems. Firstly, a partial primal-dual gradient algorithm is dynamically integrated with an active disturbance rejection control algorithm (instead of conventional Proportional-Integral (PI) controller) to realize the fast frequency recovery and enhance anti-disturbance capability. As a result, frequent adjustments of resources can be avoided and this is crucial in extending the life cycles of batteries. Then, based on the above integration, the distributed optimal control law is derived, which is independent of load measurement and fully distributed, to coordinate the microgrids to share their power economically during the frequency regulation process. This can also relieve the communication and computation burden of the system. Finally, a set of numerical simulations is presented and the effectiveness of the proposed distributed optimal control is verified by the obtained results, which include a comparison with the conventional distributed PI-based optimal control strategy.

4.
Small ; : e2006765, 2020 Dec 20.
Artigo em Inglês | MEDLINE | ID: mdl-33345467

RESUMO

2D layered photodetectors have been widely researched for intriguing optoelectronic properties but their application fields are limited by the bandgap. Extending the detection waveband can significantly enrich functionalities and applications of photodetectors. For example, after breaking through bandgap limitation, extrinsic Si photodetectors are used for short-wavelength infrared or even long-wavelength infrared detection. Utilizing extrinsic photoconduction to extend the detection waveband of 2D layered photodetectors is attractive and desirable. However, extrinsic photoconduction has yet not been observed in 2D layered materials. Here, extrinsic photoconduction-induced short-wavelength infrared photodetectors based on Ge-based chalcogenides are reported for the first time and the effectiveness of intrinsic point defects are demonstrated. The detection waveband of room-temperature extrinsic GeSe photodetectors with the assistance of Ge vacancies is broadened to 1.6 µm. Extrinsic GeSe photodetectors have an excellent external quantum efficiency (0.5%) at the communication band of 1.31 µm and polarization-resolved capability to subwaveband radiation. Moreover, room-temperature extrinsic GeS photodetectors with a detection waveband to the communication band of 1.55 µm further verify the versatility of intrinsic point defects. This approach provides design strategies to enrich the functionalities of 2D layered photodetectors.

6.
J Med Internet Res ; 22(12): e21687, 2020 Dec 09.
Artigo em Inglês | MEDLINE | ID: mdl-33295292

RESUMO

BACKGROUND: Well-designed mobile health (mHealth) interventions support a positive user experience; however, a high rate of disengagement has been reported as a common concern regarding mHealth interventions. To address this issue, it is necessary to summarize the design features that improve user engagement based on research over the past 10 years, during which time the popularity of mHealth interventions has rapidly increased due to the use of smartphones. OBJECTIVE: The aim of this review was to answer the question "Which design features improve user engagement with mHealth interventions?" by summarizing published literature with the purpose of guiding the design of future mHealth interventions. METHODS: This review followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) checklist. Databases, namely, PubMed, Web of Science, Cochrane Library, Ovid EMBASE, and Ovid PsycINFO, were searched for English and Chinese language papers published from January 2009 to June 2019. Thematic analysis was undertaken to assess the design features in eligible studies. The Mixed Methods Appraisal Tool was used to assess study quality. RESULTS: A total of 35 articles were included. The investigated mHealth interventions were mainly used in unhealthy lifestyle (n=17) and chronic disease (n=10) prevention programs. Mobile phone apps (n=24) were the most common delivery method. Qualitative (n=22) and mixed methods (n=9) designs were widely represented. We identified the following 7 themes that influenced user engagement: personalization (n=29), reinforcement (n=23), communication (n=20), navigation (n=17), credibility (n=16), message presentation (n=16), and interface aesthetics (n=7). A checklist was developed that contained these 7 design features and 29 corresponding specific implementations derived from the studies. CONCLUSIONS: This systematic review and thematic synthesis identified useful design features that make an mHealth intervention more user friendly. We generated a checklist with evidence-based items to enable developers to use our findings easily. Future evaluations should use more robust quantitative approaches to elucidate the relationships between design features and user engagement.

7.
Biomed Res Int ; 2020: 9568976, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33274232

RESUMO

There is growing evidence that microRNA-148b (miR-148b) can inhibit the growth of malignant cells while sirtuin 7 (SIRT7) may perform its carcinogenic effect by deacetylating H3K18. This study investigated the mechanism of miR-148b/SIRT7 on how it affects the malignant biological behavior of melanoma. It was established that the expression of miR-148b was downregulated in melanoma while that of SIRT7 was upregulated but negatively regulated by miR-148b through binding to the 3'UTR of SIRT7. Ectopic expression of miR-148b reduced the proliferation, migration, and invasion of melanoma cells, but SIRT7 reversed these functions of miR-148b. Moreover, tumor growth and metastasis experiments showed that miR-148b could significantly suppress proliferation and metastasis of melanoma in vivo. Overall, miR-148b inhibits the malignant biological behavior of melanoma by reducing the expression level of SIRT7. The development of miR-148b as a novel potential therapeutic approach for melanoma may be possible in the future.

