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1.
Int J Surg Case Rep ; 94: 107121, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35658292

RESUMO

INTRODUCTION: Lipomas are one of the most common benign tumors, but deep tissue and huge lipomas are rare. PRESENTATION OF CASE: A 59-year-old middle-aged woman was admitted to hospital for right hip mass resection because of numbness and pain in her right lower limb for 6 months. Ultrasound and nuclear magnetic resonance imaging (MRI) showed irregular mass. On the assumption of malignancy, the patient underwent a right hip mass resection and returned to normal with no short-term or long-term response. HE (hematoxylin-eosin) staining of the tumor showed the characteristics of a benign tumor. DISCUSSION: The pathogenesis of myolipoma is not clear, and it may be related to brown adipose tissue. When lipoma is huge, it needs interventional treatment. Complete encapsulated myolipoma can usually be completely removed, with low recurrence possibility and good prognosis. CONCLUSION: Giant intramuscular lipoma of hip and its clinical manifestations are relatively rare. And the results of ultrasound imaging are similar to those of the surrounding normal adipose tissue. No significant difference was observed by naked eye. In particular, postoperative pathological examination is needed to make a definite diagnosis and differential diagnosis. Clinically, surgical treatment is often used, and the prognosis is good, but recurrence is possible. The following report discusses the experience of one of our patients, with literature review.

2.
Materials (Basel) ; 15(11)2022 May 31.
Artigo em Inglês | MEDLINE | ID: mdl-35683231

RESUMO

Conventional neural networks tend to fall into local extremum on large datasets, while the research on the strength of rubber concrete using intelligent algorithms to optimize artificial neural networks is limited. Therefore, to improve the prediction accuracy of rubber concrete strength, an artificial neural network model with hybrid algorithm optimization was developed in this study. The main strategy is to mix the simulated annealing (SA) algorithm with the particle swarm optimization (PSO) algorithm, using the SA algorithm to compensate for the weak global search capability of the PSO algorithm at a later stage while changing the inertia factor of the PSO algorithm to an adaptive state. For this purpose, data were first collected from the published literature to create a database. Next, ANN and PSO-ANN models are also built for comparison while four evaluation metrics, MSE, RMSE, MAE, and R2, were used to assess the model performance. Finally, compared with empirical formulations and other neural network models, the result shows that the proposed optimized artificial neural network model successfully improves the accuracy of predicting the strength of rubber concrete. This provides a new option for predicting the strength of rubber concrete.

3.
Transl Pediatr ; 11(5): 642-650, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35685069

RESUMO

Background: Acute lymphoblastic leukemia (ALL) is one of the most common malignant diseases of the hematopoietic system in children. Although the etiology of ALL is unknown, it has been reported that it may be associated with Epstein-Barr virus (EBV) infection. The aim of this study was to analyze the impact of EBV infection on the clinical features and prognosis of childhood ALL. Methods: A total of 162 children with ALL admitted to Heilongjiang Provincial Hospital from January 2018 to December 2020 were selected for this stud, and were divided into 2 groups, infected group and non-infected group, according to whether they had EBV infection. Differences in clinical characteristics between the 2 groups were analyzed by χ2 or t-test. The impact of EBV infection on the prognosis of children was analyzed by Kaplan-Meier survival and Cox regression analysis. Results: The 2 groups were statistically significantly different (P<0.05) according to comparison of characteristics such as first symptoms, karyotype, immunophenotyping, clinical risk, whether secondary infection occurred during chemotherapy, and lymphocyte subsets. Logistic regression results suggested that first symptoms, karyotype, immunophenotyping, clinical risk, the presence of secondary infection during chemotherapy, and lymphocyte subsets were independently associated with EBV infection in children with ALL (P<0.05). The complete remission rate at 46 days after chemotherapy, event-free survival (EFS), overall survival (OS), and survival rate were lower in the infected group than non-infected group, and the complete remission recurrence rate was higher than non-infected group (P<0.05). The EBV DNA levels were statistically lower in the good prognosis group (1.07±0.25×103 copies/L) than poor prognosis group (8.86±1.14 ×103 copies/L) (P<0.01). The area under the curve (AUC) for EBV to predict prognosis in children with ALL was 0.921, sensitivity and sensitivity were 86.57%, 80.16%. Conclusions: Infection with EBV is associated with first symptoms, karyotype, immunophenotyping, clinical risk, secondary infection during chemotherapy, and lymphocyte subpopulation index levels in children with ALL, and children with EBV infection have a reduced clinical remission rate and poor prognosis. Therefore, the detection of EBV DNA is clinically important for assessing the prognosis of their disease.

