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J Int Med Res ; 49(6): 3000605211026117, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-34182818


Diquat is a widely used herbicide that is substituted for paraquat. With paraquat off the market, cases of diquat poisoning have been gradually increasing. The kidney is the most frequently impaired organ in diquat poisoning. Few cases of multiple organ failure caused by diquat have been reported.We herein describe a 30-year-old man who orally ingested about 160 mL of enriched diquat. Despite aggressive treatment, the patient's condition progressed to multiple organ failure and death. The pulmonary lesions in this patient were different from those previously reported. This patient did not die of renal failure but of severe respiratory failure. He exhibited three different stages of pulmonary disease.The lung lesions in this case were unique. We hope that doctors will pay more attention to the lung lesions in patients with diquat poisoning in future and find new treatment methods to save the lives of such patients.

Herbicidas , Insuficiência Respiratória , Adulto , Diquat , Humanos , Masculino , Insuficiência de Múltiplos Órgãos/induzido quimicamente , Paraquat
BMC Infect Dis ; 21(1): 398, 2021 Apr 29.
Artigo em Inglês | MEDLINE | ID: mdl-33926377


BACKGROUND: Secondary hemophagocytic lymphohistiocytosis (sHLH) is a life-threatening hyperinflammatory event and a fatal complication of viral infections. Whether sHLH may also be observed in patients with a cytokine storm induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is still uncertain. We aimed to determine the incidence of sHLH in severe COVID-19 patients and evaluate the underlying risk factors. METHOD: Four hundred fifteen severe COVID-19 adult patients were retrospectively assessed for hemophagocytosis score (HScore). A subset of 7 patients were unable to be conclusively scored due to insufficient patient data. RESULTS: In 408 patients, 41 (10.04%) had an HScore ≥169 and were characterized as "suspected sHLH positive". Compared with patients below a HScore threshold of 98, the suspected sHLH positive group had higher D-dimer, total bilirubin, alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, serum creatinine, triglycerides, ferritin, interleukin-6, C-reactive protein, procalcitonin, lactate dehydrogenase, creatine kinase isoenzyme, troponin, Sequential Organ Failure Assessment (SOFA) score, while leukocyte, hemoglobin, platelets, lymphocyte, fibrinogen, pre-albumin, albumin levels were significantly lower (all P < 0.05). Multivariable logistic regression revealed that high ferritin (>1922.58 ng/mL), low platelets (<101 × 109/L) and high triglycerides (>2.28 mmol/L) were independent risk factors for suspected sHLH in COVID-19 patients. Importantly, COVID-19 patients that were suspected sHLH positive had significantly more multi-organ failure. Additionally, a high HScore (>98) was an independent predictor for mortality in COVID-19. CONCLUSIONS: HScore should be measured as a prognostic biomarker in COVID-19 patients. In particular, it is important that HScore is assessed in patients with high ferritin, triglycerides and low platelets to improve the detection of suspected sHLH.

COVID-19/complicações , Linfo-Histiocitose Hemofagocítica/etiologia , Adulto , Idoso , Aspartato Aminotransferases/sangue , COVID-19/epidemiologia , COVID-19/terapia , China/epidemiologia , Comorbidade , Síndrome da Liberação de Citocina/complicações , Síndrome da Liberação de Citocina/virologia , Feminino , Ferritinas/sangue , Humanos , Incidência , Contagem de Linfócitos , Linfo-Histiocitose Hemofagocítica/epidemiologia , Linfo-Histiocitose Hemofagocítica/mortalidade , Masculino , Pessoa de Meia-Idade , Mortalidade , Estudos Retrospectivos , Fatores de Risco
Med Sci Monit ; 24: 614-622, 2018 Jan 31.
Artigo em Inglês | MEDLINE | ID: mdl-29382813