8.
Medicine (Baltimore) ; 99(50): e23213, 2020 Dec 11.
Artigo em Inglês | MEDLINE | ID: mdl-33327239

RESUMO

Cryptococcosis caused by Cryptococcus gattii, is a life threatening fungal infection with recently increasing prevalence. C. gattii is a species complex comprising multiple independent species. However, many biological characteristics and clinical features of cryptococcosis due to C. gattii are relatively less well defined. In this paper, we identify two cases of C. gattii infection, and laboratory findings of genotype VGI and VGII in two groups of apparently immunocompetent Chinese individuals respectively. Upon detailed review of all 35 cases of C. gattii infections, it was observed that C. gattii can cause debilitating illness in both immunocompetent and immunocompromised individuals. Cryptococcosis due to C. gattii is a serious systemic fungal infection, with pulmonary central nervous system tropism. Epidemiologically, C. gattii infection is not only restricted in tropical and subtropical regions, but also in other geographical settings.


Assuntos
Infecções Fúngicas do Sistema Nervoso Central/diagnóstico , Criptococose/diagnóstico , Criptococose/microbiologia , Cryptococcus gattii/genética , Administração Intravenosa , Adolescente , Adulto , Idoso , Anfotericina B/administração & dosagem , Anfotericina B/uso terapêutico , Antifúngicos/administração & dosagem , Antifúngicos/uso terapêutico , Grupo com Ancestrais do Continente Asiático/genética , Infecções Fúngicas do Sistema Nervoso Central/líquido cefalorraquidiano , Infecções Fúngicas do Sistema Nervoso Central/epidemiologia , Infecções Fúngicas do Sistema Nervoso Central/microbiologia , Criptococose/líquido cefalorraquidiano , Criptococose/tratamento farmacológico , Quimioterapia Combinada , Feminino , Flucitosina/administração & dosagem , Flucitosina/uso terapêutico , Genótipo , Geografia , Humanos , Hospedeiro Imunocomprometido/imunologia , Masculino , Pessoa de Meia-Idade , Prevalência , Recidiva , Punção Espinal/métodos , Resultado do Tratamento , Recusa do Paciente ao Tratamento , Adulto Jovem
9.
Cell Rep ; 33(13): 108571, 2020 Dec 29.
Artigo em Inglês | MEDLINE | ID: mdl-33378668

RESUMO

Here, we report that functional heterogeneity of macrophages in cancer could be determined by the nature of their precursors: monocytes (Mons) and monocytic myeloid-derived suppressor cells (M-MDSCs). Macrophages that are differentiated from M-MDSCs, but not from Mons, are immune suppressive, with a genomic profile matching that of M-MDSCs. Immune-suppressive activity of M-MDSC-derived macrophages is dependent on the persistent expression of S100A9 protein in these cells. S100A9 also promotes M2 polarization of macrophages. Tissue-resident- and Mon-derived macrophages lack expression of this protein. S100A9-dependent immune-suppressive activity of macrophages involves transcription factor C/EBPß. The presence of S100A9-positive macrophages in tumor tissues is associated with shorter survival in patients with head and neck cancer and poor response to PD-1 antibody treatment in patients with metastatic melanoma. Thus, this study reveals the pathway of the development of immune-suppressive macrophages and suggests an approach to their selective targeting.

10.
Phys Rev Lett ; 125(18): 180501, 2020 Oct 30.
Artigo em Inglês | MEDLINE | ID: mdl-33196221

RESUMO

Adiabatic quantum computing enables the preparation of many-body ground states. Realization poses major experimental challenges: Direct analog implementation requires complex Hamiltonian engineering, while the digitized version needs deep quantum gate circuits. To bypass these obstacles, we suggest an adiabatic variational hybrid algorithm, which employs short quantum circuits and provides a systematic quantum adiabatic optimization of the circuit parameters. The quantum adiabatic theorem promises not only the ground state but also that the excited eigenstates can be found. We report the first experimental demonstration that many-body eigenstates can be efficiently prepared by an adiabatic variational algorithm assisted with a multiqubit superconducting coprocessor. We track the real-time evolution of the ground and excited states of transverse-field Ising spins with a fidelity that can reach about 99%.