4.
Emerg Microbes Infect ; : 1-44, 2022 Jun 10.
Artigo em Inglês | MEDLINE | ID: mdl-35686572

RESUMO

Waning of neutralizing titers along with decline of protection efficacy after the second dose of COVID-19 vaccines was observed, including China-made inactivated vaccines. Efficacy of a heterologous boosting using one dose of a recombinant SARS-CoV-2 fusion protein vaccine (V-01) in inactivated vaccine-primed population was studied, aimed to restore the immunity. A randomized, double-blind and placebo-controlled phase Ⅲ trial was conducted in healthy people aged 18 years or older in Pakistan and Malaysia. Each eligible participant received one dose of V-01 vaccine developed by Livzon Mabpharm Inc. or placebo within the3-6 months after the 2-dose primary regimen, and was monitored for safety and efficacy. The primary endpoint was protection against confirmed symptomatic SARS-CoV-2 infection. A total of 10,218 participants were randomly assigned to receive vaccine or placebo. Virus-neutralizing antibodies were assessed in 419 participants. A dramatic increase (11.3-fold; 128.3 to 1452.8) of neutralizing titers was measured in V-01 group at 14 days after the booster. Over two months of surveillance, vaccine efficacy was 47.8% (95%CI: 22.6 to 64.7) according to the intention-to-treat principle. The most common adverse events were transient, mild-to-moderate pain at the injection site, fever, headache, and fatigue. Serious adverse events occurred almost equally in V-01 (0.12%) and placebo (0.16%) groups. The heterologous boosting with V-01 vaccine was safe and efficacious, which could elicit robust humoral immunity under the epidemic of the Omicron variant.

5.
Sci China Life Sci ; 2022 Jun 09.
Artigo em Inglês | MEDLINE | ID: mdl-35696017

RESUMO

Enterovirus A71 (EV-A71) causes major outbreaks of hand, foot, and mouth disease (HFMD) in many countries, most frequently affecting children, and a small proportion of cases may lead to death. Currently, no vaccine is available in most endemic regions, and no licenced treatments for EV-A71 infection are available. Here, we characterize a human monoclonal antibody (HuMAb), E1, by screening a Fab antibody phage library derived from patients who recovered from EV-A71 infection. E1 exhibits strong neutralizing activity against EV-A71 virus in cells. The cryo-electron microscopy (cryo-EM) structures of the EV-A71 virion in complex with E1 Fab fragments demonstrated that E1 recognized an epitope formed by residues in the BC and HI loops of VP1. In a mouse model, E1 effectively protected against lethal EV-A71 challenge in both prophylactic and therapeutic treatment. In particular, E1 significantly reduces virus titers and muscle damage. E1 might represent a potential adjunct to EV-A71 treatment.