BACKGROUND There is no adequate evidence on how the long duration of laparoscopic surgery affects splanchnic perfusion in elderly patients or the efficacy of acute hypervolemic fluid infusion (AHFI) during the induction of anesthesia. Our aim was to observe the effects of AHFI during the induction of general anesthesia on splanchnic perfusion. MATERIAL AND METHODS Seventy elderly patients receiving laparoscopic colorectal surgery were randomly divided into three groups: lactated Ringer's solution group (group R), succinylated gelatin group (group G), and hypertonic sodium chloride hydroxyethyl starch 40 injection group (group H). Thirty minutes after the induction of general anesthesia, patients received an infusion of target dose of these three solutions. Corresponding hemodynamic parameters, arterial blood gas analysis, and gastric mucosal carbon dioxide tension were monitored in sequences. RESULTS In all three groups, gastric-arterial partial CO2 pressure gaps (Pg-aCO2) were decreased at several beginning stages and then gradually increased, Pg-aCO2 also varied between groups due to certain time points. The pH values of gastric mucosa (pHi) decreased gradually after the induction of pneumoperitoneum in the three groups. CONCLUSIONS The AHFI of succinylated gelatin (12 ml/kg) during the induction of anesthesia can improve splanchnic perfusion in elderly patients undergoing laparoscopic surgery for colorectal cancer and maintain good splanchnic perfusion even after a long period of pneumoperitoneum (60 minutes). AHFI can improve splanchnic perfusion in elderly patients undergoing laparoscopic colorectal surgery.

Cirurgia Colorretal , Laparoscopia , Perfusão , Circulação Esplâncnica , Idoso , Anestesia , Gasometria , Perda Sanguínea Cirúrgica , Feminino , Hemodiluição , Hemodinâmica , Humanos , Masculino , Fatores de Tempo
Medicine (Baltimore) ; 96(45): e8612, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-29137091


The aim of this study is to assess the effects of hypervolemic infusion with different solutions on microcirculation perfusion during laparoscopic colorectal surgery.Thirty-six patients were randomly divided into Ringer lactate solution [RL] group, succinylated gelatin injection [Gel] group, and hypertonic saline hydroxyethyl starch 40 injection [HS] group. Hypervolemic infusion was performed during the induction period of general anesthesia. Arterial blood-gas parameters, noninvasive hemodynamics, gastric tonometry values, and central venous pressure (CVP) were compared at baseline (T1); the end of hypervolemic infusion (T2); 5 min (T3), 15 min (T4), 30 min (T5), and 60 min (T6) during pneumoperitoneum; 5 min (T7), 15 min (T8), and 25 min (T9) after pneumoperitoneum. Patients were also grouped by age for further comparisons.The hematocrit levels of all groups after T2 decreased. The gastric mucosal-arterial carbon dioxide partial pressure (Pg-aCO2) started to decrease after T2 and rebounded after T5. There was no difference in the gastric mucosal perfusion when compared between 3 groups. The blood Na of HS group increased significantly after T2, then gradually restored and returned to baseline by T8. The plasma bicarbonate (HCO3) levels of RL and Gel groups elevated from T2 to T7, after which they started to decrease, but this phenomenon was not significant in HS group. In both RL and Gel groups, blood pressure has a significant fluctuation in elder patients.Hypervolemic infusion of these solutions during the induction of anesthesia can improve gastric mucosal perfusion. HS can maintain a more stable hemodynamic effect when used with caution in patients with preoperative hypernatremia.

Colo/cirurgia , Procedimentos Cirúrgicos do Sistema Digestório , Hidratação , Laparoscopia , Microcirculação , Reto/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Anestesia Geral , Gelatina/administração & dosagem , Hematócrito , Humanos , Derivados de Hidroxietil Amido/administração & dosagem , Cuidados Intraoperatórios , Soluções Isotônicas/administração & dosagem , Pessoa de Meia-Idade , Lactato de Ringer , Solução Salina Hipertônica/administração & dosagem , Succinatos/administração & dosagem
Surg Laparosc Endosc Percutan Tech ; 20(1): 54-7, 2010 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-20173623