11.
Nat Commun ; 11(1): 5888, 2020 Nov 18.
Artigo em Inglês | MEDLINE | ID: mdl-33208738

RESUMO

Moiré lattices formed in twisted van der Waals bilayers provide a unique, tunable platform to realize coupled electron or exciton lattices unavailable before. While twist angle between the bilayer has been shown to be a critical parameter in engineering the moiré potential and enabling novel phenomena in electronic moiré systems, a systematic experimental study as a function of twist angle is still missing. Here we show that not only are moiré excitons robust in bilayers of even large twist angles, but also properties of the moiré excitons are dependant on, and controllable by, the moiré reciprocal lattice period via twist-angle tuning. From the twist-angle dependence, we furthermore obtain the effective mass of the interlayer excitons and the electron inter-layer tunneling strength, which are difficult to measure experimentally otherwise. These findings pave the way for understanding and engineering rich moiré-lattice induced phenomena in angle-twisted semiconductor van der Waals heterostructures.

12.
Phys Rev Lett ; 125(17): 170503, 2020 Oct 23.
Artigo em Inglês | MEDLINE | ID: mdl-33156665

RESUMO

We report the analog simulation of an ergodic-localized junction by using an array of 12 coupled superconducting qubits. To perform the simulation, we fabricated a superconducting quantum processor that is divided into two domains: one is a driven domain representing an ergodic system, while the second is localized under the effect of disorder. Because of the overlap between localized and delocalized states, for a small disorder there is a proximity effect and localization is destroyed. To experimentally investigate this, we prepare a microwave excitation in the driven domain and explore how deep it can penetrate the disordered region by probing its dynamics. Furthermore, we perform an ensemble average over 50 realizations of disorder, which clearly shows the proximity effect. Our work opens a new avenue to build quantum simulators of driven-disordered systems with applications in condensed matter physics and material science.

13.
Front Neurol ; 11: 516211, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33123066

RESUMO

Objective: To summarize the characteristics of muscle-specific receptor tyrosine kinase antibody-positive myasthenia gravis (MuSK-MG) in Northeast China. Methods: We retrospectively collected 183 confirmed MG patients and divided them into three groups based on the type of serum antibodies: MuSK-MG (14 cases), acetylcholine receptor (AChR)-MG (130 cases), and double-seronegative (DSN)-MG (39 cases). The clinical, diagnostic, therapeutic, and prognosis data were analyzed. Results: MuSK antibody was detected in 26.7% of seronegative MG. The mean age of onset in MuSK-MG was 53.2 ± 13.6 years. Fifty percent of MuSK-MG patients with an onset symptom of pure ocular muscle weakness. The time from onset to other muscle groups' involvement and the time from onset to myasthenic crisis had no significant difference among the three groups (P > 0.05). The proportion of Osserman classification I in MuSK-MG group was lower than that in DSN-MG group. The proportion of Osserman classification IV in MuSK-MG group was higher than that in the other two groups. The incidences of other coexisting autoimmune diseases in MuSK-MG group were higher. Prognosis after the treatment of steroid combined with tacrolimus for MuSK-MG was similar to AChR-MG treated with steroid combined with an immunosuppressant agent (P > 0.05). Conclusion: Patients with MuSK-MG in Northeast China have a modestly later onset age and a proportion of patients may have a mild form of the disease with delayed disease progression. We confirmed the existence of a rare ocular MuSK-MG phenotype, a high proportion of coexisting with other autoimmune diseases, and a good response to steroids combined with tacrolimus for our MuSK-MG series.

14.
Genome Biol Evol ; 12(12): 2486-2490, 2020 Dec 06.
Artigo em Inglês | MEDLINE | ID: mdl-33045048

RESUMO

Dendrobium huoshanense is used to treat various diseases in traditional Chinese medicine. Recent studies have identified active components. However, the lack of genomic data limits research on the biosynthesis and application of these therapeutic ingredients. To address this issue, we generated the first chromosome-level genome assembly and annotation of D. huoshanense. We integrated PacBio sequencing data, Illumina paired-end sequencing data, and Hi-C sequencing data to assemble a 1.285 Gb genome, with contig and scaffold N50 lengths of 598 kb and 71.79 Mb, respectively. We annotated 21,070 protein-coding genes and 0.96 Gb transposable elements, constituting 74.92% of the whole assembly. In addition, we identified 252 genes responsible for polysaccharide biosynthesis by Kyoto Encyclopedia of Genes and Genomes functional annotation. Our data provide a basis for further functional studies, particularly those focused on genes related to glycan biosynthesis and metabolism, and have implications for both conservation and medicine.