6.
Front Nutr ; 9: 821272, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35651504

RESUMO

Resveratrol (RSV) is a natural polyphenolic compound with potent antioxidant and anti-inflammatory properties. This study aimed to investigate the protective effects of RSV supplementation on the inflammatory responses of broilers during heat stress. A total of 432 28-d-old white-feathered broilers (817 crossbred chicken) with an average weight of 549 ± 4 g were randomly allotted to 4 equal groups (Half male and half female, 6 replicates/group, 18 chickens/replicate), including normal temperature (NT) group (24 ± 2°C for 24 h/d, basal diet), NT+RSV group (24 ± 2°C for 24 h/d, basal diet + RSV), heat stress (HT) group (37 ± 2°C for 8 h/d, basal diet), and HT+RSV group (37 ± 2°C for 8 h/d, basal diet + RSV). Serum samples were collected on d 7 and 14 of heat stress, and thymus, spleen, jejunum, and bursa of Fabricius samples were collected and analyzed on d14. RSV treatment decreased the feed conversion ratio, partially reversed the negative alternations in body weight, average daily gain, and average daily feed intake caused by heat stress. RSV treatment also decreased the elevated levels of corticosterone on d 14, adrenocorticotropic hormone, and triiodothyronine in serum on d 7 caused by heat stress, and significantly increased the villus height to crypt depth ratio in the jejunum on d 14. Dietary RSV also reduced heat stress-induced splenic pro-inflammatory cytokine concentrations. TUNEL assay showed that RSV significantly reduced heat stress-induced the number of apoptotic cells. Remarkably, RSV down-regulated some splenic related genes for apoptosis genes, including BCL-2, Apaf-1, and MDM2 mRNA levels induced by heat stress. According to GO and KEGG enrichment analyses, the differential genes between HT and HT + RSV groups were mainly associated with immune system process, hematopoietic or lymphoid organ development, and toll-like receptor signaling pathway. The relative mRNA expression of NF-κB, heat shock protein 70 (HSP70), and p38 MAPK were markedly decreased by the combination of RSV and heat stress. These findings showed that RSV might reduce the splenic inflammatory response in heat-stressed white-feather broilers by inhibiting heat stress-induced activation of NF-B, MAPK, and HSP70, as well as inhibiting the activation of mitochondrial apoptotic pathways.

7.
Angew Chem Int Ed Engl ; : e202204700, 2022 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-35642623

RESUMO

Introducing magnetic switchability into artificial molecular machines is fascinating for precise control of magnetism via external stimuli. Herein, a field-induced CoII single-molecule magnet was found to exhibit the reversible switch of Jahn-Teller distortion near room temperature, along with thermal conformational motion of the 18-crown-6 rotor, which pulls the coordinated H2 O to rotate through intermolecular hydrogen bonds and triggers a single-crystal-to-single-crystal phase transition with Twarm =282 K and Tcool =276 K. Interestingly, the molecular magnetic anisotropy probed by single-crystal angular-resolved magnetometry revealed the reorientation of easy axis by 14.6°. Moreover, ON/OFF negative magnetodielectric effects were respectively observed in the high-/low-temperature phase, which manifests the spin-lattice interaction in the high-temperature phase could be stronger, in accompanied by the hydrogen bonding between the rotating 18-crown-6 and the coordinated H2 O.

8.
Front Neurol ; 13: 907410, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35720074

RESUMO

Background: A link between body temperature and stroke outcomes has been established but not for acute basilar artery occlusion. We aimed to determine the association between body temperature and clinical outcomes in patients with acute basilar artery occlusion and temperature management range. Methods: We included patients from the Endovascular Treatment for Acute Basilar Artery Occlusion Study (BASILAR) database with records of both admission body temperature (ABT) and peak body temperature (PBT). ABT was defined as the body temperature first measured at the hospital visit, PBT was defined as the highest temperature within 24 h of treatment, and minus body temperature (MBT) was defined as PBT-ABT. The primary clinical outcome was favorable functional outcome, defined as the proportion of patients with a modified Rankin Scale score of 0-3 at 3 months. Secondary outcomes included 3-month mortality, in-hospital mortality, and symptomatic cerebral hemorrhage. Results: A total of 664 patients were enrolled in the study; 74.7% were men, with a median age of 65 (interquartile range, 57.25-74) years. In all patients, multivariate analysis indicated that PBT and MBT were independent predictors of favorable functional outcome [odds ratio (OR), 0.57 (95% CI, 0.43-0.77); OR, 0.68 (95% CI, 0.52-0.88), respectively], and higher ABT, PBT, and MBT were associated with an increased 3-month mortality [OR, 1.47 (95% CI, 1.03-2.10), OR, 1.58 (95% CI, 1.28-1.96), OR, 1.35 (95% CI, 1.11-1.65), respectively]. Proportional odds models demonstrated that when ABT, PBT, MBT were in the range of <37.5, <38.9, and -0.6-2.7°C, respectively, the benefit of the endovascular treatment is clearly greater than that of standard medical treatment in terms of favorable functional outcome. Conclusions: Body temperature is an independent predictor of clinical outcome in patients with acute basilar artery occlusion. It is necessary to control the patient body temperature within the appropriate range in clinical settings. Trial Registration: Chinese Clinical Trial Registry ChiCTR1800014759. Registered 03 February 2018. Retrospectively registered.