OBJECTIVE: The aim of this study was to compare the anesthetic outcomes of elderly and younger patients perioperatively, and to evaluate the safety of this procedure in elderly. METHODS: A total of 25 patients undergoing elective laparoscopic colorectal surgery were enrolled in this study prospectively. Ten patients were more than or equal to 70 years (Group E) and 15 patients were less than or equal to 69 years (Group Y). The parameters between groups for perioperative hemodynamics, arterial blood chemistry, and perfusion of intraabdominal organs were recorded and compared periodically from before induction of anesthesia till after the operation. RESULTS: Group E had a higher ASA degree (P<0.01) than group Y. During the operation, the HCO3 and PaCO2 value increased whereas the pH value decreased significantly. All these parameters recovered gradually at the end of the surgery; some serum electrolytes decreased, especially K and Ca. The central venous pressure increased after volume expansion and the beginning of operation, and then decreased postoperatively. Mean arterial pressure had a marked change during volume expansion period and early after the induction of anesthesia. pHi decreased when the operation began. PgCO2 increased significantly at the end of the surgery. Central venous pressure of group E was higher than that of group Y at 5 minutes during operation, whereas mean arterial pressure of elder group was lower than that of younger group at 15 minutes after the end of operation. Other hemodynamic parameters did not differ significantly from the results. CONCLUSION: There is no significantly adverse effect for elderly patients during perioperative period. Adequate intraoperative administration and monitoring are beneficial for maintaining a safe anesthesia.

Dióxido de Carbono , Colo/cirurgia , Laparoscopia/efeitos adversos , Assistência ao Paciente , Pneumoperitônio Artificial/efeitos adversos , Reto/cirurgia , Segurança , Fatores Etários , Idoso , Anestesia Geral , Gasometria , China , Feminino , Mucosa Gástrica , Humanos , Laparoscopia/métodos , Laparoscopia/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Assistência Perioperatória , Pneumoperitônio Artificial/métodos , Pneumoperitônio Artificial/estatística & dados numéricos , Estudos Prospectivos , Medição de Risco
Zhonghua Wei Chang Wai Ke Za Zhi ; 12(3): 244-8, 2009 May.
Artigo em Chinês | MEDLINE | ID: mdl-19434530


OBJECTIVE: To compare the outcomes of laparoscopic colorectal surgery in elderly (> or = 70 years) and younger(< 70 years) patients, and to evaluate the safety of laparoscopic colorectal surgery in elderly. METHODS: From Aug. 2007 to Dec. 2007, 25 patients with colorectal cancer undergone laparoscopic colorectal surgery were studied prospectively. Ten patients aged 70 years or older(Elder Group), and 15 patients less than 70 years(Younger Group). The parameters of perioperative hemodynamics, blood chemistry, and intraabdominal organs perfusion were recorded periodically during operation and compared between the two groups. RESULTS: Elder group had a higher ASA degree(P<0.01). Mean age, height, weight, the classification of the disease, operative time, blood loss and complication were not significantly different between the two groups. The HCO(3) value and PaCO(2) value increased significantly intraoperatively, while the pH value decreased significantly. These parameters returned to basal line at the end of operation, with the decreased electrolytes, especially the kaliopenia and hypocalcemia. The CVP increased significantly at the beginning of operation and after fluid expansion, and decreased postoperatively. Gastric mucosal pH(pHi) decreased when the operation began. The partial pressure of gastric mucosa(PgCO(2)) increased significantly at the end of operation. Other parameters of hemodynamics including HR, CI, and SI were not significantly different during operation. The CVP of elder group was higher than that of younger group at 5 min after the beginning of the operation, while the MAP of elder group was lower than that of younger at 15 min after the end of the operation. Other parameters of hemodynamics including oxygenation, perfusion, and blood chemistry were not significantly different. CONCLUSIONS: For laparoscopic colorectal surgery, no significant adverse response attributes to elderly patients. The compensation capacity of the elderly is lower. With the reasonable anesthesia administration, the adverse response can be controlled effectively.

Neoplasias Colorretais/cirurgia , Laparoscopia/efeitos adversos , Fatores Etários , Idoso , Humanos , Pessoa de Meia-Idade , Estudos Prospectivos