15.
J Glob Antimicrob Resist ; 23: 251-255, 2020 Oct 09.
Artigo em Inglês | MEDLINE | ID: mdl-33045440

RESUMO

OBJECTIVES: The aim of this study was to investigate the presence and genetic environment of the multiresistance gene cfr gene in Pasteurella multocida of avian origin from China. METHODS: A total of 113 P. multocida isolates were collected from sick poultries (ducks, chickens and geese) from 2003 to 2016 in Southern China and were screened for the presence of the cfr gene by PCR. The cfr-carrying P. multocida strains were subjected to antimicrobial susceptibility testing, S1 nuclease PFGE and Southern blot hybridisation, conjugative transfer and analysis of genetic environment of the cfr gene. RESULTS: Among 113 P. multocida isolates, strains FJ6671 and FJ6683 from Muscovy duck harboured the cfr gene and presented a multiresistant phenotype. The cfr gene in the two strains was located on an ∼40-kb conjugative plasmid in different genetic environments, including ISApl12-cfr-IS26 and IS26-cfr-IS256. CONCLUSIONS: These results demonstrate plasmid-carried cfr in P. multocida and suggest that transposition and homologous recombination mediated by IS26, ISApl1 and IS256 might have played an important role in transfer of the cfr gene in P. multocida. To the best of our knowledge, this is the first report of the cfr gene in P. multocida. Active and ongoing surveillance of cfr in P. multocida is urgently warranted.

16.
Virol Sin ; 2020 Oct 19.
Artigo em Inglês | MEDLINE | ID: mdl-33074475

RESUMO

Hantavirus infection is a global health challenge, causing widespread public concern. In recent years, cases of hantavirus infection in pregnant women have been reported in many countries. The infected pregnant women and their fetuses appear to have more severe clinical symptoms and worse clinical outcomes. Hence, to study the prevalence of hantavirus infection in pregnant women, this study will focus on the epidemiological distribution of the virus, different virus species penetrating the placental barrier, and factors affecting the incidence and clinical outcome of the infection in pregnant women and their fetuses. In addition, this review will also discuss the diagnostic tools and treatments for pregnant patients and provide an overview of the relevant future research.

17.
Nat Commun ; 11(1): 4946, 2020 10 02.
Artigo em Inglês | MEDLINE | ID: mdl-33009409

RESUMO

Immune-related adverse events (irAEs), caused by anti-PD-1/PD-L1 antibodies, can lead to fulminant and even fatal consequences and thus require early detection and aggressive management. However, a comprehensive approach to identify biomarkers of irAE is lacking. Here, we utilize a strategy that combines pharmacovigilance data and omics data, and evaluate associations between multi-omics factors and irAE reporting odds ratio across different cancer types. We identify a bivariate regression model of LCP1 and ADPGK that can accurately predict irAE. We further validate LCP1 and ADPGK as biomarkers in an independent patient-level cohort. Our approach provides a method for identifying potential biomarkers of irAE in cancer immunotherapy using both pharmacovigilance data and multi-omics data.


Assuntos
Genômica , Imunoterapia/efeitos adversos , Neoplasias/imunologia , Neoplasias/terapia , Biomarcadores Tumorais/metabolismo , Estudos de Coortes , Análise Fatorial , Humanos , Proteínas dos Microfilamentos/metabolismo , Reprodutibilidade dos Testes
18.
Front Neurosci ; 14: 754, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32903801

RESUMO

It has been reported that one night of acute sleep deprivation (SD) could induce brain structural changes at the synaptic and neuronal levels in animal studies, and could lead to white matter microstructure and cortical thickness change in human neuroimaging studies. In this study, we focused on changes of brain gray matter density (GMD) after one night of acute SD, which has not been explored previously. Twenty-three normal young participants completed the experiment. Each participant underwent twice T1-weighted structural image scanning with one at 08:00 after normal sleep [resting wakeful (RW)] and the other at 08:00 after 24 h of SD. Using voxel-based morphometry (VBM) analysis by FSL-VBM software, we compared GMD between RW and SD. In addition, the gray matter volume (GMV) and cortical thickness (CT) were also calculated based on volumetric and surface measures with FreeSurfer software. The psychomotor vigilance test (PVT) and the Karolinska Sleepiness Scale (KSS) were performed and evaluated for correlation analysis with GMD, GMV, and CT of the significant regions. Our results showed that the GMD in the right frontal pole (FP), right superior frontal gyrus (SFG), and right middle frontal gyrus significantly increased and GMV and CT in the right temporal pole (TP) significantly decreased after 24 h of acute SD. SD-induced changes in GMD in the right middle frontal gyrus were positively correlated with the changes of KSS scores (Spearman's correlation r = 0.625, p = 0.0014, Bonferroni correction with p < 0.05/25). Taken together, our findings suggested that one night of acute SD could induce substantial brain structure changes and the alterations in GMD in the right middle frontal gyrus (MFG) might be implicated in sleepiness after SD.