9.
Sci Total Environ ; 838(Pt 3): 156431, 2022 Jun 02.
Artigo em Inglês | MEDLINE | ID: mdl-35660611

RESUMO

Straw burning comprises more than 30% of all types of burned biomass in Asia, while the estimation of the emitted aerosols' direct radiative forcing effect suffers from large uncertainties, especially when atmospheric aging processes are considered. In this study, the light absorption properties of primary and aged straw burning aerosols in open fire were characterized at 7 wavelengths ranging from 370 nm to 950 nm in a chamber. The primary rice, corn and wheat straw burning bulk aerosols together had a mass absorption efficiency (MAE) of 2.43 ± 1.36 m2 g-1 at 520 nm and an absorption Ångström exponent (AAE) of 1.93 ± 0.71, while the primary sorghum straw burning bulk aerosols were characterized by a relatively lower MAE of 0.95 ± 0.54 m2 g-1 and a higher AAE of 4.80 ± 0.68. Both the MAE and AAE of primary aerosols can be well parameterized by the (PM-BC)/BC ratio (in wt.). The MAE of black carbon (BC) increased by 11-190% during photoreactions equivalent to 16-60 h of atmospheric aging, which was positively correlated with the (PM-BC)/(BC) ratio. The MAE of organic aerosols first slightly increased or leveled off, and then decreased. Specifically, at 370 nm, the first growth/plateau stage lasted until OH exposure reached 0.47-1.29 × 1011 molecule cm-3 s, and the following period exhibited decay rates of 1.0-2.8 × 10-12 cm3 molecule-1 s-1 against the OH radical, corresponding to half-lives of 46-134 h in a typical ambient condition. During photoreactions, competition among the lensing effect, growth/bleach of organic chromophores, and particle mass and size growth complicated the evolution of the direct radiative forcing effect. It is concluded that rice and corn straw burning aerosols maintained a warming effect after aging, while the cooling effect of fresh sorghum straw burning aerosols increased with aging.

10.
BMC Med ; 20(1): 169, 2022 05 09.
Artigo em Inglês | MEDLINE | ID: mdl-35527273

RESUMO

BACKGROUND: Identifying the causal genes at the risk loci and elucidating their roles in schizophrenia (SCZ) pathogenesis remain significant challenges. To explore risk variants associated with gene expression in the human brain and to identify genes whose expression change may contribute to the susceptibility of SCZ, here we report a comprehensive integrative study on SCZ. METHODS: We systematically integrated the genetic associations from a large-scale SCZ GWAS (N = 56,418) and brain expression quantitative trait loci (eQTL) data (N = 175) using a Bayesian statistical framework (Sherlock) and Summary data-based Mendelian Randomization (SMR). We also measured brain structure of 86 first-episode antipsychotic-naive schizophrenia patients and 152 healthy controls with the structural MRI. RESULTS: Both Sherlock (P = 3. 38 × 10-6) and SMR (P = 1. 90 × 10-8) analyses showed that TYW5 mRNA expression was significantly associated with risk of SCZ. Brain-based studies also identified a significant association between TYW5 protein abundance and SCZ. The single-nucleotide polymorphism rs203772 showed significant association with SCZ and the risk allele is associated with higher transcriptional level of TYW5 in the prefrontal cortex. We further found that TYW5 was significantly upregulated in the brain tissues of SCZ cases compared with controls. In addition, TYW5 expression was also significantly higher in neurons induced from pluripotent stem cells of schizophrenia cases compared with controls. Finally, combining analysis of genotyping and MRI data showed that rs203772 was significantly associated with gray matter volume of the right middle frontal gyrus and left precuneus. CONCLUSIONS: We confirmed that TYW5 is a risk gene for SCZ. Our results provide useful information toward a better understanding of the genetic mechanism of TYW5 in risk of SCZ.


