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Ying Yong Sheng Tai Xue Bao ; 29(7): 2269-2276, 2018 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-30039665


An experiment was conducted to examine the differences of soil microbial diversity across different land use patterns in montane region of eastern Liaoning Province, China. The relationships between soil physicochemical properties and soil microbial diversity in five different land use types, including Quercus mongolic forest, shrubland, Larix gmelinii plantation, Pinus koraiensis plantation, and Zea mays cropland were analyzed by Biolog-Eco method. The results showed that both soil total C and N contents were the highest in the Q. mongolica forest, which were 57.74 and 4.40 g·kg-1, followed by shrubland, but only 17.46 and 1.31 g·kg-1 in the Z. mays cropland, respectively. There were significant differences in microbial utilization rate of different land use types. The carbon utilization capacity by soil microbial communities was following the order of Q. mongolica forest > shrubland > L. gmelinii plantation > P. koraiensis plantation > Z. mays cropland, indicating that soil microbial metabolism and activity in Z. mays cropland were the lowest. The Shannon diversity index (2.997), Simpson diversity index (0.942) and McIntosh diversity index (5.256) of soil microbial community in the Z. mays cropland were significantly lower than those in other ecosystems. The average absorbance value (AWCD) was associated with Simpson diversity index and McIntosh diversity index. Esters, alcohols and amines were the primary carbon sources for the differentiation, which might be due to a joint action of many factors such as litter, soil nutrients, and specific soil microorganisms. The soil nutrient and soil microbial community diversity in forest land after reclamation sharply decreased, causing the loss of soil fertility and productivity. The region should keep the Q. mongolica forest, which could help restore soil fertility.

Agricultura , Ecossistema , Microbiologia do Solo , Carbono , China , Florestas , Solo
Int J Nanomedicine ; 12: 2443-2456, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28408816


Spinal cord injury (SCI) commonly leads to lifelong disability due to the limited regenerative capacity of the adult central nervous system. Nanomicelles can be used as therapeutic systems to provide effective treatments for SCI. In this study, a novel triblock monomethyl poly(ethylene glycol)-poly(l-lactide)-poly(trimethylene carbonate) copolymer was successfully synthesized. Next, polymeric nanomicelles loaded with zonisamide (ZNS), a Food and Drug Administration-approved antiepileptic drug, were prepared and characterized. The ZNS-loaded micelles (ZNS-M) were further utilized for the treatment of SCI in vitro and in vivo. The obtained ZNS-M were ~50 nm in diameter with good solubility and dispersibility. Additionally, these controlled-release micelles showed significant antioxidative and neuron-protective effects in vitro. Finally, our results indicated that ZNS-M treatment could promote motor function recovery and could increase neuron and axon density in a hemisection SCI model. In summary, these results may provide an experimental basis for the use of ZNS-M as a clinically applicable therapeutic drug for the treatment of SCI in the future.

Sistemas de Liberação de Medicamentos , Isoxazóis/uso terapêutico , Micelas , Nanopartículas/química , Polímeros/química , Traumatismos da Medula Espinal/tratamento farmacológico , Doença Aguda , Animais , Antioxidantes/farmacologia , Axônios/efeitos dos fármacos , Axônios/patologia , Barreira Hematoencefálica/efeitos dos fármacos , Barreira Hematoencefálica/patologia , Morte Celular/efeitos dos fármacos , Cromatografia em Gel , Dioxanos/síntese química , Dioxanos/química , Portadores de Fármacos , Liberação Controlada de Fármacos , Imagem por Ressonância Magnética , Camundongos , Poliésteres/síntese química , Poliésteres/química , Polietilenoglicóis/síntese química , Polietilenoglicóis/química , Espectroscopia de Prótons por Ressonância Magnética , Ratos Sprague-Dawley , Espectroscopia de Infravermelho com Transformada de Fourier , Difração de Raios X , Zonisamida