19.
Surg Oncol ; 34: 256-260, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32891339

RESUMO

PURPOSE: this study attempts to identify the independent risk factors that can predict lymph node metastasis for the patients with non-small cell lung cancer (NSCLC), and guide doctor adoption of individualized treatment for such patients. MATERIALS AND METHODS: This study was approved by the Hospital's Ethics Committee and all patients had signed informed consent forms. We retrospectively reviewed NSCLC patients who had undergone surgical resection from December 2008 to December 2013.The statistical significance of evaluation variables and lymph node metastasis was determined with Pearson's Chi-square test. The risk factors of lymph node metastasis were determined through univariate and multivariate logistic regression analysis. And for the age and tumor diameter factors, optimal cutoff points were determined with a receiver operating characteristic analysis. RESULTS: In the present study, a total of 2623 patients were included in the study, and 779 patients with lymph node metastasis. Three independent risk factors were identified: age, tumor diameter and Ki-67 index. We found that <65 years of age (Adjusted-OR:1.921), ≥2.85 cm of tumor diameter (Adjusted-OR:3.141), and 5%~25% in Ki-67 group (Adjusted-OR:2.137),≥25% (Adjusted-OR:3.341) were significant. Also we found that 307 patients with lymph node metastasis and the lymph node metastasis rate was 51.0%, when the age<65 years, Ki-67 index≥25%, and the tumor diameter≥2.85 cm. On the contrary, there were only 2 patients with lymph node metastasis, and the rate of lymph node metastasis was 5.1%. CONCLUSION: Identifying three independent risk factors that predict lymph node metastasis in non-small cell patients, Among NSCLC patients in whom all three predictors were identified, and over a half of the patients showed lymph node metastasis.

20.
Environ Health Prev Med ; 25(1): 51, 2020 Sep 10.
Artigo em Inglês | MEDLINE | ID: mdl-32912134

RESUMO

BACKGROUND: China has the largest elderly population in the world; little attention has been paid to the mental health of elderly in areas of extreme poverty. This is the first study to investigate the mental health of the rural elderly in poverty state counties in Chongqing and was part of the Chongqing 2018 health literacy promotion project. METHODS: In 2019, a cross-sectional study was conducted to investigate the mental health status of the rural elderly in fourteen poverty state counties of Chongqing, in which a total of 1400 elderly aged ≥ 65 years were interviewed, where mental health status was measured by the ten-item Kessler10 (K10) scale. Ordered multivariate logistic regression was performed to evaluate the influencing factors related to mental health of the elderly in these areas. RESULTS: The average score of K10 in 14 poverty state counties was 17.40 ± 6.31, 47.6% was labeled as good, 30.2% was moderate, 17.0% was poor, and lastly 5.1% was bad, and the mental health status of the elderly in the northeastern wing of Chongqing was better than the one in the southeastern wing of Chongqing. A worse self-rated health was the risk factor for mental health both in the northeastern and southeastern wings of Chongqing (all P < 0.001). Lower education level (OR (95% CI) = 1.45 (1.12-1.87), P = 0.004) was a risk factor in the northeastern wing, whereas older age (OR (95% CI) = 1.33 (1.13-1.56), P = 0.001) was a risk factors in the southeastern wing. CONCLUSIONS: The results showed that mental health of the elderly in poverty state counties was poor, especially in the southeastern wing of Chongqing. Particular attention needs to be paid to the males who were less educated, older, and single; female with lower annual per capital income; and especially the elderly with poor self-rated health.


Assuntos
Saúde Mental/estatística & dados numéricos , População Rural/estatística & dados numéricos , Fatores Socioeconômicos , Idoso , Idoso de 80 Anos ou mais , China , Estudos Transversais , Feminino , Política de Saúde , Humanos , Modelos Logísticos , Masculino , Análise Multivariada
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