Assuntos
Oxigenases de Função Mista , Esquizofrenia , Teorema de Bayes , Predisposição Genética para Doença , Estudo de Associação Genômica Ampla , Humanos , Oxigenases de Função Mista/genética , Polimorfismo de Nucleotídeo Único , Locos de Características Quantitativas , Esquizofrenia/diagnóstico por imagem , Esquizofrenia/genética
11.
J Colloid Interface Sci ; 623: 109-123, 2022 Apr 29.
Artigo em Inglês | MEDLINE | ID: mdl-35569220

RESUMO

In this work, a novel hierarchical 1D/2D core/shell Sb2S3-ZnIn2S4 (SB-ZIS) heterostructure with highly efficient photocatalytic activities for both hydrogen production from water and organic pollutant degradation was designed and fabricated via a simple one-step hydrothermal method. The as-prepared SB-ZIS heterostructure, where ZnIn2S4 nanosheets uniformly grew onto Sb2S3 nanorod to form a tight and large intimate contacted interface, was conducive to improve the absorption capacity of light, increase the surface area, shorten the distance of electronic transmission channels and accelerate the separation and migration of photogenerated carriers. As a result, the presented SB-ZIS composites demonstrated significantly enhanced photocatalytic performances for H2 generation and Tetracycline Hydrochloride (TCH) photodegradation. The photocatalytic H2 production rate of optimal SB-ZIS-2 sample (1685.14 µmol·g-1·h-1) was about 12.24 times as large as that of pure ZnIn2S4 (137.63 µmol·g-1·h-1). The apparent quantum efficiency (AQE) at 420 nm was up to 3.8%. In addition, the highest rate constant for TCH removal (0.514 h-1) was 20.3 and 2.89 times larger than those of pure Sb2S3 and Znln2S4, respectively. The possible reaction routes of TCH and the photocatalytic reaction mechanism of SB-ZIS sample were also discussed in detail. This work will provide some useful information for the development of dual-functional Sb2S3-based type I core-shell heterostructure with an efficient photocatalytic activity for solving environmental pollution and producing clean hydrogen energy.

12.
Med Eng Phys ; 104: 103809, 2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-35641074

RESUMO

A numerical simulation was performed to clarify renal blood flow determination by the vascular structures. Large and small vessels were modeled as symmetric and asymmetric branching vessels, respectively, with simple geometries to parameterize the vascular structures. Modeling individual vessels as straight pipes, Murray's law was used to determine the vessel diameters. Blood flow in the vascular structure was calculated by network analysis based on Hagen-Poiseuille's law. Blood flow simulations for a vascular network segment demonstrated that blood flow rate and pressure vary within the same-generation vessels because of an asymmetric vessel branch while they generally tend to decrease with vessel diameter; thus, the standard deviation of flow rate relative to the mean (relative standard deviation [RSD]) increased from 0.4 to 1.0 when the number of the daughter vessels increased from 3 to 10. Blood flow simulations for an entire vascular network of a kidney showed that the vessel number and branching style, rather than Strahler order, are major parameters in successfully reproducing renal blood flow measured in published experiments. The entire vascular network could generate variation in the physiological flow rate in afferent arterioles at 0.2-0.38 in RSD, which is at least compatible with 0.16 by diameter variation within the same-generation vessels.


Assuntos
Hemodinâmica , Modelos Cardiovasculares , Simulação por Computador , Rim , Circulação Renal
13.
Phys Chem Chem Phys ; 24(18): 10838-10850, 2022 May 11.
Artigo em Inglês | MEDLINE | ID: mdl-35506176

RESUMO

Although reasonably specified and adjustable preparation of nanostructures with specific morphologies, ordered chemical compositions and electronic structures involving advanced energy chemistries is an important research area, high-efficiency, stable, and low-cost electrocatalysts for water splitting are greatly desirable and challenging. In this study, partially delocalized Co-S-Se ultra-thin nanosheets are obtained via a liquid-liquid interface-mediated strategy at an oil-water interface. These Co-S-Se ultra-thin nanosheets exhibit different-sized lamellar structures and have an average thickness of 0.83 nm. The ternary ultra-thin Co0.45S0.38Se0.17 nanosheets demonstrate excellent performance for the OER, accompanied by an overpotential of 290 mV (1.52 V vs. RHE) at 10 mA cm-2, and a Tafel slope of 74.5 mV dec-1. In the meantime, the catalyst recombined with a stoichiometry NiOx catalyst to form a composite interface, which also exhibited a good OER performance, with an overpotential of 260 mV at 10 mA cm-2 and a smaller Tafel slope of 53.9 mV dec-1. The nanosheets can rearrange the electronic density near the metal catalytic centers and increase the electron transfer. DFT calculations indicate that the partially delocalized charges can improve electrocatalytic performances, demonstrating modulated electroreduction properties. Due to the special atomic and electronic structure of the ternary transition metal alloy chalcogenide, the compound has great potential for energy storage, which will help in the rational design and synthesis of high-efficiency electrocatalysts.

14.
Artigo em Inglês | MEDLINE | ID: mdl-35513614

RESUMO

The notion of ecological networks (EN) and their identification can support approaches to nature conservation strategies aiming at biodiversity, landscape connectivity, and people's well-being. Integrating ecosystem services (ESs), morphological spatial pattern analysis (MSPA), circuit theory, and landscape pattern index analysis, we proposed a new framework for mapping EN that was expected to promote economic development and ecological protection. Specifically, source areas were extracted through a combination of ESs and MSPA that integrated functional and morphological spatial attributes. Resistance surfaces were determined based on habitat quality. A network linking ecological source areas was then identified using circuit theory, and landscape pattern index analysis was used to identify ecological strategy nodes in view of the heterogeneity within ecological corridors. The results showed that the Sichuan Basin involved 553 ecological sources, 641 ecological corridors, and 33 ecological nodes that altogether included 20 ecological strategy nodes. Constructing regional EN can promote the transformation of multiple, chaotic, and scattered ecological elements to systematic and networked ecological elements and ultimately promote harmonious coexistence between humans and nature. This study provided a methodology for the extraction of ecological source areas and strategy nodes and can provide a significant reference for the management and optimization of EN.

15.
Zhongguo Zhong Yao Za Zhi ; 47(8): 2257-2265, 2022 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-35531743

RESUMO

Through literature research and standard retrieval, Corydalis-derived medicinal materials, the origins, and related standards were summarized. Finally, 27 medicinal materials were screened out, involving 71 species(varieties). Among them, only 11 are recorded in Chinese Pharmacopoeia(2020), National Standard for Chinese Patent Drugs·Tibetan Medicine, Tibetan Medicine Standards, and other local standards, including Corydalis Bungeanae Herba and Corydalis Herba. The names and original plants of the medicinal materials are different in different standards, and the phenomena of "same medicinal material with different names" and "same name for different medicinal materials" are prominent. Most standards only include the traits, microscopic identification, and physico-chemical property identification, with unsound quality criteria. Thus, efforts should be made to strengthen the sorting of Corydalis medicinal plants, herbal textual research, and investigation of the resources and utilization. Moreover, via modern techniques, the chemical components and medicinal material basis of different original plants should be explored and sound quality standards should be established to improve the safety and quality of Corydalis-derived medicinal materials. Summarizing Corydalis medicinal plants, Corydalis-derived medicinal materials, and related standards, this study is expected to provide a reference for the standard formulation, quality evaluation, expansion of drug sources, and rational development and utilization of Corydalis resources.


Assuntos
Corydalis , Medicamentos de Ervas Chinesas , Plantas Medicinais , Medicamentos de Ervas Chinesas/química , Medicina Tradicional Chinesa , Medicina Tradicional Tibetana , Plantas Medicinais/química , Padrões de Referência
16.
Zhongguo Gu Shang ; 35(5): 448-53, 2022 May 25.
Artigo em Chinês | MEDLINE | ID: mdl-35535533

RESUMO

OBJECTIVE: To explore the clinical effect of percutaneous endoscopic lumbar discectomy in the treatment of adjacent segment lumbar disc herniation after lumbar fusion. METHODS: From February 2010 to June 2018, 64 patients with adjacent segment lumbar disc herniation after lumbar fusion were retrospectively analyzed and divided into observation group and control group. In observation group, there were 23 males and 10 females performed with percutaneous endoscopic lumbar discectomy, including 27 cases of single segment fusion and 6 cases of double segment fusion, aged from 55 to 83 years old with an average of (65.7±7.4) years old. In control group, there were 22 males and 9 females performed with traditional open fusion revision, including 25 cases of single-segment fusion and 6 cases of double segment fusion, aged from 51 to 78 years old with an average of(64.8±7.8) years old. The operative time, intraoperative blood loss, fluoroscopy times, postoperative ambulation time and length of postoperative hospital stay were recorded. The clinical efficacy was evaluated by visual analogue scale(VAS) and Oswestry Disability Index(ODI). The complications between two groups were observed. RESULTS: All patients were followed up for at least 2 years. The observation group patients were followed up with an average of (2.4±0.5) years. The control group patients were followed up with an average of(2.6±0.7) years. Compared with control group, operation time, intraoperative blood loss, postoperative ambulation time and length of postoperative hospital stay of the observation group were significantly reduced (P<0.05), and the fluoroscopy times of observation group were significantly increased compared with control group(P<0.05). The VAS of low back and lower limb, and ODI at the latest follow-up between two groups were all significantly improved compared to those of pre-operation (P<0.05). The VAS of low back at each point and ODI at 1, 3 months after operation in observation group was significantly reduced compared with control group(P<0.05), however there was no significant difference in VAS for lower limb between two groups (P>0.05). The difference of complications between two groups was statistically significant (P<0.05). CONCLUSION: Compared with traditional open fusion revision surgery, percutaneous endoscopic lumbar discectomy for the treatment of adjacent segment lumbar disc herniation after lumbar fusion has the advantages of reducing operation time and intra-operative blood loss, shortening ambulation time and the length of postoperative hospital stay, and promoting pain and functional improvement, and decrease incidence of complications. However, long-term clinical efficacy needs further study.


Assuntos
Discotomia Percutânea , Degeneração do Disco Intervertebral , Deslocamento do Disco Intervertebral , Idoso , Idoso de 80 Anos ou mais , Perda Sanguínea Cirúrgica , Discotomia , Endoscopia , Feminino , Humanos , Degeneração do Disco Intervertebral/cirurgia , Deslocamento do Disco Intervertebral/cirurgia , Vértebras Lombares/cirurgia , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do Tratamento
17.
Environ Sci Technol ; 2022 May 10.
Artigo em Inglês | MEDLINE | ID: mdl-35536552

RESUMO

Understanding the formation and inhibition of more toxic polychlorinated byproducts from the catalytic oxidation elimination of chlorinated volatile organic compounds (Cl-VOCs) and unveiling efficient strategies have been essential and challenging. Here, RuOx supported on CePO4-doped CeO2 nanosheets (Ru/Pi-CeO2) is designed for boosting catalytic oxidation for the removal of dichloromethane (DCM) as a representative Cl-VOC. The promoted acid strength/number and sintering resistance due to the doping of electron-rich and thermally stable CePO4 are observed along with the undescended redox ability and the exposed multi-active sites, which demonstrates a high activity and durability of DCM oxidation (4000 mg/m3 and 15,000 mL/g·h, stable complete-oxidation at 300 °C), exceptional versatility for different Cl-VOCs, alkanes, aromatics, N-containing VOCs, CO and their multicomponent VOCs, and enhanced thermal stability. The suppression of polychlorinated byproducts is determined over Ru/Pi-CeO2 and oxy-anionic S, V, Mo, Nb, or W doping CeO2, thus the oxy-anionic doping strategy is proposed based on the quenching of the electron-rich oxy-anions on chlorine radicals. Moreover, the simple mechanical mixing with these oxy-anionic salts is also workable even for other catalysts such as Co, Sn, Mn, and noble metal-based catalysts. This work offers further insights into the inhibition of polychlorinated byproducts and contributes to the convenient manufacture of monolithic catalysts with superior chlorine-poisoning resistance for the catalytic oxidation of Cl-VOCs.

18.
Light Sci Appl ; 11(1): 134, 2022 May 12.
Artigo em Inglês | MEDLINE | ID: mdl-35551174

RESUMO

Three-dimensional (3D) artificial metacrystals host rich topological phases, such as Weyl points, nodal rings, and 3D photonic topological insulators. These topological states enable a wide range of applications, including 3D robust waveguides, one-way fiber, and negative refraction of the surface wave. However, these carefully designed metacrystals are usually very complex, hindering their extension to nanoscale photonic systems. Here, we theoretically proposed and experimentally realized an ideal nodal ring in the visible region using a simple 1D photonic crystal. The π-Berry phase around the ring is manifested by a 2π reflection phase's winding and the resultant drumhead surface states. By breaking the inversion symmetry, the nodal ring can be gapped and the π-Berry phase would diffuse into a toroidal-shaped Berry flux, resulting in photonic ridge states (the 3D extension of quantum valley Hall states). Our results provide a simple and feasible platform for exploring 3D topological physics and its potential applications in nanophotonics.

19.
Front Mol Neurosci ; 15: 828846, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35359575

RESUMO

Objective: Naturally occurring in-frame deletion is a unique type of genetic variations, causing the loss of one or more amino acids of proteins. A number of in-frame deletion variants in an epilepsy-associated gene SCN1A, encoding voltage gated sodium channel alpha unit 1.1 (Nav1.1), have been reported in public database. In contrast to the missense and truncation variants, the in-frame deletions in SCN1A remains largely uncharacterized. Methods: We summarized the basic information of forty-four SCN1A in-frame deletion variants and performed further analysis on six variants identified in our cases with epilepsy. Mutants of the six in-frame deletions and one truncating variant used as comparison were generated and co-transfected with beta-1 and -2 subunits in tsA201 cells, followed by patch clamp recordings. Results: Reviewing all the in-frame deletions showed that they spread over the entire Nav1.1 protein, without obvious "hot spots." The dominant type (54%) was single residue loss. There was no obvious relationship between the length or locations of deletions and their clinical phenotypes. The six in-frame deletions were two single residue deletions (p.M400del and p.I1772del), one microdeletion (p.S128_F130del) and three macrodeletions (p.T303_R322del, p.T160_Y202del, and p.V1335_V1428del). They scatter and affect different functional domains, including transmembrane helices, pore region, and P-loop. Electrophysiological recordings revealed no measurable sodium current in all of the six mutants. In contrast, the truncating mutant p.M1619Ifs*7 that loses a long stretch of peptides retains partial function. Significance: The complete loss-of-function in these shortened, abnormal mutants indicates that Nav1.1 protein is a highly accurate structure, and many of the residues have no redundancy to ion conductance. In-frame deletions caused particularly deleterious effect on protein function possibly due to the disruption of ordered residues.

20.
Angew Chem Int Ed Engl ; 61(26): e202203661, 2022 Jun 27.
Artigo em Inglês | MEDLINE | ID: mdl-35446472

RESUMO

The enantioselective cascade reaction between racemic 2-(1-hydroxyallyl)phenols and alkynols/alkynamides was realized by using a gold and iridium sequential catalytic system. In this procedure, the in situ generated exocyclic vinyl ethers or enamides undergo the asymmetric allylation/spiroketalization with π-ally-Ir amphiphilic species, which provides an efficient and straightforward access to spiroketals and spiroaminals with excellent enantioselectivities. Moreover, racemic 2-(1-hydroxyallyl)anilines were also suitable in this reaction along with a kinetic resolution process, affording enantioenriched spiroaminals and 2-(1-hydroxyallyl)anilines in good yields. The synthetic utility of this method has been demonstrated by efficient enantioselective synthesis of the analogue of Paecilospirone.


Assuntos
Ouro , Irídio , Compostos de Anilina , Catálise , Furanos , Compostos de Espiro , Estereoisomerismo
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